Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomas

Head and Neck

Volumn 32, Issue 10, 2010, Pages 1354-1362

  Hannisdal, Kirsten ^a   Burum Auensen, Espen ^b   Schjølberg, Aasa ^a   De Angelis, Paula M ^a   Clausen, Ole Petter F ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b AKERSHUS UNIVERSITY HOSPITAL   (Norway)

Author keywords

BubR1; p53; prognostic factor; spindle checkpoint proteins; tonsillar carcinomas

Indexed keywords

BUB1 RELATED PROTEIN; KI 67 ANTIGEN; PROTEIN MAD2; PROTEIN P53;

ADULT; ARTICLE; CANCER PATIENT; CANCER STAGING; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TISSUE MICROARRAY; TONSIL CARCINOMA; UNIVARIATE ANALYSIS; WART VIRUS;

AGE FACTORS; CALCIUM-BINDING PROTEINS; CARCINOMA, SQUAMOUS CELL; CELL CYCLE PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; PAPILLOMAVIRUS INFECTIONS; PROGNOSIS; PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; TONSILLAR NEOPLASMS;

EID: 78649487453     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.21342     Document Type: Article

References (49)

1. Mellin H, Friesland S, Auer G, Dalianis T, Munck-Wikland E,. Human papillomavirus and DNA ploidy in tonsillar cancer-correlation to prognosis. Anticancer Res 2003; 23: 2821-2828.
2. Hammarstedt L, Lindquist D, Dahlstrand H, et al. Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer. Int J Cancer 2006; 119: 2620-2623.
3. Akervall J,. Genomic screening of head and neck cancer and its implications for therapy planning. Eur Arch Otorhinolaryngol 2006; 263: 297-304.
4. Juhász A, Balázs M, Sziklay I, et al. Chromosomal imbalances in laryngeal and hypopharyngeal cancers detected by comparative genomic hybridization. Cytometry A 2005; 67: 151-160.
5. Lengauer C, Kinzler KW, Vogelstein B,. Genetic instability in colorectal cancers. Nature 1997; 386: 623-627.
6. Li R, Sonik A, Stindl R, Rasnick D, Duesberg P,. Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy. Proc Natl Acad Sci U S A 2000; 97: 3236-3241.
7. Sieber OM, Heinimann K, Tomlinson IP,. Genomic instability-the engine of tumorigenesis? Nat Rev Cancer 2003; 3: 701-708.
8. Veltman JA, Bot FJ, Huynen FC, Ramaekers FC, Manni JJ, Hopman AH,. Chromosome instability as an indicator of malignant progression in laryngeal mucosa. J Clin Oncol 2000; 18: 1644-1651.
9. Marx J,. Debate surges over the origins of genomic defects in cancer. Science 2002; 297: 544-546.
10. Kops GJ, Weaver BA, Cleveland DW,. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer 2005; 5: 773-785.
11. Minhas KM, Singh B, Jiang WW, Sidransky D, Califano JA,. Spindle assembly checkpoint defects and chromosomal instability in head and neck squamous cell carcinoma. Int J Cancer 2003; 107: 46-52.
12. Forastiere A, Koch W, Trotti A, Sidransky D,. Head and neck cancer. N Engl J Med 2001; 345: 1890-1900.
13. Jallepalli PV, Lengauer C,. Chromosome segregation and cancer: cutting through the mystery. Nat Rev Cancer 2001; 1: 109-117.
14. Cheung HW, Chun AC, Wang Q, et al. Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA-damaging agents. Cancer Res 2006; 66: 4357-4367.
15. Fung MK, Cheung HW, Ling MT, Cheung AL, Wong YC, Wang X,. Role of MEK/ERK pathway in the MAD2-mediated cisplatin sensitivity in testicular germ cell tumour cells. Br J Cancer 2006; 95: 475-484.
16. Wang X, Jin DY, Ng RW, et al. Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells. Cancer Res 2002; 62: 1662-1668.
17. Wang X, Jin DY, Wong HL, Feng H, Wong YC, Tsao SW,. MAD2-induced sensitization to vincristine is associated with mitotic arrest and Raf/Bcl-2 phosphorylation in nasopharyngeal carcinoma cells. Oncogene 2003; 22: 109-116.
18. Musio A, Montagna C, Zambroni D, et al. Inhibition of BUB1 results in genomic instability and anchorage-independent growth of normal human fibroblasts. Cancer Res 2003; 63: 2855-2863.
19. Baker DJ, Jeganathan KB, Cameron JD, et al. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet 2004; 36: 744-749.
20. Burum-Auensen E, DeAngelis PM, Schjølberg AR, Røislien J, MjÃland O, Clausen OP,. Reduced level of the spindle checkpoint protein BUB1B is associated with aneuploidy in colorectal cancers. Cell Prolif 2008; 41: 645-659.
21. Fang Y, Liu T, Wang X, et al. BubR1 is involved in regulation of DNA damage responses. Oncogene 2006; 25: 3598-3605.
22. Nitta M, Kobayashi O, Honda S, et al. Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents. Oncogene 2004; 23: 6548-6558.
23. Hannisdal K, Boysen M, Evensen JF,. Different prognostic indices in 310 patients with tonsillar carcinomas. Head Neck 2003; 25: 123-131.
24. Burum-Auensen E, De Angelis PM, Schjølberg AR, Kravik KL, Aure M, Clausen OP,. Subcellular localization of the spindle proteins Aurora A, Mad2, and BUBR1 assessed by immunohistochemistry. J Histochem Cytochem 2007; 55: 477-486.
25. Hannisdal K, Schjølberg A, De Angelis PM, Boysen M, Clausen OP,. Human papillomavirus (HPV)-positive tonsillar carcinomas are frequent and have a favourable prognosis in males in Norway. Acta Otolaryngol 2009;Aug 13: 1-7 [Epub ahead of print].
26. Kaplan EL, Meier P,. Nonparametric estimation from incomplete observations. J Am Statist Assoc 1958; 53: 457-481.
27. Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation for each patient. II. Analysis and examples. Br J Cancer 1977; 35: 1-39.
28. Cox DR,. Regression models and life-tables. J R Stat Soc B 1972; 34: 187-220.
29. Yamamoto Y, Matsuyama H, Chochi Y, et al. Overexpression of BUBR1 is associated with chromosomal instability in bladder cancer. Cancer Genet Cytogenet 2007; 174: 42-47.
30. Burum-Auensen E, Deangelis PM, Schjølberg AR, Røislien J, Andersen SN, Clausen OP,. Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis. J Clin Pathol 2007; 60: 1403-1408.
31. Lee YK, Choi E, Kim MA, Park PG, Park NH, Lee H,. BubR1 as a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers. Br J Cancer 2009; 101: 504-510.
32. Gladhaug IP, Westgaard A, Schjølberg AR, Burum-Auensen E, Pomianowska E, Clausen OPF,. Spindle proteins in resected pancreatic head adenocarcinomas: BubR1 is an independent prognostic factor in pancreatobiliary-type tumours. Histopathology 2009 (in press).
33. Michel LS, Liberal V, Chatterjee A, et al. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 2001; 409: 355-359.
34. Hanks S, Coleman K, Reid S, et al. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet 2004; 36: 1159-1161.
35. Bockmühl U, Petersen I,. DNA ploidy and chromosomal alterations in head and neck squamous cell carcinoma. Virchows Arch 2002; 441: 541-550.
36. Hass HG, Schmidt A, Nehls O, Kaiser S,. DNA ploidy, proliferative capacity and intratumoral heterogeneity in primary and recurrent head and neck squamous cell carcinomas (HNSCC)-potential implications for clinical management and treatment decisions. Oral Oncol 2008; 44: 78-85.
37. Hemmer J, Kraft K,. Stability of aneuploid clones during oral squamous cell carcinoma metastasis. Anticancer Res 2001; 21: 1459-1464.
38. Pearlstein RP, Benninger MS, Carey TE, et al. Loss of 18q predicts poor survival of patients with squamous cell carcinoma of the head and neck. Genes Chromosomes Cancer 1998; 21: 333-339.
39. Bauer VL, Braselmann H, Henke M, et al. Chromosomal changes characterize head and neck cancer with poor prognosis. J Mol Med 2008; 86: 1353-1365.
40. Bergamo NA, da Silva Veiga LC, dos Reis PP, et al. Classic and molecular cytogenetic analyses reveal chromosomal gains and losses correlated with survival in head and neck cancer patients. Clin Cancer Res 2005; 11 (2 Pt 1): 621-631.
41. Wreesmann VB, Shi W, Thaler HT, et al. Identification of novel prognosticators of outcome in squamous cell carcinoma of the head and neck. J Clin Oncol 2004; 22: 3965-3972.
42. Dahlgren L, Mellin H, Wangsa D, et al. Comparative genomic hybridization analysis of tonsillar cancer reveals a different pattern of genomic imbalances in human papillomavirus-positive and -negative tumors. Int J Cancer 2003; 107: 244-249.
43. Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D,. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 2005; 437: 1043-1047.
44. Ha GH, Baek KH, Kim HS, et al. p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation. Cancer Res 2007; 67: 7155-7164.
45. Wang L, Yin F, Du Y, et al. MAD2 as a key component of mitotic checkpoint: a probable prognostic factor for gastric cancer. Am J Clin Pathol 2009; 131: 793-801.
46. Li GQ, Li H, Zhang HF,. Mad2 and p53 expression profiles in colorectal cancer and its clinical significance. World J Gastroenterol 2003; 9: 1972-1975.
47. Rimkus C, Friederichs J, Rosenberg R, Holzmann B, Siewert JR, Janssen KP,. Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer. Int J Cancer 2007; 120: 207-211.
48. Coleman SC, Stewart ZA, Day TA, Netterville JL, Burkey BB, Pietenpol JA,. Analysis of cell-cycle checkpoint pathways in head and neck cancer cell lines: implications for therapeutic strategies. Arch Otolaryngol Head Neck Surg 2002; 128: 167-176.
49. Kim M, Liao J, Dowling ML, et al. TRAIL inactivates the mitotic checkpoint and potentiates death induced by microtubule-targeting agents in human cancer cells. Cancer Res 2008; 68: 3440-3449.