Synthesis of enantiopure Δ2-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human β-adrenergic receptor subtypes

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 13, 2006, Pages 4393-4401

  Dallanoce, Clelia ^a   Meroni, Giuseppe ^a   De Amici, Marco ^a   Hoffmann, Carsten ^b   Klotz, Karl Norbert ^b   De Micheli, Carlo ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

2 Isoxazoline derivatives; Antagonist; Binding affinity; Efficacy; Human adrenergic receptor subtypes; Synthesis

Indexed keywords

3 ISOPROPENYL DERIVATIVE; ALKENYL GROUP; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; DELTA 2 IDOXAZOLINE DERIVATIVE; DELTA 2 ISOXAZOLIN 5 YL ETHANOLAMINE DERIVATIVE; ISOXAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; ISOXAZOLE DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYCLOADDITION; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN EXPRESSION; STEREOCHEMISTRY; SUBSTITUTION REACTION; ANIMAL; CHEMISTRY; CHO CELL; CRICETULUS; DRUG EFFECT; HAMSTER; HUMAN; STEREOISOMERISM; SYNTHESIS;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; ISOXAZOLES; RECEPTORS, ADRENERGIC, BETA; STEREOISOMERISM;

EID: 33646548291     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.02.038     Document Type: Article

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