The antioxidant enzyme GPX1 gene polymorphisms are associated with low BMD and increased bone turnover markers

Disease Markers

Volumn 29, Issue 2, 2010, Pages 71-80

  Mlakar, Simona Jurkovic ^a   Osredkar, Josko ^a   Prezelj, Janez ^a   Marc, Janja ^b  

^a UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

bone mineral density; glutathione peroxidase 1; osteocalcin; Osteoporosis; oxidative stress

Indexed keywords

ANTIOXIDANT; BIOCHEMICAL MARKER; CARBOXY TERMINAL TELOPEPTIDE; GLUTATHIONE PEROXIDASE 1; OSTEOCALCIN;

AGED; ARTICLE; BONE DENSITY; BONE TURNOVER; DNA POLYMORPHISM; FEMALE; FEMUR NECK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; OSTEOPOROSIS; PRIORITY JOURNAL;

EID: 78649517604     PISSN: 02780240     EISSN: None     Source Type: Journal    
DOI: 10.3233/DMA-2010-0728     Document Type: Article

References (51)

1. B. Oh, S.Y. Kim, D.J. Kim, J.Y. Lee, J.K. Lee, K. Kimm, B.L. Park, H.D. Shin, T.H. Kim, E.K. Park, J.M. Koh and G.S. Kim, Associations of catalase gene polymorphisms with bone mineral density and bone turnover markers in postmenopausal women, J Med Genet 44 (2007), e62.
2. M. Almeida, L. Han, M. MartinMillan, L.I. Plotkin, S.A. Stewart, P.K. Roberson, S. Kousteni, C.A. Obrien, T. Bellido, A.M. Parfitt, R.S. Weinstein, R.L. Jilka and S.C. Manolagas, Skeletal involution by ageassociated oxidative stress and its acceleration by loss of sex steroids, J Biol Chem 282(37) (2007), 27285-27297.
3. M. Peacock, C.H. Turner, M.J. Econs and T. Foroud, Genetics of Osteoporosis, Endocr Rev 23(3) (2002), 303-326.
4. L.G. Raisz, Pathogenesis of osteoporosis: concepts, conflicts, and prospects, J Clin Invest 115(12) (2005), 3318-3325. Review.
5. J.A. Eisman, Genetics of osteoporosis, Endoc Rev 20 (1999), 788-804. Review.
6. M.A. SanchezRodriguez, M. RuizRamos, E. CorreaMunoza and V.M. MendozaNunez, Oxidative stress as a risk factor for osteoporosis in elderly Mexicans as characterized by antioxidant enzymes, BMCMusculoskelet Disord 8 (2007), 124.
7. S. Ozgocmen, H. Kaya, E. Fadillioglu, R. Aydogan and Z. Yilmaz, Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis, Mol Cell Biochem 295(1-2) (2007), 45-52.
8. D. Maggio, M. Barabani, M. Pierandrei, M.C. Polidori, M. Catani, P. Mecocci, U. Senin, R. Pacifici and A. Cherubini, Marked decrease in plasma antioxidants in aged osteoporotic women: results of a crosssectional study, J Clin Endocrinol Metab 88(4) (2003), 1523-1527.
9. M. Hahn, G.M.M. Conterato, C.P. Frizzo, P.R. Augusti, J.C. da Silva, T.C. Unfer and T. Emanuelli, Effects of bone disease and calcium supplementation on antioxidant enzymes in postmenopausal women, Clin Biochem 41(2008), 69-74.
10. J.M. Lean, C.J. Jagger, B. Kirstein, K. Fuller and T.J. Chambers, Hydrogen peroxide is essential for estrogendeficiency bone loss and osteoclast formation, Endocrinology 146(2) (2005), 728-735.
11. S. Basu, K. Michaelsson, H. Olofsson, S. Johansson and H. Melhus, Association between oxidative stress and bone mineral density, Biochem Biophys Res Commun 288(1) (2001), 275-279.
12. J.M. Lean, J.T. Davies, K. Fuller, C.J. Jagger, B. Kirstein, G.A. Partington, Z.L. Urry and T.J. Chambers, A crucial role for thiol antioxidants in estrogendeficiency bone loss, J Clin Invest 112(6) (2003), 915-923.
13. K.M. Surapaneni and G. Venkataramana, Status of lipid peroxidation, glutathione, ascorbic acid, vitamin E and antioxidant enzymes in patients with osteoarthritis, Indian J Med Sci 61(1) (2007), 9-14. (Pubitemid 46045614)
14. S.A. Sheweita and K.I. Khoshhal, Calcium metabolism and oxidative stress in bone fractures: role of antioxidants, Curr Drug Metab 8(5) (2007), 519-525.
15. R.L. Jilka, R.S. Weinstein, A.M. Parfitt and S.C. Manolagas, Quantifying osteoblast and osteocyte apoptosis: challenges and rewards, J Bone Miner Res 22(10) (2007), 1492-1501.
16. C.J. Hurson, J.S. Butler, D.T. Keating, D.W. Murray, D.M. Sadlier, J.M. O Byrne and P.P. Doran, Gene expression analysis in human osteoblasts exposed to dexamethasone identifies altered developmental pathways as putative drivers of osteoporosis, BMC Muskoskelet Disord 8(2007), 12.
17. S. Muthusami, I. Ramachandran, B. Muthusamy, G. Vasudevan, V. Prabhu, V. Subramaniam, A. Jagadeesan and S. Narasimhan, Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats, Clin Chim Acta 360(1-2) (2005), 81-86.
18. I.R. Garrett, B.F. Boyce, R.O. Oreffo, L. Bonewald, J. Poser and G.R. Mundy, Oxygenderived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo, J Clin Invest 85(3) (1990), 632-639.
19. A.A. Fatokun, T.W. Stone and R.A. Smith, Responses of differentiated MC3T3E1 osteoblastlike cells to reactive oxygen species, Eur J Pharmacol 587(1-3) (2008), 35-41.
20. S. Ozgocmen, H. Kaya, E. Fadillioglu and Z. Yilmaz, Effects of calcitonin, risedronate, and raloxifene on erythrocyte antioxidant enzyme activity, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis, Arch Med Res 38(2) (2007), 196-205.
21. A.N. Sontakke and R.S. Tare, A duality in the roles of reactive oxygen species with respect to bone metabolism, Clin Chim Acta 318(1-2) (2002), 145-148.
22. F.Y. Deng, Y.Z. Liu, L.M. Li, C. Jiang, S. Wu, Y. Chen, H. Jiang, F. Yang, J.X. Xiong, P. Xiao, S.M. Xiao, L.J. Tan, X. Sun, X.Z. Zhu, M.Y. Liu, S.F. Lei, X.D. Chen, J.Y. Xie, G.G. Xiao, S.P. Liang and H.W. Deng, Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density, Proteomics 8(20) (2008), 4259-4272.
23. S.J. Pardo, M.J. Patel, M.C. Sykes, M.O. Platt, N.L. Boyd, G.P. Sorescu, M. Xu, J.J. van Loon, M.D. Wang and H. Jo, Simulated microgravity using the Random Positioning Machine inhibits differentiation and alters gene expression profiles of 2T3 preosteoblasts, Am J Physiol Cell Physiol 288(6) (2005), C1211-C1221.
24. Z. Trošt, R. Trebše, J. Preželj, R. Komadina, D. Bitenc Logar and J.Marc, Amicroarray based identification of osteoporosisrelated genes in primary culture of human osteoblasts, Bone, 46(1) (2010), 72-80.
25. Y.H. Lee, Y.H. Rho, S.J. Choi, J.D. Ji and G.G. Song, Metaanalysis of genomewide linkage studies for bonemineral density, J Hum Genet 51(5) (2006), 480-486.
26. Q.Y. Huang, G.H. Li, W.M. Cheung, Y.Q. Song and A.W. Kung, Prediction of osteoporosis candidate genes by computational diseasegene identification strategy, J Hum Genet 53(7) (2008), 644-655.
27. D.Ratnasinghe, J.A. Tangrea,M.R. Forman, T.Hartman, E.W. Gunter, Y.L. Qiao, S.X. Yao, M.J. Barett, C.A. Giffen, Y. Erozan, M.S. Tockman and P.R. Taylor, Serum tocopherols, selenium and lung cancer risk among tin miners in China, Cancer Causes Control 11(2) (2000), 129-135.
28. G. RavnHaren, A. Olsen, A. Tjonneland, L.O.Dragsted, B.A. Nexo, H.Wallin, K.Overvad, O. RaaschouNielsen andU.Vogel, Associations between GPX1 Pro198Leu polymorphism, erythrocyteGPXactivity, alcohol consumption and breast cancer risk in a prospective cohort study, Carcinogenesis 27(4) (2006), 820-825.
29. Y. Hu, R.V. Benya, R.E. Caroll and A.M. Diamond, Allelic loss of the gene for the GPX1 seleniumcontaining protein is a common event in cancer, J Nutr 135(12 Suppl) (2005), 3021S-3024S.
30. J.A. Knight, U.V. Onay, S.Wells, H. Li, E.J. Shi, I.L. Andrulis and H. Ozcelik, Genetic variants of GPX1 and SOD2 and breast cancer risk at the Ontario site of the breast cancer family registry, Cancer Epidemiol Biomarkers Prev 13(1) (2004), 146-149. (Pubitemid 38116633)
31. Z. KoteJarai, Durocher F, Edwards SM, Hamoudi R, Jackson RA, A. ArdernJones, A.Murkin, D.P. Dearnaley, R. Kirby, R. Houlston, D.F. Easton and R. Eeles, Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer, Prostate Cancer Prostatic Dis 5(3) (2002), 189-192.
32. X.G. Lei andW.H. Cheng, New roles for an old selenoenzyme evidence from glutathione peroxidase1 null and overexpressing mice, J Nutr 135(10) (2005), 2295-2298.
33. R.A. Sunde, B.M. Thompson, M.D. Palm, S.L. Weiss, K.M. Thompson and J.K. Evenson, Selenium regulation of seleniumdependent glutathione peroxidases in animals and transfected CHO cells, Biomed Environ Sci 10(2-3) (1997), 346-355.
34. T. Hamanishi, H. Furuta, H. Kato, A. Doi, M. Tamai, H. Shimomura, S. Sakagashira, M. Nishi, H. Sasaki, T. Sanke and K. Nanjo, Functional variants in the glutathione peroxidase1 (GPx1) gene are associated with increased intimaemedia thickness of carotid arteries and risk ofmacrovascular diseases in Japanese type 2 diabetic patients, Diabetes 53(9) (2004), 2455-2460.
35. Q. Shen, P.L. Townes, C. Padden and P.E. Newburger, An inframe trinucleotide repeat in the coding region of the human cellular glutathione peroxidase (GPX1) gene: in vivo polymorphism and in vitro instability, Genomics 23(1) (1994), 292-294.
36. J.P. Winter, Y. Gong, P.J. Grant and C.P. Wild, Glutathione peroxidase 1 genotype is associated with an increased risk of coronary artery disease, Coron Artery Dis 14(2) (2003), 149-153.
37. D.Matsuzawa, K. Hashimoto, E. Shimizu, M. Fujisaki andM. Iyo, Functional polymorphism of the glutathione peroxidase 1 gene is associated with personality traits in healthy subjects, Neuropsychobiology 52(2) (2005), 68-70.
38. World Health Organisation, Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO Study Group, World health Organisation Technical Report Series 843 (1994), 121-129.
39. S.A. Miller, D.D. Dykes and H.F. Polesky, A simple salting out procedure for extracting DNAfromhuman nucleated cells, Nucleic Acids Res 16(3) (1988), 1215.
40. T. Vincze, J. Posfai and R.J. Roberts, NEBcutter: a program to cleave DNA with restriction enzymes, Nucleic Acids Research 31 (2003), 3688-3691.
41. J.C. Mueller, Linkage disequilibrium for different scales and applications, Brief Bioinform 5(4) (2004), 355-364. Review.
42. S. Jurkovic, J. Osredkar and J.Marc, Molecular impact of glutathione peroxidases in antioxidant processes, Biochem Medica 18(2) (2008), 162-174.
43. O. Garnero, E. SornayRendu, M.C. Chapuy and P.D.Delmas, Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis, J Bone Miner Res 11 (1996), 337-349.
44. O. Altindag, O. Erel, N. Soran, H. Celik and S. Selek, Total oxidative/antioxidative status and relation to bone mineral density in osteoporosis, Rheumatol Int 28 (2008), 317-321.
45. N.K. Lee, Y.G. Choi, J.Y. Baik, S.Y. Han, D.W. Jeong, Y.S. Bae, N. Kim and S.Y. Lee, A crucial role for reactive oxygen species in RANKLinduced osteoclast differentiation, Blood 06 (2005), 852-859.
46. M. Lateef, M. Baig and A. Azhar, Estimation of serum osteocalcin and telopeptideC in postmenopausal osteoporotic females, Osteoporos Int 14 [Epub ahead of print].
47. R. Civitelli, R. ArmamentoVillareal and N. Napoli, Bone turnover markers: understanding their value in clinical trials and clinical practice, Osteoporos Int 20 (2009), 843-851.
48. B. Kalpakcioglu and K. Senel, The interrelation of glutathione reductase, catalase, glutathione peroxidase, superoxide dismutase, and glucose6phosphate in the pathogenesis of rheumatoid arthritis, Clin Rheumatol 27(2) (2008), 141-145.
49. D. Ratnasinghe, J.A. Tangrea, M.R. Andersen, M.J. Barrett, J. Virtamo, P.R. Taylor and D. Albanes, Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk, Cancer Res 60(22) (2000), 6381-6383.
50. Z. Arsova-Sarafinovska, N. Matevska, A. Eken, D. Petrovski, S. Banev, S. Dzikova, V. Georgiev, A. Sikole, O. Erdem, A. Sayal, A. Aydin and A.J. Dimovski, Glutathione peroxidise 1 (GPX1) genetic polymorphism, erythrocyte GPX activity, and prostate cancer risk, Int Urol Nephrol 41(1) (2009), 63-70.
51. C. Kiss, J. Li, A. Szeles, R.Z. Gizatullin, V.I. Kashuba, T. Lushnikova, A.I. Protopopv, M. Kelve, H. Kiss, I.D. Kholodnyuk, S. Imreh, G. Klein and E.R. Zabarovsky, Assignment of the ARHA and GPX1 genes to human chromosome bands 3p21.3 by in situ hybridization, Cytogenet Cell Genet 79(3-4) (1997), 228-230.