The galactosyltransferase family

Cellular and Molecular Life Sciences

Volumn 59, Issue 7, 2002, Pages 1081-1095

  Hennet, T ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Cell biology; Enzyme; Galactose; Gene family; Glycosylation; Golgi

Indexed keywords

GALACTOSE; GALACTOSYLTRANSFERASE; GLYCOCONJUGATE; LACTOSE; LIPOPOLYSACCHARIDE; POLYSACCHARIDE;

BIOSYNTHESIS; CATALYSIS; ENZYME LOCALIZATION; EUKARYOTE; GLYCOSYLATION; GOLGI COMPLEX; HUMAN; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; PHYLOGENY; PROKARYOTE; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; BACTERIA; CARBOHYDRATE SEQUENCE; GALACTOSYLTRANSFERASES; GLYCOCONJUGATES; MOLECULAR SEQUENCE DATA; PHYLOGENY; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

EUKARYOTA; MAMMALIA; PROKARYOTA;

EID: 0036637625     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-002-8489-4     Document Type: Review

References (128)

1. The lipooligosaccharides of pathogenic gram-negative bacteria
2. Functional analysis of glycosyltransferases encoded by the capsular polysaccharide biosynthesis locus of Streptococcus pneumoniae serotype 14
3. Identification of a novel gene involved in pilin glycosylation in Neisseria meningitidis
4. Localization of an α1,2 galactosyltransferase activity to the Golgi apparatus of Schizosaccharomyces pombe
5. Biochemical and topological properties of type A MGDG synthase, a spinach chloroplast envelope enzyme catalyzing the synthesis of both prokaryotic and eukaryotic MGDG
6. Two types of MGDG synthase genes, found widely in both 16:3 and 18:3 plants, differentially mediate galactolipid syntheses in photosynthetic and nonphotosynthetic tissues in Arabidopsis thaliana
7. Purification, cloning and heterologous expression of a catalytically efficient flavonol 3-O-galactosyltransferase expressed in the male gametophyte of Petunia hybrida
8. Molecular characterisation of a membrane-bound galactosyltransferase of plant cell wall matrix polysaccharide biosynthesis
9. Biosynthesis and immunolocalization of Lewis a-containing N-glycans in the plant cell
10. Ceramide UDPgalactosyltransferase from myelinating rat brain: Purification, cloning and expression
11. UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum
12. Sequence-function relationships of prokaryotic and eukaryotic galactosyltransferases
13. Glycoprotein biosynthesis: Studies on the receptor specificity of the polypeptidyl: N-acetylgalactosaminyltransferase from bovine submaxillary glands
14. Issues in searching molecular sequence databases
15. Galactosylation of N-linked oligosaccharides by human β-1,4-galactosyltransferases I, II, III, IV, V and VI expressed in Sf-9 cells
16. Bovine galactosyltransferase: Identification of a clone by direct immunological screening of a cDNA expression library
17. Cloning and sequencing of cDNA of bovine N-acetylglucosamine (β1-4)galactosyltransferase
18. The isolation and identification of the B protein of lactose synthetase as α-lactalbumin
19. Transcriptional regulation of murine β1,4-galactosyltransferase in somatic cells. Analysis of a gene that serves both a housekeeping and a mammary gland-specific function
20. Immunohistochemical localization of galactosyltransferase in human fibroblasts and HeLa cells
21. Immunocytochemical localization of galactosyltransferase in HeLa cells: Codistribution with thiamine pyrophosphatase in trans-Golgi cisternae
22. Cell surface galactosyltransferase: Current issues
23. Blood-group-related carbohydrate antigens are expressed on human milk galactosyltransferase and are immunogenic in rabbits
24. Genomic structure of murine β-1,4-galactosyltransferase
25. Crystal structures of the bovine β4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose
26. Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the β1,4-galactosyltransferase-I
27. The O-linked fucose glycosylation pathway: Identification and characterization of a uridine diphosphoglucose: Fucose-β1,3-glucosyltransferase activity from Chinese hamster ovary cells
28. Fringe modulation of Jagged 1-induced Notch signaling requires the action of β4galactosyltransferase-1
29. Growth retardation and early death of β-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells
30. Sperm from β1,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly
31. Targeted mutation in β1,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality
32. A family of human α-4-galactosyltransferases; cloning and expression of two novel UDP-galactose: β-N-acetylglucosamine β1,4-galactosyltransferases, β4Gal-T2 and β4Gal-T3
33. The expanding β4-galactosyltransferase gene family: Messages from the databanks
34. Cloning of a novel member of the UDP-galactose-β-N-acetylglucosamine β-1,4-galactosyltransferase family, β-4Gal-T4, involved in glycosphingolipid biosynthesis
35. Synthesis of poly-N-acetyllactosamine in core 2 branched O-glycans. The requirement of novel β-1,4-galtactosyltransferase IV and β-1,3-N-acetylglucosaminyltransferase
36. Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase
37. A Lymnaea stagnalis gene, with sequence similarity to that of mammalian β1,4-galactosyltransferases, encodes a novel UDP-GlcNAc:GlcNAc β-r β1-4-N-acetylglucosaminyltransferase
38. β-1,4-galactosylation of N-glycans is a complex process
39. The acceptor substrate specificity of human β4-galactosyltransferase V indicates its potential function in O-glycosylation
40. Purification, cDNA cloning and expression of UDP-Gal: Glucosylceramide β-1,4-galactosyltransferase from rat brain
41. Chinese hamster ovary (CHO) cells may express six β4-galactosyltransferases (β4GalTs). Consequences of the loss of functional β4GalT-1, β4GalT-6, or both in CHO glycosylation mutants
42. Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans
43. Cloning and expression of a proteoglycan UDP-galactose:β-xylose β1,4-galactosyltransferase I. A seventh member of the human β4-galactosyltransferase gene family
44. A genetic defect in the biosynthesis of dermatan sulfate proteoglycan: Galactosyltransferase I deficiency in fibroblasts from a patient with a progeroid syndrome
45. Molecular basis for the progeroid variant of Ehlers-Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I gene
46. Three proteins involved in Caerohhabditis elegans vulval invagination are similar to components of a glycosylation pathway
47. Biosynthesis of galactosyl-β1,3-N-acetylglucosamine
48. Characterization of UDP-galactose:2-acetamido-2-deoxy-D-glucose 3β-galactosyltransferase from pig trachea
49. Genetic locus for the biosynthesis of the variable portion of Neisseria gonorrhoeae lipooligosaccharide
50. A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases
51. Identification and characterization of three novel β1,3-N-acetylglucosaminyltransferases structurally related to the β1,3-galactosyltransferase family
52. Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide β1,3-N-acetylglucosaminlytransferase (β3Gn-T5), an essential enzyme for the expression of the HNK-1 and Lewis X epitopes on glycolipids
53. Cloning of a mouse β1,3 N-acetylglucosaminyltransferase GlcNAc(β1,3)Gal(β1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis
54. Genomic cloning and expression of three murine UDP-galactose:β-N-acetylglucosamine β1,3-galactosyltransferase genes
55. Sialylated N-glycans in adult rat brain tissue - A widespread distribution of disialylated antennae in complex and hybrid structures
56. Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3β-galactosyltransferse catalyzing the formation of type 1 chains
57. A family of human β-3-galactosyltransferases: Characterization of four members of a UDP-galactose-N-acetylglucosamine/β-N-acetylgalactosamine β-1,3-galactosyltransferase family
58. Expression cloning of human globoside synthase cDNAs. Identification of β3GalT3 as UDP-N-acetylgalactosamine:globotriaosylceramide β1,3-N-acetylgalactosaminyltransferase
59. The neurogenic genes egghead and brainiae define a novel signaling pathway essential for epithelial morphogenesis during Drosophila oogenesis
60. Secreted Fringe-like signaling molecules may be glycosyltransferases
61. A murine homologue of the Drosophila brainiac gene shows homology to glycosyltransferases and is required for preimplantation development of the mouse
62. Al
63. Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects
64. Complex gangliosides are essential in spermatogenesis of mice: Possible roles in the transport of testosterone
65. Cloning, expression and characterization of a novel UDP-galactose: β-N-acetylglucosamine β1,3-galactosyltransferase (β3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom
66. Molecular cloning of a human UDP-galactose: GlcNAcβ1,3GalNAc β1,3 galactosyltransferase gene encoding an O-linked core3-elongation enzyme
67. The β1,3-galactosyltransferase β3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase
68. Monoclonal antibody to murine embryos defines a stage-specific embryonic antigen expressed on mouse embryos and human teratocarcinoma cells
69. Bt toxin resistance from loss of a putative carbohydrate-modifying enzyme
70. Biosynthesis of the linkage region of glycosaminoglycans: Cloning and activity of galactosyltransferase II, the sixth member of the β1,3galactosyltransferase family (β3GalT6)
71. Cloning and expression of human core 1 β1,3 galactosyltransferase
72. Purification, characterization and subunit structure of rat core 1 β1,3 galactosyltransferase
73. Tn-syndrome
74. Permanent mixed-field polyagglutinable erythrocytes lack galactosyltransferase activity
75. Galactosyltransferase and membrane glycoprotein abnormality in human platelets from Tn-syndrome donors
76. 1 glycosylation?
77. 1 O-glycans in IgA nephropathy by fluorophore-assisted carbohydrate electrophoresis
78. Serologically active fucose-containing oligosaccharides isolated from human blood-group A and B substances
79. Contributions of quantitative immunochemistry to knowledge of blood group A, B, H, Le, I and i antigens
80. Genetic and biochemical aspects of human blood-group A-, B-, H-, Le-a- and Le-b-specificity
81. Human blood group glycosyltransferases. I. Purification of N-acetylgalactosaminyltransferase
82. Human blood group glycosyltransferase. II. Purification of galactosyltransferase
83. Molecular genetic basis of the histo-blood group ABO system
84. Genomic organization of human histo-blood group ABO genes
85. Biosynthesis of terminal Gal α1-3Gal β1-4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide α1-3-galactosyltransferase from calf thymus
86. Bovine α1-3-galactosyltransferase: Isolation and characterization of a cDNA clone identification of homologous sequences in human genomic DNA
87. Murine α1,3-galactosyltransferase. A single gene locus specifies four isoforms of the enzyme by alternative splicing
88. Bovine α1,3-galactosyltransferase catalytic domain structure and its relationship with ABO histo-blood group and glycosphingolipid glycosyltransferases
89. Structure of UDP complex of UDP-galactose:β-galactoside-α-1,3-galactosyltransferase at 1.53-Å resolution reveals a conformational change in the catalytically important C terminus
90. X-ray crystal structure of rabbit N-acetylglucosaminyltransferase I: Catalytic mechanism and a new protein superfamily
91. Characterization of an α1-3-galactosyltransferase homologue on human chromosome 12 that is organized as a processed pseudogene
92. Gene sequences suggest inactivation of α-1,3-galactosyltransferase in catarrhines after the divergence of apes from monkeys
93. Oocyte Gal α1,3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse
94. The α-1,3-galactosyltransferase knockout mouse. Implications for xenotransplantation
95. Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids
96. Expression cloning of Forssman glycolipid synthetase: A novel member of the histo-blood group ABO gene family
97. Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions
98. Microbial recognition of target-cell glycoconjugates
99. CD77: An antigen of germinal center B cells entering apoptosis
100. A molecular approach to the structure, polymorphism and function of blood groups
101. Cloning of Gb3 Synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of α1,4-glycosyltransferases conserved in plants, insects, and mammals
102. Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids
103. Cloning and expression of the histo-blood group Pk UDP-galactose: Galβ-4Glcβ1-cer α1,4-galactosyltransferase. Molecular genetic basis of the p phenotype
104. Expression cloning of a human α1,4-N-acetylglucosaminyltransferase that forms GlcNAcα1→4Galβ→R, a glycan specifically expressed in the gastric gland mucous cell-type mucin
105. 1Pk antibodies and possible relationship with early abortions of p. mothers
106. The glycosphingolipid composition of the placenta of a blood group P fetus delivered by a blood group Pk1 woman and analysis of the anti-globoside antibodies found in maternal serum
107. Bacterial adherence: A pathogenetic mechanism in urinary tract infections caused by Escherichia coli
108. Synthesis of galactosyl ceramide and glucosyl ceramide by rat brain: Assay procedures and changes with age
109. Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis
110. Reduction of α-Gal epitopes in transgenic pig by introduction of human α1-2 fucosyltransferase
111. God must love galectins; he made so many of them
112. The remodeling of glycoconjugates in mice
113. Sensitization of cells and retroviruses to human serum by (α1-3) galactosyltransferase
114. Evolutionary considerations in relating oligosaccharide diversity to biological function
115. Lipopolysaccharide O-antigen biosynthesis in Shigella dysenteriae serotype 1: Analysis of the plasmid-carried rfp determinant
116. Expression of Campylobacter hyoilei lipooligosaccharide (LOS) antigens in Escherichia coli
117. Role of Rfe and RfbF in the initiation of biosynthesis of D-galactan I, the lipopolysaccharide O antigen from Klebsiella pneumoniae serotype O1
118. Cloning of rfaG, B, I and J genes for glycosyltransferase enzymes for synthesis of the lipopolysaccharide core of Salmonella typhimurium
119. Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs
120. Molecular analysis of the ams operon required for exopolysaccharide synthesis of Erwinia amylovora
121. Identification of bacteriophage K20 binding regions of OmpF and lipopolysaccharide in Escherichia coli K-12
122. Salmonella typhimurium mutants defective in UDP-D- galactose:lipopolysaccharide alpha 1,6-D-galactosyltransferase. Structural, immunochemical, and enzymologic studies of rfaB mutants
123. Cloning and overexpression of glycosyltransferases that generate the lipopolysaccharide core of Rhizobium leguminosarum
124. Biosynthesis of ganglioside mimics in Campylobacter jejuni OH4384. Identification of the glycosyltransferase genes, enzymatic synthesis of model compounds, and characterization of nanomole amounts by 600-Mhz (1)h and (13)C NMR analysis
125. Phase variation of a β-1,3 galactosyltransferase involved in generation of the ganglioside GM1-like lipo-oligosaccharide of Campylobacter jejuni
126. The assembly system for the outer core portion of R1- and R4-type lipopolysaccharides of Eseheriehia coli. The R1 core-specific β-glucosyltransferase provides a novel attachment site for O-polysaccharides
127. Cloning and expression of β1,4-galactosyltransferase gene from Helicobacter pylori