Hypoxia-induced expression of HIF-1α and its target genes in umbilical venous endothelial cells of Tibetans and immigrant Han

Comparative Biochemistry and Physiology - C Toxicology and Pharmacology

Volumn 141, Issue 1, 2005, Pages 93-100

  Gao, Wenxiang ^a   Gao, Yuqi ^a   Zhang, Guobing ^a   Song, Ling ^a   Sun, Bingyong ^a   Shi, JingQuan ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

HIF 1 ; Hypoxia; NOS; Tibetan; VEGF

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; OXYGEN; VASCULOTROPIN;

ALTITUDE ACCLIMATIZATION; ARTICLE; CELL CULTURE; CHINA; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ETHNIC GROUP; FEMALE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; HYPOXIA; IMMIGRANT; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME SERIES ANALYSIS; UMBILICAL VEIN; UPREGULATION; WESTERN BLOTTING;

EID: 21844453669     PISSN: 15320456     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2005.05.006     Document Type: Article

References (31)

1. P. Carmeliet, Y. Dor, J.M. Herbert, D. Fukumura, K. Brusselmans, M. Dewerchin, M. Neeman, F. Bono, R. Abramovitch, P. Maxwell, C.J. Koch, P. Ratcliffe, L. Moons, R.K. Jain, D. Collen, and E. Keshert Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis Nature 394 1998 485 490
2. J.A. Forsythe, B.H. Jiang, N.V. Iyer, F. Agani, S.W. Leung, R.D. Koos, and G.L. Semenza Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 Mol. Cell. Biol. 16 1996 4604 4613
3. P.W. Hochachka, J.L. Rupert, and C. Monge Adaptation and conservation of physiological systems in the evolution of human hypoxia tolerance Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 124 1999 1 17
4. E.C. Hoffman, H. Reyes, F.F. Chu, F. Sander, L.H. Conley, B.A. Brooks, and O. Hankinson Cloning of a factor required for activity of the Ah (dioxin) receptor Science 252 1991 954 958
5. L.E. Huang, Z. Arany, D.M. Livingston, and H.F. Bunn Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit J. Biol. Chem. 271 1996 32253 32259
6. 2-dependent degradation domain via the ubiquitin-proteasome pathway Proc. Natl. Acad. Sci. U. S. A. 95 1998 7987 7992
7. E.A. Jaffe, R.L. Nachman, C.G. Becker, and C.R. Minick Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria J. Clin. Invest. 52 1973 2745 2756
8. B.H. Jiang, E. Rue, G.L. Wang, R. Roe, and G.L. Semenza Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1 J. Biol. Chem. 271 1996 17771 17778
9. 2 tension Am. J. Physiol. 271 1996 C1172 C1180
10. P.J. Kallio, I. Pongratz, K. Gradin, J. McGuire, and L. Poellinger Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor Proc. Natl. Acad. Sci. U. S. A. 94 1997 5667 5672
11. P.J. Kallio, W.J. Wilson, S. O'Brien, Y. Makino, and L. Poellinger Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway J. Biol. Chem. 274 1999 6519 6525
12. L.P. McQuillan, G.K. Leung, P.A. Marsden, S.K. Kostyk, and S. Kourembanas Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms Am. J. Physiol. 267 1994 H1921 H1927
13. G. Melillo, T. Musso, A. Sica, L.S. Taylor, G.W. Cox, and L. Varesio A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter J. Exp. Med. 182 1995 1683 1693
14. L.G. Moore, F. Armaza, M. Villena, and E. Vargas Comparative aspects of high-altitude adaptation in human populations Adv. Exp. Med. Biol. 475 2000 45 62
15. L.G. Moore, D. Young, R.E. McCullough, T. Droma, and S. Zamudio Tibetan protection from intrauterine growth restriction (IUGR) and reproductive loss at high altitude Am. J. Human Biol. 13 2001 635 644
16. L.G. Moore, S. Zamudio, J. Zhuang, S. Sun, and T. Droma Oxygen transport in Tibetan women during pregnancy at 3,658 m Am. J. Phys. Anthropol. 114 2001 42 53
17. L.A. Palmer, G.L. Semenza, M.H. Stoler, and R.A. Johns Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1 Am. J. Physiol. 274 1998 L212 L219
18. H.E. Ryan, J. Lo, and R.S. Johnson HIF-1 alpha is required for solid tumor formation and embryonic vascularization EMBO J. 17 1998 3005 3015
19. S. Salceda, and J. Caro Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes J. Biol. Chem. 272 1997 22642 22647
20. 2 homeostasis Curr. Opin. Genet. Dev. 8 1998 588 594
21. 2 homeostasis by hypoxia-inducible factor 1 Annu. Rev. Cell Dev. Biol. 15 1999 551 578
22. G.L. Semenza, and G.L. Wang A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation Mol. Cell. Biol. 12 1992 5447 5454
23. G.L. Semenza, B.H. Jiang, S.W. Leung, R. Passantino, J.P. Concordet, P. Maire, and A. Giallongo Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1 J. Biol. Chem. 271 1996 32529 32537
24. P.W. Shaul, A.J. North, T.S. Brannon, K. Ujiie, L.B. Wells, P.A. Nisen, C.J. Lowenstein, S.H. Snyder, and R.A. Star Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung Am. J. Respir. Cell Mol. Biol. 13 1995 167 174
25. K. Suzuki, T. Kizaki, Y. Hitomi, M. Nukita, K. Kimoto, N. Miyazawa, K. Kobayashi, Y. Ohnuki, and H. Ohno Genetic variation in hypoxia-inducible factor 1 alpha and its possible association with high altitude adaptation in Sherpas Med. Hypotheses 61 2003 385 389
26. M.C. Tissot van Patot, J. Drick-Peart, V.E. Beckey, N. Serkova, and L. Zwerdlinger Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia Am. J. Physiol., Lung Cell. Mol. Physiol. 287 2004 L525 L532
27. G.L. Wang, and G.L. Semenza General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia Proc. Natl. Acad. Sci. U. S. A. 90 1993 4304 4308
28. 2 tension Proc. Natl. Acad. Sci. U. S. A. 92 1995 5510 5514
29. G.L. Wang, and G.L. Semenza Purification and characterization of hypoxia-inducible factor 1 J. Biol. Chem. 270 1995 1230 1237
30. R.H. Wenger, I. Kvietikova, A. Rolfs, M. Gassmann, and H.H. Marti Hypoxia-inducible factor-1 alpha is regulated at the post-mRNA level Kidney Int. 51 1997 560 563
31. Zhan,W.H., 1989. [Morphology and histology of the placenta from parturients of various nationalities in the Tibet plateau]. Zhonghua Fu Chan Ke. Za Zhi. 24, 341-3, 381.