Tetra substituted thiophenes as anti-inflammatory agents: Exploitation of analogue-based drug design

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 24, 2005, Pages 6685-6692

  Pillai, Ajay D ^a   Rathod, Parendu D ^b   Xavier, Franklin P ^b   Padh, Harish ^b   Sudarsanam, Vasudevan ^b   Vasu, K Kamala ^b  

^a M S RAMAIAH UNIVERSITY OF APPLIED SCIENCES   (India)

^b B V PATEL PHARMACEUTICAL EDUCATION AND RESEARCH DEVELOPMENT PERD CENTRE   (India)

Author keywords

Anti inflammatory activity; Drug designs; Tetra substituted thiophenes

Indexed keywords

2 CARBETHOXYAMINO 5 (2 CARBOXANILIDOACETYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 CARBETHOXYAMINO 5 (2 ETHOXYCARBONYL 2 HYDROXYIMINOACETYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 CARBETHOXYAMINO 5 (2 ETHOXYCARBONYL 2 METHOXYIMINOACETYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 CARBETHOXYAMINO 5 (3,5 DIMETHYL 4 METHOXY 2 PYRIDYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 CARBETHOXYAMINO 5 (4 METHYLMERCAPTOBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 CARBETHOXYAMINO 5 (4 METHYLSULFONYLBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 ETHYLAMINO 5 (2 ETHOXYCARBONYL 2 ACETYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 ETHYLAMINO 5 (2 ETHOXYCARBONYL 2 HYDROXYIMINOACETYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 ETHYLAMINO 5 (2 ETHOXYCARBONYL 2 METHOXYIMINOACETYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 ETHYLAMINO 5 (3,5 DIMETHYL 4 METHOXY 2 PYRIDYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 ETHYLAMINO 5 (4 METHYLMERCAPTOBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 ETHYLAMINO 5 (4 METHYLSULFONYLBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 METHYLAMINO 5 (2 ETHOXYCARBONYL 2 HYDROXYIMINOACETYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 METHYLAMINO 5 (2 ETHOXYCARBONYL 2 METHOXYIMINOACETYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 METHYLAMINO 5 (3,5 DIMETHYL 4 METHOXY 2 PYRIDYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 METHYLAMINO 5 (4 METHYLMERCAPTOBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; 2 METHYLAMINO 5 (4 METHYLSULFONYLBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID METHYL ESTER; ACRYLIC ACID; ANTIINFLAMMATORY AGENT; AP 11; AP 121; AP 155; AP 156; AP 157; AP 45; AP 46; AP 53; AP 56; AP 57; AP 58; AP 59; AP 60; AP 61; AP 62; AP 63; CARRAGEENAN; ESTER; LIPOXYGENASE INHIBITOR; PEROXY RADICAL; PROSTAGLANDIN SYNTHASE INHIBITOR; ROMAZARIT; TENIDAP; THIOPHENE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL BOND; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; IN VIVO STUDY; INFLAMMATION; MALE; METABOLISM; NONHUMAN; PAW EDEMA; PHARMACOPHORE; RAT; TOXICITY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; DRUG DESIGN; EDEMA; EXTREMITIES; FEMALE; MALE; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

ANIMALIA;

EID: 27644594573     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.07.044     Document Type: Article

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