Molecular aspects of embryonic hemoglobin function

Molecular Aspects of Medicine

Volumn 23, Issue 4, 2002, Pages 293-342

  Brittain, Thomas ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Development; Embryonic; Function; Hemoglobin; Structure

Indexed keywords

CARBON MONOXIDE; GLOBIN; HEMOGLOBIN; HEMOPROTEIN; LIGAND; MESSENGER RNA; PROTEIN SUBUNIT; HEMOGLOBIN F; OXYGEN; OXYHEMOGLOBIN;

ALLOSTERISM; CARBON MONOXIDE INTOXICATION; CHROMOSOME STRUCTURE; DIMERIZATION; DISSOCIATION; EMBRYO; GENE ACTIVATION; GENE EXPRESSION; GENE LOCATION; GENE SWITCHING; HEMATOPOIESIS; HUMAN; LIGAND BINDING; OXIDATION REDUCTION REACTION; OXYGEN AFFINITY; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; REVIEW; RNA STABILITY; BINDING SITE; KINETICS; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; TRANSPORT AT THE CELLULAR LEVEL;

ALLOSTERIC REGULATION; BINDING SITES; BIOLOGICAL TRANSPORT; EMBRYO; FETAL HEMOGLOBIN; HEMATOPOIESIS; HUMAN; KINETICS; OXYGEN; OXYHEMOGLOBINS; PROTEIN BINDING; HUMANS;

EID: 0036018464     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0098-2997(02)00004-3     Document Type: Review

References (279)

1. Hydropathic analysis of the non-covalent interactions between molecular subunits of structurally characterized hemoglobins
2. Molecular code for cooperativity in hemoglobin
3. 2 globin genes in humans and in transgenic mice
4. Erythroid transcription factor NF-E2 is a hemopoietic-specific basic-leucine zipper protein
5. Studies on the relations between molecular and functional properties of hemoglobin. The influence of temperature an the Bohr effect in human and horse hemoglobin
6. A SW1/SNF-related chromatin remodeling complex, E-RC1, is required for tissue - specific transcriptional regulation by EKLF in vitro
7. Human embryonic hemoglobins; Acetylserylleucyl-threonine is the amino terminal sequence of zeta-chains
8. Structure and function of hemoglobin
9. Haemoglobin: The structural changes related to ligand binding and its allosteric mechanism
10. Different effects of 2,3 diphosphoglycerate and adenosine triphosphate on the oxygen affinity of adult and foetal human haemoglobin
11. ′ sequences direct adult erythroid-specific expression of human β-globin genes in transgenic mice
12. Binding of diphosphoglycerate and ATP to oxyhemoglobin dimmers
13. The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro
14. Allosteric mechanism of hemoglobin: Rupture of salt bridges raises oxygen affinity of the T-structure
15. Exons and the structure, function and evolution of hemoglobin
16. Hematopoiesis in young human embryos
17. Chloride masks effects of opposing positive charges in HbA and Hb Hinsdale (β 139 Asn-Lys) that can modulate cooperativity as well as oxygen affinity
18. 2 hemoglobin
19. Fetal hemoglobin restriction to a few erythrocytes (F-cells) in normal human adults
20. Stopped-flow kinetics of oxygen uptake and release by embryonic red blood cells
21. A two state analysis of cooperative oxygen binding in the three human embryonic haemoglobins
22. 5 and some oxidized haemoglobins the role of ionic strength
23. Expression of α and β globin genes occurs within different nuclear domains in hemopoietic cells
24. Tetrahymena histone acetyl-transferase A: A homolog to yeast Gen 5p linking histone acetylation to gene activation
25. Anion Bohr effect of human hemoglobin
26. Synergistic regulation of human β globin gene switching by locus control region element HS3 and HS4
27. Immortalisation of multipotent growth-factor dependent hemopoietic progenitors from mice transgenic for GATA-1 driven SV40 tsA58 gene
28. Cloning Nrf1 and NF-E2 related transcription factor, by genetic selection in yeast
29. Effects of hydroxyurea on the frequency of painful crises in sickle cell anaemia
30. Regulation of protein synthesis by heme regulated eIF-2α kinase
31. Studies on the reaction of haptoglobin with hemoglobin and hemoglobin chains
32. Structure of the zeta chain of human embryonic hemoglobin
33. Nature of oxygen and carbon monoxide binding to metalloprphyrins and heme proteins
34. Oxygen and carbon monoxide binding to iron (II) porphyrins. A comparison of the "picket fence" and "pocket" porphyrins
35. The water effect on allosteric regulation of hemoglobin probed in water/glucose and water/glycine solutions
36. 2 binding
37. Reevaluation of chloride regulation of hemoglobin oxygen uptake: The neglected contribution of protein hydration in allosterism
38. Stimulation of GAL 4 derivative binding to nucleosomal DNA by the yeast SW1/SNF complex
39. Analysis of SP1 in vivo reveals multiple transcription domains including a novel glutamine-rich activation motif
40. Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments
41. 2 binding properties of the product of the central exon of β globin gene
42. Phosphorylation of the erythroid transcription factor GATA-1
43. Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1
44. Phosphorylation of initiation factor eIF-2alpha, binding of mRNA to 48S complexes and its reutilization in initiation of protein synthesis
45. The interaction of 2,3 diphosphoglycerate with human deoxy and oxy hemoglobin
46. Stereochemistry of carbon monoxide binding to normal human adult and Cowtown haemoglobins
47. 5-Azacytidine stimulates fetal hemoglobin synthesis in anaemic baboons
48. o
49. Allosteric interpretation of the oxygen binding reaction of human hemoglobin tetramers
50. The structure of cytochrome c and the rate of molecular evolution
51. Localisation of human alpha globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay
52. Chromosomal localization of human beta globin gene on chromosome 11 in somatic cell hybrids
53. Human γ-globin genes silenced independently of other genes in the beta-globin locus
54. Role of erythroid Kruppel-like factor in human γ and β globin gene switching
55. Temperature and pH dependence of the oxygen binding reaction of human foetal haemoglobin
56. Regulation of oxygen affinity by quaternary enhancement: Does hemoglobin Ypsilanti represent an allosteric intermediate?
57. Exchange of subunit interfaces between recombinant adult and fetal hemoglobins
58. The relationship between coding sequences and function in hemoglobin
59. The structure and evolution of the human beta-globin gene family
60. ′HS2 constructs function and locus control regions only in multicopy transgene concatamers
61. ′ hypersensitive site 3 of the human β-globin locus control region
62. 5 - experimental and theoretical analysis
63. Looping, linking and chromatin activity
64. Embryonic hemoglobins in man and other mammals
65. Haemoglobin and myoglobin
66. The crystal structure of deoxyhaemoglobin at 1.7 A resolution
67. Regulation of embryonic/fetal globin genes by nuclear hormone receptors: A novel perspective on hemoglobin switching
68. The relationship between chromosome structure and function at a human teleomeric region
69. ′ exonuclease in an in vitro RNA stability system
70. A developmentally stable chromatin structure in the human β-globin gene cluster
71. Molecular analysis of the human β-globin locus activation region
72. DNase hypersensitive sites 1, 2 and 3 of the human β-globin dominant control region direct position-independent expression
73. Each hypersensitive site of the human β-globin locus control region confers a different developmental pattern of expression on the globin genes
74. Structure of human foetal deoxyhaemoglobin
75. Solvent regulation of oxygen affinity in hemoglobin sensitivity of bovine hemoglobin to chloride ions
76. Hemoglobin tertiary structural change on ligand binding: Its role in the cooperative mechanism
77. The multiple functions of hemoglobin
78. Rates of reaction of native human globins with some hemes
79. Correlation of DNA exonic regions with protein structural units in hemoglobin
80. Position independent high level expression of the human β-globin gene in transgenic mice
81. The dynamics of globin gene expression and gene therapy results
82. The regulation of human globin gene switching
83. The regulation of human gene expression
84. Differential phylogenetic footprinting as a means to identify base changes responsible for recruitment of the anthropoid γ gene to a fetal expression pattern
85. Erythroid Kruppel-like factor is essential for beta globin gene expression even in the absence of gene competition, but is not sufficient to induce the switch from gamma-globin to beta-globin gene expression
86. Importance of globin gene order for correct developmental expression
87. Hemoglobins from bacteria to man: Evaluation of different patterns of gene expression
88. Locus control regions of mammalian β-globin gene clusters: Combining phylogenetic analyses and experimental results to gain functional insight
89. The stability of holomyoglobin is determined by heme affinity
90. Site directed mutagenesis in hemoglobin: Functional and structural studies of the intersubunit hydrogen bond of threonine -38(C3) alpha-1-beta-1 interface in human hemoglobin
91. 2) assembled in complex transgenic-knockout mice
92. Functional effects of replacing human α and β globins with their embryonic globin homologues in defined haemoglobin heterotetramers
93. Nomograms and empirical equations relating oxygen tension, percentage saturation and pH in maternal and fetal blood
94. Can a two state MWC allosteric model explain hemoglobin kinetics?
95. Predominance of Hb Gower I in early embryonic development
96. A major positive regulatory region is located far upstream of the human α-globin gene cluster
97. The possible effects of aggregation of the molecules of haemoglobin on its oxygen dissociation curve
98. Carbon monoxide exchange between the human fetus and mother: A mathematical model
99. How much do we know about the Bohr effect of hemoglobin?
100. The regulation of β-globin gene expression and β thalassaemia
101. Ligand binding kinetics and dissociation of the human embryonic haemoglobins
102. Partitioning of oxygen and carbon monoxide in the three human embryonic hemoglobins
103. Allosteric modulation of oxygen binding to the three human embryonic haemoglobins
104. The chloride effect in human embryonic haemoglobins
105. The control of oxygen affinity in the three human embryonic haemoglobins by respiration linked metabolites
106. An allosteric model of hemoglobin: I Kinetics
107. Derepression of human embryonic ζ globin promoter by a locus control region sequence
108. The structure and function of haemoglobin: Clinical disorders due to abnormal haemoglobin structure
109. Oxygen dissociation properties of human embryonic red cells
110. The present status of the heterogeneity of fetal hemoglobin in β thalassaemia: An attempt to unify some observations in thalassaemia and related conditions
111. The chemical heterogeneity of fetal hemoglobin in normal newborn infants and in adults
112. Homogeneous cytochrome b5 from human erythrocytes
113. Regulation of transcription by dimerisation of erythroid factor NF-E2 with small Maf proteins
114. Levels of GATA-1/GATA-2 transcription factors modulate expression of embryonic and fetal hemoglobins
115. Sequences within and flanking hypersensitive sites 3 and 2 of the β-globin locus control region are required for synergistic versus additive interaction with the ε globin gene reporter
116. Role of DNA sequences outside the cores of DNase hypersensitive sites (HS's) in functions of the β-globin locus control region: Domain opening and synergism between HS2 and HS3
117. The regulation of initiation of mammalian protein synthesis
118. Molecular mechanisms of hemoglobin switching
119. Understanding fetal globin gene expression: A step towards effective HbF reactivation in haemoglobinopathies
120. Identification of a stage selector element in the human gamma globin gene promoter that fosters preferential interactions with the 5' HS2 enhancer when in competition with the beta promoter
121. The quaternary structure of carbonmonoxy hemoglobin Ypsilanti
122. Characterisation of the major regulatory element upstream of the human alpha globin gene cluster
123. Aγ globin proportions in hemoglobin F
124. Heme orientational heterogeneity in deuterohemin reconstituted horse and human hemoglobin characterised by proton NMR spectroscopy
125. A steric mechanism for inhibition of CO binding to heme proteins
126. Eukaryotic transcription: An interlaced network of transcription factors and chromatin-modifying machines
127. Structure determination of aquomet porcine hemoglobin at 2.8 A resolution
128. Reactions of haemoglobin dimers after ligand dissociation
129. 2) at low pH
130. 4) a marker for α-thalassaemia
131. The role of β chains in the control of hemoglobin oxygen binding function: Chimeric human/mouse proteins, structure and function
132. 5 and some oxidized haemoglobins
133. Influence of DPG on the Bohr effect of human haemoglobin
134. The Bohr effect of human hemoglobin
135. 2 combination and reduction of the Bohr effect in haemoglobin chemically modified at its α amino groups
136. Interaction of hemoglobin with hydrogen ions, carbon dioxide and organic phosphates
137. Direct measurement of the pK values of an alkaline Bohr effect group in human haemoglobin
138. Role of Bohr group salt bridges in cooperativity in hemoglobin
139. Cotranslational heme binding to nascent globin chains
140. Comparison of experimental binding data and theoretical models in protein containing subunits
141. The proximal element of the β-globin locus control region is not functionally required in vivo
142. 1 NMR characterization of metastable and equilibrium heme orientation heterogeneity in reconstituted and native hemoglobin
143. Linear free energy relationships in binding of oxygen and carbon monoxide with heme model compounds and heme proteins
144. Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40
145. The constituents of normal blood
146. 5-azacytidine selectively increases gamma globin synthesis in a patient with beta thalassaemia
147. 5-azacytidine increases γ globin synthesis and reduces the proportion of dense cells in patients with sickle cell anaemia
148. ′-flanking sequence of the human epsilon globin gene
149. Multiple epsilon-promoter elements participate in the developmental control of epsilon-globin genes in transgenic mice
150. Hypersensitive site 5 of the human β globin locus control region functions as a chromatin insulator
151. Structure of liganded T-state of hemoglobin identifies the origin of co-operative oxygen binding
152. Modulating carbon monoxide binding affinity and kinetics in myoglobin: The role of the distal histidine and heme pocket docking site
153. Carbon monoxide in the pregnant mother and fetus and its exchange across the placenta
154. Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
155. A change in the stability of globin mRNA during the induction of murine erythroleukemic cells
156. NMR reveals hydrogen bonds between oxygen and distal histidines in oxyhemoglobin
157. Remote contributions to subunit interactions: Lessons from adult and fetal hemoglobin
158. Non equivalence of chains in hemoglobin oxidation
159. Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages
160. Haem rotational disorder in recombinant and reticulocyte derived haemoglobins: Evidence for a directed haem insertion reaction in eukaryotes
161. Identification of DNA sequences required for transcription of human alpha-globin gene in a new SV40 host-vector system
162. Two tissue specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene
163. A novel erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins
164. Heterochromatin effects on the frequency and duration of LCR mediated gene transcription
165. Isolation of NF-E2 related factor 2 (Nrf2) a NF-E2 like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the β-globin locus control region
166. Eukaryotic protein synthesis
167. On the nature of allosteric transitions: A plausible model
168. ′ hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice
169. The binding of hemoglobin to haptoglobin and its relation to subunit dissociation of hemoglobin
170. Tandem AP-1-binding sites within the human β-globin dominant control region function as an inducible enhancer in erythroid cells
171. Regulation of hemoglobin synthesis during the development of the red cell
172. Structure and expression of globin genes in erythroid cells
173. Oxygen linked binding sites for inorganic ions
174. Electrostatic effects in the Brownian dynamics of association and orientation of heme proteins
175. Brownian dynamics of cytochrome c and cytochrome c peroxidase association
176. X ray diffraction and solution studies of specifically carbamylated human hemoglobin A
177. The role of the distal histidine in myoglobin and hemoglobin
178. Globin gene regulation and switching
179. Regulation of globin gene expression in erythroid cells
180. 5 reductase from erythrocytes
181. Haemoglobin in human fetuses: Evidence for adult haemoglobin production after the 11th gestation week
182. Gγ globin genes in transgenic mice
183. Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF
184. Silencing of human fetal globin expression is impaired in the absence of the adult β-globin gene activator protein EKLF
185. Butyrate infusions in the ovine fetus delay the biological clock for globin gene switching
186. Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with HbSS and β thalassaemia
187. Steriochemistry of co-operative effects in hemoglobin
188. Haem-haem interactions
189. Regulation of oxygen affinity of haemoglobin: Influence of structure of the globin on the haem
190. Structure of haemoglobin. A three-dimensional Fourier structure at 2 A resolution
191. Identification of residues responsible for the alkaline Bohr effect in haemoglobin
192. Identification of residues contributing to the Bohr effect in human haemoglobin
193. Stereochemistry of co-operative effects in hemoglobin
194. A novel allosteric mechanism in haemoglobin: Structure of bovine deoxyhaemoglobin, absence of specific chloride binding sites and origin of chloride linked Bohr effect in bovine and human haemoglobin
195. The chloride effect in human haemoglobin. A new kind of allosteric mechanism
196. Protein-DNA interactions in the ε-globin gene silencer
197. ′HS2 of the human β-globin LCR on the developmental regulation of globin gene expression in β-YAC transgenic mice
198. The SW1-SNF complex: A chromatin remodeling machine?
199. Role of gene order in developmental control of human gamma-and beta-globin gene expression
200. The minimal requirements for activity in transgenic mice of hypersenstive site 3 of the β-globin locus control region
201. Globin gene expression in hereditary persistence of fetal hemoglobin and δβ°-thalassaemia
202. The developmental regulation of the human zeta globin gene in transgenic mice employing beta-galactosidase as a reporter gene
203. Demonstration of a human ε globin gene silencer with studies in transgenic mice
204. GATA-1 and YY1 are developmental repressors of the human ε-globin gene
205. Position dependent variegation of globin transgene expression in mice
206. Conformational relaxation and ligand binding to singly reduced human embryonic hemoglobins
207. Heme stability in human embryonic haemoglobins
208. The kinetic mechanism of heme binding to human apo-hemoglobin
209. MRNA stability in mammalian cells
210. Studies on the oxygen and carbon monoxide equilibria of human myoglobin
211. Co-operative hemoglobins: Conserved fold, diverse quaternary assemblies and allosteric mechanisms
212. Reversal of lethal α and β thalassaemias in mice by expression of human embryonic globins
213. A proton NMR investigation of histidyl residues in human normal adult hemoglobin
214. A single erythroid specific DNase I super-hypersensitive site activates high levels of human β-globin gene expression in transgenic mice
215. ′ to the human zeta globin gene
216. Messenger RNA degradation in eukaryotes
217. Regulation of the catalytic utilization of eIF-2
218. The mechanism of translational inhibition in hemin-deficient lysates
219. Some effects of post-translational N-terminal acetylation of human embryonic ζ globin protein
220. The synthesis and chemical heterogeneity of human fetal hemoglobin
221. Postnatal changes in chemical heterogeneity of human fetal hemoglobin
222. Allosteric intermediates indicate R2 is the liganded hemoglobin end state
223. Structure of human oxyhaemoglobin at 2.1 A resolution
224. Analysis of the human α-globin upstream regulatory element (HS-40) in transgenic mice
225. Analysis of the human α-globin gene cluster in transgenic mice
226. Developmentally regulated and erythroid specific expression of the human embryonic β-globin gene in transgenic mice
227. A mutagenic study of the allosteric linkage of His (HC 3) 146 β in haemoglobin
228. On the significance of hydrogen bonds for the discrimination between carbon monoxide and oxygen by myoglobin
229. A third quaternary structure of human hemoglobin A at 1.7 A resolution
230. Myoglobin models and steric origins of the discrimination between oxygen and carbon monoxide
231. The pattern of replication at a human telometric region (16p 13.3): Its relationship to chromosome structure and gene expression
232. Cyanomet human hemoglobin crystallized under physiological conditions exhibits the Y quaternary structure
233. The mutation β 99 Asp-Tyr stabilizes Y - a new composite quaternary state of human hemoglobin
234. Cycle dependent initiation and lineage dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors
235. Discrimination between oxygen and carbon monoxide and inhibition of autoxidation by myoglobin
236. The T-R transformation in hemoglobin: A reevaluation
237. Hemoglobin switching
238. Human fetal hemoglobin F: Acetylation status
239. In vivo protein DNA interactions at hypersensitive site 3 of the human beta globin locus control region
240. 2) haemoglobin at 2.9 A resolution
241. A mathematical model for structure function relations in hemoglobin
242. A dominant control region from the human β-globin locus conferring integration site-independent gene expression
243. Detailed analysis of the site 3 region of the human β-globin dominant control region
244. What is the true structure of liganded haemoglobin?
245. ′HS3 of the beta globin locus control region
246. Human globin locus activation region (LAR): Role in temporal control
247. Binding of oxygen and carbon monoxide to hemes and hemoproteins
248. 1,3 Adamantane-2 13-porphyrin-6-6-cyclophane crystal structure of free base and steric effects on ligation of the iron-II complex
249. Anthracene heme cyclophanes steric effects in carbon monoxide, oxygen and isocyanide binding
250. ′ enhancer contributes to the stage-specific expression of the human β-globin gene
251. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells
252. An erythroid-specific developmental-stage-independent enhancer far upstream of the human 'β-like globin' genes
253. Oxygen dissociation curve of haemoglobin Portland
254. Identification of the residues involved in the oxygen linked chloride ion binding sites in human deoxyhemoglobin and oxyhemoglobin
255. A new family of powerful multivariate statistical sequence analysis techniques
256. Stability of globin mRNA in terminally differentiating mouse erythroleukemic cells
257. Cis-acting sequences regulating expression of the human α-globin cluster lie within constitutively open chromatin
258. Synthesis of wild type and mutant human hemoglobin in Saccharomyces cerevisiae
259. Mechanism for the autoxidation of hemoglobin by phenol, nitrite and oxidant drugs: Peroxide formation by one electron donation to bound oxygen
260. Mechanism of autoxidation of hemoglobins and myoglobins
261. ′ untranslated region ribonucleoprotein complex associated with human β-globin mRNA stability
262. Nature of the iron-oxygen bond in oxyhemoglobin
263. Erythroid cell-specific determinants of β-globin mRNA stability
264. Transcription complex stability and chromatin dynamics in vivo
265. Heme proteins
266. Linked functions and reciprocal effects in hemoglobin: A second look
267. Allosteric linkage
268. Linkage graphs: A study in thermodynamics of macromolecules
269. 1 NMR study of dynamics and thermodynamics of heme rotational disorder in native and reconstituted hemoglobin A
270. ′ matrix-attachment region and the polyoma enhancer together confer position-independent transcription
271. Transcriptional activation of human zeta-2 globin promoter by the alpha globin regulatory element (HS40): Functional role of specific nuclear factor-DNA complexes
272. The role of amino acid α38 in the control of oxygen binding to human adult and embryonic haemoglobin Portland