Transcriptional targets of the vitamin D3 receptor-mediating cell cycle arrest and differentiation

Journal of Nutrition

Volumn 129, Issue 2 SUPPL., 1999, Pages

  Freedman, Leonard P ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Dimerization; Myeloid cell differentiation; Target genes; Vitamin D receptor

Indexed keywords

VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR;

BONE MARROW CELL; CANCER PREVENTION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONFERENCE PAPER; GENE CONTROL; GENE TARGETING; GROWTH INHIBITION; GROWTH REGULATION; HUMAN; NONHUMAN;

EID: 0032907768     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/129.2.581s     Document Type: Conference Paper

References (34)

1. Abe, E., Miyaura, C., Sakagami, H., Takeda, M., Konno, K., Yamazaki, T., Yoshiki, S. & Suda, T. (1981) Differentiation of mouse myeloid leukemia cells induced by 1,25-dihydroxyvitamin D3. Proc. Natl. Acad. Sci. U.S.A. 78: 4990-4994.
2. Abe, E., Miyaura, C., Tananka, H., Yoshiki, S. & Suda, T. (1983) 1, 25 dihydroxyvitamin D3 promotes fusion of mouse alveolar macrophages both by a direct mechanism and by a spleen cell-mediated indirect mechanism. Proc. Natl. Acad. Sci. U.S.A. 80: 5583-5587.
3. Alroy, I., Towers, T. L. & Freedman, L. P. (1995) Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFAT-AP1 complex formation by a nuclear hormone receptor. Mol. Cell. Biol. 15: 5789-5799.
4. Ayer, D. E., Jretzner, L. & Eisenman, R. N. (1993) Mad: a heterodimeric partner of Max that antagonizes Myc transcriptional activity. Cell 72: 211-222.
5. Bar-Shavit, Z., Teitelbaum, S. L., Reitsma, P., Hall, A., Pegg, L. E., Trial, J. & Kahn, A. J. (1983) Induction of monocytic differentiation and bone resorption by 1,25 dihydroxyvitamin D3. Proc. Natl. Acad. Sci. U.S.A. 80: 5907-5911.
6. Bories, D., Raynal, M.-C., Solomon, D. H., Darzynkiewicz, Z. & Cayre, Y. E. (1989) Down-regulation of a serine protease, myeoblastin, causes growth arrest and differentiation of promyeolyctic leukemia cells. Cell 59: 959-968.
7. Breitman, T., Collins, S. & Keene, B. (1981) Terminal differentiation of human promyelocytic leukemia cells in primary culture in response to retinoic acid. Blood 57: 1000-1007.
8. Candeliere, G. A., Jurukta, P. W., Haussler, M. R. & St-Arnaud, R. (1996) A composite element binding the vitamin D receptor, retinoid X receptor α, and a member of the CTF/NF-1 family of transcription factors mediates the vitamin D responsiveness of the c-fos promoter. Mol. Cell. Biol. 16: 584-592.
9. Cheskis, B. & Freedman, L. P. (1994) Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers. Mol. Cell. Biol. 14: 3329-3338.
10. Cheskis, B. & Freedman, L. P. (1996) Detailed analysis of nuclear receptor interactions and their modulation by ligands using surface plasmon resonance. Biochemistry 35: 3309-3318.
11. Cheskis, B., Lemon, B. D., Lomedico, P., Uskokovic, M. & Freedman, L. P, (1995) Vitamin D3-retinoid X receptor dimerization, DNA binding, and transactivation are differentially affected by analogues of 1,25 dihydroxyvitamin D3. Mol. Endocrinol. 9: 1814-1824.
12. Collins, S. J. (1987) The HI-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood 70: 1233-1244.
13. Collins, S. J., Ruscetti, F. W., Gallagher, R. E., and Gallo, R. C. (1978) Terminal differentiation of human promyelocytic leukemia HL-60 cells induced by dimethyl sulfoxide and other polar compounds. Proc. Natl. Acad. Sci. U.S.A. 75: 2458-2462.
14. Datta, R., Sherman, M. L., Stone, R. M. & Kufe, D. (1991) Expression of the ju-B gene during induction of monocytic differentiation. Cell Growth Differ. 2: 43-49.
15. El-Diery, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W. & Vogelstein, B. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825.
16. 3 receptor in the absence of the retinoid X receptor. Mol. Endocrinol. 8: 265-273.
17. Grosso, L. E. & Pitot, H.C. (1985) Transcriptional regulation of c-myc during chemically induced differentiation of HL-60 cultures. Cancer Res. 45: 847-850.
18. Halevy, O., Novitch, B. G., Spicer, D. B., Skapek, S. X., Rhee, J., Hannon, G. J., Beach, D. & Lassar, A. B. (1995) Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science (Washington, DC) 267: 1018-1021.
19. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. & Elledge, S. J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclir-dependent kinases. Cell 75: 805-816.
20. Lawrence, H. J., Sauvageau, G., Ahmadi, N., Lopez, A. R., LeBeau, M. M., Link, M., Humphries, K. & Largman, C. (1995) Stage-and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells. Exp. Hematol. 23: 1160-1166.
21. 3-dependent cell-free transcription. Mol. Cell. Biol. 17: 1923-1937.
22. Lemon, B. D. & Freedman, L. P. (1996) Selective effects of ligands on vitamin D3 receptor and retinoid X receptor gene activation in vivo. Mol. Cell. Biol. 16: 1006-1016.
23. Liu, M., Lee, M.-H., Bommakanti, M., Cohen, M. & Freedman, L. P. (1996) Transcriptional activation of the p21 gene by vitamin D3 leads to the differentiation of the myelomonocytic cell line U937. Genes Dev. 10: 142-153.
24. Mangelsdorf, D. J., Pike, J. W. & Haussler, M. R. (1984) 1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. J. Cell Biol. 98: 391-398.
25. McCarthy, D. M., San Miguel, J. F. & Freake, H. C. (1983) 1,25-Dihydroxyvitamin D3 inhibits proliferation of human promyleocytic leukemia (HL-60) cells and induces monocyte-macrophage differentiation in HL-60 and normal human bone marrow cells. Leuk. Res. 7: 51-60.
26. Obeid, L. M., Okazaki. T., Karolak, L. A. & Hannun, Y. A. (1990) Transcriptional regulation of protein kinase C by 1,25-dihydroxyvitamin D3 in HL-60 cells. J. Biol. Chem. 265: 2370-2374.
27. Ollson, I., Gullberg, U., Ivhed, I. & Nilsson, K. (1983) Induction of differentiation of the human histiocytic lymphoma cell line U-937 by 1,25 dihydroxyvitamin D3. Cancer Res. 43: 5862-5870.
28. Polyak, K., Kato, J.-Y., Solomon, M. J., Sherr, C. J., Massague, J., Roberts, J. M. & Koff, A. (1994) p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-b and contact inhibition to cell cycle arrest. Genes Dev. 8: 9-22.
29. 3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev. 12: 1787-1800.
30. Reitsma, P. H., Rothberg, P. G., Astrin, S. M., Trial, J. & Bar-Shavil, Z. (1983) Regulation of myc expression in HL-60 leukaemia cells by a vitamin D metabolite. Nature (Lond.) 306: 492-494.
31. Rots, N. Y., Liu, M., Anderson, E.C. & Freedman, L. P. (1998) A differential screen for ligand-regulated genes: identification of HoxA10 as a target for vitamin D3 induction in myeloid leukemic cells. Mol. Cell. Biol. 18: 1911-1918.
32. Sariban, E., Mitchell, T. & Kufe, D. (1985) Expression of the c-fms protooncogene during human monocytic differentiation. Nature (Lond.) 316: 64-66.
33. Sherr, C. J. & Roberts, J. M. (1995) Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9: 1149-1163.
34. Solomon, D. H., Raynal, M. C., Tejwani, G. A. & Cayre, Y. E. (1988) Activation of the fructose 1,6-biphosphatase gene by 1,25-dihydroxyvitamin D3 during monocytic differentiation. Proc. Natl. Acad. Sci. U.S.A. 85: 6904-6908.