Upregulation of eNOS in pregnant ovine uterine arteries by chronic hypoxia

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 280, Issue 2 49-2, 2001, Pages

  Xiao, Daliao ^a   Bird, Ian M ^b   Magness, Ronald R ^b   Longo, Lawrence D ^a   Zhang, Lubo ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Endothelial nitric oxide synthase; Endothelium; Gene expression; High altitude

Indexed keywords

8 BROMO CYCLIC GMP; CALCIMYCIN; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; NORADRENALIN;

ALTITUDE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; GENE EXPRESSION; HYPOXIA; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; SHEEP; UTERINE ARTERY;

EID: 0035008375     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.280.2.h812     Document Type: Article

References (38)

1. Arnet UA, McMillan A, Dinerman JL, Ballermann B, and Lowenstein CJ. Regulation of endothelial nitric-oxide synthase during hypoxia. J Biol Chem 271: 15069-15073, 1996.
2. Bird IM, Sullivan JA, Di T, Cale JM, Zhang L, Zheng J, and Magness RR. Pregnancy-dependent changes in cell signaling underlie changes in differential control of vasodilator production in uterine artery endothelial cells. Endocrinology 141: 1107-1117, 2000.
3. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
4. Conrad KP, Joffe GM, Kruszyna H, Kruszyna R, Rochelle LG, Smith RP, Charvez JE, and Mosher MD. Identification of increased nitric oxide biosynthesis during pregnancy in rats. FASEB J 7: 566-571, 1993.
5. 1-adrenergic receptors in the ovine uterine artery: function and binding studies. Am J Physiol Heart Circ Physiol 270: H1001-H1007, 1996.
6. Hu XQ, Yang S, Pearce WJ, Longo LD, and Zhang L. Effect of chronic hypoxia on alpha-1 adrenoceptor-mediated inositol 1,4,5-trisphosphate signaling in ovine uterine artery. J Pharmacol Exp Ther 288: 977-983, 1999.
7. Hu XQ and Zhang L. Chronic hypoxia suppresses pharmacomechanical coupling of the uterine artery in near-term pregnant sheep. J Physiol (Lond) 499: 551-559, 1997.
8. Isaacson TC, Hampl V, Weir EK, Nelson DP, and Archer SL. Increased endothe hum-derived nitric oxide in hypertensive pulmonary circulation of chronically hypoxic rats. J Appl Physiol 76: 933-940, 1994.
9. Kamitomo M, Longo LD, and Gilbert RD. Right and left ventricular function in fetal sheep exposed to long-term high-altitude hypoxemia. Am J Physiol Heart Circ Physiol 262: H399-H405, 1992.
10. Koga T, Yoshida Y, Cai JQ, and Imai S. Purification and characterization of 240-kDa cGMP-dependent protein kinase substrate of vascular smooth muscle. Close resemblance to inositol 1,4,5-trisphosphate receptor. J Biol Chem 269: 11640-11647, 1994.
11. Komalavilas P and Lincoln TM. Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase. J Biol Chem 269: 8701-8707, 1994.
12. Kondo S, Kono T, Samder DN, and McKenzie RC. IL-8 gene expression and production in human keratinocytes and their modulation by UVB. J Invest Dermatol 101: 690-694, 1993.
13. Kozak M. An analysis of vertebrate mRNA sequences: intimations of translational control. J Cell Biol 115: 887-903, 1991.
14. Le Cras TD, Tyler RC, Horan MP, Morris KG, Tuder RM, McMurtry IF, Johns A RA, and Abman SH. Effects of chronic hypoxia and altered heimodynamics on endothelial nitric oxide synthase expression in the adult rat lung. J Clin Invest 101: 795-801, 1998.
15. Le Cras TD, Xue C, Rengasmy A, and Johns RA. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am J Physiol Lung Cell Mol Physiol 270: L164-L170, 1996.
16. Liao JK, Zulueta JJ, Yu FS, Peng HB, Cote CG, and Hassoun PM. Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen. J Clin Invest 96: 2661-2666, 1995.
17. Magness RR, Shaw CE, Phernetton TM, Zheng J, and Bird IM. Endothelial vasodilator production by uterine and systemic arteries. II. Pregnancy effects on NO synthase expression. Am J Physiol Heart Circ Physiol 272: H1730-H1740, 1997.
18. McQuillan LP, Leung GK, Marsden PA, Kostyk SK, and Kourembanas S. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. Am J Physiol Heart Circ Physiol 267: H1921-H1927, 1994.
19. Miller VM and Vanhoutte PM. Enhanced release of endothelium-derived factor(s) by chronic increases in blood flow. Am J Physiol Heart Circ Physiol 255: H446-H451, 1988.
20. Moore LG, Hershey DW, Jahhigen D, and Bowes W. The incidence of pregnancy-induced hypertension is increased among Colorado residents of high altitude. Am J Obstet Gynecol 144: 423-429, 1982.
21. Moore LG, Brodeur P, Chumbe O, D'Brot J, Hofmeister S, and Monge C. Maternal hypoxic ventilatory response, ventilation and birth weight at 4,300 m. J Appl Physiol 60: 1401-1406, 1986.
22. Nelson SH and Suresh MS. Comparison of nitroprusside and hydralazine in isolated uterine arteries from pregnant and non-pregnant patients. Anesthesiology 68: 541-547, 1988.
23. Ni Y, Meyer M, and Osol G. Gestation increases nitric oxide-mediated vasodilation in rat uterine arteries. Am J Obstet Gynecol 176: 856-864, 1997.
24. Phelan MW and Faller DV. Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells. J Cell Physiol 167: 469-476, 1996.
25. Ranjan V, Xiao Z, and Diamond SL. Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress. Am J Physiol Heart Circ Physiol 269: H550-H555, 1995.
26. Resta TC, Chicoine LG, Omdahl JL, and Walker BR. Maintained upregulation of pulmonary eNOS gene and protein expression during recovery from chronic hypoxia. Am J Physiol Heart Circ Physiol 276: H699-H708, 1999.
27. Resta TC and Walker BR. Chronic hypoxia selectively augments endothelium-dependent pulmonary arterial vasodilation. Am J Physiol Heart Circ Physiol 270: H888-H896, 1996.
28. Shaul PW, North AJ, Brannon TS, Ujiie K, Wells LB, Nisen PA, Lowenstein CJ, Snyder SH, and Star RA. Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung. Am J Respir Cell Mol Biol 13: 167-174, 1995.
29. Sladek SM, Magness RR, and Conrad KP. Nitric oxide and pregnancy. Am J Physiol Regulatory Integrative Comp Physiol 272: R441-R463, 1997.
30. Toporsian M, Govindaraju K, Nagi M, Eidelman D, Thibault G, and Ward ME. Downregulation of endothelial nitric oxide synthase in rat aorta after prolonged hypoxia in vivo. Circ Res 86: 671-675, 2000.
31. 1-adrenergic stimulation. J Appl Physiol 85: 2322-2329, 1998.
32. White MM, McCullough RE, Dyckes R, Robertson AD, and Moore LG. Chronic hypoxia, pregnancy, and endothelium-mediated relaxation in guinea pig uterine and thoracic arteries. Am J Physiol Heart Circ Physiol 278: H2069-H2075, 2000.
33. Xiao DL, Liu Y, Pearce WJ, and Zhang L. Endothelial nitric oxide release in isolated perfused ovine uterine arteries: effect of pregnancy. Eur J Pharmacol 367: 223-230, 1999.
34. Zamudio S, Palmer SK, Dahms TE, Berman JC, Young DA, and Moore LG. Alterations in uteroplacental blood flow precede hypertension in preeclampsia at high altitude. J Appl Physiol 79: 15-22, 1995.
35. Zamudio S, Palmer SK, Droma T, Stamm E, Coffin C, and Moore LG. Effects of altitude on uterine artery blood flow during normal pregnancy. J Appl Physiol 79: 7-14, 1995.
36. Zhang L, Hu XQ, and Pearce WJ. Chronic hypoxia suppresses pharmacomechanical coupling in the uterine artery of near-term pregnant sheep: role of cGMP (Abstract). J Soc Gynecol Investig 4: 88A, 1997.
37. 2+ sensitivity of myofilaments in uterine arteries. Am J Physiol Heart Circ Physiol 274: H132-H138, 1998.
38. Zhang L, Xiao DL, and Bouslough DB. Chronic hypoxia increase plasma nitrate levels in pregnant ewes and their fetuses. Am J Obstet Gynecol 179: 1594-1598, 1998.