New analogues of epiboxidine incorporating the 4,5-dihydroisoxazole nucleus: Synthesis, binding affinity at neuronal nicotinic acetylcholine receptors, and molecular modeling investigations

Chemistry and Biodiversity

Volumn 6, Issue 2, 2009, Pages 244-259

  Dallanoce, Clelia ^a   Magrone, Pietro ^a   Bazza, Paola ^a   Grazioso, Giovanni ^a   Rizzi, Luca ^a   Riganti, Loredana ^a   Gotti, Cecilia ^a   Clementi, Francesco ^a   Frydenvang, Karla ^b   De Amici, Marco ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 METHYLISOXAZOL 5 YL) 7 AZABICYCLO[2.2.1]HEPTAN 2 OL; 2 (4,5 DIHYDRO 3 METHYLISOXAZOL 5 YL) 7 AZABICYCLO[2.2.1]HEPTAN 2 OL; 3' METHYL SPIRO[7 AZABICYCLO[2.2.1]HEPTANE 2,5' (4H) ISOXAZOLE]; 4,5 DIHYDRO 3 METHYLISOXAZOLYL DERIVATIVE; 5 METHYL 3 OXA 4,10 DIAZATRICYCLO[5.2.1.0]DEC 4 ENE; ACETONITRILE; ALKENE DERIVATIVE; ANALGESIC AGENT; EPIBATIDINE; EPIBOXIDINE; ISOXAZOLE DERIVATIVE; NICOTINIC AGENT; NICOTINIC RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYCLOADDITION; DIASTEREOISOMER; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; MOLECULAR MODEL; NONHUMAN; RAT; STRUCTURE ANALYSIS;

ISOXAZOLES; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64549128369     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200800077     Document Type: Article

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