Semi-synthesis and anti-tumor activity of 5,8-O-dimethyl acylshikonin derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 6005-6011

  Zhou, Wen ^a   Peng, Ying ^a   Li, Shao Shun ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Anti tumor activity; Semi synthesis; Shikonin derivatives; Structure activity relationship

Indexed keywords

1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXOAPHTHALENT 2 YL) 4 METHYLPENT 3 ENYL 2 METHOXYBENZOIC ACID; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXOAPHTHALENT 2 YL) 4 METHYLPENT 3 ENYL 4 METHOXYBENZOIC ACID; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXOAPHTHALENT 2 YL) 4 METHYLPENT 3 ENYL 4 NITROBENZOIC ACID; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXOAPHTHALENT 2 YL) 4 METHYLPENT 3 ENYLACETIC ACID; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXOAPHTHALENT 2 YL) 4 METHYLPENT 3 ENYLBUTYRIC ACID; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXOAPHTHALENT 2 YL) 4 METHYLPENT 3 ENYLCINNAMIC ACID; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXOAPHTHALENT 2 YL) 4 METHYLPENT 3 ENYLISOBUTYRIC ACID; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXOAPHTHALENT 2 YL) 4 METHYLPENT 3 ENYLPROPIONIC ACID; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXOAPHTHALENT 2 YL) 4 METHYPENT 3 ENYLBENZOIC ACID; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXOAPHTHALENT 2 YL) 4 METHYPENT 3 ENYLISONICOTINIC ACID; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXOAPHTHALENT 2 YL) 4 METHYPENT 3 ENYLNICOTINIC ACID; 1 (1,4 DIHYDRODO 5,8 DIMETHOXY 1,4 DIOXOAPHTHALENT 2 YL) 4 METHYLPENT 3 ENYLNICOTINIC ACID; 1 (5,8 DIMETHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 4 METHYLPENT 3 ENYL 2 (4 METHOXYPHENYL)ACETIC ACID; 1 (5,8 DIMETHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 4 METHYLPENT 3 ENYL 2 METHYLBUTANOIC ACID; 1 (5,8 DIMETHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 4 METHYLPENT 3 ENYL 3 (3,4 DIMETHOXYPHENYL)ACRYLIC ACID; 1 (5,8 DIMETHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 4 METHYLPENT 3 ENYL 3 HYDROXY 3 METHYLBUTANOIC ACID; 1 (5,8 DIMETHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 4 METHYLPENT 3 ENYL 3 METHYLBUT 2 ENOIC ACID; 1 (5,8 DIMETHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 4 METHYLPENT 3 ENYL 3 PHENYLPROPANOIC ACID; 1 (5,8 DIMETHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 4 METHYLPENT 3 ENYLBUT 2 ENOIC ACID; 1 (5,8 DIMETHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 4 METHYLPENT 3 ENYLFURAN 2 CARBOXYLIC ACID; 1 (5,8 DIMETHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 4 METHYLPENT 3 ENYLFURAN 3 CARBOXYLIC ACID; 1 (5,8 DIMETHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 4 METHYLPENT 3 ENYLTETRAHYDROFURAN 2 CARBOXYLIC ACID; 1 (5,8 DIMETHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 4 METHYLPENT 3 ENYLTETRAHYDROFURAN 3 CARBOXYLIC ACID; 5,8 O DIMETHYLACYLSHIKONIN DERIVATIVE; FLUOROURACIL; SHIKONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN MCF 7; CYTOTOXICITY; DRUG DESIGN; DRUG EFFICACY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; METHYLATION; MOUSE; NONHUMAN;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; NAPHTHOQUINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 78649332634     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.068     Document Type: Article

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