Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 5594-5601

  Dallanoce, Clelia ^a   Magrone, Pietro ^a   Matera, Carlo ^a   Lo Presti, Leonardo ^a   De Amici, Marco ^a   Riganti, Loredana ^a   Clementi, Francesco ^a   Gotti, Cecilia ^a   De Micheli, Carlo ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

1,3 Dipolar cycloaddition; ABT 418; Binding affinity; Neuronal nicotinic acetylcholine receptors; Nicotinic ligands

Indexed keywords

3 BROMO 5 (1 METHYLPYRROLIDIN 2 YL) 4,5 DIHYDROISOXAZOLE; 3 BROMO 5 PYRROLIDIN 2 YL 4,5 DIHYDROISOXAZOLE SYN; 3 METHOXY 5 (1 METHYLPYRROLIDIN 2 YL) 4,5 DIHYDROISOXAZOLE; 3 METHOXY 5 PYRROLIDIN 2 YL 4,5 DIHYDROISOXAZOLE; 3 METHYL 5 (1 METHYL 2 PYRROLIDINYL)ISOXAZOLE; 3 METHYL 5 (1 METHYLPYRROLIDIN 2 YL) 4,5 DIHYDROISOXAZOLE; 3 METHYL 5 PYRROLIDIN 2 YL 4,5 DIHYDROISOXAZOLE; 3 TERT BUTOXY 5 PYRROLIDIN 2 YL 4,5 DIHYDROISOXAZOLE; ABT 148; ISOXAZOLINE DERIVATIVE; NICOTINE; NICOTINIC RECEPTOR; TERT BUTYL 2 (3 BROMO 4,5 DIHYDROISOXAZOL 5 YL)PYRROLIDINE 1 CARBOXYLATE; TERT BUTYL 2 (3 METHOXY 4,5 DIHYDROISOXAZOL 5 YL)PYRROLIDINE 1 CARBOXYLATE; TERT BUTYL 2 (3 METHYL 4,5 DIHYDROISOXAZOL 5 YL)PYRROLIDINE 1 CARBOXYLATE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYCLOADDITION; DRUG BINDING; DRUG DETERMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; ISOMERISM; NERVE CELL; NONHUMAN; RAT;

CRYSTALLOGRAPHY, X-RAY; ISOXAZOLES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEURONS; PYRROLIDINES; RECEPTORS, NICOTINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649315931     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.009     Document Type: Article

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