Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: A comparison to the prototype cigarette smoke mutagens B(a)P and NNK

Chemical Research in Toxicology

Volumn 23, Issue 11, 2010, Pages 1682-1690

  Weems, Jessica M ^b   Lamb, John G ^b   D'Agostino, Jaime ^a   Ding, Xinxin ^a   Yost, Garold S ^b  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; BENZO[A]PYRENE; CIGARETTE SMOKE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2A13; CYTOCHROME P450 2F3; SKATOLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BASE PAIRING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME METABOLISM; FRAMESHIFT MUTATION; HUMAN; HUMAN CELL; INCUBATION TIME; LIVER CELL; LUNG ALVEOLUS CELL; MICROSOME; MUTAGENICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; QUANTITATIVE ANALYSIS; RAT; SALMONELLA TYPHIMURIUM; WESTERN BLOTTING;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BENZO(A)PYRENE; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DNA DAMAGE; HUMANS; LIVER; LUNG; MICROSOMES; MUTAGENICITY TESTS; MUTAGENS; NITROSAMINES; RATS; RIBOSOMAL PROTEINS; SALMONELLA TYPHIMURIUM; SKATOLE; SMOKING;

RATTUS; SALMONELLA TYPHIMURIUM;

EID: 78649275212     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx100147z     Document Type: Article

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