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Volumn 10, Issue 4, 2008, Pages 344-349

Novel approaches to imatinib-and sunitinib-resistant GIST

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; BCR ABL PROTEIN; BEVACIZUMAB; CD135 ANTIGEN; CEDIRANIB; DASATINIB; DOXORUBICIN; EVEROLIMUS; FLAVOPIRIDOL; HEAT SHOCK PROTEIN 90; IMATINIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MIDOSTAURIN; MOTESANIB; NILOTINIB; PERIFOSINE; PLACEBO; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; SORAFENIB; STEM CELL FACTOR; SUNITINIB; TANESPIMYCIN; TANESPIMYCIN HYDROQUINONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; VATALANIB; XL 820; INDOLE DERIVATIVE; PIPERAZINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

EID: 56149126724     PISSN: 15233790     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11912-008-0053-4     Document Type: Review
Times cited : (29)

References (28)
  • 2
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y, et al.: Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998, 279:577-580.
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3
  • 3
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • Heinrich MC, Corless CL, Demetri GD, et al.: Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 2003, 21:4342-4349.
    • (2003) J Clin Oncol , vol.21 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3
  • 4
    • 33746401591 scopus 로고    scopus 로고
    • KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours
    • Debiec-Rychter M, Sciot R, Le Cesne A, et al.: KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer 2006, 42:1093-1103.
    • (2006) Eur J Cancer , vol.42 , pp. 1093-1103
    • Debiec-Rychter, M.1    Sciot, R.2    Le Cesne, A.3
  • 5
    • 33745099617 scopus 로고    scopus 로고
    • An update on molecular genetics of gastrointestinal stromal tumours
    • Tornillo L, Terracciano LM: An update on molecular genetics of gastrointestinal stromal tumours. J Clin Pathol 2006, 59:557-563.
    • (2006) J Clin Pathol , vol.59 , pp. 557-563
    • Tornillo, L.1    Terracciano, L.M.2
  • 6
    • 20844433223 scopus 로고    scopus 로고
    • Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial
    • Verweij J, Casali PG, Zalcberg J, et al.: Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial. Lancet 2004, 364:1127-1134.
    • (2004) Lancet , vol.364 , pp. 1127-1134
    • Verweij, J.1    Casali, P.G.2    Zalcberg, J.3
  • 7
    • 39149123549 scopus 로고    scopus 로고
    • Long-term results from a randomized phase II trial of standard-versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT
    • Blanke CD, Demetri GD, von Mehren M, et al.: Long-term results from a randomized phase II trial of standard-versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT. J Clin Oncol 2008, 26:620-625.
    • (2008) J Clin Oncol , vol.26 , pp. 620-625
    • Blanke, C.D.1    Demetri, G.D.2    von Mehren, M.3
  • 8
    • 39149127634 scopus 로고    scopus 로고
    • Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033
    • Blanke CD, Rankin C, Demetri GD, et al.: Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. J Clin Oncol 2008, 26:626-632.
    • (2008) J Clin Oncol , vol.26 , pp. 626-632
    • Blanke, C.D.1    Rankin, C.2    Demetri, G.D.3
  • 9
    • 39049100282 scopus 로고    scopus 로고
    • Comparison of two doses of imatinib for the treatment of gastro-intestinal stromal tumors (GIST): A meta-analysis based on 1640 patients
    • [ASCO abstract 10004]
    • Van Glabbeke MM, Owzar K, Rankin C, et al.: Comparison of two doses of imatinib for the treatment of gastro-intestinal stromal tumors (GIST): A meta-analysis based on 1640 patients [ASCO abstract 10004]. J Clin Oncol 2007, 25(18S):10004.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 10004
    • Van Glabbeke, M.M.1    Owzar, K.2    Rankin, C.3
  • 10
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Demetri GD, von Mehren M, Blanke CD, et al.: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002, 347:472-480.
    • (2002) N Engl J Med , vol.347 , pp. 472-480
    • Demetri, G.D.1    von Mehren, M.2    Blanke, C.D.3
  • 11
    • 33750595859 scopus 로고    scopus 로고
    • Molecular correlates of imatinib resistance in gastrointestinal stromal tumors
    • Heinrich MC, Corless CL, Blanke CD, et al.: Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. J Clin Oncol 2006, 24:4764-4774.
    • (2006) J Clin Oncol , vol.24 , pp. 4764-4774
    • Heinrich, M.C.1    Corless, C.L.2    Blanke, C.D.3
  • 12
    • 33749505836 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
    • Demetri GD, van Oosterom AT, Garrett CR, et al.: Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial. Lancet 2006, 368:1329-1338.
    • (2006) Lancet , vol.368 , pp. 1329-1338
    • Demetri, G.D.1    van Oosterom, A.T.2    Garrett, C.R.3
  • 13
    • 33947701220 scopus 로고    scopus 로고
    • Initial results of a multicenter single arm phase 2 study of AMG 706, an oral multikinase inhibitor, for the treatment of advanced imatinib-resistant gastrointestinal stromal tumors (GIST)
    • [abstract 641]. Presented at the November 2-4, 2006; Venice, Italy
    • Benjamin RS, Schoffski P, Hartmann JT, et al.: Initial results of a multicenter single arm phase 2 study of AMG 706, an oral multikinase inhibitor, for the treatment of advanced imatinib-resistant gastrointestinal stromal tumors (GIST) [abstract 641]. Presented at the 12th Annual Meeting of the Connective Tissue Oncology Society; November 2-4, 2006; Venice, Italy.
    • 12th Annual Meeting of the Connective Tissue Oncology Society
    • Benjamin, R.S.1    Schoffski, P.2    Hartmann, J.T.3
  • 14
    • 60749096434 scopus 로고    scopus 로고
    • Phase II study of motesanib diphosphonate (AMG 706) in Japanese patients with advanced gastrointestinal stromal tumors (GIST) who developed progressive disease or relapsed while on imatinib mesylate
    • [abstract]. Presented at the January 25-27, 2008; Orlando, FL. Abstract 107
    • Yamada Y, Sawaki A, Nishida T, et al.: Phase II study of motesanib diphosphonate (AMG 706) in Japanese patients with advanced gastrointestinal stromal tumors (GIST) who developed progressive disease or relapsed while on imatinib mesylate [abstract]. Presented at the 2008 ASCO Gastrointestinal Cancers Symposium; January 25-27, 2008; Orlando, FL. Abstract 107.
    • 2008 ASCO Gastrointestinal Cancers Symposium
    • Yamada, Y.1    Sawaki, A.2    Nishida, T.3
  • 15
    • 37849009384 scopus 로고    scopus 로고
    • Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate
    • Joensuu H, De Braud F, Coco P, et al.: Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate. Ann Oncol 2008, 19:173-177.
    • (2008) Ann Oncol , vol.19 , pp. 173-177
    • Joensuu, H.1    De Braud, F.2    Coco, P.3
  • 16
    • 13844251975 scopus 로고    scopus 로고
    • Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
    • Weisberg E, Manley PW, Breitenstein W, et al.: Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 2005, 7:129-141.
    • (2005) Cancer Cell , vol.7 , pp. 129-141
    • Weisberg, E.1    Manley, P.W.2    Breitenstein, W.3
  • 17
    • 33646516407 scopus 로고    scopus 로고
    • Cellular uptake of the tyrosine kinase inhibitors imatinib and AMN107 in gastrointestinal stromal tumor cell lines
    • Prenen H, Guetens G, de Boeck G, et al.: Cellular uptake of the tyrosine kinase inhibitors imatinib and AMN107 in gastrointestinal stromal tumor cell lines. Pharmacology 2006, 77:11-16.
    • (2006) Pharmacology , vol.77 , pp. 11-16
    • Prenen, H.1    Guetens, G.2    de Boeck, G.3
  • 18
    • 34147187338 scopus 로고    scopus 로고
    • Resistance to c-KIT kinase inhibitors conferred by V654A mutation
    • Roberts KG, Odell AF, Byrnes EM, et al.: Resistance to c-KIT kinase inhibitors conferred by V654A mutation. Mol Cancer Ther 2007, 6:1159-1166.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1159-1166
    • Roberts, K.G.1    Odell, A.F.2    Byrnes, E.M.3
  • 19
    • 39349106967 scopus 로고    scopus 로고
    • A phase I study of nilotinib alone and in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors (GIST): Study update
    • [ASCO abstract 10023]
    • von Mehren M, Reichardt P, Casali PG, et al.: A phase I study of nilotinib alone and in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors (GIST): Study update [ASCO abstract 10023]. J Clin Oncol 2007, 25(18S):10023.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 10023
    • von Mehren, M.1    Reichardt, P.2    Casali, P.G.3
  • 20
    • 31544459272 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
    • Schittenhelm MM, Shiraga S, Schroeder A, et al.: Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res 2006, 66:473-481.
    • (2006) Cancer Res , vol.66 , pp. 473-481
    • Schittenhelm, M.M.1    Shiraga, S.2    Schroeder, A.3
  • 21
    • 33745914717 scopus 로고    scopus 로고
    • Phase I dose-escalation study of the SRC and multi-kinase inhibitor BMS-354825 in patients with GIST and other solid tumors
    • [ASCO abstract 3034]
    • Evans TR, Morgan JA, van den Abbeele AD, et al.: Phase I dose-escalation study of the SRC and multi-kinase inhibitor BMS-354825 in patients with GIST and other solid tumors [ASCO abstract 3034]. J Clin Oncol 2005, 23(16S):3034.
    • (2005) J Clin Oncol , vol.23 , Issue.16 S , pp. 3034
    • Evans, T.R.1    Morgan, J.A.2    van den Abbeele, A.D.3
  • 22
    • 55649091971 scopus 로고    scopus 로고
    • Activity of sorafenib in patients with imatinib and sunitinib-resistant gastrointestinal stromal tumors: A phase II trial of the University of Chicago Phase II Consortium
    • [abstract 7]. Presented at the January 25-27, 2008; Orlando, FL
    • Nimeiri HS, Maki RG, Kasza K, et al.: Activity of sorafenib in patients with imatinib and sunitinib-resistant gastrointestinal stromal tumors: A phase II trial of the University of Chicago Phase II Consortium [abstract 7]. Presented at the 2008 ASCO Gastrointestinal Cancers Symposium; January 25-27, 2008; Orlando, FL.
    • 2008 ASCO Gastrointestinal Cancers Symposium
    • Nimeiri, H.S.1    Maki, R.G.2    Kasza, K.3
  • 23
    • 14944352767 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants
    • Debiec-Rychter M, Cools J, Dumez H, et al.: Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants. Gastroenterology 2005, 128:270-279.
    • (2005) Gastroenterology , vol.128 , pp. 270-279
    • Debiec-Rychter, M.1    Cools, J.2    Dumez, H.3
  • 24
    • 26044454246 scopus 로고    scopus 로고
    • A phase I/II trial of the oral PKC-inhibitor PKC412 in combination with imatinib mesylate in patients with gastrointestinal stromal tumor (GIST) refractory to IM
    • [ASCO abstract 3016]
    • Reichardt P, Pink D, Lindner T, et al.: A phase I/II trial of the oral PKC-inhibitor PKC412 in combination with imatinib mesylate in patients with gastrointestinal stromal tumor (GIST) refractory to IM [ASCO abstract 3016]. J Clin Oncol 2005, 23(16S):3016.
    • (2005) J Clin Oncol , vol.23 , Issue.16 S , pp. 3016
    • Reichardt, P.1    Pink, D.2    Lindner, T.3
  • 25
    • 26044479980 scopus 로고    scopus 로고
    • A phase I/II trial of the oral mTOR-inhibitor everolimus and imatinib mesylate in patients with gastrointestinal stromal tumor (GIST) refractory to IM: Study update
    • [ASCO abstract 9033]
    • Van Oosterom A, Reichardt P, Blay JY, et al.: A phase I/II trial of the oral mTOR-inhibitor everolimus and imatinib mesylate in patients with gastrointestinal stromal tumor (GIST) refractory to IM: Study update [ASCO abstract 9033]. J Clin Oncol 2005, 23(16S):9033.
    • (2005) J Clin Oncol , vol.23 , Issue.16 S , pp. 9033
    • Van Oosterom, A.1    Reichardt, P.2    Blay, J.Y.3
  • 26
    • 33749461709 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor
    • Bauer S, Yu LK, Demetri GD, Fletcher JA: Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor. Cancer Res 2006, 66:9153-9161.
    • (2006) Cancer Res , vol.66 , pp. 9153-9161
    • Bauer, S.1    Yu, L.K.2    Demetri, G.D.3    Fletcher, J.A.4
  • 27
    • 37649018967 scopus 로고    scopus 로고
    • Inhibition of the heat shock protein 90 (Hsp90) chaperone with the novel agent IPI-504 to overcome resistance to tyrosine kinase inhibitors in metastatic GIST: Updated results of a phase I trial
    • [ASCO abstract 10024]
    • Demetri GD, George S, Morgan JA, et al.: Inhibition of the heat shock protein 90 (Hsp90) chaperone with the novel agent IPI-504 to overcome resistance to tyrosine kinase inhibitors in metastatic GIST: Updated results of a phase I trial [ASCO abstract 10024]. J Clin Oncol 2007, 25(18S):10024.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 10024
    • Demetri, G.D.1    George, S.2    Morgan, J.A.3
  • 28
    • 33745259006 scopus 로고    scopus 로고
    • Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells
    • Sambol EB, Ambrosini G, Geha RC, et al.: Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells. Cancer Res 2006, 66:5858-5866.
    • (2006) Cancer Res , vol.66 , pp. 5858-5866
    • Sambol, E.B.1    Ambrosini, G.2    Geha, R.C.3


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