Antimicrobial Peptides and Their Superior Fluorinated Analogues: Structure-Activity Relationships as Revealed by NMR Spectroscopy and MD Calculations

ChemBioChem

Volumn 11, Issue 17, 2010, Pages 2424-2432

  Díaz, M Dolores ^a   Palomino Schätzlein, Martina ^b   Corzana, Francisco ^c   Andreu, Cecilia ^d   Carbajo, Rodrigo J ^b   Del Olmo, Marcellí ^d   Canales Mayordomo, Angeles ^e   Pineda Lucena, Antonio ^b   Asensio, Gregorio ^d   Jiménez Barbero, Jesús ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^c UNIVERSITY OF LA RIOJA   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

^e UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Antimicrobial peptides; Fluorine; Membranes; Molecular dynamics; NMR spectroscopy; SDS micelles

Indexed keywords

PHENYLALANINE 4 FLUORO PHENYLALANINYLRGINYLPHENYLALANYL 4 FLUORO PHENYLALANINAMIDE; PHENYLALANINE 4 FLUOROPHENYLALANYLLYSL PHENYLALANINE 4 FLUOROPHENYLALANINAMIDE; PHENYLALANYLARGINYLPHENYLALANYLARGINYLPHENYLALANINAMIDE; PHENYLALANYLLYSYLPHENYLALANYLLYSYLPHENYLALANINAMIDE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; DRUG STRUCTURE; ESCHERICHIA COLI; FLUORINATION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTIMICROBIAL CATIONIC PEPTIDES; ESCHERICHIA COLI; HALOGENATION; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PROTEIN CONFORMATION; SODIUM DODECYL SULFATE; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 78649261564     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201000424     Document Type: Article

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