Phylogenetic and mutational analyses reveal key residues for UDP-glucuronic acid binding and activity of β1,3-glucuronosyltransferase I (GlcAT-I)

Protein Science

Volumn 15, Issue 7, 2006, Pages 1667-1678

  Fondeur Gelinotte, Magali ^a   Lattard, Virginie ^a   Oriol, Rafael ^b   Mollicone, Rosella ^b   Jacquinet, Jean Claude ^c   Mulliert, Guillermo ^d   Gulberti, Sandrine ^a   Netter, Patrick ^a   Magdalou, Jacques ^a   Ouzzine, Mohamed ^a   Fournel Gigleux, Sylvie ^a,e  

^a Biopôle de l Université de Lorraine   (France)

^b INSERM   (France)

^c UNIVERSITÉ D'ORLÉANS   (France)

^d Nancy University CNRS   (France)

^e CNRS   (France)

Author keywords

Enzyme kinetics; Glucuronosyltransferase family; Glycosaminoglycan synthesis; Phylogeny; Site directed mutagenesis; UDP glucuronic acid binding site

Indexed keywords

AMINO ACID DERIVATIVE; BETA1,3 GLUCURONOSYLTRANSFERASE 1 ENZYME; GLUCURONOSYLTRANSFERASE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONIC ACID;

ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; GLYCOSAMINOGLYCAN METABOLISM; HUMAN; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; UNINDEXED SEQUENCE;

AMINO ACIDS; ANIMALS; BINDING SITES; CONSERVED SEQUENCE; GLUCURONOSYLTRANSFERASE; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHYLOGENY; URIDINE DIPHOSPHATE GLUCURONIC ACID;

INVERTEBRATA; VERTEBRATA;

EID: 33745712764     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.062089106     Document Type: Article

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