Expression of vascular endothelial growth factor and endothelial nitric oxide synthase is increased in the placenta of sheep at high altitude in the Andes

Canadian Journal of Veterinary Research

Volumn 74, Issue 3, 2010, Pages 193-199

  Parraguez, Víctor H ^a,b   Atlagich, Miljenko A ^a   Urquieta, Bessie ^a   Galleguillos, Marco ^a   De Los Reyes, Mónica ^a   Kooyman, David L ^c   Araneda, Silvia ^c   Raggi, Luis A ^a,b  

^a UNIVERSITY OF CHILE   (Chile)

^b BRIGHAM YOUNG UNIVERSITY   (United States)

^c UNIVERSITÉ LYON 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; VASCULOTROPIN;

ALTITUDE; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HYPOXIA; IMMUNOHISTOCHEMISTRY; NONHUMAN; PLACENTA DEVELOPMENT; PREGNANCY; PROTEIN EXPRESSION; VASCULARIZATION;

ALTITUDE; ANIMALS; BLOOD GAS ANALYSIS; FEMALE; FETAL DEVELOPMENT; GENE EXPRESSION REGULATION, ENZYMOLOGIC; NITRIC OXIDE SYNTHASE TYPE III; PLACENTA; PREGNANCY; SHEEP; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA; OVIS ARIES;

EID: 78649559610     PISSN: 08309000     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. De Carolis G. Descripción del sistema ganadero y hábitos alimentarios de camélidos domésticos y ovinos en el bofedal de Parinacota. Section 4.1.4. Manejo reproductivo. [dissertation]. Santiago, Chile: Universidad de Chile, 1987. 146-164.
2. Huddleston B, Ataman E, de Salvo P, et al. Towards a GIS-based analysis of mountain environments and populations. Section 4.3: Main farming systems in mountain areas. Environment and natural resources working paper 10. Rome, Italy: Food and Agriculture Organization of the United Nations. 2003. 13-16.
3. Barry JS, Anthony RV. The pregnant sheep as a model for human pregnancy. Theriogenology 2008; 69:55-67.
4. Moore LG, Niermeyer S, Zamudio S. Human adaptation to high altitude: Regional and life-cycle perspectives. Am J Phys Anthropol 1998; Suppl 27:25-64.
5. Parraguez VH, Atlagich MA, Behn C, Bruzzone ME, Raggi LA. Fertility in ewes at high altitude: Comparison between animals with long- and short-time residence at high altitude and the effect of antioxidant vitamins. Reprod Dom Anim 2006; 41:372.
6. Parraguez VH, Atlagich M, Díaz R, Bruzzone ME, Behn C, Raggi LA. Effect of hypobaric hypoxia on lamb intrauterine growth: Comparison between high and low altitude native ewes. Reprod Fertil Dev 2005; 17:497-505.
7. Parraguez VH, Atlagich M, Díaz R, et al. Ovine placenta at high altitudes: Comparison of animals with different times of adaptation to hypoxic environment. Anim Reprod Sci 2006; 95:151-157. Epub 2005 Dec 5.
8. Borowicz PP, Arnold DR, Johnson ML, Grazul-Bilska AT, Redmer DA, Reynolds LP. Placental growth throughout the last two thirds of pregnancy in sheep: Vascular development and angiogenic factor expression. Biol Reprod 2007; 76:259-267.
9. Reynolds LP, Borowicz PP, Vonnahme KA, et al. Placental angiogenesis in sheep models of compromised pregnancy. J Physiol 2005; 565:43-58. Epub 2005 Mar 10.
10. Semenza GL. HIF-1, O2, and the 3 PHDs: How animal cells signal hypoxia to the nucleus. Cell 2001; 107:1-3.
11. Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998; 394:485-490.
12. Kroll J, Waltenberger J. VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR). Biochem Biophys Res Commun 1998; 252:743-746.
13. Bouloumié A, Schini-Kerth VB, Busse R. Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells. Cardiovasc Res 1999; 41:773-780.
14. Ziche M, Morbidelli L, Choudhuri R, et al. Nitric oxide synthase lies downstream from vascular endothelial growth factorinduced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest 1997; 99:2625-2634.
15. Papapetropoulus A, García-Cardeña G, Madri JA, Sessa WC. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest 1997; 100:3131-3139.
16. Matsumoto LC, Bogic L, Brace RA, Cheung CY. Prolonged hypoxia upregulates vascular endothelial growth factor messenger RNA expression in ovine fetal membranes and placenta. Am J Obstet Gynecol 2002; 186:303-310.
17. Xiao D, Bird IM, Magness RR, Longo LD, Zhang L. Upregulation of eNOS in pregnant ovine uterine arteries by chronic hypoxia. Am J Physiol Heart Circ Physiol 2001; 280:H812-H820.
18. Committee on Animal Nutrition, National Research Council. Nutrient Requirements of Sheep. 6th ed. Washington, DC: National Acad Pr, 1985. pp. 45.
19. Girish V, Vijayalakshmi A. Affordable image analysis using NIH image/ImageJ [letter]. Indian J Cancer 2004; 41:47.
20. Parraguez VH, Atlagich M, Díaz R, Bruzzone ME, Behn C, Raggiz LA. Lambs growth at high altitude: Comparison between animals with different time of adaptation to hypoxic environment. Agro-Ciencia 2004; 20:39-45.
21. Kaufmann P, Mayhew TM, Charnock-Jones DS. Aspects of human fetoplacental vasculogenesis and angiogenesis. II. Changes during normal pregnancy. Placenta 2004; 25:114-126.
22. Kingdom JC, Kaufmann P. Oxygen and placental vascular development. Adv Exp Med Biol 1999; 474:259-275.
23. Padavala S, Pope N, Baker P, Crocker I. An imbalance between vascular endothelial growth factor and its soluble receptor in placental villous explants of intrauterine growth-restricted pregnancies. J Soc Gynecol Investig 2006; 13:40-47. Epub 2005 Nov 21.
24. Bdolah Y, Karumanchi SA, Sachs BP. Recent advances in understanding preeclampsia. Croat Med J 2005; 46:728-736.
25. Wang GL, Semenza GL. General involvement of hypoxia inducible factor-1 in transcriptional response to hypoxia. Proc Natl Acad Sci U S A 1993; 90:4304-4308.
26. 2 tension. Proc Natl Acad Sci U S A 1995; 92:5510-5514.
27. Lee JW, Bae SH, Jeong JW, Kim SH, Kim KW. Hypoxia-inducible factor (HIF-1)a: Its protein stability and biological functions. Exp Mol Med 2004; 36:1-12.
28. Gao W, Gao Y, Zhang G, Song L, Sun B, Shi J. Hypoxia-induced expression of HIF-1a and its target genes in umbilical venous endothelial cells of Tibetans and immigrant Han. Comp Biochem Physiol 2005; 141:93-100.
29. Tissot van Patot MC, Bendrick-Peart J, Beckey VE, Serkova N, Zwerdlinger L. Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 2004; 287:L525-L532.
30. Arroyo JA, Anthony RV, Parker TA, Galan HL. Differential expression of placental vascular endothelial nitric oxide synthase in an ovine model of fetal growth restriction. Am J Obstet Gynecol 2006; 195:771-777.
31. Kiss H, Schneeberger C, Tschugguel W, et al. Expression of endothelial (type III) nitric oxide synthase in cytotrophoblastic cell lines: Regulation by hypoxia and inflammatory cytokines. Placenta 1998; 19:603-611.
32. Faxén M, Nisell H, Kublickiene KR. Altered mRNA expression of ecNOS and iNOS in myometrium and placenta from women with preeclampsia. Arch Gynecol Obstet 2001; 265:45-50.
33. Schmid M, Sollwedel A, Thuere C, et al. Murine preeclampsia induced by unspecific activation of the immune system correlates with alterations in the eNOS and AT1 receptor expression in the kidneys and placenta. Placenta 2007; 28:688-700.
34. Jensen E, Wood CE, Keller-Wood M. Reduction of maternal adrenal steroids results in increased VEGF protein without increased eNOS in the ovine placenta. Placenta 2007; 28:658-667.
35. Asenjo R. Efecto de la hipoxia hipobárica en las concentraciones plasmáticas maternas y fetales de cortisol, glucosa e insulina en ovinos adaptados y no adaptados a la altura [dissertation]. Santiago, Chile: Universidad de Chile, 2006. 27-31.
36. Myers DA, Hyatt K, Mlynarczyk M, Bird IM, Ducsay CA. Longterm hypoxia represses the expression of key genes regulating cortisol biosynthesis in the near term ovine fetus. Am J Physiol Integr Comp Physiol 2005; 289:R1707-R1714.