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Volumn 109, Issue 5, 2010, Pages 1552-1561

Posttranslational modifications in histones underlie heat acclimation-mediated cytoprotective memory

Author keywords

Cytoprotective memory; Epigenome; Heat shock factor 1 heat shock element binding; Histone H3 phosphorylation; Histone H4 acetylation; Hsp70; Hsp90

Indexed keywords

DNA BINDING PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK TRANSCRIPTION FACTOR; HISTONE; HISTONE ACETYLTRANSFERASE; TRANSCRIPTION FACTOR;

EID: 78549289516     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00469.2010     Document Type: Article
Times cited : (45)

References (52)
  • 1
    • 0037423005 scopus 로고    scopus 로고
    • Heat acclimation prolongs the time to central nervous system oxygen toxicity in the rat. Possible involvement of HSP72
    • Arieli Y, Eynan M, Gancz H, Arieli R, Kashi Y. Heat acclimation prolongs the time to central nervous system oxygen toxicity in the rat. Possible involvement of HSP72. Brain Res 962: 15-20, 2003.
    • (2003) Brain Res , vol.962 , pp. 15-20
    • Arieli, Y.1    Eynan, M.2    Gancz, H.3    Arieli, R.4    Kashi, Y.5
  • 2
    • 34047268910 scopus 로고    scopus 로고
    • Chromatin remodeling in DNA double-strand break repair
    • Bao Y, Shen X. Chromatin remodeling in DNA double-strand break repair. Curr Opin Genet Dev 17: 126-131, 2007.
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 126-131
    • Bao, Y.1    Shen, X.2
  • 4
    • 78549286802 scopus 로고    scopus 로고
    • A new model for the understanding of "heat acclimation- ischemia/reperfusion cross-tolerance"
    • (MSc thesis). Jerusalem, Israel: Hebrew University
    • .Bromberg Z. A New Model for the Understanding of "Heat Acclimation- Ischemia/Reperfusion Cross-Tolerance": The Heat Acclimated Mouse Heart (MSc thesis). Jerusalem, Israel: Hebrew University, 2003.
    • (2003) The Heat Acclimated Mouse Heart
    • Bromberg, Z.1
  • 5
    • 0033636595 scopus 로고    scopus 로고
    • Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation
    • Cheung P, Tanner KG, Cheung WL, Sassone-Corsi P, Denu JM, Allis CD. Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol Cell 5: 905-915, 2000.
    • (2000) Mol Cell , vol.5 , pp. 905-915
    • Cheung, P.1    Tanner, K.G.2    Cheung, W.L.3    Sassone-Corsi, P.4    Denu, J.M.5    Allis, C.D.6
  • 6
    • 0034679625 scopus 로고    scopus 로고
    • Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation
    • Clayton AL, Rose S, Barratt MJ, Mahadevan LC. Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. EMBO J 19: 3714-3726, 2000.
    • (2000) EMBO J , vol.19 , pp. 3714-3726
    • Clayton, A.L.1    Rose, S.2    Barratt, M.J.3    Mahadevan, L.C.4
  • 7
    • 19244365881 scopus 로고    scopus 로고
    • AcK-knowledge reversible acetylation
    • Cohen T, Yao TP. AcK-knowledge reversible acetylation. Sci STKE 2004: p. 42, 2004.
    • (2004) Sci STKE 2004 , pp. 42
    • Cohen, T.1    Yao, T.P.2
  • 8
    • 18344390450 scopus 로고    scopus 로고
    • The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling
    • Dunn KL, Espino PS, Drobic B, He S, Davie JR. The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling. Biochem Cell Biol 83: 1-14, 2005.
    • (2005) Biochem Cell Biol , vol.83 , pp. 1-14
    • Dunn, K.L.1    Espino, P.S.2    Drobic, B.3    He, S.4    Davie, J.R.5
  • 9
    • 34248158068 scopus 로고    scopus 로고
    • Molecular mechanisms underlying thermal adaptation of xeric animals
    • Evgen'ev MB, Garbuz DG, Shilova VY, Zatsepina OG. Molecular mechanisms underlying thermal adaptation of xeric animals. J Biosci 32: 489-499, 2007.
    • (2007) J Biosci , vol.32 , pp. 489-499
    • Evgen'ev, M.B.1    Garbuz, D.G.2    Shilova, V.Y.3    Zatsepina, O.G.4
  • 10
    • 34248523169 scopus 로고    scopus 로고
    • Recovery of learning and memory is associated with chromatin remodelling
    • Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH. Recovery of learning and memory is associated with chromatin remodelling. Nature 447: 178-182, 2007.
    • (2007) Nature , vol.447 , pp. 178-182
    • Fischer, A.1    Sananbenesi, F.2    Wang, X.3    Dobbin, M.4    Tsai, L.H.5
  • 11
    • 0032918622 scopus 로고    scopus 로고
    • Heat stress proteins and myocardial protection: Experimental model or potential clinical tool?
    • Gray CC, Amrani M, Yacoub MH. Heat stress proteins and myocardial protection: experimental model or potential clinical tool? Int J Biochem Cell Biol 31: 559-573, 1999.
    • (1999) Int J Biochem Cell Biol , vol.31 , pp. 559-573
    • Gray, C.C.1    Amrani, M.2    Yacoub, M.H.3
  • 12
    • 1342327598 scopus 로고    scopus 로고
    • Fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses
    • Hirota K, Hasemi T, Yamada T, Mizuno KI, Hoffman CS, Shibata T, Ohta K. Fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses. Nucleic Acids Res 32: 855-862, 2004.
    • (2004) Nucleic Acids Res , vol.32 , pp. 855-862
    • Hirota, K.1    Hasemi, T.2    Yamada, T.3    Mizuno, K.I.4    Hoffman, C.S.5    Shibata, T.6    Ohta, K.7
  • 13
    • 0037359902 scopus 로고    scopus 로고
    • Preconditioning with heat shock further improved functional recovery in young adult but not in middle-aged rat hearts
    • Honma Y, Tani M, Yamamura K, Takayama M, Hasegawa H. Preconditioning with heat shock further improved functional recovery in young adult but not in middle-aged rat hearts. Exp Gerontol 38: 299-306, 2003.
    • (2003) Exp Gerontol , vol.38 , pp. 299-306
    • Honma, Y.1    Tani, M.2    Yamamura, K.3    Takayama, M.4    Hasegawa, H.5
  • 14
    • 0017103109 scopus 로고
    • Acclimatization of rats to moderate heat: Body water distribution and adaptability of the submaxillary salivary gland
    • Horowitz M. Acclimatization of rats to moderate heat: body water distribution and adaptability of the submaxillary salivary gland. Pflügers Arch 366: 173-176, 1976.
    • (1976) Pflügers Arch , vol.366 , pp. 173-176
    • Horowitz, M.1
  • 15
    • 34447528879 scopus 로고    scopus 로고
    • Heat acclimation and cross-tolerance against novel stressors: Genomic-physiological linkage
    • Horowitz M. Heat acclimation and cross-tolerance against novel stressors: genomic-physiological linkage. Prog Brain Res 162: 373-392, 2007.
    • (2007) Prog Brain Res , vol.162 , pp. 373-392
    • Horowitz, M.1
  • 16
    • 77649127622 scopus 로고    scopus 로고
    • Heat acclimation-mediated cross-tolerance in cardioprotection: Do HSP70 and HIF-1alpha play a role
    • Horowitz M, Assadi H. Heat acclimation-mediated cross-tolerance in cardioprotection: do HSP70 and HIF-1alpha play a role? Ann N Y Acad Sci 1188: 199-206, 2010.
    • (2010) Ann N Y Acad Sci , vol.1188 , pp. 199-206
    • Horowitz, M.1    Assadi, H.2
  • 17
    • 4644309905 scopus 로고    scopus 로고
    • Stress-related genomic responses during the course of heat acclimation and its association with ischemic-reperfusion cross-tolerance
    • Horowitz M, Eli-Berchoer L, Wapinski I, Friedman N, Kodesh E. Stress-related genomic responses during the course of heat acclimation and its association with ischemic-reperfusion cross-tolerance. J Appl Physiol 97: 1496-1507, 2004.
    • (2004) J Appl Physiol , vol.97 , pp. 1496-1507
    • Horowitz, M.1    Eli-Berchoer, L.2    Wapinski, I.3    Friedman, N.4    Kodesh, E.5
  • 18
    • 33745713133 scopus 로고    scopus 로고
    • Regulation of chromatin structure by histone H3S10 phosphorylation
    • Johansen KM, Johansen J. Regulation of chromatin structure by histone H3S10 phosphorylation. Chromosome Res 14: 393-404, 2006.
    • (2006) Chromosome Res , vol.14 , pp. 393-404
    • Johansen, K.M.1    Johansen, J.2
  • 19
    • 70449720612 scopus 로고    scopus 로고
    • A critical role for dynamic changes in histone H3 methylation at the Bdnf promoter during postnatal thermotolerance acquisition
    • Kisliouk T, Meiri N. A critical role for dynamic changes in histone H3 methylation at the Bdnf promoter during postnatal thermotolerance acquisition. Eur J Neurosci 30: 1909-1922, 2009.
    • (2009) Eur J Neurosci , vol.30 , pp. 1909-1922
    • Kisliouk, T.1    Meiri, N.2
  • 20
    • 0037229898 scopus 로고    scopus 로고
    • Phosphorylation of histone H3 during transcriptional activation depends on promoter structure
    • Labrador M, Corces VG. Phosphorylation of histone H3 during transcriptional activation depends on promoter structure. Genes Dev 17: 43-48, 2003.
    • (2003) Genes Dev , vol.17 , pp. 43-48
    • Labrador, M.1    Corces, V.G.2
  • 21
    • 13244276460 scopus 로고    scopus 로고
    • Epigenetic mechanisms in memory formation
    • Levenson JM, Sweatt JD. Epigenetic mechanisms in memory formation. Nat Rev Neurosci 6: 108-118, 2005.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 108-118
    • Levenson, J.M.1    Sweatt, J.D.2
  • 22
    • 0027228264 scopus 로고
    • Heat acclimation improves cardiac mechanics and metabolic performance during ischemia and reperfusion
    • Levi E, Vivi A, Hasin Y, Tassini M, Navon G, Horowitz M. Heat acclimation improves cardiac mechanics and metabolic performance during ischemia and reperfusion. J Appl Physiol 75: 833-839, 1993.
    • (1993) J Appl Physiol , vol.75 , pp. 833-839
    • Levi, E.1    Vivi, A.2    Hasin, Y.3    Tassini, M.4    Navon, G.5    Horowitz, M.6
  • 23
    • 33645795743 scopus 로고    scopus 로고
    • HIF-1alpha-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart
    • Maloyan A, Eli-Berchoer L, Semenza GL, Gerstenblith G, Stern MD, Horowitz M. HIF-1alpha-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart. Physiol Genomics 23: 79-88, 2005.
    • (2005) Physiol Genomics , vol.23 , pp. 79-88
    • Maloyan, A.1    Eli-Berchoer, L.2    Semenza, G.L.3    Gerstenblith, G.4    Stern, M.D.5    Horowitz, M.6
  • 24
    • 0033043766 scopus 로고    scopus 로고
    • Heat acclimation increases the basal HSP72 level and alters its production dynamics during heat stress
    • Maloyan A, Palmon A, Horowitz M. Heat acclimation increases the basal HSP72 level and alters its production dynamics during heat stress. Am J Physiol Regul Integr Comp Physiol 276: R1506-R1515, 1999.
    • (1999) Am J Physiol Regul Integr Comp Physiol , vol.276
    • Maloyan, A.1    Palmon, A.2    Horowitz, M.3
  • 25
    • 0032535245 scopus 로고    scopus 로고
    • Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
    • Morimoto RI. Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev 12: 3788-3796, 1998.
    • (1998) Genes Dev , vol.12 , pp. 3788-3796
    • Morimoto, R.I.1
  • 26
    • 0033639243 scopus 로고    scopus 로고
    • Phosphorylation of histone H3 correlates with transcriptionally active loci
    • Nowak SJ, Corces VG. Phosphorylation of histone H3 correlates with transcriptionally active loci. Genes Dev 14: 3003-3013, 2000.
    • (2000) Genes Dev , vol.14 , pp. 3003-3013
    • Nowak, S.J.1    Corces, V.G.2
  • 27
    • 0031856497 scopus 로고    scopus 로고
    • Time course of heat acclimation and its decay
    • Pandolf KB. Time course of heat acclimation and its decay. Int J Sports Med 19, Suppl 2: S157-S160, 1998.
    • (1998) Int J Sports Med , vol.19 , Issue.SUPPL. 2
    • Pandolf, K.B.1
  • 28
    • 0017513561 scopus 로고
    • Role of physical fitness in heat acclimatisation, decay and reinduction
    • Pandolf KB, Burse RL, Goldman RF. Role of physical fitness in heat acclimatisation, decay and reinduction. Ergonomics 20: 399-408, 1977.
    • (1977) Ergonomics , vol.20 , pp. 399-408
    • Pandolf, K.B.1    Burse, R.L.2    Goldman, R.F.3
  • 29
    • 67650046369 scopus 로고    scopus 로고
    • Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading
    • Pandorf CE, Haddad F, Wright C, Bodell PW, Baldwin KM. Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading. Am J Physiol Cell Physiol 297: C6-C16, 2009.
    • (2009) Am J Physiol Cell Physiol , vol.297
    • Pandorf, C.E.1    Haddad, F.2    Wright, C.3    Bodell, P.W.4    Baldwin, K.M.5
  • 30
    • 41149111451 scopus 로고    scopus 로고
    • The Hsp90 molecular chaperone: An open and shut case for treatment
    • Pearl LH, Prodromou C, Workman P. The Hsp90 molecular chaperone: an open and shut case for treatment. Biochem J 410: 439-453, 2008.
    • (2008) Biochem J , vol.410 , pp. 439-453
    • Pearl, L.H.1    Prodromou, C.2    Workman, P.3
  • 31
    • 0027939551 scopus 로고
    • Structure and expression of an inducible HSP70-encoding gene from Mus musculus
    • Perry MD, Aujame L, Shtang S, Moran LA. Structure and expression of an inducible HSP70-encoding gene from Mus musculus. Gene 146: 273-278, 1994.
    • (1994) Gene , vol.146 , pp. 273-278
    • Perry, M.D.1    Aujame, L.2    Shtang, S.3    Moran, L.A.4
  • 32
    • 0022391884 scopus 로고
    • Physiological acclimatization to heat after a spell of cold conditioning in tropical subjects
    • Pichan G, Sridharan K, Swamy YV, Joseph S, Gautam RK. Physiological acclimatization to heat after a spell of cold conditioning in tropical subjects. Aviat Space Environ Med 56: 436-440, 1985.
    • (1985) Aviat Space Environ Med , vol.56 , pp. 436-440
    • Pichan, G.1    Sridharan, K.2    Swamy, Y.V.3    Joseph, S.4    Gautam, R.K.5
  • 33
    • 4143070452 scopus 로고    scopus 로고
    • Redox modulation of chromatin remodeling: Impact on histone acetylation and deacetylation, NF-[kappa]B and pro-inflammatory gene expression
    • Rahman I, Marwick J, Kirkham P. Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-[kappa]B and pro-inflammatory gene expression. Biochem Pharmacol 68: 1255-1267, 2004.
    • (2004) Biochem Pharmacol , vol.68 , pp. 1255-1267
    • Rahman, I.1    Marwick, J.2    Kirkham, P.3
  • 34
    • 34547686501 scopus 로고    scopus 로고
    • Epigenetic mechanisms in stress-related memory formation
    • Reul JM, Chandramohan Y. Epigenetic mechanisms in stress-related memory formation. Psychoneuroendocrinology 32, Suppl 1: S21-S25, 2007.
    • (2007) Psychoneuroendocrinology , vol.32 , Issue.SUPPL. 1
    • Reul, J.M.1    Chandramohan, Y.2
  • 36
    • 30344450389 scopus 로고    scopus 로고
    • Decay of heat acclimation during exercise in cold and exposure to cold environment
    • Saat M, Sirisinghe RG, Singh R, Tochihara Y. Decay of heat acclimation during exercise in cold and exposure to cold environment. Eur J Appl Physiol 95: 313-320, 2005.
    • (2005) Eur J Appl Physiol , vol.95 , pp. 313-320
    • Saat, M.1    Sirisinghe, R.G.2    Singh, R.3    Tochihara, Y.4
  • 37
    • 0023948705 scopus 로고
    • Mapping protein-DNA interactions in vivo with formaldehyde: Evidence that histone H4 is retained on a highly transcribed gene
    • Solomon MJ, Larsen PL, Varshavsky A. Mapping protein-DNA interactions in vivo with formaldehyde: evidence that histone H4 is retained on a highly transcribed gene. Cell 53: 937-947, 1988.
    • (1988) Cell , vol.53 , pp. 937-947
    • Solomon, M.J.1    Larsen, P.L.2    Varshavsky, A.3
  • 38
    • 33747882071 scopus 로고    scopus 로고
    • Tip60 in DNA damage response and growth control: Many tricks in one HAT
    • Squatrito M, Gorrini C, Amati B. Tip60 in DNA damage response and growth control: many tricks in one HAT. Trends Cell Biol 16: 433-442, 2006.
    • (2006) Trends Cell Biol , vol.16 , pp. 433-442
    • Squatrito, M.1    Gorrini, C.2    Amati, B.3
  • 39
    • 0019364745 scopus 로고
    • Heat acclimatization, its decay and reinduction in young Caucasian females
    • Stephens RL, Hoag LL. Heat acclimatization, its decay and reinduction in young Caucasian females. Am Ind Hyg Assoc J 42: 12-17, 1981.
    • (1981) Am Ind Hyg Assoc J , vol.42 , pp. 12-17
    • Stephens, R.L.1    Hoag, L.L.2
  • 41
    • 0035694785 scopus 로고    scopus 로고
    • Independent dynamic regulation of histone phosphorylation and acetylation during immediate-early gene induction
    • Thomson S, Clayton AL, Mahadevan LC. Independent dynamic regulation of histone phosphorylation and acetylation during immediate-early gene induction. Mol Cell 8: 1231-1241, 2001.
    • (2001) Mol Cell , vol.8 , pp. 1231-1241
    • Thomson, S.1    Clayton, A.L.2    Mahadevan, L.C.3
  • 42
    • 4344592639 scopus 로고    scopus 로고
    • Distinct stimulusspecific histone modifications at hsp70 chromatin targeted by the transcription factor heat shock factor-1
    • Thomson S, Hollis A, Hazzalin CA, Mahadevan LC. Distinct stimulusspecific histone modifications at hsp70 chromatin targeted by the transcription factor heat shock factor-1. Mol Cell 15: 585-594, 2004.
    • (2004) Mol Cell , vol.15 , pp. 585-594
    • Thomson, S.1    Hollis, A.2    Hazzalin, C.A.3    Mahadevan, L.C.4
  • 43
    • 33845877732 scopus 로고    scopus 로고
    • Defining an epigenetic code
    • Turner BM. Defining an epigenetic code. Nat Cell Biol 9: 2-6, 2007.
    • (2007) Nat Cell Biol , vol.9 , pp. 2-6
    • Turner, B.M.1
  • 44
    • 0033848849 scopus 로고    scopus 로고
    • Histone acetylation and an epigenetic code
    • Turner BM. Histone acetylation and an epigenetic code. Bioessays 22: 836-845, 2000.
    • (2000) Bioessays , vol.22 , pp. 836-845
    • Turner, B.M.1
  • 45
    • 0033109641 scopus 로고    scopus 로고
    • Introduction: Chromatin-a target for intracellular signalling pathways
    • Turner BM. Introduction: chromatin-a target for intracellular signalling pathways. Semin Cell Dev Biol 10: 165-167, 1999.
    • (1999) Semin Cell Dev Biol , vol.10 , pp. 165-167
    • Turner, B.M.1
  • 46
    • 33750732647 scopus 로고    scopus 로고
    • The role of chromatin structure in regulating stress-induced transcription in Saccharomyces cerevisiae. Special issue of the 27th International West Coast Chromatin and Chromosome Conference
    • Uffenbeck SR, Krebs JK. The role of chromatin structure in regulating stress-induced transcription in Saccharomyces cerevisiae. Special issue of the 27th International West Coast Chromatin and Chromosome Conference. Biochem Cell Biol 84: 477-489, 2006.
    • (2006) Biochem Cell Biol , vol.84 , pp. 477-489
    • Uffenbeck, S.R.1    Krebs, J.K.2
  • 47
    • 5444223019 scopus 로고    scopus 로고
    • Site-specific analysis of histone methylation and acetylation
    • Umlauf D, Goto Y, Feil R. Site-specific analysis of histone methylation and acetylation. Methods Mol Biol 287: 99-120, 2004.
    • (2004) Methods Mol Biol , vol.287 , pp. 99-120
    • Umlauf, D.1    Goto, Y.2    Feil, R.3
  • 48
    • 36049046992 scopus 로고    scopus 로고
    • Quantification of the decay and re-induction of heat acclimation in dry-heat following 12 and 26 days without exposure to heat stress
    • Weller AS, Linnane DM, Jonkman AG, Daanen HA. Quantification of the decay and re-induction of heat acclimation in dry-heat following 12 and 26 days without exposure to heat stress. Eur J Appl Physiol 102: 57-66, 2007.
    • (2007) Eur J Appl Physiol , vol.102 , pp. 57-66
    • Weller, A.S.1    Linnane, D.M.2    Jonkman, A.G.3    Daanen, H.A.4
  • 49
    • 35348854946 scopus 로고    scopus 로고
    • HSF2 binds to the Hsp90, Hsp27, and c-Fos promoter constitutively and modulates their expression
    • Wilkerson DC, Skaggs HS, Sarge KD. HSF2 binds to the Hsp90, Hsp27, and c-Fos promoter constitutively and modulates their expression. Cell Stress Chaperones 12: 283-290, 2007.
    • (2007) Cell Stress Chaperones , vol.12 , pp. 283-290
    • Wilkerson, D.C.1    Skaggs, H.S.2    Sarge, K.D.3
  • 50
    • 7044250740 scopus 로고    scopus 로고
    • Lysine acetylation and the bromodomain: A new partnership for signaling
    • Yang XJ. Lysine acetylation and the bromodomain: a new partnership for signaling. Bioessays 26: 1076-1087, 2004.
    • (2004) Bioessays , vol.26 , pp. 1076-1087
    • Yang, X.J.1
  • 52
    • 26444545490 scopus 로고    scopus 로고
    • Domain-wide displacement of histones by activated heat shock factor occurs independently of Swi/Snf and is not correlated with RNA polymerase II density
    • Zhao J, Herrera-Diaz J, Gross DS. Domain-wide displacement of histones by activated heat shock factor occurs independently of Swi/Snf and is not correlated with RNA polymerase II density. Mol Cell Biol 25: 8985-8999, 2005.
    • (2005) Mol Cell Biol , vol.25 , pp. 8985-8999
    • Zhao, J.1    Herrera-Diaz, J.2    Gross, D.S.3


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