Gastrointestinal stromal tumors (GISTs): An updated experience

Digestive Diseases and Sciences

Volumn 55, Issue 12, 2010, Pages 3315-3327

  MacHairas, Anastasios ^a   Karamitopoulou, Eva ^a   Tsapralis, Dimitrios ^a   Karatzas, Theodore ^a   MacHairas, Nickolas ^a   Misiakos, Evangelos P ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Gastrointestinal; GIST; Stromal tumors

Indexed keywords

ANGIOGENESIS INHIBITOR; IMATINIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; NILOTINIB; PLACEBO; PROTEIN TYROSINE KINASE INHIBITOR; SUNITINIB;

CANCER GROWTH; CANCER INHIBITION; CANCER RECURRENCE; CANCER SURGERY; CLINICAL FEATURE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC ACCURACY; DIGESTIVE SYSTEM; DRUG EFFICACY; ENDOSCOPY; GASTROINTESTINAL STROMAL TUMOR; GASTROINTESTINAL TUMOR; HISTOPATHOLOGY; HUMAN; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SOLID TUMOR; SURGICAL APPROACH; TREATMENT OUTCOME; TUMOR CLASSIFICATION;

ANTINEOPLASTIC AGENTS; DIAGNOSIS, DIFFERENTIAL; DISEASE PROGRESSION; ENDOSCOPY, GASTROINTESTINAL; GASTROINTESTINAL STROMAL TUMORS; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM RECURRENCE, LOCAL; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; TUMOR MARKERS, BIOLOGICAL;

EID: 78649318938     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-010-1360-9     Document Type: Review

References (125)

1. H Joensuu PJ Roberts M Sarlomo-Rikala 2001 Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor N Engl J Med 344 1052 11287975 1:STN:280:DC%2BD3M3gvVekuw%3D%3D
2. CDM Fletcher JJ Berman C Corless, et al. 2002 Diagnosis of gastrointestinal tumors: a consensus approach Hum Pathol 33 459 465 12094370
3. T Tran JA Davilla HB El-Serag, et al. 2005 The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000 Am J Gastronterol 100 162 168
4. BP Rubin MC Heinrich CL Corless, et al. 2007 Gastrointestinal stromal tumors Lancet 369 1731 1741 17512858 1:CAS:528:DC%2BD2sXlsFertrk%3D
5. RP DeMatteo JJ Lewis D Leung, et al. 2000 Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival Ann Surg 23 51 58
6. M Miettinen LH Sobin M Sarlomo-Rikala, et al. 2000 Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT) Mod Pathol 13 1134 1142 11048809 1:STN:280: DC%2BD3crgtFektQ%3D%3D
7. MT Mazur HB Clark, et al. 1983 Gastric stromal tumors. Reappraisal of histogenesis Am J Surg Pathol 7 507 519 6625048 1:STN:280:DyaL2c%2FitFGitw%3D%3D
8. J Gold R DeMatteo, et al. 2006 Combined surgical and molecular therapy. The gastrointestinal stromal tumor model Ann Surg 244 176 184 16858179
9. S Van der Zwan RP DeMatteo 2005 Gastrointestinal stromal tumor: 5 years later Cancer 104 1781 1788 16136600
10. M Miettinen J Lasota, et al. 2006 Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis Arch Pathol Lab Med 130 1466 1478 17090188 1:CAS:528:DC%2BD28XhtFyhs7%2FN
11. DT Efron KD Lillemoe JL Cameron, et al. 2001 Surgical management of gastrointestinal stromal tumors: A single institution 33-year experience Gastroenterology 120 41A
12. PJ Roberts B Eisenberg 2002 Clinical presentation of gastrointestinal stromal tumors and treatment of operable disease Eur J Cancer 38 S37 S38 12528771
13. EM Connoly E Gaffney JV Reynolds, et al. 2004 Gastrointestinal stromal tumors Br J Surg 91 252 253
14. A Chompret C Kannengiesser M Barrois, et al. 2004 PDGFRA germline mutation in a family with multiple cases of GISTs Gastroenterology 126 318 321 14699510 1:CAS:528:DC%2BD2cXhtFGnurw%3D
15. CL Corless JA Fletcher MC Heinrich, et al. 2004 Biology of gastrointestinal stromal tumors J Clin Oncol 22 3813 3825 15365079 1:CAS:528:DC%2BD2cXhtVCitb%2FL
16. J Lasota M Miettinen, et al. 2006 KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTS) Semin Diagn Pathol 23 91 102 17193822
17. ME Robson E Glogowski G Sommer, et al. 2004 Pleomorphic characteristics of a germline KIT mutation in a large kindred with GISTs, hyperpigmentation, and dysphagia Clin Cancer Res 10 1250 1254 14977822 1:CAS:528:DC%2BD2cXhsVCqtb4%3D
18. FP Li JA Fletcher MC Heinrich, et al. 2005 Familial gastrointestinal stromal tumor syndrome: phenotypic and molecular features in a kindred J Clin Oncol 23 2735 2743 15837988 1:CAS:528:DC%2BD2MXktleqtrs%3D
19. K Kinoshita S Hirota K Isozaki, et al. 2004 Absence of c-kit gene mutations in gastrointestinal stromal tumors from neurofibromatosis type 1 patients J Pathol 202 80 85 14694524 1:CAS:528:DC%2BD2cXnslCntg%3D%3D
20. JA Carney 1999 Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney triad): Natural history, adrenocortical component, and possible familial occurrence Mayo Clin Proc 74 543 552 10377927 1:STN:280:DyaK1MzgsFKqsg%3D%3D
21. PS Amieux 2004 Getting the GIST of the Carney triad: growth factors, rare tumors, and cellular respiration Pediatr Dev Pathol 7 306 308 15383926
22. RA Erlandson JM Woodruff, et al. 1998 Role of electron microscopy in the evaluation of soft tissue neoplasms, with emphasis on spindle cell and pleomorphic tumors Hum Pathol 29 1372 1381 9865822 1:STN:280: DyaK1M%2FotFChsg%3D%3D
23. M Miettinen J Lasota, et al. 2001 Gastrointestinal stromal tumors-definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis Virchows Arch 438 1 12 11213830 1:CAS:528:DC%2BD3MXlt1Kquw%3D%3D
24. LG Kindblom HE Rmotti F Aldenborg, et al. 1998 Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal Am J Pathol 152 1259 1269 9588894 1:STN:280:DyaK1c3kvVejug%3D%3D
25. M Miettinen J Lasota 2006 Gastrointestinal stromal tumors: Pathology and prognosis at different sites Semin Diagn Pathol 23 70 83 17193820
26. LG Kindblom HE Remotti F Aldenborg, et al. 1998 Gastrointestinal pace-maker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the intestinal cells of Cajal Am J Pathol 152 1259 1269 9588894 1:STN:280:DyaK1c3kvVejug%3D%3D
27. RB West CL Corless X Chen, et al. 2004 The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status Am J Pathol 165 107 113 15215166 1:CAS:528: DC%2BD2cXmtFygsLs%3D
28. I Espinosa CH Lee MK Kim, et al. 2008 A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors Am J Surg Pathol 32 210 218 18223323
29. T Tsujimura C Makiishi-Shimobayashi J Lundvist, et al. 2001 Expression of the intermediate filament nestin in gastrointestinal stromal tumors and intestinal cells of Cajal Am J Pathol 158 817 823 11238030 1:CAS:528: DC%2BD3MXitlOnur8%3D
30. M Sarlomo-Rikala T Tsujimura U Lendahl, et al. 2002 Patterns of nestin and other intermediate filament expression distinguish between gastrointestinal stromal tumors, leiomyomas and schwannomas APMIS 110 499 507 12193211 1:CAS:528:DC%2BD38XmslOlurk%3D
31. P Blay A Astudillo JM Buessa, et al. 2004 Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias Clin Cancer Res 10 4089 4095 15217944 1:CAS:528:DC%2BD2cXltFWmurg%3D
32. A Motegl S Sakurai H Nakayama, et al. 2005 PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for intentifying KIT-negative tumors Pathol Int 55 106 112
33. A Duensing NE Joseph F Medeiros, et al. 2004 Protein kinase C theta (PKC theta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs) Cancer Res 64 5127 5131 15289315 1:CAS:528:DC%2BD2cXmtF2mtL8%3D
34. R Kirsch ZH Gao R Riddel, et al. 2007 Gastrointestinal stromal tumor: diagnostic challenges and practical approach to differential diagnosis Adv Anat Pathol 14 261 285 17592256
35. M Miettinen J Lasota 2001 Gastrointestinal stromal tumors-definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis Virchows Arch 438 1 12 11213830 1:CAS:528: DC%2BD3MXlt1Kquw%3D%3D
36. P Dhimes M Lopez-Carreira MP Ortega-Serrano, et al. 1995 Gastrointestinal autonomic nerve tumors and their separation from other gastrointestinal stromal tumors: An ultrastructural and immunohistochemical study of 7 cases Virchows Arch 426 27 35 7704320 1:STN:280:DyaK2M3hvFWmuw%3D%3D
37. SC Abraham 2007 Distinguishing gastrointestinal stromal tumors from their mimics: an update Adv Anat Pathol 14 178 188 17452814
38. M Sarlomo-Rikala AJ Kovatich A Barusevicius, et al. 1998 CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34 Mod Pathol 11 728 734 9720500 1:STN:280:DyaK1czosFCmtg%3D%3D
39. AR Perez-Atayde RC Shamberger HW Kozakewich, et al. 1993 Neuroectodermal differentiation of the gastrointestinal stromal tumors in the Carney triad. An ultrastructural and immunohistochemical study Am J Surg Pathol 17 706 714 8317611 1:STN:280:DyaK3szgsVGlug%3D%3D
40. FH Qiu P Ray K Brown, et al. 1988 Primary structure of c-KIT: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus EMBO J 7 1003 1011 2456920 1:CAS:528:DyaL1cXlsVelsrg%3D
41. B Liegl-Atzwanger JA Fletcher CDM Fletcher 2010 Gastrointestinal stromal tumors Virchows Arch 456 111 127 20165865
42. RA Fleischman 1993 From white spots to stem cells: The role of the KIT receptor in mammalian development Trends Genet 9 285 290 7691001 1:STN:280:DyaK3szpt1agtw%3D%3D
43. SM Ward AJ Burns S Torihashi, et al. 1994 Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine J Physiol 480 91 97 7853230 1:CAS:528:DyaK2cXmslOqt78%3D
44. Q Tian HFJ Frierson GW Krystal, et al. 1999 Activating c-kit gene mutations in human germ cell tumors Am J Pathol 154 1643 1647 10362788 1:CAS:528:DyaK1MXjvFGrtrc%3D
45. BP Rubin S Singer C Tsao, et al. 2001 KIT activation is a ubiquitous feature of gastrointestinal stromal tumors Cancer Res 61 8118 8121 11719439 1:CAS:528:DC%2BD3MXovVShs7w%3D
46. CR Rossi S Mocellin R Mencarelli, et al. 2003 Gastrointestinal stromal tumors: From a surgical to a molecular approach Int J Cancer 107 171 176 12949790 1:CAS:528:DC%2BD3sXnsFahsbk%3D
47. EM Connolly E Gaffney JV Reynolds, et al. 2003 Gastrointestinal stromal tumors Br J Surg 90 1178 1186 14515284 1:STN:280:DC%2BD3svltl2itw%3D%3D
48. K Isozaki B Terris J Belghiti 2000 Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors Am J Pathol 157 1581 1585 11073817 1:CAS:528:DC%2BD3cXosFyhsrc%3D
49. S Bauer CL Corless MC Heinrich, et al. 2003 Response to imatinib mesylate of a gastrointestinal stromal tumor with very low expression of KIT Cancer Chemother Pharmacol 51 261 265 12655446
50. F Medeiros CL Corless A Duensing, et al. 2004 KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic complications Am J Surg Pathol 33 484 495
51. MC Heinrich BP Rubin BJ Longley, et al. 2002 Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations Hum Pathol 33 484 495 12094373 1:CAS:528:DC%2BD38XlslCls7s%3D
52. MC Heinrich CL Corless A Duensing, et al. 2003 PDGFRA activating mutations in gastrointestinal stromal tumors Science 299 708 710 12522257 1:CAS:528:DC%2BD3sXntFWitQ%3D%3D
53. S Hirota A Ohashi T Nishida, et al. 2003 Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors Gastroenterology 125 660 667 12949711 1:CAS:528:DC%2BD3sXnvVSiur8%3D
54. L Boccon-Gibod F Boman S Boudjemaa, et al. 2004 Separate occurrence of extra-adrenal paraganglioma and gastrointestinal stromal tumor in monozygotic twins: probable familial Carney syndrome Pediatr Dev Pathol 7 380 384 15383933
55. E Lerma SJ Lee D Tugues, et al. 1994 Ploidy of 36 stromal tumors of the gastrointestinal tract: A comparative study with flow cytometry and image analysis Anal Quant Cytol Histol 16 435 440 7710619 1:STN:280: DyaK2M3isF2jtw%3D%3D
56. P Rudolph K Gloeckner R Parwaresch, et al. 1998 Immunophenotype, proliferation, DNA ploidy, and biological behavior of gastrointestinal stromal tumors: A multivariate clinicopathologic study Hum Pathol 29 791 800 9712419 1:STN:280:DyaK1czns1altg%3D%3D
57. MG House MZ Guo DT Efron, et al. 2003 Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behavior J Gastroint Surg 7 1004 1014
58. S Sakurai M Fukayama Y Kaizaki, et al. 1998 Telomerase activity in gastrointestinal stromal tumors Cancer 83 2060 2066 9827709 1:CAS:528: DyaK1cXnvFShs7Y%3D
59. E Vrettou G Karkavelas B Christoforidou, et al. 1995 Immunohistochemical phenotyping and DNA detection in gastrointestinal stromal tumors Anticancer Res 15 943 950 7645984 1:STN:280:DyaK2Mzntl2lsg%3D%3D
60. CC Yu CD Fletcher PL Newman, et al. 1992 A comparison of proliferating cell nuclear antigen (PCNA) immunostaining, nucleolar organizer region (AgNOR) staining, and histological grading in gastrointestinal stromal tumors J Pathol 166 147 152 1348532 1:STN:280:DyaK383hvFSmsg%3D%3D
61. Kontogianni K, Demonakou M, Kavantzas N, et al. Prognostic predictors of gastrointestinal stromal tumors: A multi-institutional analysis of 102 patients with definition of a prognostic index. Eur J Surg Oncol 2003; 29:548-556.
62. N Koon R Schneider-Stock M Sarlomo-Rikala J Lasota M Smolkin G Petroni A Zaika C Boltze F Meyer L Anderson S Knuuitila M Miettinen W El-Rifai, et al. 2004 Molecular targets for tumor progression in gastrointestinal stromal tumors Gut 53 235 240 14724156 1:CAS:528:DC%2BD2cXhs1GhtLc%3D
63. J Andersson P Bumming JM Meis-Kindblom, et al. 2006 Gstrointestinal stromal tumors with KIT exon 11 deletions are associated with poor prognosis Gastroenterology 130 1573 1581 16697720 1:CAS:528:DC%2BD28Xls1Wisbg%3D
64. LR Chirieac JC Trent DM Steinert, et al. 2006 Correlation of immunophenotype with progression-free survival in patients with gastrointestinal stromal tumors treated with imatinib mesylate Cancer 107 2237 2244 16998931 1:CAS:528:DC%2BD28Xht1Olt7vL
65. J Martin A Poveda A Llombart-Bosch, et al. 2005 Deletions affecting codons 557-558 of the c-kit gene indicate a poor prognosis in patients with completely resected gastrointestinal stromal tumors: a study by the Spanish Group for Sarcoma Research (GEIS) J Clin Oncol 23 6190 6198 16135486 1:CAS:528:DC%2BD2MXhtVKgtbrO
66. U Tateishi T Hasegawa M Satake, et al. 2003 Gastrointestinal stromal tumors: Correlation of computed tomography findings with tumor grade and mortality J Comput Assist Tomogr 27 792 798 14501372
67. GJC Burkill M Badran O Al-Muderis, et al. 2003 Malignant gastrointestinal stromal tumor: Distribution, imaging findings, and pattern of metastatic spread Radiology 226 527 532 12563150
68. JS Gong M Zuo P Yang, et al. 2008 Value of CT in the diagnosis and follow-up of gastrointestinal stromal tumors Clin Imaging 32 172 177 18502343
69. M Scarpa M Bertin C Ruffolo L Polese DF d'Amico I Angriman, et al. 2008 A systematic review of the clinical diagnosis of gastrointestinal stromal tumors J Surg Oncol 98 384 392 18668671
70. R Logrono P Bhanot C Chaya L Cao I Waxman MS Bhutani, et al. 2006 Imaging, morphology, and immunohistochemical correlation in gastrointestinal stromal tumors Cancer 108 257 266 16795074
71. N Ghanem C Altehoefer A Furtwangler, et al. 2003 Computed tomography in gastrointestinal stromal tumors Eur Radiol 13 1669 1678 12835984
72. K Sandrasegaran A Rajesh DA Rushing J Rudberg FM Akisik JD Henley, et al. 2005 Gastrointestinal stromal tumors: CT and MRI findings Eur Radiol 15 1407 1414 15761716
73. M Matsui H Goto Y Niwa, et al. 1998 Preliminary results of fine-needle aspiration biopsy histology in upper gastrointestinal submucosal tumors Endoscopy 30 750 755 9932753 1:STN:280:DyaK1M7ivFGgsQ%3D%3D
74. HJ Chu JY Byun KA Chun, et al. 1998 Gastrointestinal leiomyoma and leiomyosarcoma: CT differentiation J Comput Assist Tomogr 22 69 74
75. KM Horton K Juluru E Montogomery, et al. 2004 Computed tomography imaging of gastrointestinal stromal tumors with pathology correlation J Comput Assist Tomogr 28 811 817 15538156
76. AD Levy HE Remotti WM Thompson, et al. 2003 Gastrointestinal stromal tumors: radiologic features and pathologic correlation Radiographics 23 283 304 12640147
77. H Choi, et al. 2008 Response evaluation of gastrointestinal stromal tumors Oncologist 2 4 7
78. CH Holdsworth RD Badawi JB Manola, et al. 2007 CT and PET: early prognostic indicators of response to imatinib mesylate in patients with gastrointestinal stromal tumor Am J Roentgenol 189 324 330
79. T Heinicke E Wardelmann T Sauerbruch 2005 et al. Very early detection of response to imatinib mesylate therapy of gastrointestinal stromal tumors using 18fluorodeoxyglucose-positron emission tomography Anticancer Res 2 5 4591 4594
80. S Basu KM Mohandas H Peshive R Asopa M Unawahare, et al. 2008 FDG-PET and PET-CT in the clinical management of GISTs Nucl Med Commun 29 1026 1039 18987522
81. G Antoch J Kanja S Bauer, et al. 2004 Comparison of PET, CT and dual modality PET/CT imaging for monitoring imatinib (STI571) therapy in patients with GISTs J Nucl Med 45 357 365 15001674 1:CAS:528:DC%2BD2cXivVCjur0%3D
82. M Everett H Gutman, et al. 2008 Surgical management of gastrointestinal stromal tumors: Analysis of outcome with respect to surgical margins and technique J Surg Oncol 98 588 593 19072850
83. S Wang, et al. 2007 Surgical management of gastrointestinal stromal tumors Zhonghua Wei Chang Wai Ke Za Zhi 10 5 7 17253163 1:CAS:528: DC%2BD2sXmsFGmtro%3D
84. Bonvalot S. An update of the surgical indications for gastrointestinal stromal tumors. J Chir (Paris) 2008;3:6S8-11.
85. Demetri GD, Benjamin RS, Blanke CD, et al. NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST)-update of the NCCN clinical practice guidelines. J Natl Compr Canc Netw 2007; 5(Suppl2):S1-29.
86. EH Ng RE Pollock MM Romsdahl, et al. 1992 Prognostic implications of patterns of failure for gastrointestinal leiomyosarcomas Cancer 69 1334 1341 1540870 1:STN:280:DyaK387nsVSmtQ%3D%3D
87. H Chen A Pruitt TL Nicol, et al. 1998 Complete hepatic resection of metastases from leiomyosarcoma prolongs survival J Gastrointest Surg 2 151 155 9834411 1:STN:280:DyaK1M%2FlvF2mtg%3D%3D
88. T Aparicio V Boige JC Sabourin, et al. 2004 Prognostic factors after surgery of primary resectable gastrointestinal stromal tumors Eur J Surg Oncol 30 1098 1103 15522557 1:STN:280:DC%2BD2crltVOlsQ%3D%3D
89. MG Blum KY Bilimoria JD Wayne, et al. 2007 Surgical considerations for the management and resection of esophageal gastrointestinal stromal tumors Ann Thorac Surg 84 1717 1723 17954092
90. Y Otani T Furukawa M Yoshida Y Saikawa N Wada M Ueda T Kubota M Mukai K Kameyama Y Sugino K Kumai M Kitajima, et al. 2006 Operative indications for relatively small (2-5cm) gastrointestinal stromal tumor of the stomach based on analysis of 60 operative cases Surgery 139 484 492 16627057
91. RD Winfield SN Hochwald SB Vogel, et al. 2006 Presentation and management of gastrointestinal stromal tumors of the duodenum Am Surg 72 719 722 16913316
92. RP Dematteo RG Maki C Antonescu, et al. 2003 Targeted molecular therapy for cancer: the application of STI571 to gastrointestinal stromal tumor Curr Probl Surg 40 144 193 12571542
93. YW Novitsky KW Kercher RF Sing, et al. 2006 Long-term outcomes of laparoscopic resection of gastric gastrointestinal stromal tumors Ann Surg 243 738 745 16772777
94. SM Choi MC Kim GJ Jung, et al. 2007 Laparoscopic wedge resection for gastric GIST: long-term follow up results Eur J Surg Oncol 33 444 447 17174060
95. IR Lai WJ Lee SC Yu, et al. 2006 Minimally invasive surgery for gastric stromal tumors: intermediate follow up results J Gastrointest Surg 10 563 566 16627222
96. A Hindmarsh B Koo MP Lewis, et al. 2005 Laparoscopic resection of gastric gastrointestinal stromal tumors Surg Endosc 19 1109 1112 16021371 1:STN:280:DC%2BD2MrlvVOhsw%3D%3D
97. J Nishimura K Nakajima T Omori, et al. 2007 Surgical strategy for gastric gastrointestinal stromal tumors: laparoscopic vs open resection Surg Endosc 21 875 878 17180273
98. H Joensuu C Fletcher S Dimitrijevic, et al. 2002 Management of malignant gastrointestinal stromal tumors Lancet Oncol 3 655 664 12424067 1:CAS:528:DC%2BD38Xotlygs7Y%3D
99. JP Pierie U Choudry A Muzikansky, et al. 2001 The effect of surgery and grade on outcome of gastrointestinal stromal tumors Arch Surg 136 383 389 11296107 1:STN:280:DC%2BD3M3kvVemsA%3D%3D
100. JK Trupiano RE Stewart C Misick, et al. 2002 Gastric stromal tumors: A clinicopathologic study of 77 cases with correlation of features with nonaggressive and aggressive clinical behaviors Am J Surg Pathol 26 705 714 12023574
101. RH Andtbacka CS Ng CL Scaife, et al. 2007 Surgical resection of gastrointestinal stromal tumors after treatment with imatinib Ann Surg Oncol 14 14 24 17072676
102. B Nilsson K Sjolund LG Kindblom, et al. 2007 Adjuvant imatinib treatment improves recurrence-free survival in patients with high-risk GIST Br J Cancer 96 1656 1658 17533389 1:CAS:528:DC%2BD2sXlvVShtrg%3D
103. DeMatteo RP, Owzar K, Maki RG, et al. Adjuvant imatinib mesylate increases recurrence free survival in patients with completely resected localized primary gastrointestinal stromal tumor (GIST): North American Intergroup Phase III trial ACOSOG Z9001. Proceedings of the American Society of Clinical Oncology, 2007 ASCO Annual Meeting.
104. DeMatteo RP, Antonescu CR, Chadaram V, et al. Adjuvant imatinib mesylate in patients with primary high risk GIST following complete resection: safety results from the U.S. Intergroup Phase II trial ACOSOG Z 9000. Proceedings of the American Society of Clinical Oncology, 2005;23(16S).
105. M Heinrich D Griffith B Druker, et al. 2000 Inhibition of c-KIT receptor tyrosine kinase activity by STI571, a selective tyrosine kinase inhibitor Blood 96 925 932 10910906 1:CAS:528:DC%2BD3cXltlKitLw%3D
106. KF Croom CM Perry, et al. 2003 Imatinib mesylate: in the treatment of gastrointestinal stromal tumors Drugs 63 513 522 12600228 1:CAS:528: DC%2BD3sXjtVyrurc%3D
107. C Tarn AK Godwin, et al. 2005 Molecular research directions in the management of gastrointestinal stromal tumors Curr Treat Options Oncol 6 473 486 16242052
108. D Tuveson N Willis T Jacks, et al. 2001 STI571 inactivation of the gastrointestinal stromal tumor c-Kit oncoprotein, biological and clinical implication Oncogene 20 5054 5058 11526490 1:CAS:528:DC%2BD3MXmtlCks7g%3D
109. H Joensuu P Roberts 2001 Sarlomo-Rikala, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with metastatic gastrointestinal stromal tumor N Engl J Med 344 1052 1056 11287975 1:STN:280:DC%2BD3M3gvVekuw%3D%3D
110. GD Demetri M von Mehren CD Blanke, et al. 2002 Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors N Engl J Med 347 472 480 12181401 1:CAS:528:DC%2BD38XmtV2nt7s%3D
111. Benjamin RS, Rankin C, Fletcher C, et al. Phase III dose-randomized trial of imatinib mesylate (STI571) for GIST: Intergroup S0033 early results. Proceedings of the American Society of Clinical Oncology, 2003;22.
112. J Verweij PG Casali J Zalcberg 2004 Progression-free survival in gastrointestinal stromal tumors with high-dose imatinib: randomized trial Lancet 364 1127 1134 15451219 1:CAS:528:DC%2BD2cXnvVOiu7o%3D
113. M Debiec-Rychter H Dumez I Judson, et al. 2004 Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumors entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group Eur J Cancer 40 689 695 15010069 1:CAS:528:DC%2BD2cXhvVOrtL8%3D
114. JY Blay A Le Cense I Ray-Coquard, et al. 2007 Prospective multicentric randomized phase III study of imatinib in patients with advanced gastrointestinal stromal tumors comparing interruption versus continuation of treatment beyond 1 year: the French Sarcoma Group J Clin Oncol 25 1107 1113 17369574 1:CAS:528:DC%2BD2sXksVyrs7s%3D
115. P Rutkowski M Symonides M Zdzienicki JA Siedlecki, et al. 2008 Developments in targeted therapy of advanced gastrointestinal tumors Recent Patents Anticancer Drug Discov 3 88 99 1:CAS:528:DC%2BD1cXotF2nsbk%3D
116. M Van Glabbeke J Verweij PG Casali, et al. 2005 Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: a European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study J Clin Oncol 23 5795 5804 16110036
117. MC Heinrich CL Corless GD Demetri, et al. 2003 Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor J Clin Oncol 21 4342 4349 14645423 1:CAS:528:DC%2BD2cXpsVWqu7Y%3D
118. KH Lim MJ Huanq LT Chen TE Wanq CL Liu CS Chanq MC Liu RK Hsieh CY Tzen, et al. 2008 Molecular analysis of secondary kinase mutations in imatinib-resistant gastrointestinal stromal tumors Med Oncol 25 207 213 18488160 1:CAS:528:DC%2BD1cXotVOgtbY%3D
119. NP Aqaram GC Wonq T Guo RG Maki S Sinqer RP Dematteo P Besmer CR Antonescu, et al. 2008 Novel V600E mutations in imatinib-naïve and imatinib-resistant GISTs Genes Chromosomes Cancer 47 853 859
120. A Italiano B Bui 2008 Gastrointestinal stromal tumors: molecular aspects and therapeutic implications Bull Cancer 95 107 116 18230576 1:CAS:528:DC%2BD1cXktVyrsrc%3D
121. GD Demetri AT van Oosterom CR Garrett, et al. 2006 Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumors after failure of imatinib: a randomized controlled trial Lancet 368 1329 1338 17046465 1:CAS:528:DC%2BD28XhtVOrtL%2FL
122. PA Cassier A Dufresne S Arifi, et al. 2008 Novel approaches to gastrointestinal stromal tumors resistant to imatinib and sunitinib Curr Gastroenterol Rep 10 555 561 19006610
123. P Reichardt, et al. 2008 Novel approaches to imatinib- and sunitinib-resistant GIST Curr Oncol Rep 10 344 349 18778561 1:CAS:528: DC%2BD1cXhtFems7nE
124. P Bumming J Andersson JM Meis-Kindblom, et al. 2003 Neoadjuvant, adjuvant, and palliative treatment of GISTs with imatinib: a centre-based study of 17 patients Br J Cancer 89 460 464 12888812 1:STN:280:DC%2BD3szlsFansA%3D%3D
125. JC Gutierrez EA Perez FL Moffat, et al. 2007 Should soft tissue sarcomas be treated at high-volume centers? An analysis of 4205 patients Ann Surg 245 952 958 17522521