Age and sex dependent changes in liver gene expression during the life cycle of the rat

BMC Genomics

Volumn 11, Issue 1, 2010, Pages

  Kwekel, Joshua C ^a   Desai, Varsha G ^a   Moland, Carrie L ^a   Branham, William S ^a   Fuscoe, James C ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; APOLIPOPROTEIN A1; ARYLDIALKYLPHOSPHATASE 1; C REACTIVE PROTEIN; CYTOCHROME P450 2B1; CYTOCHROME P450 2C11; CYTOCHROME P450 2D6; CYTOCHROME P450 3A2; CYTOCHROME P450 REDUCTASE; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RNA; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA MICROARRAY; FEMALE; GENE EXPRESSION; HISTOLOGY; LIFE CYCLE; LIVER; MALE; MICROARRAY ANALYSIS; NONHUMAN; OXIDATIVE STRESS; RAT; RNA ISOLATION; SEX DIFFERENCE; XENOBIOTIC METABOLISM; AGING; ANIMAL; BODY WEIGHT; CLUSTER ANALYSIS; FISCHER 344 RAT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PRINCIPAL COMPONENT ANALYSIS; REPRODUCIBILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEXUAL DEVELOPMENT; TIME;

RATTUS;

AGING; ANIMALS; BODY WEIGHT; CLUSTER ANALYSIS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LIFE CYCLE STAGES; LIVER; MALE; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, INBRED F344; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEX CHARACTERISTICS; TIME FACTORS;

EID: 78649493404     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-11-675     Document Type: Article

References (58)

1. McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev 2004, 56(2):163-184. 10.1124/pr.56.2.4, 15169926.
2. Schwartz JB. The current state of knowledge on age, sex, and their interactions on clinical pharmacology. Clin Pharmacol Ther 2007, 82(1):87-96. 10.1038/sj.clpt.6100226, 17495875.
3. Phan VH, Moore MM, McLachlan AJ, Piquette-Miller M, Xu H, Clarke SJ. Ethnic differences in drug metabolism and toxicity from chemotherapy. Expert Opin Drug Metab Toxicol 2009, 5(3):243-257. 10.1517/17425250902800153, 19331590.
4. Choudhuri S, Klaassen CD. Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. Int J Toxicol 2006, 25(4):231-259. 10.1080/10915810600746023, 16815813.
5. Murray M. Altered CYP expression and function in response to dietary factors: potential roles in disease pathogenesis. Curr Drug Metab 2006, 7(1):67-81. 10.2174/138920006774832569, 16454693.
6. Meeks R. Hepatotoxicity. 1991, Boca Raton: CRC Press.
7. Moslen M. Toxic Response of the Liver. Casarrett and Doull's Toxicology, the basic science of poisons 1996, 403-416. Doull Ca: McGraw-Hill Professional Publishing.
8. Perucca E, Beghi E, Dulac O, Shorvon S, Tomson T. Assessing risk to benefit ratio in antiepileptic drug therapy. Epilepsy Res 2000, 41(2):107-139. 10.1016/S0920-1211(00)00124-8, 10940614.
9. Russo MW, Galanko JA, Shrestha R, Fried MW, Watkins P. Liver transplantation for acute liver failure from drug induced liver injury in the United States. Liver Transpl 2004, 10(8):1018-1023. 10.1002/lt.20204, 15390328.
10. Ostapowicz G, Fontana RJ, Schiodt FV, Larson A, Davern TJ, Han SH, McCashland TM, Shakil AO, Hay JE, Hynan L, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 2002, 137(12):947-954.
11. Andrade RJ, Lucena MI, Fernandez MC, Pelaez G, Pachkoria K, Garcia-Ruiz E, Garcia-Munoz B, Gonzalez-Grande R, Pizarro A, Duran JA, et al. Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology 2005, 129(2):512-521.
12. Carey EJ, Vargas HE, Douglas DD, Balan V, Byrne TJ, Harrison ME, Rakela J. Inpatient admissions for drug-induced liver injury: results from a single center. Dig Dis Sci 2008, 53(7):1977-1982. 10.1007/s10620-008-0250-x, 18392678.
13. Lucena MI, Andrade RJ, Kaplowitz N, Garcia-Cortes M, Fernandez MC, Romero-Gomez M, Bruguera M, Hallal H, Robles-Diaz M, Rodriguez-Gonzalez JF, et al. Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex. Hepatology 2009, 49(6):2001-2009. 10.1002/hep.22895, 19475693.
14. Lee MD, Ayanoglu E, Gong L. Drug-induced changes in P450 enzyme expression at the gene expression level: a new dimension to the analysis of drug-drug interactions. Xenobiotica 2006, 36(10-11):1013-1080. 10.1080/00498250600861785, 17118918.
15. Fielden MR, Pearson C, Brennan R, Kolaja KL. Preclinical drug safety analysis by chemogenomic profiling in the liver. Am J Pharmacogenomics 2005, 5(3):161-171. 10.2165/00129785-200505030-00003, 15952870.
16. Lord PG, Nie A, McMillian M. Application of genomics in preclinical drug safety evaluation. Basic Clin Pharmacol Toxicol 2006, 98(6):537-546. 10.1111/j.1742-7843.2006.pto_444.x, 16700814.
17. Mori K, Blackshear PE, Lobenhofer EK, Parker JS, Orzech DP, Roycroft JH, Walker KL, Johnson KA, Marsh TA, Irwin RD, et al. Hepatic transcript levels for genes coding for enzymes associated with xenobiotic metabolism are altered with age. Toxicol Pathol 2007, 35(2):242-251. 10.1080/01926230601156286, 17366318.
18. Lee JS, Ward WO, Wolf DC, Allen JW, Mills C, DeVito MJ, Corton JC. Coordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats. Toxicol Sci 2008, 106(1):263-283. 10.1093/toxsci/kfn144, 18653662.
19. Rinn JL, Rozowsky JS, Laurenzi IJ, Petersen PH, Zou K, Zhong W, Gerstein M, Snyder M. Major molecular differences between mammalian sexes are involved in drug metabolism and renal function. Dev Cell 2004, 6(6):791-800. 10.1016/j.devcel.2004.05.005, 15177028.
20. Waxman DJ, Holloway MG. Sex differences in the expression of hepatic drug metabolizing enzymes. Mol Pharmacol 2009, 76(2):215-228. 10.1124/mol.109.056705, 2713118, 19483103.
21. Mikhailova ON, Gulyaeva LF, Filipenko ML. Gene expression of drug metabolizing enzymes in adult and aged mouse liver: a modulation by immobilization stress. Toxicology 2005, 210(2-3):189-196. 10.1016/j.tox.2005.01.018, 15840432.
22. Wauthier V, Waxman DJ. Sex-specific early growth hormone response genes in rat liver. Mol Endocrinol 2008, 22(8):1962-1974. 10.1210/me.2007-0549, 2725767, 18483176.
23. Cameron TP, Hickman RL, Kornreich MR, Tarone RE. History, survival, and growth patterns of B6C3F1 mice and F344 rats in the National Cancer Institute Carcinogenesis Testing Program. Fundam Appl Toxicol 1985, 5(3):526-538. 10.1016/0272-0590(85)90100-9, 4007310.
24. Rao GN, Haseman JK, Grumbein S, Crawford DD, Eustis SL. Growth, body weight, survival, and tumor trends in F344/N rats during an eleven-year period. Toxicol Pathol 1990, 18(1 Pt 1):61-70.
25. Haseman JK, Hailey JR, Morris RW. Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two-year carcinogenicity studies: a National Toxicology Program update. Toxicol Pathol 1998, 26(3):428-441. 10.1177/019262339802600318, 9608650.
26. Fang H, Harris SC, Su Z, Chen M, Qian F, Shi L, Perkins R, Tong W. ArrayTrack: an FDA and public genomic tool. Methods Mol Biol 2009, 563:379-398. full_text, 19597796.
27. Anantharaju A, Feller A, Chedid A. Aging Liver. A review. Gerontology 2002, 48(6):343-353. 10.1159/000065506, 12393949.
28. Birnbaum LS. Endocrine effects of prenatal exposure to PCBs, dioxins, and other xenobiotics: implications for policy and future research. Environ Health Perspect 1994, 102(8):676-679. 10.2307/3432197, 1567315, 7895708.
29. Maes OC, An J, Sarojini H, Wang E. Murine microRNAs implicated in liver functions and aging process. Mech Ageing Dev 2008, 129(9):534-541. 10.1016/j.mad.2008.05.004, 18561983.
30. Doria G, Frasca D. Age-related changes of DNA damage recognition and repair capacity in cells of the immune system. Mech Ageing Dev 2001, 122(9):985-998. 10.1016/S0047-6374(01)00251-2, 11348662.
31. Neafsey P, Ginsberg G, Hattis D, Sonawane B. Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity. J Toxicol Environ Health B Crit Rev 2009, 12(5-6):334-361.
32. Wood RD, Mitchell M, Lindahl T. Human DNA repair genes, 2005. Mutat Res 2005, 577(1-2):275-283.
33. Kacew S, Festing MF. Role of rat strain in the differential sensitivity to pharmaceutical agents and naturally occurring substances. J Toxicol Environ Health 1996, 47(1):1-30.
34. McConnell EE. Pathology requirements for rodent two-year studies. I. A review of current procedures. Toxicol Pathol 1983, 11(1):60-64. 10.1177/019262338301100111, 6681398.
35. Quinn R. Comparing rat's to human's age: how old is my rat in people years?. Nutrition 2005, 21(6):775-777. 10.1016/j.nut.2005.04.002, 15925305.
36. Butler AA, LeRoith D. Minireview: tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology. Endocrinology 2001, 142(5):1685-1688. 10.1210/en.142.5.1685, 11316729.
37. Du H, Vitiello D, Sarno JL, Taylor HS. 3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells. Reproduction 139(1):237-245. 10.1530/REP-08-0376, 19778996.
38. Snell K, Weber G. Enzymic imbalance in serine metabolism in rat hepatomas. Biochem J 1986, 233(2):617-620. 1153072, 3082329.
39. Kaina B, Christmann M, Naumann S, Roos WP. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair (Amst) 2007, 6(8):1079-1099. 10.1016/j.dnarep.2007.03.008, 17485253.
40. Chen DP, Weber SC, Constantinou PS, Ferris TA, Lowe HJ, Butte AJ. Novel integration of hospital electronic medical records and gene expression measurements to identify genetic markers of maturation. Pac Symp Biocomput 2008, 243-254. 2716394, 18229690.
41. Finn RD, McLaughlin LA, Ronseaux S, Rosewell I, Houston JB, Henderson CJ, Wolf CR. Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5. J Biol Chem 2008, 283(46):31385-31393. 10.1074/jbc.M803496200, 2581580, 18805792.
42. Hart SN, Zhong XB. P450 oxidoreductase: genetic polymorphisms and implications for drug metabolism and toxicity. Expert Opin Drug Metab Toxicol 2008, 4(4):439-452. 10.1517/17425255.4.4.439, 18433346.
43. Abraham NG, Asija A, Drummond G, Peterson S. Heme oxygenase -1 gene therapy: recent advances and therapeutic applications. Curr Gene Ther 2007, 7(2):89-108. 10.2174/156652307780363134, 17430129.
44. Wauthier V, Verbeeck RK, Buc Calderon P. Age-related changes in the protein and mRNA levels of CYP2E1 and CYP3A isoforms as well as in their hepatic activities in Wistar rats. What role for oxidative stress?. Arch Toxicol 2004, 78(3):131-138. 10.1007/s00204-003-0526-z, 14600803.
45. Shekunova EV, Bespalov AY. Estrous cycle stage-dependent expression of acute tolerance to morphine analgesia in rats. Eur J Pharmacol 2004, 486(3):259-264. 10.1016/j.ejphar.2004.01.012, 14985047.
46. Boedigheimer MJ, Wolfinger RD, Bass MB, Bushel PR, Chou JW, Cooper M, Corton JC, Fostel J, Hester S, Lee JS, et al. Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories. BMC Genomics 2008, 9:285. 10.1186/1471-2164-9-285, 2453529, 18549499.
47. Table of Valid Genomic Biomarkers in the Context of Approved Drug Labels. , http://www.fda.gov/Drugs/ScienceResearch/ResearchAreas/Pharmacogenetics/ucm083378.htm
48. Zhang YK, Yeager RL, Klaassen CD. Circadian expression profiles of drug-processing genes and transcription factors in mouse liver. Drug Metab Dispos 2009, 37(1):106-115. 10.1124/dmd.108.024174, 2683654, 18838502.
49. Claudel T, Cretenet G, Saumet A, Gachon F. Crosstalk between xenobiotics metabolism and circadian clock. FEBS Lett 2007, 581(19):3626-3633. 10.1016/j.febslet.2007.04.009, 17451689.
50. Gachon F, Olela FF, Schaad O, Descombes P, Schibler U. The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification. Cell Metab 2006, 4(1):25-36. 10.1016/j.cmet.2006.04.015, 16814730.
51. Hofman MA, Swaab DF. Living by the clock: the circadian pacemaker in older people. Ageing Res Rev 2006, 5(1):33-51. 10.1016/j.arr.2005.07.001, 16126012.
52. Waxman DJ, O'Connor C. Growth hormone regulation of sex-dependent liver gene expression. Mol Endocrinol 2006, 20(11):2613-2629. 10.1210/me.2006-0007, 16543404.
53. Clodfelter KH, Holloway MG, Hodor P, Park SH, Ray WJ, Waxman DJ. Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. Mol Endocrinol 2006, 20(6):1333-1351. 10.1210/me.2005-0489, 16469768.
54. Laz EV, Holloway MG, Chen CS, Waxman DJ. Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver. Endocrinology 2007, 148(7):3327-3337. 10.1210/en.2006-1192, 2585771, 17412818.
55. Jeffery B, Choudhury AI, Horley N, Bruce M, Tomlinson SR, Roberts RA, Gray TJ, Barrett DA, Shaw PN, Kendall D, et al. Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver. Arch Biochem Biophys 2004, 429(2):231-236. 10.1016/j.abb.2004.06.025, 15313227.
56. Muller DN, Schmidt C, Barbosa-Sicard E, Wellner M, Gross V, Hercule H, Markovic M, Honeck H, Luft FC, Schunck WH. Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. Biochem J 2007, 403(1):109-118. 10.1042/BJ20061328, 1828894, 17112342.
57. Gene Expression Omnibus - Accession Display for GSE21335. , http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE21335
58. Shi L, Reid LH, Jones WD, Shippy R, Warrington JA, Baker SC, Collins PJ, de Longueville F, Kawasaki ES, Lee KY, et al. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol 2006, 24(9):1151-1161. 10.1038/nbt1239, 16964229.