Methylation Pattern of the IFN-γ Gene in Human Dental Pulp

Journal of Endodontics

Volumn 36, Issue 4, 2010, Pages 642-646

  Cardoso, Fabiano Pereira ^a   Viana, Michelle Beatriz ^a   Sobrinho, Antônio Paulino Ribeiro ^a   Diniz, Marina Gonçalves ^a   Brito, João Artur Ricieri ^a   Gomes, Carolina Cavaliéri ^a   Moreira, Paula Rocha ^a   Gomez, Ricardo Santiago ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Dental pulp; inflammation; interferon gamma; methylation

Indexed keywords

GAMMA INTERFERON;

ADOLESCENT; ADULT; ARTICLE; BIOSYNTHESIS; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; CHILD; CYTOLOGY; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; NONPARAMETRIC TEST; PATHOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PROMOTER REGION; PULPITIS; TOOTH PULP;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHILD; DENTAL PULP; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; PULPITIS; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 77949463514     PISSN: 00992399     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joen.2009.12.017     Document Type: Article

References (30)

1. Adcock I.A., Tsaprouni L., Bhavsar P., and Ito K. Epigenetic regulation of airway inflammation. Curr Opin Immunol 19 (2007) 694-700
2. Bäckdahl L., Bushell A., and Beck S. Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation. Int J Biochem Cell Biol 41 (2009) 176-184
3. Jones P.L., Veenstra G.J., Wade P.A., et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19 (1998) 187-191
4. Egger G., Liang G., Aparicio A., et al. Epigenetics in human disease and prospects for epigenetic therapy. Nature 429 (2004) 457-463
5. Wilson A.G. Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases. J Periodontol 79 (2008) 1514-1519
6. Sanders V.M. Epigenetic regulation of Th1 and Th2 cell development. Brain Behav Immun 20 (2006) 317-324
7. Kang G.H., Lee H.J., Hwang K.S., et al. Aberrant CpG island hypermethylation of chronic gastric, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. Am J Pathol 163 (2003) 1551-1556
8. Offenbacher S., Barros S.P., and Beck J.D. Rethinking periodontal inflammation. J Periodontol 79 (2008) 1577-1584
9. Kwon N.-H., Kim J.-S., Le J.-Y., et al. DNA methylation and he expression of IL-4 and IFN-g promoter genes in patients with bronchial asthma. J Clin Immunol 28 (2008) 139-146
10. White G.P., Watt P.M., Holt B.J., et al. Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells. J Immunol 168 (2002) 2820-2827
11. Aitken A.E., and Morgan E.T. Gene-specific effects of inflammatory cytokines on cytochrome P4502C, 2B6 and 3A4 mRNA levels in human hepatocytes. Drug Metab Dispos 35 (2007) 1687-1693
12. Doherty G.M., Lange J.R., Langstein H.N., et al. Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha. J Immunol 149 (1992) 1666-1670
13. Hahn C., Best A.M., and Tew J.G. Cytokine induction by Streptococcus mutans and pulpal pathogenesis. Infect Immun 68 (2000) 6785-6789
14. Goldenberg D., Harden S., Masayesva B.G., et al. Intraoperative molecular margin analysis in head and neck cancer. Arch Otolaryngol Head Neck Surg 130 (2004) 39-44
15. Bonilla-Henao V., Martinez R., Sobrinho F., et al. Different signaling pathways inhibit DNA methylation activity and up-regulate IFN-γ in human lymphocytes. J Leukoc Biol 78 (2005) 1339-1346
16. Brakensiek K., Langer F., Kreipe H., et al. Absence of p21(CIP1), p27(KIP1) and p57(KIP2) methylation in MDS and AML. Leuk Res 29 (2005) 1357-1360
17. Kwong J., Lo K.W., Chow L.S., et al. Silencing of the retinoid response gene TIG1 by promoter hypermethylation in nasopharyngeal carcinoma. Int J Cancer 113 (2005) 386-392
18. Zhang C., Li K., Wei L., et al. p300 expression repression by hypermethylation associated with tumour invasion and metastasis in oesophageal squamous cell carcinoma. J Clin Pathol 60 (2007) 1249-1253
19. Dutzan N., Vernal R., Hernandez M., et al. Levels of interferon- gamma and transcription factor T-bet in progressive periodontal lesions in patients with chronic periodontitis. J Periodontol 80 (2009) 290-296
20. Livak K.J., and Schimittgen T. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method. Methods 25 (2001) 402-408
21. Yu C., and Abbott P.V. An overview of the dental pulp: its functions and responses to injury. Aust Dent J 52 (2007) S4-S16
22. McLachlan J.L., Smith A.J., Bujalska I.J., et al. Gene expression profiling of pulpal tissue reveals the molecular complexity of dental caries. Biochim Biophys Acta 1741 (2005) 271-281
23. Zehnder M., Delaleu N., Du Y., et al. Cytokine gene expression-part of host defence in pulpitis. Cytokine 22 (2003) 84-88
24. Hahn C., and Liewehr F.R. Innate immune response of the dental pulp to caries. J Endod 33 (2007) 643-651
25. Hahn C., and Liewehr F.R. Relationships between caries bacteria, host responses, and clinical signs and symptoms of pulpitis. J Endod 33 (2007) 213-219
26. De Rossi A., Rocha L.B., and Rossi M.A. Interferon-gamma, interleukin-10, intercellular adhesion molecule-1, and chemokine receptor 5, bt not interleukin-4, attenuate the development of periapical lesions. J Endod 34 (2008) 31-38
27. Kersh E.N., Fitzpatrick D.R., Murali-Krishma K., et al. Rapid demethylation of the IFN-γ gene occurs in memory but not naïve CD8 T cells. J Immunol 176 (2006) 4083-4093
28. Ooi S., and Bestor T. The colorful history of active DNA demethylation. Cell 133 (2008) 1145-1148
29. Bruniquel D., and Schwartz R.H. Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process. Nat Immunol 4 (2003) 235-240
30. Hamm S., Just G., Lacoste N., et al. On the mechanism of demethylation of 5-methylcytosine in DNA. Bioorg Med Chem Lett 18 (2008) 1046-1049