Comparison of the antiobesity effects of the protopanaxadiol- and protopanaxatriol-type saponins of red ginseng

Phytotherapy Research

Volumn 23, Issue 1, 2009, Pages 78-85

  Kim, Ji Hyun ^a   Kang, Soon Ah ^b   Han, Seung Moo ^c   Shim, Insop ^a  

^a The Catholic University of Korea   (South Korea)

^b Seoul University of Venture and Information   (South Korea)

^c Kyung Hee University   (South Korea)

Author keywords

Cholecystokinin; Leptin; Neuropeptide Y; Protopanaxadiol and protopanaxatriol type saponins

Indexed keywords

ANTIOBESITY AGENT; APPETITE STIMULANT; CHOLECYSTOKININ; CHOLESTEROL; FAT; LEPTIN; NEUROPEPTIDE Y; PROTOPANAXADIOL; PROTOPANAXATRIOL; SAPONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG EFFECT; FAT CONTENT; FOOD INTAKE; GINSENG; HYPOTHALAMUS; LIPID DIET; MALE; NONHUMAN; OBESITY; RAT; SPRAGUE DAWLEY RAT; TREATMENT DURATION;

ANIMALS; ANTI-OBESITY AGENTS; BODY WEIGHT; CHOLECYSTOKININ; CHOLESTEROL; EATING; HYPOTHALAMUS; LEPTIN; MALE; NEUROPEPTIDE Y; OBESITY; PANAX; RATS; RATS, SPRAGUE-DAWLEY; SAPOGENINS; TRIGLYCERIDES;

PANAX GINSENG; RATTUS;

EID: 58149523226     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2561     Document Type: Article

References (46)

1. Barrachina MD, Martines V, Wang L, Wei JY, Tache Y. 1997. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA 94: 10455-10460.
2. Billington CJ, Briggs JE, Harker S, Grace M, Levine AS. 1994. Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism. Am J Physiol Regul Integr Comp Physiol 266: R1765-R1770.
3. Birketvedt GS, Travis A, Langbakk B, Florholmen JR. 2002. Dietary supplementation with bean extract improves lipid profile in overweight and obese subjects. Nutrition 18: 729-733.
4. Blevins JE, Schwartz MW, Baskin DG. 2002. Peptide signals regulating food intake and energy homeostasis. Can J Physiol Pharmacol 80: 396-406.
5. Boozer CN, Daly PA, Homel P et al. 2002. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. Int J Obes Relat Metab Disord 26: 593604.
6. Chaput J-P, Tremblay A. 2006. Current and novel approaches to the drug therapy of obesity. Eur J Clin Pharmacol 62: 793-803.
7. Dourish CT, Rycroft W, Iverson SD. 1989. Postponement of satiety by blockade of brain cholecystokinin (CCK-B) receptors. Science 245: 1509-1511.
8. Flier JS. 2004. Obesity wars: molecular progress confronts an expanding epidemic. Cell 116: 337-350.
9. Gibbs J, Young RC, Smith GP. 1973. Cholecystokinin decreases food intake in rats. J Comp Physiol Psychol 84: 488-495.
10. Han KH, Choe SC, Kim HS et al. 1998. Effects of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension. Am J Chin Med 26: 199-209.
11. Han LK, Takaku T, Li J, Kimura Y, Okuda H. 1999. Anti-obesity action of oolong tea. Int J Obes Relat Metab Disord 23: 98-105.
12. Han LK, Zheng YH, Xu BJ, Okuda H, Kimura Y. 2002. Saponins from Platycodi radix ameliorate high fat diet-induced obesity in mice. J Nutr 132: 2241-2245.
13. Harrold JA. 2004. Hypothalamic control of energy balance. Curr Drug Targets 5: 207-219.
14. Hebebrand J, Friedel S, Scheuble N, Geller F, Hinney A. 2003. Perspectives: molecular genetic research in human obesity. Obes Rev 4: 139-146.
15. Inoue M, Wu CZ, Dou DQ, Chen YJ, Ogihara Y. 1999. Lipoprotein lipase activity by red ginseng saponins in hyperlipidemia model animals. Phytomedicine 6: 257-265.
16. Jaenicke B, Kim EJ, Ahn JW, Lee HS. 1991. Effect of Panax ginseng extract on passive avoidance retention in old rats. Arch Pharm Res14: 25-29.
17. Jin SH, Park JK, Nam KY, Park SN, Jung NP. 1999. Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice. J Ethnopharmacol 66: 123-129.
18. Jung NP, Jin SH. 1996. Studies on the physiological and biochemical effects of Korean ginseng. Korean J Ginseng Sci 20: 431-471.
19. Kalra SP, Dube MG, Sahu A, Phelps CP, Kalra PS. 1991. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci USA 88: 10931-10935.
20. Kim CS, Jeong SI, Lee YG. 1998a. A rapid separation of an edible panaxadiol and panaxatriol in ginseng saponins by benzene ethylene resin absorption. J Ginseng Res 22: 211-215.
21. Kim DY, Chang JC. 1998. Radioprotective effect of ginseng components on antioxidant enzymes, glutathione and lipid peroxidation of liver in γ-irradiated mice. Korean J Ginseng Sci 22: 1-10.
22. Kim JH, Hahm DH, Yang DC, Kim JH, Lee HJ, Shim I. 2005. Effect of crude saponin of Korean red ginseng on high-fat diet-induced obesity in the rat. J Pharmacol Sci 97: 124-131.
23. Kim SK, Kwak YS, Kim SW, Hwang SY, Ko YS, Yoo CM. 1998b. Improved method for the preparation of crude ginseng saponin. J Ginseng Res 22: 155-160.
24. Klein S. 2004. The case of visceral fat: argument for the defense. J Clin Invest 113: 1530-1532.
25. Konturek PC, Konturek JW, Cześnikeiwicz-Guzik M, Brzozowski T, Sito E, Konturek SJ. 2005. Neuro-hormonal control of food intake; Basic mechanisms and clinical implications. J Physiol Pharmacol 56 (Suppl 6): 5-25.
26. Konturek SJ, Konturek JW, Pawlik Y, Brzozowski T. 2004. Brain-gut axis and its role in control of food intake. J Physiol Pharmacol 55 (Suppl 1): 137-154.
27. Koza RA, Nikonova L, Hogan J et al. 2006. Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. PLoS Genet 2: 769-780.
28. Lauterio TJ, Davies MJ, DeAngelo M, Peyser M, Lee J. 1999. Neuropeptide Y expression and endogenous leptin concentrations in a dietary model of obesity. Obes Res 7: 498-505.
29. Lee IS, Nam YS, Lee CH et al. 2004. Expressional changes of neuropeptide Y and cholecystokinin in the arcuate and paraventricular nuclei after capsaicin administration. J Nutr Sci Vitaminol 50: 144-148.
30. Levin BE. 1999. Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats. Am J Physiol Regul Integr Comp Physiol 276: R382-R387.
31. Levin BE, Dunn-Meynell AA. 1997. Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol 272: R1365-R1370.
32. Levin BE, Dunn-Meynell AA. 2002. Defense of body weight depends on dietary composition and palatability in rats with diet-induced obesity. 282: R46-R54.
33. Levin BE, Keesey RE. 1998. Defense of differing body weight set points in diet-induced obese and resistant rats. Am J Physiol 274: R412-R419.
34. Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW. 1997. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46: 1768-1774.
35. Ohnuki K, Haramizu S, Oki K, Watanabe T, Yazawa S, Fushiki T. 2001. Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice. Biosci Biotechnol Biochem 65: 2735-2740.
36. Oomura Y. 1985. Feeding control through bioassay of body chemistry. Jpn J Physiol 35: 1-19.
37. Park JK, Nam KY, Hyan HC, Jin SH, Chepurnov SD, Chepunora NE. 1994. Effect of red ginseng trial saponin fraction on the spatial memory function studied with 17-arm radial maze. Korean J Ginseng Sci18: 32-38.
38. Paxinos G, Watson C. 1986. The Rat Brain in Stereotaxic Coordinates, 4th edn. New York Academic Press: San Diego.
39. Schwartz MW, Woods SC, Orte D, Seeley RJ, Baskin DG. 2000. Central nervous system control of food intake. Nature 404: 661-671.
40. Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. 2004. Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides. J Am Coll Nutr 23: 248-258.
41. Smith GP, Gibbs J. 1992. The development and proof of the CCK hypothesis of satiety. In Multiple Cholecystokinin Receptors in the CNS, Dourish CT, Cooper SJ, Iversen SD, Iversen LL (eds). Oxford University Press: Oxford, 166-182.
42. Sotaniemi EA, Haapakoski E, Rautia A. 1995. Ginseng therapy in non-insulin-dependent diabetes patients. Diabetes Care 18: 1373-1375.
43. Spiegelman BM, Jeffery SF. 2001. Obesity and the regulation of energy balance. Cell 104: 531-543.
44. Surwit RS, Feinglos MN, Rodin J et al. 1995. Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 44: 645-651.
45. Weigle DS. 2003. Pharmacological therapy of obesity: past, present, and future. J Clin Endocrinol Metab 88: 2462-2469.
46. Zhao HL, Sim J-S, Shim SH, Ha YW, Kang SS, Kim YS. 2005. Antiobese and hypolipidemic effects of platycodin saponins in diet-induced obsess rats: evidence for lipase inhibition and calorie intake restriction. Int J Obes 29: 983-990.