A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence

Journal of Pathology

Volumn 214, Issue 5, 2008, Pages 533-544

  Jones, A M ^a   Mitter, R ^a   Springall, R ^b   Graham, T ^a,c   Winter, E ^a   Gillett, C ^b   Hanby, A M ^d   Tomlinson, I P M ^a   Sawyer, E J ^a,b   Walker, Rosemary ^e   Pinder, Sarah ^f   Jones, Louise ^g   Ellis, Ian ^h   Puay, Hoon Tan ⁱ   Macartney, James ^j   Green, David ^k   Hales, Sally ^l   Harding Mackean, Claudia ^l   Colclough, Angela ^m   MacNeil, Fiona ^m   Rowlands, David ⁿ   Smith, Christopher ^o   Fentiman, Ian ^p   Cane, Paul ^p   Desai, Anil ^q   Goderya, Rashida ^q   Nerurkar, Ashutosh ^r   Kissin, Mark ^s   Jackson, Peter ^s   more..

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^e UNIVERSITY OF LEICESTER   (United Kingdom)

^f ADDENBROOKE S HOSPITAL   (United Kingdom)

^g ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^h NOTTINGHAM CITY HOSPITAL   (United Kingdom)

ⁱ SINGAPORE GENERAL HOSPITAL   (Singapore)

^j WALSGRAVE HOSPITAL   (United Kingdom)

^k QUEEN S HOSPITAL   (United Kingdom)

^l Countess of Chester Hospital ^*  (United Kingdom)

^m ESSEX COUNTY HOSPITAL   (United Kingdom)

ⁿ NEW CROSS HOSPITAL   (United Kingdom)

^o FRIMLEY PARK HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^p GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^q Princess Royal University Hospital   (United Kingdom)

^r ROYAL MARSDEN HOSPITAL   (United Kingdom)

^s ROYAL SURREY COUNTY HOSPITAL   (United Kingdom)

more..

Author keywords

Array CGH; Goldengate assay; p16INK4a; p53; Phyllodes tumour; Recurrence; Sub clones

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ARTICLE; CANCER CLASSIFICATION; CANCER RECURRENCE; CONTROLLED STUDY; CYSTOSARCOMA PHYLLOIDES; GENE DELETION; GENE LOCUS; GENE MUTATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC ANALYSIS; GENETIC HETEROGENEITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; METHYLATION; PHENOTYPE; PRIORITY JOURNAL; STROMA;

BREAST NEOPLASMS; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 9; CLUSTER ANALYSIS; DISEASE PROGRESSION; DNA METHYLATION; DNA, NEOPLASM; FEMALE; GENE EXPRESSION PROFILING; GENES, P16; HUMANS; MUTATION; NEOPLASM RECURRENCE, LOCAL; NUCLEIC ACID HYBRIDIZATION; PHYLLODES TUMOR; RNA, MESSENGER;

EID: 41649118931     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2320     Document Type: Article

References (20)

1. Rosen PP, Dershaw D, Liberman L. Breast Pathology. Lippincott, Williams and Wilkins: Philadelphia, 1999.
2. Lae M, Vincent-Salomon A, Savignoni A, Huon I, Freneaux P, Sigal-Zafrani B et al. Phyllodes tumors of the breast segregate in two groups according to genetic criteria. Mod Pathol 2007;20(4):435-444.
3. Moffat CJ, Pinder SE, Dixon AR, Elston CW, Blamey RW, Ellis IO. Phyllodes tumours of the breast: a clinicopathological review of 32 cases. Histopathology 1995;27:205-218.
4. Lindquist KD, van Heerden JA, Weiland LH, Martin JK. Recurrent and metastatic cystosarcoma phyllodes. Am J Surg 1982;144:341-343.
5. Lester J, Stout AP. Cystosarcoma phyllodes. Cancer 1954;7: 335-353.
6. Tan PH, Jayabaskar T, Chuah KL, Lee HY, Tan Y, Hilmy M et al. Phyllodes tumors of the breast: the role of pathologic parameters. Am J Clin Pathol 2005;123:529-540.
7. Hajdu SI, Espinosa MH, Robbins GF. Recurrent cystosarcoma phyllodes: a clinicopathologic study of 32 cases. Cancer 1976;38:1402-1406.
8. Abdalla HM, Sakr MA. Predictive factors of local recurrence and survival following primary surgical treatment of phyllodes tumors of the breast. J Egypt Natl Cane Inst 2006;18(2):125-133.
9. Tan EY, Tan PH, Yong WS, Wong HB, Ho GH, Yeo AW et al. Recurrent phyllodes tumours of the breast: pathological features and clinical implications. ANZ J Surg 2006;76(6):476-480.
10. Barrio AV, Clark BD, Goldberg JI, Hoque LW, Bernik SF, Flynn LW et al. Clinicopathologic features and long-term outcomes of 293 phyllodes tumors of the breast. Ann Surg Oncol 2007;14:2961-2970.
11. Fiegler H, Carr P, Douglas EJ, Burford DC, Hunt S, Scott CE et al. DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. Genes Chromosomes Cancer 2003;36(4):361-374.
12. Jones AM, Douglas EJ, Halford SE, Fiegler H, Gorman PA, Roylance RR et al. Array-CGH analysis of microsatellite-stable, near-diploid bowel cancers and comparison with other types of colorectal carcinoma. Oncogene 2005;6([24(1)]):118-129.
13. Lingjaerde OC, Baumbusch LO, Liestol K, Glad IK, Borresen-Dale AL. CGH-Explorer: a program for analysis of array-CGH data. Bioinformatics 2005;21(6):821-822.
14. de Hoon MJL, Imoto S, Nolan J, Miyano S. Open Source Clustering Software. Bioinformatics 2004;20(9):1453-1454.
15. Lu YJ, Birdsall S, Osin P, Gusterson B, Shipley J. Phyllodes tumors of the breast analyzed by comparative genomic hybridization and association of increased 1q copy number with stromal overgrowth and recurrence. Genes Chromosomes Cancer 1997;20:275-281.
16. Kuijper A, de Vos RA, Lagendijk JH, van der Wall E, van Diest PJ. Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors. Am J Clin Pathol 2005;123(5):690-698.
17. Feakins RM, Mulcahy HE, Nickols CD, Wells CA. p53 expression in phyllodes tumours is associated with histological features of malignancy but does not predict outcome. Histopathology 1999;35:162-169.
18. Tan PH, Jayabaskar T, Yip G, Tan Y, Hilmy M, Selvarajan S et al. p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study. Mod Pathol 2005;18(12):1527-1534.
19. Tse GM, Putti TC, Kung FY, Scolyer RA, Law BK, Lau TS et al. Increased p53 protein expression in malignant mammary phyllodes tumors. Mod Pathol 2002;15(7):734-740.
20. Yonemori K, Hasegawa T, Shimizu C, Shibata T, Matsumoto K, Kouno T et al. Correlation of p53 and MIB-1 expression with both the systemic recurrence and survival in cases of phyllodes tumors of the breast. Pathol Res Pract 2006;202(10):705-712.