Defining the in vivo role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5

Journal of Biological Chemistry

Volumn 283, Issue 46, 2008, Pages 31385-31393

  Finn, Robert D ^a   McLaughlin, Lesley A ^a   Ronseaux, Sebastien ^a   Rosewell, Ian ^b   Houston, J Brian ^c   Henderson, Colin J ^a   Wolf, C Roland ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETICS; BIOCHEMISTRY; ENZYMES; METABOLISM; OXYGENATION; PHARMACOKINETICS; PHYSIOLOGY;

CYTOCHROME B; DRUG ABSORPTIONS; IN VITRO; IN VITRO STUDIES; IN-VIVO; METOPROLOL; MICROSOMAL CYTOCHROMES; MIDAZOLAM; PLASMA CONCENTRATIONS;

SUBSTRATES;

CHLORZOXAZONE; CYTOCHROME B5; CYTOCHROME P450; METOPROLOL; MIDAZOLAM; PHENACETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TOLBUTAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; ENZYME METABOLISM; ENZYME SUBSTRATE; FEMALE; GENE DELETION; LIVER METABOLISM; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; NULL ALLELE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES B5; KINETICS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSOMES, LIVER; NAD; NADP; PHARMACEUTICAL PREPARATIONS;

MUS;

EID: 57649128309     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803496200     Document Type: Article

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