Dependence of the cytotoxicity of DNA-damaging agents on the mismatch repair status of human cells

Cancer Research

Volumn 64, Issue 10, 2004, Pages 3391-3394

  Papouli, Efterpi ^a   Cejka, Petr ^a   Jiricny, Josef ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; CISPLATIN; CYTOTOXIC AGENT; ETOPOSIDE; LOMUSTINE; MELPHALAN; MITOMYCIN C; PSORALEN;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DESENSITIZATION; DNA DAMAGE; DRUG EFFECT; GENOTOXICITY; HUMAN; HUMAN CELL; IONIZING RADIATION; MAMMAL CELL; MISMATCH REPAIR; PRIORITY JOURNAL; ULTRAVIOLET A RADIATION;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; BASE PAIR MISMATCH; CAMPTOTHECIN; CARRIER PROTEINS; CELL LINE; CISPLATIN; DNA REPAIR; DRUG SCREENING ASSAYS, ANTITUMOR; ETOPOSIDE; HUMANS; INHIBITORY CONCENTRATION 50; MELPHALAN; MITOMYCIN; NEOPLASM PROTEINS; NITROSOUREA COMPOUNDS; NUCLEAR PROTEINS; PSORALENS;

EID: 2442706833     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-0513     Document Type: Article

References (21)

1. Jiricny J, Marra G. DNA repair defects in colon cancer. Curr Opin Genet Dev 2003;13:61-9.
2. Karran P. Mechanisms of tolerance to DNA damaging therapeutic drugs. Carcinogenesis (Lond.) 2001;22:1931-7.
3. Fritzell JA, Narayanan L, Baker SM, et al. Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. Cancer Res 1997;57:5143-7.
4. Zeng M, Narayanan L, Xu XS, Prolla TA, Liskay RM, Glazer PM. Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways. Cancer Res 2000;60:4889-93.
5. 2-arrest responses without altering survival after ionizing radiation. Cancer Res 2001;61:8290-7.
6. 2 phase. Oncogene 2003;22:2110-20.
7. Fedier A, Schwarz VA, Walt H, Carpini RD, Haller U, Fink D. Resistance to topoisomerase poisons due to loss of DNA mismatch repair. Int J Cancer 2001;93:571-6.
8. Pichierri P, Franchitto A, Piergentili R, Colussi C, Palitti F. Hypersensitivity to camptothecin in MSH2-deficient cells is correlated with a role for MSH2 protein in recombinational repair. Carcinogenesis (Lond.) 2001;22:1781-7.
9. Jacob S, Aguado M, Fallik D, Praz F. The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells. Cancer Res 2001;61:6555-62.
10. Fedier A, Ruefenacht UB, Schwarz VA, Haller U, Fink D. Increased sensitivity of p53-deficient cells to anticancer agents due to loss of Pms2. Br J Cancer 2002;87:1027-33.
11. Aquilina G, Ceccotti S, Martinelli S, Hampson R, Bignami M. N-(2-Chloroethyl)-N′-cyclohexyl-N-nitrosourea sensitivity in mismatch repair-defective human cells. Cancer Res 1998;58:135-41.
12. 2-M cell cycle arrest and lethality after DNA damage. Carcinogenesis (Lond.) 1999;20:2317-26.
13. Aquilina G, Ceccotti S, Martinelli S, et al. Mismatch repair and p53 independently affect sensitivity to N-(2-chloroethyl)-N′ -cyclohexyl-N-nitrosourea. Clin Cancer Res 2000;6:671-80.
14. 2-M arrest requires a full complement of the mismatch repair protein hMLH1. EMBO J 2003;22:2245-54.
15. di Pietro M, Marra G, Cejka P, et al. Mismatch repair-dependent transcriptome changes in human cells treated with the methylating agent MNNG. Cancer Res 2003;63:8158-66.
16. N1 type methylating agents requires the ATR kinase. Genes Dev 2004, in press.
17. Brown R, Hirst GL, Gallagher WM, et al. hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents. Oncogene 1997;15:45-52.
18. Fink D, Zheng H, Nebel S, et al. In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair. Cancer Res 1997;57:1841-5.
19. Drummond JT, Anthoney A, Brown R, Modrich P. Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line. J Biol Chem 1996;271:19645-8.
20. Villemure JF, Abaji C, Cousineau I, Belmaaza A. MSH2-deficient human cells exhibit a defect in the accurate termination of homology-directed repair of DNA double-strand breaks. Cancer Res 2003;63:3334-9.
21. Kanaar R, Hoeijmakers JH, van Gent DC. Molecular mechanisms of DNA double strand break repair. Trends Cell Biol 1998;8:483-9.