Bone resorptive activity of osteoclast-like cells generated in vitro by PEG-induced macrophage fusion

Biological Research

Volumn 43, Issue 2, 2010, Pages 205-224

  Murillo, Andrea ^a   Guerrero, Carlos A ^a   Acosta, Orlando ^a   Cardozo, Carmen A ^a  

^a UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

Author keywords

Bone resorption; Macrophage fusion; Osteoclast activity; Osteoclast differentiation; PEG; RANKL

Indexed keywords

BOVINAE;

EID: 78549237829     PISSN: 07169760     EISSN: 07176287     Source Type: Journal    
DOI: 10.4067/S0716-97602010000200009     Document Type: Article

References (76)

1. AMEDEE J, BAREILLE R, ROUAIS F, CUNNINGHAM N, REDDI H, HARMAND MF (1994) Osteogenin (bone morphogenic protein 3) inhibits proliferation and stimulates differentiation of osteoprogenitors in human bone marrow. Differentiation 58: 157-164.
2. ANANDARAJAH AP (2009) Role of RANKL in bone diseases. Trends Endocrinol. Metab 20: 88-94.
3. ANDERSON DM, MARASKOVSKY E, BILLINGSLEY WL, DOUGALL WC, TOMETSKO ME, ROUX ER, TEEPE MC, DU BOSE RF, COSMANAND D, GALIBERT LA (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390: 175-195.
4. BAISM V, WIGNERA N, YOUNG M, TOHOLKA R, GRAVES DT, MORGAN EF, GERSTENFELD LC, EINHORN TA (2009) BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells. Bone (in press).
5. BLESSING M, SCHIRMACHER P, KAISER S (1996) Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice; inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoratic lesions. J Cell Biol 135: 227-239.
6. BOYCE BF, XING L (2008) Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys 473: 139-146.
7. BOYLE WJ, SIMONET WS, LACEY DL (2003) Osteoclast differentiation and activation. Nature 423: 337-342.
8. BROCKSTEDT H, KASSEM M, ERICKSEN EF, MOSEKILDE L, MELSEN F (1993) Age- and sex-related changes in the iliac cortical bone mass and remodeling. Bone 14: 681-691.
9. BURDON RH (1986) Laboratory Techniques in Biochemistry and Molecular Biology. Elsevier. pp 120-134.
10. CHERNOMORDIK LV, FROLOV V, LEIKINA E, BRONK P, ZIMMERBERG J (1998) The pathway of membrane fusion catalyzed by infuenza hemagglutinin: restriction of lipids, hemifusion, and lipidic fusion pore formation. J Cell Biol 140: 1369-1382.
11. CHERNOMORDIK LV, LEIKINA E, FROLOV V, ZIMMERBERG J (1997) An early stage of membrane fusion mediated by the low pH conformation of infuenza hemmagglutinin depends upon membrane lipids. J Cell Biol 136: 81-93.
12. COLLINOSDOBY P, ANDERSON F. OSDOBY, P (2003) Primary Isolation and culture of rabbit osteoclast In: HELFRICH MH, STUART H (eds) Bone Research Protocols. New Jersey: Humana Press. pp: 65-88.
13. DIMENT S, MARTINY KJ, STAHL PD (1989) Cleavage of Parathyroid Hormone in Macrophage Endosomes Illustrates a Novel Pathway for Intracellular Processing of Proteins. J Biol Chem 264: 13403-13406.
14. EVANS KN, NGUYEN L, CHAN J, INNES BA, BULMER JN, KILBY MD, HEWISON M (2006) Cyclic hydrostatic pressure and particles increase synthesis of 1,25-dihydroxyvitamin D3 by human macrophages in vitro. Biol Reprod 75: 816-22.
15. FREEDMAN L P (1999) TRANSCRIPTIONAL TARGETS OF THE VITAMIN D3 RECEPTOR-MEDIATING CELL cycle arrest and differentiation. J Nutr 129: 581S-586S.
16. FULLER K, OWENS JM, JAGGER CJ, WILSON A, MOSS R, CHAMBERS TJ (1993) Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts. J Exp Med 178: 1733-44.
17. HAN X, STERLING H, CHEN Y, SAGINARIO CH, BROWN EJ, FRAZIER WA, LINDBERG FP, VIGNERY A (2000) CD47, a ligand for the macrophage fusion receptor, participates in macrophage multinucleation. J Biol Chem 276: 37984-37992.
18. HARLOW DL (1988) Antibodies a Laboratory Manual, Cold Spring Harbor laboratory. pp: 405
19. HELMING L, GORDON S (2007) The molecular basis of macrophage fusion. Immunobiol 212: 785-93.
20. HISATAKE J, O ́KELLY J, USOKOKOVIC MR, TOMAYASU S, KOEFFLER HP (2001) Novel vitamin D3 analog 21-(3-methyl-3-hydroxybutyl)19-nor D3, that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells. Blood 97: 2427-2433.
21. ITOH K, UDAGAWA N, KATAGIRI T, IEMURA S, UENO Y, YASUDA S, HIGASHIO K, QUINN J, GILLESPIE MT, MARTÍN TJ, SUDA T, TAKAHASHI N (2001) Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand. Endocrinology 142: 3656-3662.
22. IWASAKI R, NINOMIYA K, MIYAMOTO K, SUZUKI T, SATO Y, KAWANA H, NAKAGAWA T, SUDA T, MIYAMOTO T (2008) Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity Biochem Biophys Res Commun 377: 899-904.
23. JIMI E, AKIYAMA S, TSURUKAI T, OKAHASHI N, KOBAYASHI K, UDAGAWA N, NISHIHARA T, TAKAHASHI N (1999) Osteoclast differentiation factor as a multifunctional regulator in murine osteoclast differentiation and function. J Immunol 163 434-442.
24. JONES G, STRUGNELL SA, DELUCA HF (1998) Current understanding of the molecular actions of the vitamin. D Physiol Rev 78: 1193-231.
25. JURDIC P, SALTEL F, CHABADEL A, DESTAING O (2006) Podosome and sealing zone: Specifcity of the osteoclast model Eur. J Cell Biol 85: 195-202.
26. KAMEDA T, MANO H, YUASA T, MORI Y, MIYAZAWA K, SHIOKAWA M, NAKAMARU Y, HIROI E, HIURA K, KAMEDA A, YANG NN, HAKEDA Y, KUMEGAWA M (1997) Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J Exp Med 186: 489-95.
27. KAMEL HK (2007) Update on osteoporosis management in long-term care: focus on bisphosphonates. J Am Med Dir Assoc 8: 434-40.
28. KAMOLMATYAKUL S, CHEN W, LI YP (2001) Interferon-g down-regulates gene expression of cathepsin K in osteoclasts and inhibits osteoclast formation. J Dent Res 80: 351-355.
29. KANSAKI H., CHIBA M., SHIMIZU Y., MITANI H (2001) Dual regulation of osteoclast differentiation by periodontal ligament cells through RANKL stimulation and OPG inhibition. J Dent Res 80: 887-891.
30. KONETY B, LAVELLE J, PIRTSSKALAISHVILI G, DHIR R, MEYERS SA, NGUYEN T, P HERSHBERGER, SHURIN M, JOHNSON CS, TRUMP D, ZEIDEL ML. GETZENBERG H (2001) Effects of vitamin D (Calcitriol) on transitional cell carcinoma of the bladder in vitro and in vivo. J Urol 185: 253-258.
31. KUKITA A, KUKITA T, SHIN J, KOHASHI O (1993) Induction of mononuclear precursors cells with osteoclastic phenotypes in rat bone marrow culture system depleted of stromal cells. Biochem Biophys Res Commun 196: 1383-1389.
32. KWAK HB, LEE SW, LI YJ, KIM YA, HAN SY, JHON GJ, KIM HH, LEE ZH SCOH (2004) Inhibition of osteoclast differentiation and bone resorption by a novel lysophosphatidylcholine derivative. Biochem Pharmacol 67: 1239-1248.
33. LACEY DL, TAN HL, LU J, KAUFMAN S, VAN G, QIU W, RATTAN A, SCULLY S, FLETCHER F, JUAN T, KELLEY M, BURGESS TL, BOYLE WJ, POLVERINO AJ, (2000) Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am J Pathol 157: 435-48.
34. LEE SE, CHUNG WJ, KWAK HB, CHUNG CH, KWACK KB, LEE ZH, KIM HH (2001) Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK. J Biol Chem: 276: 49343-19349.
35. LEE SK, LORENZO JA (1999) Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formation. Endocrinology 140: 3552-3561.
36. LEE ZH, LEE SE, KIM CW, LEE SH, KIM SW, KWACK K, WALSH K, KIM HH (2002) IL-1alpha stimulation of osteoclast survival through the PI 3- kinase/Akt and ERK pathways. J Biochem 131: 161-166.
37. LEES RL, SABHARWAL VK, HEERSCHE NM (2001) Resorptive state and cell size infuence intracellular pH regulation in rabbit osteoclast cultured on collagen-hydroxyapatite flms. Bone 28: 187-194.
38. LENTZ JK, LEE J (1999) Poly(ethylene glycol) (PEG)-mediated fusion between pure lipid bilayers: a mechanism in common with viral fusion and secretory vesicle release? Mol Membr Biol 16: 279-296.
39. LIU BY, WU PW, BRINGHURST R, WANG JT (2002) Estrogen inhibition of PTH-stimulated osteoclast formation and attachment in vitro: involvement of both PKA and PKC. Endocrinology 143: 627-635.
40. MANABE N, KAWAGUCHI H, CHIKUDA H, MIYAURA CH, INADA M, NAGAI R, NABESHIMA Y, NAKAMURA K, SINCLAIR AM, SCHEUERMANN RH, KURO M (2001) Connection between B lymphocyte and osteoclast differentiation pathways. J Immunol 167: 2625-2631.
41. MATSUZAKI K, KATAYAMA K, TAKAHASHI Y, NAKAMURA I, UDAGAWA N, TSURUKAI T, NISHINAKAMURA R, TOYAMA Y, YABE Y, HORI M, TAKAHASHI N, SUDA T (1999) Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene. Endocrinology 140:925-932.
42. Mawer Eb, Berry Jl, Cundall Jp, Still Pe, White A (1990) A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3). Clin Chim Acta 190: 199-209.
43. Mccarthy TL, Centrella M, CANALIS E, (1988) Further biochemical and molecular characetrization of primery rat parietal bone cells cultures J Bone Miner Res 3: 401-408.
44. MEE AP, HOYLAND JA, BRAIDMAN IP, FREEMONT AJ, DAVIES M, MAWER EB (1996) Demonstration of Vitamin D receptor transcripts in actively resorbing osteoclasts in bone sections. Bone 18: 295-299.
45. MOFFATT KA, JOHANNES WU, HEDLUND TE, MILLER GJ (2001) Growth inhibitory effects of 1,25-dihydroxyvitamin D3 are mediated by increases levels of p21in the prostatic carcinoma cell line ALVA-31. Cancer Res 61: 7122-7129.
46. MORGAN J, HOLTMAN KR, KELLER JC, STANFORD CM (1996) In vitro mineralization and implant calcium phosphate-hydroxyapatite crystallinity. Implant Dent 5: 264-271.
47. MURAKAMI H, TAKAHASHI N, TANAKA S, NAKAMURA I, UDAGAWA N, NAKAJO S, NAKAYA K, ABE M, YUDA Y, KONNO F, BARBIER A., SUDA T (1997) Tiludronate inhibits protein tyrosine phosphatase activity in osteoclasts. Bone 20: 399-404.
48. MURAKAMI T, YAMAMOTO M, ONO K, NISHIKAWA M, NAGATA N, MOTOYOSHI K, AKATSU T (1998) Transforming growth factor-beta1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/ stromal cells and inhibits the survival of murine osteoclast-like cells Biochem Biophys Res Commun 252: 747 52.
49. NAKCHBANDI IA, WEIR EE, INSONGA KL, PHILBRICK WM, BROADUS AE (2000) Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade. Proc Natl Acad Sci USA 97: 7296-7300.
50. OKADA Y, LORENZO JA, FREEMAN AM, TOMITA M, MORHAM SG, RAISZ LG, PILBEAM CC (2000) Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture. J Clin Invest 105: 823-832.
51. OTSUKA E, KATO Y, HIROSE S, HAGIWARA H (2000) Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix. Endocrinology 141: 3006-3011.
52. PARK H, PARK OJ, SHIN J, CHOI Y (2005) Receptor activator of NF-KB ligand enhances the activity of macrophages as antigen presenting cells. Exp Mol Med 37: 524-532.
53. PASSMORE JS, LUKEY PT, RESS SR (2001) The human macrophage cell line U937 as an in vitro model for selective evaluation of mycobacterial antigen-specifc cytotoxic T-cell function. Immunology 102: 146-156.
54. PUENTES F, DIAZ D, HOYA RD, GUTIERREZ JA, LOZANO JM, PATARROYO ME, MORENO A (2000) Cultivation and characterization of stable Leishmania guyanensis complex axenic amastigotes derived from infected U937cells. Am J Trop Med Hyg 63: 102-110.
55. REDDY SV, KURIHARA N, MENAA C, LANDUCCI G, FORTHAL D, KOOP BA, WINDLE JJ, ROODMAN GD (2001) Osteoclast formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of Pagetic osteoclast. Endocrinology 142: 2898-2905.
56. SAGINARIO CH, STERLING H, BECKERS C, KOBAYASHI R, SOLIMENA M, ULLU E, VIGNERY A (1998) MFR, a putative receptor mediating the fusion of macrophages. Mol. Cell Biol 18: 6213-6223.
57. SALO J (2002) Bone resorbing osteoclasts reveal two basal plasma membrane domains and transcytosis of degraded matrix material. Academic Dissertation. University of Oulu.
58. SUDA N, KITAHARA Y, HAMMOND VE, OHYAMA K (2003) Development of a novel mouse osteoclast culture system including cells of mandibular body and erupting teeth. Bone 33: 38-45.
59. SUDA T, TAKAHASHI N, UDAGAWA N, IIMI E, GILLESPIE M T, MARTIN TJ (1999) Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligands families. Endocr Rev 20: 345-357.
60. TANAKA H, HRUSKAP KA, SEINO Y, MALONE JD, NISHII Y, TEITELBAUM SL (1991) Disassociation of the Macrophage-maturational Effects of Vitamin D from Respiratory Burst Priming. J Biol Chem 266: 10888-10892.
61. TETLOW L, WOOLLEY DE (1999) Vitamin D receptors in the rheumatoid lesion: expression by chondrocytes, macrophages, and synoviocytes. Ann N Y Acad Sci 878:615-618.
62. THEILL LE (2002) RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu. Rev. Immunol 20: 795-823.
63. UDAGAWA N, TAKAHASHI N, AKATSU T, TANAKA H, SASAKI T, NISHIHARA T, KOGA T, MARTIN J, SUDA T (1990) Origin of osteoclast: mature monocytes and macrophages are capable of differentiating into osteoclast under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A 87: 7260-7264.
64. VANDERKENKEN K, ASOSHING K, WILLEMS A, DE RAEVE H, COUCK P, GORUS F, CROUCHER P, VAN CAMP B (2005) In: ROSS D, BROWN P, JOY H (eds) Multiple myeloma: methods and protocols. Humana Press. pp.201.
65. VERMA RA, BABU A (1989) Human chromosomes. Manual of basic techniques. Pergamon Press, New York.
66. VERTUTDOÏ A, HIDEKI ISHIWATA B, KOICHIRO M (1996) Binding and uptake of liposomes containing a poly(ethylene glycol) derivative of cholesterol (stealth liposomes) by the macrophage cell line J774: infuence of PEG content and its molecular weight. Biochimica et Biophysica Acta 1278: 19-28
67. VIGNERY A (2000) Osteoclasts and giant cells:macrophage-macrophage fusion mechanism Int. J Exp Path 81: 291-304.
68. VIGNERY A (2005) Macrophage fusion: the making of osteoclasts and giant cells. J Exp Med 202: 337-40.
69. WADA T, NAKASHIMA T, HIROSHI N, PENNINGER JM (2006) RANKL-RANK signaling in osteoclastogenesis and bone disease Trends Mol Med 12: 17-25.
70. WAGNER E, MATSUO K (2003) Signalling in osteoclasts and the role of Fos/AP1 proteins. Ann Rheum Dis 62:ii83-ii85.
71. WALSH MC, CHOI Y (2003) Biology of the TRANCE axis. Cytokine Growth Factor Rev 14: 251-63.
72. WOO JT, KASAI S, STERN PH, NAGAI K (2000) Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts. J Bone Miner Res 15: 650-62.
73. YAMAGISHI T, OTSUKA E, HAGIWARA H (2001) Reciprocal control of expression of mRNAs for osteoclast differentiation factor and OPG in osteogenic stromal cells by genistein: evidence for the involvement of topoisomerase II in osteoclastogenesis. Endocrinology 142: 3632-3637.
74. YAMAGIWA H, ENDO N, TOKUNAGA K, HAYAMI T, HATANO H, TAKAHASHI HE (2001) In vivo bone-forming capacity of human bone marrow-derived stromal cells is stimulated by recombinant human bone morphogenetic protein-2. J Bone Miner Metab 19: 20-28.
75. YAO Z, XING L, QIN C, SCHWARZ M, BOYCE BF (2008) Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism. J Biol Chem 283: 9917-9924.
76. YASUDA H, SHIMA N, NAKAGAWA N, YAMAGUCHI K, KINOSAKI M, MOCHIZUKI S, TOMOYASU A, YANO K, GOTO M, MURAKAMI A. TSUDA E, MORINAGA T, HIGASHIO K. UDAGAWA N, TAKAHASHI N, SUDA T (1998) Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 95: 3597-3602.