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Volumn 10, Issue 6, 2008, Pages 555-561

Novel approaches to gastrointestinal stromal tumors resistant to imatinib and sunitinib

Author keywords

[No Author keywords available]

Indexed keywords

AFINITOR; ANTINEOPLASTIC AGENT; DASATINIB; EVEROLIMUS; HEAT SHOCK PROTEIN; IMATINIB; MIDOSTAURIN; MOTESANIB; NILOTINIB; PHOSPHOTRANSFERASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; SORAFENIB; STEM CELL FACTOR; SUNITINIB; TANESPIMYCIN HYDROQUINONE; UNCLASSIFIED DRUG;

EID: 60749129979     PISSN: 15228037     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11894-008-0102-z     Document Type: Review
Times cited : (9)

References (67)
  • 1
    • 13444270334 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era - A population-based study in western Sweden
    • Nilsson B, Bumming P, Meis-Kindblom JM, et al.: Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era - a population-based study in western Sweden. Cancer 2005, 103: 821-829.
    • (2005) Cancer , vol.103 , pp. 821-829
    • Nilsson, B.1    Bumming, P.2    Meis-Kindblom, J.M.3
  • 2
    • 39349113416 scopus 로고    scopus 로고
    • Incidence of gastrointestinal stromal tumors (GISTs) in France: Results of the PROGIST survey conducted among pathologists
    • [abstract]
    • Monges G, Coindre J, Scoazec J, et al.: Incidence of gastrointestinal stromal tumors (GISTs) in France: Results of the PROGIST survey conducted among pathologists [abstract]. J Clin Oncol (Meeting Abstracts) 2007, 25: 10047.
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , pp. 10047
    • Monges, G.1    Coindre, J.2    Scoazec, J.3
  • 4
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Demetri GD, von Mehren M, Blanke CD, et al.: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002, 347: 472-480.
    • (2002) N Engl J Med , vol.347 , pp. 472-480
    • Demetri, G.D.1    von Mehren, M.2    Blanke, C.D.3
  • 5
    • 20844433223 scopus 로고    scopus 로고
    • Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial
    • Verweij J, Casali PG, Zalcberg J, et al.: Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial. Lancet 2004, 364: 1127-1134.
    • (2004) Lancet , vol.364 , pp. 1127-1134
    • Verweij, J.1    Casali, P.G.2    Zalcberg, J.3
  • 6
    • 33750627675 scopus 로고    scopus 로고
    • Long-term follow-up of a phase II randomized trial in advanced gastrointestinal stromal tumor (GIST) patients (pts) treated with imatinib mesylate
    • [abstract]
    • Blanke CD, Demetri GD, Von Mehren M, et al.: Long-term follow-up of a phase II randomized trial in advanced gastrointestinal stromal tumor (GIST) patients (pts) treated with imatinib mesylate [abstract]. J Clin Oncol (Meeting Abstracts) 2006, 24: 9528.
    • (2006) J Clin Oncol (Meeting Abstracts) , vol.24 , pp. 9528
    • Blanke, C.D.1    Demetri, G.D.2    Von Mehren, M.3
  • 7
    • 33748948155 scopus 로고    scopus 로고
    • Sunitinib (SU) response in imatinib-resistant (IM-R) GIST correlates with KIT and PDGFRA mutation status
    • [abstract]
    • Heinrich MC, Maki RG, Corless CL, et al.: Sunitinib (SU) response in imatinib-resistant (IM-R) GIST correlates with KIT and PDGFRA mutation status [abstract]. J Clin Oncol (Meeting Abstracts) 2006, 24: 9502.
    • (2006) J Clin Oncol (Meeting Abstracts) , vol.24 , pp. 9502
    • Heinrich, M.C.1    Maki, R.G.2    Corless, C.L.3
  • 8
    • 33749505836 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
    • Demetri GD, van Oosterom AT, Garrett CR, et al.: Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial. Lancet 2006, 368: 1329-1338.
    • (2006) Lancet , vol.368 , pp. 1329-1338
    • Demetri, G.D.1    van Oosterom, A.T.2    Garrett, C.R.3
  • 9
    • 0041984595 scopus 로고    scopus 로고
    • 18FDGpositron emission tomography for the early prediction of response in advanced soft tissue sarcoma treated with imatinib mesylate (Glivec)
    • Stroobants S, Goeminne J, Seegers M, et al.: 18FDGpositron emission tomography for the early prediction of response in advanced soft tissue sarcoma treated with imatinib mesylate (Glivec). Eur J Cancer 2003, 39: 2012-2020.
    • (2003) Eur J Cancer , vol.39 , pp. 2012-2020
    • Stroobants, S.1    Goeminne, J.2    Seegers, M.3
  • 10
    • 2342561799 scopus 로고    scopus 로고
    • Comparison of PET, CT, and dual-modality PET/CT imaging for monitoring of imatinib (STI571) therapy in patients with gastrointestinal stromal tumors
    • Antoch G, Kanja J, Bauer S, et al.: Comparison of PET, CT, and dual-modality PET/CT imaging for monitoring of imatinib (STI571) therapy in patients with gastrointestinal stromal tumors. J Nucl Med 2004, 45: 357-365.
    • (2004) J Nucl Med , vol.45 , pp. 357-365
    • Antoch, G.1    Kanja, J.2    Bauer, S.3
  • 11
    • 34249085905 scopus 로고    scopus 로고
    • Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: Proposal of new computed tomography response criteria
    • Choi H, Charnsangavej C, Faria SC, et al.: Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: Proposal of new computed tomography response criteria. J Clin Oncol 2007, 25: 1753-1759.
    • (2007) J Clin Oncol , vol.25 , pp. 1753-1759
    • Choi, H.1    Charnsangavej, C.2    Faria, S.C.3
  • 12
    • 34249030871 scopus 로고    scopus 로고
    • We should desist using RECIST, at least in GIST
    • Benjamin RS, Choi H, Macapinlac HA, et al.: We should desist using RECIST, at least in GIST. J Clin Oncol 2007, 25: 1760-1764.
    • (2007) J Clin Oncol , vol.25 , pp. 1760-1764
    • Benjamin, R.S.1    Choi, H.2    Macapinlac, H.A.3
  • 13
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P, Arbuck SG, Eisenhauer EA, et al.: New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000, 92: 205-216.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 14
    • 24344507650 scopus 로고    scopus 로고
    • Effect of angiosonography to monitor response during imatinib treatment in patients with metastatic gastrointestinal stromal tumors
    • De Giorgi U, Aliberti C, Benea G, et al.: Effect of angiosonography to monitor response during imatinib treatment in patients with metastatic gastrointestinal stromal tumors. Clin Cancer Res 2005, 11: 6171-6176.
    • (2005) Clin Cancer Res , vol.11 , pp. 6171-6176
    • De Giorgi, U.1    Aliberti, C.2    Benea, G.3
  • 15
    • 18844457915 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumor: New nodule-within-a-mass pattern of recurrence after partial response to imatinib mesylate
    • Shankar S, Vansonnenberg E, Desai J, et al.: Gastrointestinal stromal tumor: New nodule-within-a-mass pattern of recurrence after partial response to imatinib mesylate. Radiology 2005, 235: 892-898.
    • (2005) Radiology , vol.235 , pp. 892-898
    • Shankar, S.1    Vansonnenberg, E.2    Desai, J.3
  • 16
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • Heinrich MC, Corless CL, Demetri GD, et al.: Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 2003, 21: 4342-4349.
    • (2003) J Clin Oncol , vol.21 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3
  • 17
    • 23944476156 scopus 로고    scopus 로고
    • PDGFRA mutations in gastrointestinal stromal tumors: Frequency, spectrum and in vitro sensitivity to imatinib
    • Corless CL, Schroeder A, Griffith D, et al.: PDGFRA mutations in gastrointestinal stromal tumors: Frequency, spectrum and in vitro sensitivity to imatinib. J Clin Oncol 2005, 23: 5357-5364.
    • (2005) J Clin Oncol , vol.23 , pp. 5357-5364
    • Corless, C.L.1    Schroeder, A.2    Griffith, D.3
  • 18
    • 14944352767 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinibresistant mutants
    • Debiec-Rychter M, Cools J, Dumez H, et al.: Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinibresistant mutants. Gastroenterology 2005, 128: 270-279.
    • (2005) Gastroenterology , vol.128 , pp. 270-279
    • Debiec-Rychter, M.1    Cools, J.2    Dumez, H.3
  • 19
    • 33750595859 scopus 로고    scopus 로고
    • Molecular correlates of imatinib resistance in gastrointestinal stromal tumors
    • Heinrich MC, Corless CL, Blanke CD, et al.: Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. J Clin Oncol 2006, 24: 4764-4774.
    • (2006) J Clin Oncol , vol.24 , pp. 4764-4774
    • Heinrich, M.C.1    Corless, C.L.2    Blanke, C.D.3
  • 20
    • 12144291080 scopus 로고    scopus 로고
    • Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group
    • Debiec-Rychter M, Dumez H, Judson I, et al.: Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer 2004, 40: 689-695.
    • (2004) Eur J Cancer , vol.40 , pp. 689-695
    • Debiec-Rychter, M.1    Dumez, H.2    Judson, I.3
  • 21
    • 39049100282 scopus 로고    scopus 로고
    • Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors (GIST): A metaanalysis based on 1,640 patients (pts)
    • [abstract]
    • Van Glabbeke MM, Owzar K, Rankin C, et al.: Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors (GIST): A metaanalysis based on 1,640 patients (pts) [abstract]. J Clin Oncol (Meeting Abstracts) 2007, 25: 10004.
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , pp. 10004
    • Van Glabbeke, M.M.1    Owzar, K.2    Rankin, C.3
  • 22
    • 20344393896 scopus 로고    scopus 로고
    • Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation
    • Antonescu CR, Besmer P, Guo T, et al.: Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin Cancer Res 2005, 11: 4182-4190.
    • (2005) Clin Cancer Res , vol.11 , pp. 4182-4190
    • Antonescu, C.R.1    Besmer, P.2    Guo, T.3
  • 23
    • 67349171674 scopus 로고    scopus 로고
    • Correlation of imatinib plasma levels with clinical benefit in patients (Pts) with unresectable/metastatic gastrointestinal tumors (GIST)
    • [abstract 3]. Presented at the Orlando, FL; January 25-27
    • Demetri GD, Wang Y, Wehrle E, et al.: Correlation of imatinib plasma levels with clinical benefit in patients (Pts) with unresectable/ metastatic gastrointestinal tumors (GIST) [abstract 3]. Presented at the 2008 Gastrointestinal Cancers Symposium. Orlando, FL; January 25-27, 2008.
    • (2008) 2008 Gastrointestinal Cancers Symposium
    • Demetri, G.D.1    Wang, Y.2    Wehrle, E.3
  • 24
    • 20844448396 scopus 로고    scopus 로고
    • A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient
    • Tamborini E, Bonadiman L, Greco A, et al.: A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient. Gastroenterology 2004, 127: 294-299.
    • (2004) Gastroenterology , vol.127 , pp. 294-299
    • Tamborini, E.1    Bonadiman, L.2    Greco, A.3
  • 25
    • 3042747267 scopus 로고    scopus 로고
    • Late resistance to imatinib therapy in a metastatic gastrointestinal stromal tumour is associated with a second KIT mutation
    • Wakai T, Kanda T, Hirota S, et al.: Late resistance to imatinib therapy in a metastatic gastrointestinal stromal tumour is associated with a second KIT mutation. Br J Cancer 2004, 90: 2059-2061.
    • (2004) Br J Cancer , vol.90 , pp. 2059-2061
    • Wakai, T.1    Kanda, T.2    Hirota, S.3
  • 26
    • 20844460619 scopus 로고    scopus 로고
    • A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors
    • Chen LL, Trent JC, Wu EF, et al.: A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res 2004, 64: 5913-5919.
    • (2004) Cancer Res , vol.64 , pp. 5913-5919
    • Chen, L.L.1    Trent, J.C.2    Wu, E.F.3
  • 27
    • 14644421558 scopus 로고    scopus 로고
    • KIT/Val654 Ala receptor detected in one imatinib-resistant GIST patient
    • [letter]
    • Tamborini E, Gabanti E, Lagonigro MS, et al.: KIT/Val654 Ala receptor detected in one imatinib-resistant GIST patient [letter]. Cancer Res 2005, 65: 1115.
    • (2005) Cancer Res , vol.65 , pp. 1115
    • Tamborini, E.1    Gabanti, E.2    Lagonigro, M.S.3
  • 28
    • 30344481113 scopus 로고    scopus 로고
    • Imatinib binding and cKIT inhibition is abrogated by the cKIT kinase domain I missense mutation Val654Ala
    • McLean SR, Gana-Weisz M, Hartzoulakis B, et al.: Imatinib binding and cKIT inhibition is abrogated by the cKIT kinase domain I missense mutation Val654Ala. Mol Cancer Ther 2005, 4: 2008-2015.
    • (2005) Mol Cancer Ther , vol.4 , pp. 2008-2015
    • McLean, S.R.1    Gana-Weisz, M.2    Hartzoulakis, B.3
  • 29
    • 20144387198 scopus 로고    scopus 로고
    • Acquired resistance to imatinib in gastrointestinal stromal tumours caused by multiple KIT mutations
    • Wardelmann E, Thomas N, Merkelbach-Bruse S, et al.: Acquired resistance to imatinib in gastrointestinal stromal tumours caused by multiple KIT mutations. Lancet Oncol 2005, 6: 249-251.
    • (2005) Lancet Oncol , vol.6 , pp. 249-251
    • Wardelmann, E.1    Thomas, N.2    Merkelbach-Bruse, S.3
  • 30
    • 24044434901 scopus 로고    scopus 로고
    • Resistance to imatinib, low-grade FDG-avidity on PET, and acquired KIT exon 17 mutation in gastrointestinal stromal tumour
    • Grimpen F, Yip D, McArthur G, et al.: Resistance to imatinib, low-grade FDG-avidity on PET, and acquired KIT exon 17 mutation in gastrointestinal stromal tumour. Lancet Oncol 2005, 6: 724-727.
    • (2005) Lancet Oncol , vol.6 , pp. 724-727
    • Grimpen, F.1    Yip, D.2    McArthur, G.3
  • 31
    • 33750464379 scopus 로고    scopus 로고
    • Acquired resistance to imatinib and secondary KIT exon 13 mutation in gastrointestinal stromal tumour
    • Bertucci F, Goncalves A, Monges G, et al.: Acquired resistance to imatinib and secondary KIT exon 13 mutation in gastrointestinal stromal tumour. Oncol Rep 2006, 16: 97-101.
    • (2006) Oncol Rep , vol.16 , pp. 97-101
    • Bertucci, F.1    Goncalves, A.2    Monges, G.3
  • 32
    • 33645693156 scopus 로고    scopus 로고
    • Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate
    • Wardelmann E, Merkelbach-Bruse S, Pauls K, et al.: Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate. Clin Cancer Res 2006, 12: 1743-1749.
    • (2006) Clin Cancer Res , vol.12 , pp. 1743-1749
    • Wardelmann, E.1    Merkelbach-Bruse, S.2    Pauls, K.3
  • 33
    • 33846635001 scopus 로고    scopus 로고
    • Surgical management after neoadjuvant imatinib therapy in gastrointestinal stromal tumours (GISTs) with respect to imatinib resistance caused by secondary KIT mutations
    • Haller F, Detken S, Schulten HJ, et al.: Surgical management after neoadjuvant imatinib therapy in gastrointestinal stromal tumours (GISTs) with respect to imatinib resistance caused by secondary KIT mutations. Ann Surg Oncol 2007, 14: 526-532.
    • (2007) Ann Surg Oncol , vol.14 , pp. 526-532
    • Haller, F.1    Detken, S.2    Schulten, H.J.3
  • 34
    • 35148861056 scopus 로고    scopus 로고
    • Focal progression in patients with gastrointestinal stromal tumors after initial response to imatinib mesylate: A three-center-based study of 38 patients
    • Al-Batran SE, Hartmann JT, Heidel F, et al.: Focal progression in patients with gastrointestinal stromal tumors after initial response to imatinib mesylate: A three-center-based study of 38 patients. Gastric Cancer 2007, 10: 145-152.
    • (2007) Gastric Cancer , vol.10 , pp. 145-152
    • Al-Batran, S.E.1    Hartmann, J.T.2    Heidel, F.3
  • 35
    • 37349051430 scopus 로고    scopus 로고
    • Secondary c-kit mutation in a recurrent gastrointestinal stromal tumor under long-term treatment with imatinib mesylate: Report of a case
    • Utsunomiya T, Okamoto M, Yano S, et al.: Secondary c-kit mutation in a recurrent gastrointestinal stromal tumor under long-term treatment with imatinib mesylate: Report of a case. Surg Today 2008, 38: 65-67.
    • (2008) Surg Today , vol.38 , pp. 65-67
    • Utsunomiya, T.1    Okamoto, M.2    Yano, S.3
  • 36
    • 34848816032 scopus 로고    scopus 로고
    • Clonal evolution of resistance to imatinib in patients with metastatic gastrointestinal stromal tumors
    • Desai J, Shankar S, Heinrich MC, et al.: Clonal evolution of resistance to imatinib in patients with metastatic gastrointestinal stromal tumors. Clin Cancer Res 2007, 13: 5398-5405.
    • (2007) Clin Cancer Res , vol.13 , pp. 5398-5405
    • Desai, J.1    Shankar, S.2    Heinrich, M.C.3
  • 37
    • 34347271967 scopus 로고    scopus 로고
    • Double resistance to imatinib and AMG 706 caused by multiple acquired KIT exon 17 mutations in a gastrointestinal stromal tumour
    • Grabellus F, Ebeling P, Worm K, et al.: Double resistance to imatinib and AMG 706 caused by multiple acquired KIT exon 17 mutations in a gastrointestinal stromal tumour. Gut 2007, 56: 1025-1026.
    • (2007) Gut , vol.56 , pp. 1025-1026
    • Grabellus, F.1    Ebeling, P.2    Worm, K.3
  • 38
    • 20444448971 scopus 로고    scopus 로고
    • KIT overexpression and amplification in gastrointestinal stromal tumors (GISTs)
    • Tabone S, Theou N, Wozniak A, et al.: KIT overexpression and amplification in gastrointestinal stromal tumors (GISTs). Biochim Biophys Acta 2005, 1741: 165-172.
    • (2005) Biochim Biophys Acta , vol.1741 , pp. 165-172
    • Tabone, S.1    Theou, N.2    Wozniak, A.3
  • 39
    • 42249108361 scopus 로고    scopus 로고
    • KIT mutations induce intracellular retention and activation of an immature form of the KIT protein in gastrointestinal stromal tumors
    • Tabone-Eglinger S, Subra F, El Sayadi H, et al.: KIT mutations induce intracellular retention and activation of an immature form of the KIT protein in gastrointestinal stromal tumors. Clin Cancer Res 2008, 14: 2285-2294.
    • (2008) Clin Cancer Res , vol.14 , pp. 2285-2294
    • Tabone-Eglinger, S.1    Subra, F.2    El Sayadi, H.3
  • 40
    • 27744569283 scopus 로고    scopus 로고
    • Multidrug resistance proteins in gastrointestinal stromal tumors: Site-dependent expression and initial response to imatinib
    • Theou N, Gil S, Devocelle A, et al.: Multidrug resistance proteins in gastrointestinal stromal tumors: Site-dependent expression and initial response to imatinib. Clin Cancer Res 2005, 11: 7593-7598.
    • (2005) Clin Cancer Res , vol.11 , pp. 7593-7598
    • Theou, N.1    Gil, S.2    Devocelle, A.3
  • 41
    • 39349116694 scopus 로고    scopus 로고
    • Mechanisms of sunitinib malate (SU) resistance in gastrointestinal stromal tumors (GISTs)
    • [abstract]
    • Heinrich MC, Corless CL, Liegl B, et al.: Mechanisms of sunitinib malate (SU) resistance in gastrointestinal stromal tumors (GISTs) [abstract]. J Clin Oncol (Meeting Abstracts) 2007, 25: 10006.
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , pp. 10006
    • Heinrich, M.C.1    Corless, C.L.2    Liegl, B.3
  • 42
    • 33845619526 scopus 로고    scopus 로고
    • Impact of surgery on advanced gastrointestinal stromal tumors (GIST) in the imatinib era
    • Bonvalot S, Eldweny H, Pechoux CL, et al.: Impact of surgery on advanced gastrointestinal stromal tumors (GIST) in the imatinib era. Ann Surg Oncol 2006, 13: 1596-1603.
    • (2006) Ann Surg Oncol , vol.13 , pp. 1596-1603
    • Bonvalot, S.1    Eldweny, H.2    Pechoux, C.L.3
  • 43
    • 33845633389 scopus 로고    scopus 로고
    • Surgical resection of gastrointestinal stromal tumors after treatment with imatinib
    • Andtbacka RH, Ng CS, Scaife CL, et al.: Surgical resection of gastrointestinal stromal tumors after treatment with imatinib. Ann Surg Oncol 2007, 14: 14-24.
    • (2007) Ann Surg Oncol , vol.14 , pp. 14-24
    • Andtbacka, R.H.1    Ng, C.S.2    Scaife, C.L.3
  • 44
    • 33744795769 scopus 로고    scopus 로고
    • Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors
    • Raut CP, Posner M, Desai J, et al.: Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors. J Clin Oncol 2006, 24: 2325-2331.
    • (2006) J Clin Oncol , vol.24 , pp. 2325-2331
    • Raut, C.P.1    Posner, M.2    Desai, J.3
  • 45
    • 34247615184 scopus 로고    scopus 로고
    • Surgery of residual disease following molecular-targeted therapy with imatinib mesylate in advanced/metastatic GIST
    • Gronchi A, Fiore M, Miselli F, et al.: Surgery of residual disease following molecular-targeted therapy with imatinib mesylate in advanced/ metastatic GIST. Ann Surg 2007, 245: 341-346.
    • (2007) Ann Surg , vol.245 , pp. 341-346
    • Gronchi, A.1    Fiore, M.2    Miselli, F.3
  • 46
    • 33845601781 scopus 로고    scopus 로고
    • Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity
    • Weisberg E, Wright RD, Jiang J, et al.: Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity. Gastroenterology 2006, 131: 1734-1742.
    • (2006) Gastroenterology , vol.131 , pp. 1734-1742
    • Weisberg, E.1    Wright, R.D.2    Jiang, J.3
  • 47
    • 39349106967 scopus 로고    scopus 로고
    • A phase I study of nilotinib alone and in combination with imatinib (IM) in patients (pts) with imatinib-resistant gastrointestinal stromal tumors (GIST) - Study update
    • [abstract]
    • Von Mehren M, Reichardt P, Casali PG, et al.: A phase I study of nilotinib alone and in combination with imatinib (IM) in patients (pts) with imatinib-resistant gastrointestinal stromal tumors (GIST) - study update [abstract]. J Clin Oncol (Meeting Abstracts) 2007, 25: 10023.
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , pp. 10023
    • Von Mehren, M.1    Reichardt, P.2    Casali, P.G.3
  • 48
    • 33749000911 scopus 로고    scopus 로고
    • AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts
    • Polverino A, Coxon A, Starnes C, et al.: AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res 2006, 66: 8715-8721.
    • (2006) Cancer Res , vol.66 , pp. 8715-8721
    • Polverino, A.1    Coxon, A.2    Starnes, C.3
  • 49
    • 34347235531 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors
    • Rosen LS, Kurzrock R, Mulay M, et al.: Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors. J Clin Oncol 2007, 25: 2369-2376.
    • (2007) J Clin Oncol , vol.25 , pp. 2369-2376
    • Rosen, L.S.1    Kurzrock, R.2    Mulay, M.3
  • 50
    • 33847224896 scopus 로고    scopus 로고
    • Response of gastrointestinal stromal tumors (GISTs) to imatinib by Choi criteria and response evaluation criteria in solid tumors (RECIST) as surrogates for survival and time to progression
    • [abstract]. (Meeting Abstracts)
    • Benjamin RS, Choi H, Macapinlac HA, et al.: Response of gastrointestinal stromal tumors (GISTs) to imatinib by Choi criteria and response evaluation criteria in solid tumors (RECIST) as surrogates for survival and time to progression [abstract]. J Clin Oncol (Meeting Abstracts) 2006, 24: 9506.
    • (2006) J Clin Oncol , vol.24 , pp. 9506
    • Benjamin, R.S.1    Choi, H.2    Macapinlac, H.A.3
  • 51
    • 60749096434 scopus 로고    scopus 로고
    • Phase II study of motesanib diphosphate (AMG 706) in Japanese patients (pts) with advanced gastrointestinal stromal tumors (GISTs) who developed progressive disease or relapsed while on imatinib mesylate
    • [abstract 107]. Presented at the Orlando, FL; January 25-27
    • Yamada Y, Sawaki A, Nishida T, et al.: Phase II study of motesanib diphosphate (AMG 706) in Japanese patients (pts) with advanced gastrointestinal stromal tumors (GISTs) who developed progressive disease or relapsed while on imatinib mesylate [abstract 107]. Presented at the 2008 Gastrointestinal Cancers Symposium. Orlando, FL; January 25-27, 2008.
    • (2008) 2008 Gastrointestinal Cancers Symposium
    • Yamada, Y.1    Sawaki, A.2    Nishida, T.3
  • 52
    • 33749238553 scopus 로고    scopus 로고
    • Discovery and development of sorafenib: A multikinase inhibitor for treating cancer
    • Wilhelm S, Carter C, Lynch M, et al.: Discovery and development of sorafenib: A multikinase inhibitor for treating cancer. Nat Rev Drug Discov 2006, 5: 835-844.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 835-844
    • Wilhelm, S.1    Carter, C.2    Lynch, M.3
  • 53
    • 34548061196 scopus 로고    scopus 로고
    • Sorafenib inhibits the imatinib-resistant KITT670I gatekeeper mutation in gastrointestinal stromal tumor
    • Guo T, Agaram NP, Wong GC, et al.: Sorafenib inhibits the imatinib-resistant KITT670I gatekeeper mutation in gastrointestinal stromal tumor. Clin Cancer Res 2007, 13: 4874-4881.
    • (2007) Clin Cancer Res , vol.13 , pp. 4874-4881
    • Guo, T.1    Agaram, N.P.2    Wong, G.C.3
  • 54
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al.: Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007, 356: 125-134.
    • (2007) N Engl J Med , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 55
    • 59949103514 scopus 로고    scopus 로고
    • Activity of sorafenib (SOR) in patients with imatinib (IM) and sunitinib (SU)-resistant (RES) gastrointestinal stromal tumors (GIST): A phase II trial of the University of Chicago Phase II Consortium
    • [abstract]. (Meeting Abstracts)
    • Wiebe L, Kasza KE, Maki RG, et al.: Activity of sorafenib (SOR) in patients with imatinib (IM) and sunitinib (SU)-resistant (RES) gastrointestinal stromal tumors (GIST): A phase II trial of the University of Chicago Phase II Consortium [abstract]. J Clin Oncol (Meeting Abstracts) 2008, 26: 10502.
    • (2008) J Clin Oncol , vol.26 , pp. 10502
    • Wiebe, L.1    Kasza, K.E.2    Maki, R.G.3
  • 57
    • 31544459272 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
    • Schittenhelm MM, Shiraga S, Schroeder A, et al.: Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res 2006, 66: 473-481.
    • (2006) Cancer Res , vol.66 , pp. 473-481
    • Schittenhelm, M.M.1    Shiraga, S.2    Schroeder, A.3
  • 58
    • 0035281737 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C
    • Propper DJ, McDonald AC, Man A, et al.: Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C. J Clin Oncol 2001, 19: 1485-1492.
    • (2001) J Clin Oncol , vol.19 , pp. 1485-1492
    • Propper, D.J.1    McDonald, A.C.2    Man, A.3
  • 59
    • 19944427559 scopus 로고    scopus 로고
    • Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412
    • Stone RM, DeAngelo DJ, Klimek V, et al.: Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood 2005, 105: 54-60.
    • (2005) Blood , vol.105 , pp. 54-60
    • Stone, R.M.1    DeAngelo, D.J.2    Klimek, V.3
  • 60
    • 1342310067 scopus 로고    scopus 로고
    • Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein kinase C inhibitor, combined with gemcitabine and cisplatin in patients with non-small-cell lung cancer
    • Monnerat C, Henriksson R, Le Chevalier T, et al.: Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein kinase C inhibitor, combined with gemcitabine and cisplatin in patients with non-small-cell lung cancer. Ann Oncol 2004, 15: 316-323.
    • (2004) Ann Oncol , vol.15 , pp. 316-323
    • Monnerat, C.1    Henriksson, R.2    Le Chevalier, T.3
  • 61
    • 10744221763 scopus 로고    scopus 로고
    • A phase I trial of daily oral 4-N-benzoyl-staurosporine in combination with protracted continuous infusion 5-fluorouracil in patients with advanced solid malignancies
    • Eder JP Jr, Garcia-Carbonero R, Clark JW, et al.: A phase I trial of daily oral 4-N-benzoyl-staurosporine in combination with protracted continuous infusion 5-fluorouracil in patients with advanced solid malignancies. Invest New Drugs 2004, 22: 139-150.
    • (2004) Invest New Drugs , vol.22 , pp. 139-150
    • Eder Jr., J.P.1    Garcia-Carbonero, R.2    Clark, J.W.3
  • 62
    • 36749030022 scopus 로고    scopus 로고
    • KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway
    • Bauer S, Duensing A, Demetri GD, Fletcher JA: KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway. Oncogene 2007, 26: 7560-7568.
    • (2007) Oncogene , vol.26 , pp. 7560-7568
    • Bauer, S.1    Duensing, A.2    Demetri, G.D.3    Fletcher, J.A.4
  • 63
    • 2542520755 scopus 로고    scopus 로고
    • Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
    • Duensing A, Medeiros F, McConarty B, et al.: Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene 2004, 23: 3999-4006.
    • (2004) Oncogene , vol.23 , pp. 3999-4006
    • Duensing, A.1    Medeiros, F.2    McConarty, B.3
  • 64
    • 8344253460 scopus 로고    scopus 로고
    • Combination signal transduction inhibition: A phase I/II trial of the oral mTOR-inhibitor everolimus (E, RAD001) and imatinib mesylate (IM) in patients (pts) with gastrointestinal stromal tumor (GIST) refractory to IM
    • [abstract]. (Meeting Abstracts)
    • van Oosterom AT, Dumez H, Desai J, et al.: Combination signal transduction inhibition: A phase I/II trial of the oral mTOR-inhibitor everolimus (E, RAD001) and imatinib mesylate (IM) in patients (pts) with gastrointestinal stromal tumor (GIST) refractory to IM [abstract]. J Clin Oncol (Meeting Abstracts) 2004, 22: 3002.
    • (2004) J Clin Oncol , vol.22 , pp. 3002
    • van Oosterom, A.T.1    Dumez, H.2    Desai, J.3
  • 65
    • 26044479980 scopus 로고    scopus 로고
    • A phase I/II trial of the oral mTOR-inhibitor everolimus (E) and imatinib mesylate (IM) in patients (pts) with gastrointestinal stromal tumor (GIST) refractory to IM: Study update
    • [abstract]. (Meeting Abstracts)
    • van Oosterom A, Reichardt P, Blay JY, et al.: A phase I/II trial of the oral mTOR-inhibitor everolimus (E) and imatinib mesylate (IM) in patients (pts) with gastrointestinal stromal tumor (GIST) refractory to IM: Study update [abstract]. J Clin Oncol (Meeting Abstracts) 2005, 23: 9033.
    • (2005) J Clin Oncol , vol.23 , pp. 9033
    • van Oosterom, A.1    Reichardt, P.2    Blay, J.Y.3
  • 66
    • 25844519550 scopus 로고    scopus 로고
    • HSP90 and the chaperoning of cancer
    • Whitesell L, Lindquist SL: HSP90 and the chaperoning of cancer. Nat Rev Cancer 2005, 5: 761-772.
    • (2005) Nat Rev Cancer , vol.5 , pp. 761-772
    • Whitesell, L.1    Lindquist, S.L.2
  • 67
    • 51449118446 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 (Hsp90) with the novel agent IPI-504 in metastatic GIST following failure of tyrosine kinase inhibitors (TKIs) or other sarcomas: Clinical results from a phase I trial
    • Wagner AJ, Morgan JA, Chugh R, et al.: Inhibition of heat shock protein 90 (Hsp90) with the novel agent IPI-504 in metastatic GIST following failure of tyrosine kinase inhibitors (TKIs) or other sarcomas: Clinical results from a phase I trial. J Clin Oncol (Meeting Abstracts) 2008, 26: 10503.
    • (2008) J Clin Oncol (Meeting Abstracts) , vol.26 , pp. 10503
    • Wagner, A.J.1    Morgan, J.A.2    Chugh, R.3


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