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Volumn 2, Issue 5, 2010, Pages 319-329

Therapeutic modulation of epigenetic drivers of drug resistance in ovarian cancer

Author keywords

CpG islands; DNA methylation; drug resistance; epigenetics; histones; ovarian cancer; therapies

Indexed keywords

3 DEAZANEPLANOCIN A; 4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; 5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; BELINOSTAT; BRCA1 PROTEIN; CARBOPLATIN; CISPLATIN; CYTIDINE; DEATH ASSOCIATED PROTEIN KINASE; DEPSIPEPTIDE; DNA; DNA METHYLTRANSFERASE 1; FANCONI ANEMIA GROUP F PROTEIN; HISTONE METHYLTRANSFERASE; HYDRALAZINE; MG 98; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; N (2 AMINOPHENYL) 4 [4 (3 PYRIDINYL) 2 PYRIMIDINYLAMINOMETHYL]BENZAMIDE; N PHTHALOYLTRYPTOPHAN; PACLITAXEL; PANOBINOSTAT; PIVALOYLOXYMETHYL BUTYRATE; POLYCOMB GROUP PROTEIN; PROCAINAMIDE; PROCAINE; PROTEIN MLH1; ROMIDEPSIN; SK 7041; SK 7068; TRICHOSTATIN A; TUBACIN; TUMOR MARKER; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; VORINOSTAT;

EID: 78649297210     PISSN: 17588340     EISSN: None     Source Type: Journal    
DOI: 10.1177/1758834010375759     Document Type: Review
Times cited : (39)

References (80)
  • 1
    • 0043240182 scopus 로고    scopus 로고
    • Ovarian cancer: strategies for overcoming resistance to chemotherapy
    • Agarwal, R. and Kaye, S.B. ( 2003) Ovarian cancer: strategies for overcoming resistance to chemotherapy. Nat Rev Cancer 3: 502-516.
    • (2003) Nat Rev Cancer , vol.3 , pp. 502-516
    • Agarwal, R.1    Kaye, S.B.2
  • 2
    • 34548414620 scopus 로고    scopus 로고
    • Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors
    • Appleton, K., Mackay, H.J., Judson, I., Plumb, J.A., McCormick, C., Strathdee, G. et al. (2007) Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors. J Clin Oncol 25: 4603-4609.
    • (2007) J Clin Oncol , vol.25 , pp. 4603-4609
    • Appleton, K.1    Mackay, H.J.2    Judson, I.3    Plumb, J.A.4    McCormick, C.5    Strathdee, G.6
  • 3
    • 33644822360 scopus 로고    scopus 로고
    • EZH 2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    • Bachmann, I.M., Halvorsen, O.J., Collett, K., Stefansson, I.M., Straume, O., Haukaas, S.A. et al. (2006) EZH 2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol 24: 268-273.
    • (2006) J Clin Oncol , vol.24 , pp. 268-273
    • Bachmann, I.M.1    Halvorsen, O.J.2    Collett, K.3    Stefansson, I.M.4    Straume, O.5    Haukaas, S.A.6
  • 4
    • 67349222049 scopus 로고    scopus 로고
    • (2009) Histone deacetylase inhibitors as anti-neoplastic agents
    • Batty, N., Malouf, G.G. and Issa, J.P. (2009) Histone deacetylase inhibitors as anti-neoplastic agents. Cancer Lett 280: 192-200.
    • Cancer Lett , vol.280 , pp. 192-200
    • Batty, N.1    Malouf, G.G.2    Issa, J.P.3
  • 5
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird, A. ( 2002) DNA methylation patterns and epigenetic memory. Genes Dev 16: 6-21.
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 6
    • 0030442652 scopus 로고    scopus 로고
    • The relationship of DNA methylation to cancer
    • Bird, A.P. ( 1996) The relationship of DNA methylation to cancer. Cancer Surv 28: 87-101.
    • (1996) Cancer Surv , vol.28 , pp. 87-101
    • Bird, A.P.1
  • 7
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • Bolden, J.E., Peart, M.J. and Johnstone, R.W. ( 2006) Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 5: 769-784.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 769-784
    • Bolden, J.E.1    Peart, M.J.2    Johnstone, R.W.3
  • 8
    • 70349826431 scopus 로고    scopus 로고
    • (2009) Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib
    • Broxterman, H.J., Gotink, K.J. and Verheul, H.M. (2009) Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib. Drug Resist Updat 12: 114-126.
    • Drug Resist Updat , vol.12 , pp. 114-126
    • Broxterman, H.J.1    Gotink, K.J.2    Verheul, H.M.3
  • 9
    • 22244435605 scopus 로고    scopus 로고
    • Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    • Brueckner, B., Garcia Boy, R., Siedlecki, P., Musch, T., Kliem, H.C., Zielenkiewicz, P. et al. (2005) Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res 65: 6305-6311.
    • (2005) Cancer Res , vol.65 , pp. 6305-6311
    • Brueckner, B.1    Garcia Boy, R.2    Siedlecki, P.3    Musch, T.4    Kliem, H.C.5    Zielenkiewicz, P.6
  • 10
    • 34250638678 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors for cancer therapy
    • Brueckner, B., Kuck, D. and Lyko, F. ( 2007) DNA methyltransferase inhibitors for cancer therapy. Cancer J 13: 17-22.
    • (2007) Cancer J , vol.13 , pp. 17-22
    • Brueckner, B.1    Kuck, D.2    Lyko, F.3
  • 11
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron, E.E., Bachman, K.E., Myohanen, S., Herman, J.G. and Baylin, S.B. ( 1999) Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21: 103-107.
    • (1999) Nat Genet , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 12
    • 69249115697 scopus 로고    scopus 로고
    • (2009) Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations
    • Carter, H., Chen, S., Isik, L., Tyekucheva, S., Velculescu, V.E., Kinzler, K.W. et al. (2009) Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations. Cancer Res 69: 6660-6667.
    • Cancer Res , vol.69 , pp. 6660-6667
    • Carter, H.1    Chen, S.2    Isik, L.3    Tyekucheva, S.4    Velculescu, V.E.5    Kinzler, K.W.6
  • 13
    • 0037403380 scopus 로고    scopus 로고
    • Improved survival in women with BRCA-associated ovarian carcinoma
    • Cass, I., Baldwin, R.L., Varkey, T., Moslehi, R., Narod, S.A. and Karlan, B.Y. ( 2003) Improved survival in women with BRCA-associated ovarian carcinoma. Cancer 97: 2187-2195.
    • (2003) Cancer , vol.97 , pp. 2187-2195
    • Cass, I.1    Baldwin, R.L.2    Varkey, T.3    Moslehi, R.4    Narod, S.A.5    Karlan, B.Y.6
  • 14
    • 0033549557 scopus 로고    scopus 로고
    • DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain
    • Cohen, O., Inbal, B., Kissil, J.L., Raveh, T., Berissi, H., Spivak-Kroizaman, T. et al. (1999) DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain. J Cell Biol 146: 141-148.
    • (1999) J Cell Biol , vol.146 , pp. 141-148
    • Cohen, O.1    Inbal, B.2    Kissil, J.L.3    Raveh, T.4    Berissi, H.5    Spivak-Kroizaman, T.6
  • 15
    • 51249115196 scopus 로고    scopus 로고
    • Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands
    • Dai, W., Teodoridis, J.M., Graham, J., Zeller, C., Huang, T.H., Yan, P. et al. (2008) Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands. BMC Bioinformatics 9: 337.
    • (2008) BMC Bioinformatics , vol.9 , pp. 337
    • Dai, W.1    Teodoridis, J.M.2    Graham, J.3    Zeller, C.4    Huang, T.H.5    Yan, P.6
  • 16
    • 0033607055 scopus 로고    scopus 로고
    • hMutSalpha and MutLalpha dependent phosphorylation of p 53 in response to DNA methylator damage
    • Duckett, D.R., Bronstein, S.M., Taya, Y. and Modrich, P. ( 1999) hMutSalpha and MutLalpha dependent phosphorylation of p 53 in response to DNA methylator damage. Proc Natl Acad Sci USA 96: 12384-12388.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12384-12388
    • Duckett, D.R.1    Bronstein, S.M.2    Taya, Y.3    Modrich, P.4
  • 17
    • 33845996135 scopus 로고    scopus 로고
    • Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
    • Duvic, M., Talpur, R., Ni, X., Zhang, C., Hazarika, P., Kelly, C. et al. (2007) Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 109: 31-39.
    • (2007) Blood , vol.109 , pp. 31-39
    • Duvic, M.1    Talpur, R.2    Ni, X.3    Zhang, C.4    Hazarika, P.5    Kelly, C.6
  • 19
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger, G., Liang, G., Aparicio, A. and Jones, P.A. ( 2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature 429: 457-463.
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 20
    • 33748122556 scopus 로고    scopus 로고
    • Cancer-linked DNA hypomethylation and its relationship to hypermethylation
    • Ehrlich, M. ( 2006) Cancer-linked DNA hypomethylation and its relationship to hypermethylation. Curr Top Microbiol Immunol 310: 251-274.
    • (2006) Curr Top Microbiol Immunol , vol.310 , pp. 251-274
    • Ehrlich, M.1
  • 21
    • 62849104641 scopus 로고    scopus 로고
    • (2009) Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study
    • Fenaux, P., Mufti, G.J., Hellstrom-Lindberg, E., Santini, V., Finelli, C., Giagounidis, A. et al. (2009) Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 10: 223-232.
    • Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3    Santini, V.4    Finelli, C.5    Giagounidis, A.6
  • 23
    • 70350494322 scopus 로고    scopus 로고
    • (2009) Combined epigenetic therapy with the histone methyltransferase EZH 2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
    • Fiskus, W., Wang, Y., Sreekumar, A., Buckley, K.M., Shi, H., Jillella, A. et al. (2009) Combined epigenetic therapy with the histone methyltransferase EZH 2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood 114: 2733-2743.
    • Blood , vol.114 , pp. 2733-2743
    • Fiskus, W.1    Wang, Y.2    Sreekumar, A.3    Buckley, K.M.4    Shi, H.5    Jillella, A.6
  • 24
    • 33750530675 scopus 로고    scopus 로고
    • Phase 1 / 2 study of the combination of 5aza-2'-deoxycytidine with valproic acid in patients with leukemia
    • Garcia-Manero, G., Kantarjian, H.M., Sanchez-Gonzalez, B., Yang, H., Rosner, G., Verstovsek, S. et al. (2006) Phase 1 / 2 study of the combination of 5aza-2'-deoxycytidine with valproic acid in patients with leukemia. Blood 108: 3271-3279.
    • (2006) Blood , vol.108 , pp. 3271-3279
    • Garcia-Manero, G.1    Kantarjian, H.M.2    Sanchez-Gonzalez, B.3    Yang, H.4    Rosner, G.5    Verstovsek, S.6
  • 25
    • 38949096781 scopus 로고    scopus 로고
    • Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
    • Garcia-Manero, G., Yang, H., Bueso-Ramos, C., Ferrajoli, A., Cortes, J., Wierda, W.G. et al. (2008) Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes. Blood 111: 1060-1066.
    • (2008) Blood , vol.111 , pp. 1060-1066
    • Garcia-Manero, G.1    Yang, H.2    Bueso-Ramos, C.3    Ferrajoli, A.4    Cortes, J.5    Wierda, W.G.6
  • 26
    • 18944383889 scopus 로고    scopus 로고
    • 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal
    • Ghoshal, K., Datta, J., Majumder, S., Bai, S., Kutay, H., Motiwala, T. et al. (2005) 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal. Mol Cell Biol 25: 4727-4741.
    • (2005) Mol Cell Biol , vol.25 , pp. 4727-4741
    • Ghoshal, K.1    Datta, J.2    Majumder, S.3    Bai, S.4    Kutay, H.5    Motiwala, T.6
  • 27
    • 3042774430 scopus 로고    scopus 로고
    • The acquisition of hMLH 1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients
    • Gifford, G., Paul, J., Vasey, P.A., Kaye, S.B. and Brown, R. ( 2004) The acquisition of hMLH 1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients. Clin Cancer Res 10: 4420-4426.
    • (2004) Clin Cancer Res , vol.10 , pp. 4420-4426
    • Gifford, G.1    Paul, J.2    Vasey, P.A.3    Kaye, S.B.4    Brown, R.5
  • 28
    • 77954091256 scopus 로고    scopus 로고
    • Randomized phase II study of decitabine in combination with carboplatin compared with carboplatin alone in patients with recurrent advanced ovarian cancer
    • Glasspool, R.M., Gore, M., Rustin, G., McNeish, I., Wilson, R., Pledge, S. et al. (2009) Randomized phase II study of decitabine in combination with carboplatin compared with carboplatin alone in patients with recurrent advanced ovarian cancer. J Clin Oncol 27: 15s.
    • (2009) J Clin Oncol , vol.27 , pp. 15s
    • Glasspool, R.M.1    Gore, M.2    Rustin, G.3    McNeish, I.4    Wilson, R.5    Pledge, S.6
  • 29
    • 33646128506 scopus 로고    scopus 로고
    • Epigenetics as a mechanism driving polygenic clinical drug resistance
    • Glasspool, R.M., Teodoridis, J.M. and Brown, R. ( 2006) Epigenetics as a mechanism driving polygenic clinical drug resistance. Br J Cancer 94: 1087-1092.
    • (2006) Br J Cancer , vol.94 , pp. 1087-1092
    • Glasspool, R.M.1    Teodoridis, J.M.2    Brown, R.3
  • 30
    • 64049097640 scopus 로고    scopus 로고
    • (2009) The promises and pitfalls of epigenetic therapies in solid tumours
    • Graham, J.S., Kaye, S.B. and Brown, R. (2009) The promises and pitfalls of epigenetic therapies in solid tumours. Eur J Cancer 45: 1129-1136.
    • Eur J Cancer , vol.45 , pp. 1129-1136
    • Graham, J.S.1    Kaye, S.B.2    Brown, R.3
  • 33
    • 37549022694 scopus 로고    scopus 로고
    • DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes
    • Griffiths, E.A. and Gore, S.D. ( 2008) DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes. Semin Hematol 45: 23-30.
    • (2008) Semin Hematol , vol.45 , pp. 23-30
    • Griffiths, E.A.1    Gore, S.D.2
  • 35
    • 10344260184 scopus 로고    scopus 로고
    • CpG island methylator phenotype in cancer
    • Issa, J.P. ( 2004) CpG island methylator phenotype in cancer. Nat Rev Cancer 4: 988-993.
    • (2004) Nat Rev Cancer , vol.4 , pp. 988-993
    • Issa, J.P.1
  • 36
    • 34250213859 scopus 로고    scopus 로고
    • DNA methylation as a therapeutic target in cancer
    • Issa, J.P. ( 2007) DNA methylation as a therapeutic target in cancer. Clin Cancer Res 13: 1634-1637.
    • (2007) Clin Cancer Res , vol.13 , pp. 1634-1637
    • Issa, J.P.1
  • 37
    • 10744233452 scopus 로고    scopus 로고
    • Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies
    • Issa, J.P., Garcia-Manero, G., Giles, F.J., Mannari, R., Thomas, D., Faderl, S. et al. (2004) Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies. Blood 103: 1635-1640.
    • (2004) Blood , vol.103 , pp. 1635-1640
    • Issa, J.P.1    Garcia-Manero, G.2    Giles, F.J.3    Mannari, R.4    Thomas, D.5    Faderl, S.6
  • 38
    • 21244431605 scopus 로고    scopus 로고
    • Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate
    • Issa, J.P., Gharibyan, V., Cortes, J., Jelinek, J., Morris, G., Verstovsek, S. et al. (2005) Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate. J Clin Oncol 23: 3948-3956.
    • (2005) J Clin Oncol , vol.23 , pp. 3948-3956
    • Issa, J.P.1    Gharibyan, V.2    Cortes, J.3    Jelinek, J.4    Morris, G.5    Verstovsek, S.6
  • 39
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones, P.A. and Baylin, S.B. ( 2007) The epigenomics of cancer. Cell 128: 683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 40
    • 0030457071 scopus 로고    scopus 로고
    • Genomic instability and tolerance to alkylating agents
    • Karran, P. and Hampson, R. ( 1996) Genomic instability and tolerance to alkylating agents. Cancer Surveys 28: 69-85.
    • (1996) Cancer Surveys , vol.28 , pp. 69-85
    • Karran, P.1    Hampson, R.2
  • 41
    • 0035400494 scopus 로고    scopus 로고
    • Recognition of cisplatin adducts by cellular proteins
    • Kartalou, M. and Essigmann, J.M. ( 2001) Recognition of cisplatin adducts by cellular proteins. Mutat Res 478: 1-21.
    • (2001) Mutat Res , vol.478 , pp. 1-21
    • Kartalou, M.1    Essigmann, J.M.2
  • 42
    • 37349022478 scopus 로고    scopus 로고
    • Methylated TMS 1 and DAPK genes predict prognosis and response to chemotherapy in gastric cancer
    • Kato, K., Iida, S., Uetake, H., Takagi, Y., Yamashita, T., Inokuchi, M. et al. (2008) Methylated TMS 1 and DAPK genes predict prognosis and response to chemotherapy in gastric cancer. Int J Cancer 122: 603-608.
    • (2008) Int J Cancer , vol.122 , pp. 603-608
    • Kato, K.1    Iida, S.2    Uetake, H.3    Takagi, Y.4    Yamashita, T.5    Inokuchi, M.6
  • 44
    • 0037672689 scopus 로고    scopus 로고
    • An epigenetic road map for histone lysine methylation
    • Lachner, M., O'Sullivan, R.J. and Jenuwein, T. ( 2003) An epigenetic road map for histone lysine methylation. J Cell Sci 116: 2117-2124.
    • (2003) J Cell Sci , vol.116 , pp. 2117-2124
    • Lachner, M.1    O'Sullivan, R.J.2    Jenuwein, T.3
  • 45
    • 0037112447 scopus 로고    scopus 로고
    • Promoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype
    • Lehmann, U., Celikkaya, G., Hasemeier, B., Langer, F. and Kreipe, H. ( 2002) Promoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype. Cancer Res 62: 6634-6638.
    • (2002) Cancer Res , vol.62 , pp. 6634-6638
    • Lehmann, U.1    Celikkaya, G.2    Hasemeier, B.3    Langer, F.4    Kreipe, H.5
  • 46
    • 68249159896 scopus 로고    scopus 로고
    • (2009) Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer
    • Li, M., Balch, C., Montgomery, J.S., Jeong, M., Chung, J.H., Yan, P. et al. (2009) Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer. BMC Med Genomics 2: 34.
    • BMC Med Genomics , vol.2 , pp. 34
    • Li, M.1    Balch, C.2    Montgomery, J.S.3    Jeong, M.4    Chung, J.H.5    Yan, P.6
  • 47
    • 23844481408 scopus 로고    scopus 로고
    • Mechanisms of drug resistance in cancer chemotherapy
    • (Suppl
    • Luqmani, Y.A. ( 2005) Mechanisms of drug resistance in cancer chemotherapy. Med Princ Pract 14(Suppl 1): 35-48.
    • (2005) Med Princ Pract , vol.14 , Issue.1 , pp. 35-48
    • Luqmani, Y.A.1
  • 48
    • 67650090545 scopus 로고    scopus 로고
    • (2009) Histone deacetylase inhibitors: Potential in cancer therapy
    • Marks, P.A. and Xu, W.S. (2009) Histone deacetylase inhibitors: Potential in cancer therapy. J Cell Biochem 107: 600-608.
    • J Cell Biochem , vol.107 , pp. 600-608
    • Marks, P.A.1    Xu, W.S.2
  • 49
    • 73949106115 scopus 로고    scopus 로고
    • (2010) Epigenetic therapies for chemoresensitization of epithelial ovarian cancer
    • Matei, D.E. and Nephew, K.P. (2010) Epigenetic therapies for chemoresensitization of epithelial ovarian cancer. Gynecol Oncol 116: 195-201.
    • Gynecol Oncol , vol.116 , pp. 195-201
    • Matei, D.E.1    Nephew, K.P.2
  • 50
    • 67649371461 scopus 로고    scopus 로고
    • (2009) DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
    • Miranda, T.B., Cortez, C.C., Yoo, C.B., Liang, G., Abe, M., Kelly, T.K. et al. (2009) DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol Cancer Ther 8: 1579-1588.
    • Mol Cancer Ther , vol.8 , pp. 1579-1588
    • Miranda, T.B.1    Cortez, C.C.2    Yoo, C.B.3    Liang, G.4    Abe, M.5    Kelly, T.K.6
  • 51
    • 0033136042 scopus 로고    scopus 로고
    • Modulation of drug resistance mediated by loss of mismatch repair by the DNA polymerase inhibitor aphidicolin
    • Moreland, N.J., Illand, M., Kim, Y.T., Paul, J. and Brown, R. ( 1999) Modulation of drug resistance mediated by loss of mismatch repair by the DNA polymerase inhibitor aphidicolin. Cancer Res 59: 2102-2106.
    • (1999) Cancer Res , vol.59 , pp. 2102-2106
    • Moreland, N.J.1    Illand, M.2    Kim, Y.T.3    Paul, J.4    Brown, R.5
  • 52
    • 38449106861 scopus 로고    scopus 로고
    • Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: basic concepts and clinical applications
    • Mund, C., Brueckner, B. and Lyko, F. ( 2006) Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: basic concepts and clinical applications. Epigenetics 1: 7-13.
    • (2006) Epigenetics , vol.1 , pp. 7-13
    • Mund, C.1    Brueckner, B.2    Lyko, F.3
  • 53
    • 34547683194 scopus 로고    scopus 로고
    • Phase IIb multi-center trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma
    • Olsen, E.A., Kim, Y.H., Kuzel, T.M., Pacheco, T.R., Foss, F.M., Parker, S. et al. (2007) Phase IIb multi-center trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J Clin Oncol 25: 3109-3115.
    • (2007) J Clin Oncol , vol.25 , pp. 3109-3115
    • Olsen, E.A.1    Kim, Y.H.2    Kuzel, T.M.3    Pacheco, T.R.4    Foss, F.M.5    Parker, S.6
  • 54
    • 2442706833 scopus 로고    scopus 로고
    • Dependence of the cytotoxicity of DNA-damaging agents on the mismatch repair status of human cells
    • Papouli, E., Cejka, P. and Jiricny, J. ( 2004) Dependence of the cytotoxicity of DNA-damaging agents on the mismatch repair status of human cells. Cancer Res 64: 3391-3394.
    • (2004) Cancer Res , vol.64 , pp. 3391-3394
    • Papouli, E.1    Cejka, P.2    Jiricny, J.3
  • 56
    • 0034326784 scopus 로고    scopus 로고
    • Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidineinduced demethylation of the hMLH 1 gene promoter
    • Plumb, J.A., Strathdee, G., Sludden, J., Kaye, S.B. and Brown, R. ( 2000) Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidineinduced demethylation of the hMLH 1 gene promoter. Cancer Res 60: 6039-6044.
    • (2000) Cancer Res , vol.60 , pp. 6039-6044
    • Plumb, J.A.1    Strathdee, G.2    Sludden, J.3    Kaye, S.B.4    Brown, R.5
  • 57
    • 39549091276 scopus 로고    scopus 로고
    • Ovarian carcinomas with genetic and epigenetic BRCA 1 loss have distinct molecular abnormalities
    • Press, J.Z., de Luca, A., Boyd, N., Young, S., Troussard, A., Ridge, Y. et al. (2008) Ovarian carcinomas with genetic and epigenetic BRCA 1 loss have distinct molecular abnormalities. BMC Cancer 8: 17.
    • (2008) BMC Cancer , vol.8 , pp. 17
    • Press, J.Z.1    de Luca, A.2    Boyd, N.3    Young, S.4    Troussard, A.5    Ridge, Y.6
  • 58
    • 73949140461 scopus 로고    scopus 로고
    • (2010) Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer
    • Ramalingam, S.S., Maitland, M.L., Frankel, P., Argiris, A.E., Koczywas, M., Gitlitz, B. et al. (2010) Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer. J Clin Oncol 28: 56-62.
    • J Clin Oncol , vol.28 , pp. 56-62
    • Ramalingam, S.S.1    Maitland, M.L.2    Frankel, P.3    Argiris, A.E.4    Koczywas, M.5    Gitlitz, B.6
  • 59
    • 0344284564 scopus 로고    scopus 로고
    • Interaction of mismatch repair protein PMS 2 and the p53-related transcription factor p 73 in apoptosis response to cisplatin
    • Shimodaira, H., Yoshioka-Yamashita, A., Kolodner, R.D. and Wang, J.Y. ( 2003) Interaction of mismatch repair protein PMS 2 and the p53-related transcription factor p 73 in apoptosis response to cisplatin. Proc Natl Acad Sci U S A 100: 2420-2425.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2420-2425
    • Shimodaira, H.1    Yoshioka-Yamashita, A.2    Kolodner, R.D.3    Wang, J.Y.4
  • 60
    • 61749093379 scopus 로고    scopus 로고
    • (2009) Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo
    • Steele, N., Finn, P., Brown, R. and Plumb, J.A. (2009) Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo. Br J Cancer 100: 758-763.
    • Br J Cancer , vol.100 , pp. 758-763
    • Steele, N.1    Finn, P.2    Brown, R.3    Plumb, J.A.4
  • 61
    • 66649105473 scopus 로고    scopus 로고
    • (2009) Decitabine effect on tumor global DNA methylation and other parameters in a phase I trial in refractory solid tumors and lymphomas
    • Stewart, D.J., Issa, J.P., Kurzrock, R., Nunez, M.I., Jelinek, J., Hong, D. et al. (2009) Decitabine effect on tumor global DNA methylation and other parameters in a phase I trial in refractory solid tumors and lymphomas. Clin Cancer Res 15: 3881-3888.
    • Clin Cancer Res , vol.15 , pp. 3881-3888
    • Stewart, D.J.1    Issa, J.P.2    Kurzrock, R.3    Nunez, M.I.4    Jelinek, J.5    Hong, D.6
  • 62
    • 2442670292 scopus 로고    scopus 로고
    • Mismatch repair-dependent G 2 checkpoint induced by low doses of SN 1 type methylating agents requires the ATR kinase
    • Stojic, L., Mojas, N., Cejka, P., Di Pietro, M., Ferrari, S., Marra, G. et al. (2004) Mismatch repair-dependent G 2 checkpoint induced by low doses of SN 1 type methylating agents requires the ATR kinase. Genes Dev 18: 1331-1344.
    • (2004) Genes Dev , vol.18 , pp. 1331-1344
    • Stojic, L.1    Mojas, N.2    Cejka, P.3    Di Pietro, M.4    Ferrari, S.5    Marra, G.6
  • 63
    • 33645086120 scopus 로고    scopus 로고
    • Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines
    • Stresemann, C., Brueckner, B., Musch, T., Stopper, H. and Lyko, F. ( 2006) Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res 66: 2794-2800.
    • (2006) Cancer Res , vol.66 , pp. 2794-2800
    • Stresemann, C.1    Brueckner, B.2    Musch, T.3    Stopper, H.4    Lyko, F.5
  • 65
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan, J., Yang, X., Zhuang, L., Jiang, X., Chen, W., Lee, P.L. et al. (2007) Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev 21: 1050-1063.
    • (2007) Genes Dev , vol.21 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3    Jiang, X.4    Chen, W.5    Lee, P.L.6
  • 66
    • 0034692447 scopus 로고    scopus 로고
    • Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer
    • Tang, X., Khuri, F.R., Lee, J.J., Kemp, B.L., Liu, D., Hong, W.K. et al. (2000) Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer. J Natl Cancer Inst 92: 1511-1516.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1511-1516
    • Tang, X.1    Khuri, F.R.2    Lee, J.J.3    Kemp, B.L.4    Liu, D.5    Hong, W.K.6
  • 67
    • 12744280832 scopus 로고    scopus 로고
    • Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cells
    • Tang, X., Wu, W., Sun, S.Y., Wistuba, I.I., Hong, W.K. and Mao, L. ( 2004) Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cells. Mol Cancer Res 2: 685-691.
    • (2004) Mol Cancer Res , vol.2 , pp. 685-691
    • Tang, X.1    Wu, W.2    Sun, S.Y.3    Wistuba, I.I.4    Hong, W.K.5    Mao, L.6
  • 68
    • 0038075462 scopus 로고    scopus 로고
    • Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors
    • Taniguchi, T., Tischkowitz, M., Ameziane, N., Hodgson, S.V., Mathew, C.G., Joenje, H. et al. (2003) Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat Med 9: 568-574.
    • (2003) Nat Med , vol.9 , pp. 568-574
    • Taniguchi, T.1    Tischkowitz, M.2    Ameziane, N.3    Hodgson, S.V.4    Mathew, C.G.5    Joenje, H.6
  • 69
    • 25444485414 scopus 로고    scopus 로고
    • CpG island methylation of DNA damage response genes in advanced ovarian cancer
    • Teodoridis, J.M., Hall, J., Marsh, S., Kannall, H.D., Smyth, C., Curto, J. et al. (2005) CpG island methylation of DNA damage response genes in advanced ovarian cancer. Cancer Res 65: 8961-8967.
    • (2005) Cancer Res , vol.65 , pp. 8961-8967
    • Teodoridis, J.M.1    Hall, J.2    Marsh, S.3    Kannall, H.D.4    Smyth, C.5    Curto, J.6
  • 71
    • 18244379333 scopus 로고    scopus 로고
    • Cellular processing of platinum anticancer drugs
    • Wang, D. and Lippard, S.J. ( 2005) Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov 4: 307-320.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 307-320
    • Wang, D.1    Lippard, S.J.2
  • 72
  • 73
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood, L.D., Parsons, D.W., Jones, S., Lin, J., Sjoblom, T., Leary, R.J. et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318: 1108-1113.
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3    Lin, J.4    Sjoblom, T.5    Leary, R.J.6
  • 74
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: molecular mechanisms of action
    • Xu, W.S., Parmigiani, R.B. and Marks, P.A. ( 2007) Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 26: 5541-5552.
    • (2007) Oncogene , vol.26 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3
  • 75
    • 0037426577 scopus 로고    scopus 로고
    • High frequency of DAP-kinase gene promoter methylation in colorectal cancer specimens and its identification in serum
    • Yamaguchi, S., Asao, T., Nakamura, J., Ide, M. and Kuwano, H. ( 2003) High frequency of DAP-kinase gene promoter methylation in colorectal cancer specimens and its identification in serum. Cancer Lett 194: 99-105.
    • (2003) Cancer Lett , vol.194 , pp. 99-105
    • Yamaguchi, S.1    Asao, T.2    Nakamura, J.3    Ide, M.4    Kuwano, H.5
  • 76
    • 57749105325 scopus 로고    scopus 로고
    • MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer
    • Yang, N., Kaur, S., Volinia, S., Greshock, J., Lassus, H., Hasegawa, K. et al. (2008) MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer. Cancer Res 68: 10307-10314.
    • (2008) Cancer Res , vol.68 , pp. 10307-10314
    • Yang, N.1    Kaur, S.2    Volinia, S.3    Greshock, J.4    Lassus, H.5    Hasegawa, K.6
  • 77
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: past, present and future
    • Yoo, C.B. and Jones, P.A. ( 2006) Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 5: 37-50.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2
  • 78
    • 33646503204 scopus 로고    scopus 로고
    • ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts
    • Yoshioka, K., Yoshioka, Y. and Hsieh, P. ( 2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell 22: 501-510.
    • (2006) Mol Cell , vol.22 , pp. 501-510
    • Yoshioka, K.1    Yoshioka, Y.2    Hsieh, P.3
  • 79
    • 36349017912 scopus 로고    scopus 로고
    • A polycomb repression signature in metastatic prostate cancer predicts cancer outcome
    • Yu, J., Rhodes, D.R., Tomlins, S.A., Cao, X., Chen, G., Mehra, R. et al. (2007) A polycomb repression signature in metastatic prostate cancer predicts cancer outcome. Cancer Res 67: 10657-10663.
    • (2007) Cancer Res , vol.67 , pp. 10657-10663
    • Yu, J.1    Rhodes, D.R.2    Tomlins, S.A.3    Cao, X.4    Chen, G.5    Mehra, R.6
  • 80
    • 49249091523 scopus 로고    scopus 로고
    • Identification and characterization of ovarian cancer-initiating cells from primary human tumors
    • Zhang, S., Balch, C., Chan, M.W., Lai, H.C., Matei, D., Schilder, J.M. et al. (2008) Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res 68: 4311-4320.
    • (2008) Cancer Res , vol.68 , pp. 4311-4320
    • Zhang, S.1    Balch, C.2    Chan, M.W.3    Lai, H.C.4    Matei, D.5    Schilder, J.M.6


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