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Volumn 33, Issue 4, 1998, Pages 212-225

Inflammatory mediators of the terminal dentition in adult and early onset periodontitis

Author keywords

Cytokines; Disease progression; Gingival crevicular fluid; Monocytes; Periodontal diseases; Prostaglandins; T helper cells; Terminal dentition; Tooth loss

Indexed keywords

AUTACOID; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

EID: 0032062299     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.1998.tb02193.x     Document Type: Article
Times cited : (154)

References (58)
  • 3
    • 0030280463 scopus 로고    scopus 로고
    • Periodontal diseases: Pathogenesis
    • Offenbacher S. Periodontal diseases: pathogenesis. Ann Periodontol 1996; 1: 821-878.
    • (1996) Ann Periodontol , vol.1 , pp. 821-878
    • Offenbacher, S.1
  • 4
    • 0025410805 scopus 로고
    • Terminal dentition in elderly patients and implant therapy alternatives
    • Zarb GA, Schmitt A. Terminal dentition in elderly patients and implant therapy alternatives. Int Dent J 1990; 40: 67-73.
    • (1990) Int Dent J , vol.40 , pp. 67-73
    • Zarb, G.A.1    Schmitt, A.2
  • 5
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins J Immunol 1986; 136: 2348-2357.
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 6
    • 0025807152 scopus 로고
    • Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigens of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production
    • Del Prete GF, De Carli M, Mastromauro C, et al. Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigens of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J Clin Invest 1991; 88: 346-350.
    • (1991) J Clin Invest , vol.88 , pp. 346-350
    • Del Prete, G.F.1    De Carli, M.2    Mastromauro, C.3
  • 9
    • 0031068551 scopus 로고    scopus 로고
    • Inflammatory mediator response as a potential risk marker for periodontal diseases in insulin-dependent diabetes mellitus patients
    • Salvi GE, Yalda B, Collins JG, et al. Inflammatory mediator response as a potential risk marker for periodontal diseases in insulin-dependent diabetes mellitus patients. J Periodontol 1997; 68: 127-135.
    • (1997) J Periodontol , vol.68 , pp. 127-135
    • Salvi, G.E.1    Yalda, B.2    Collins, J.G.3
  • 11
    • 0027772234 scopus 로고
    • Gingival mononuclear cells from chronic inflammatory periodontal tissues produce Interleukin (IL)-5 and IL-6 but not IL-2 and IL-4
    • Fujihashi K, Beagley KW, Kono Y, et al. Gingival mononuclear cells from chronic inflammatory periodontal tissues produce Interleukin (IL)-5 and IL-6 but not IL-2 and IL-4. Am J Pathol 1993; 142: 1239-1250.
    • (1993) Am J Pathol , vol.142 , pp. 1239-1250
    • Fujihashi, K.1    Beagley, K.W.2    Kono, Y.3
  • 12
    • 0024623811 scopus 로고
    • Cellular analysis of functional mononuclear cells from chronically inflamed gingival tissue
    • McGhee ML, Ogawa T, Pitts AM, et al. Cellular analysis of functional mononuclear cells from chronically inflamed gingival tissue. Reg Immunol 1989; 2: 103-110.
    • (1989) Reg Immunol , vol.2 , pp. 103-110
    • McGhee, M.L.1    Ogawa, T.2    Pitts, A.M.3
  • 13
    • 0024586656 scopus 로고
    • Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissue
    • Ogawa T, Tarkowski A, McGhee ML, et al. Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissue. J Immunol 1989; 142: 1150-1158.
    • (1989) J Immunol , vol.142 , pp. 1150-1158
    • Ogawa, T.1    Tarkowski, A.2    McGhee, M.L.3
  • 14
    • 0025759870 scopus 로고
    • Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6 mediated polyclonal IgG and IgA in inflamed human gingiva
    • Kono Y, Beagley KW, Fujihashi K, et al. Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6 mediated polyclonal IgG and IgA in inflamed human gingiva. J Immunol 1991; 146: 1812-1821.
    • (1991) J Immunol , vol.146 , pp. 1812-1821
    • Kono, Y.1    Beagley, K.W.2    Fujihashi, K.3
  • 15
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 16
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell subsets; Th1, Th2 and more
    • Mosmann TR, Sad S. The expanding universe of T-cell subsets; Th1, Th2 and more. Immunol Today 1996, 17: 138-146.
    • (1996) Immunol Today , vol.17 , pp. 138-146
    • Mosmann, T.R.1    Sad, S.2
  • 17
    • 0028541127 scopus 로고
    • Some microbiological, histopathological and immunohistochemical characteristics of progressive periodontal disease
    • Liljenberg B, Lindhe J, Berglundh T, Dahlen G, Jonsson R. Some microbiological, histopathological and immunohistochemical characteristics of progressive periodontal disease. J Clin Periodontol 1994; 21: 720-727.
    • (1994) J Clin Periodontol , vol.21 , pp. 720-727
    • Liljenberg, B.1    Lindhe, J.2    Berglundh, T.3    Dahlen, G.4    Jonsson, R.5
  • 18
    • 0026509451 scopus 로고
    • IL-4 enhances programmed cell death (apoptosis) in stimulated human monocytes
    • Mangan DF, Robertson B, Wahl SM. IL-4 enhances programmed cell death (apoptosis) in stimulated human monocytes. J Immunol 1992; 148: 1812-1816.
    • (1992) J Immunol , vol.148 , pp. 1812-1816
    • Mangan, D.F.1    Robertson, B.2    Wahl, S.M.3
  • 19
    • 0028176655 scopus 로고
    • Interleukin-13, an interleukin-4-like cytokine that acts on monocytes and B cells, but not on T cells
    • Zurawski G, deVries JE. Interleukin-13, an interleukin-4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 1994; 15: 19-26.
    • (1994) Immunol Today , vol.15 , pp. 19-26
    • Zurawski, G.1    DeVries, J.E.2
  • 20
    • 0030030884 scopus 로고    scopus 로고
    • Absence of exogenous IL-4 induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseases
    • Yamamoto M, Kawabata K, Fujihashi K, et al. Absence of exogenous IL-4 induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseases. Am J Pathol 1996; 148: 331-339.
    • (1996) Am J Pathol , vol.148 , pp. 331-339
    • Yamamoto, M.1    Kawabata, K.2    Fujihashi, K.3
  • 21
    • 0025133545 scopus 로고
    • Interleukin-4 (IL-4) inhibits secretion of IL-1β, tumor necrosis factor α and IL-6 by human monocytes
    • Te Velde AA, Huijbens RJF, Heije K, de Vries JE, Figdor CG. Interleukin-4 (IL-4) inhibits secretion of IL-1β, tumor necrosis factor α and IL-6 by human monocytes. Blood 1990; 76: 1392-1397.
    • (1990) Blood , vol.76 , pp. 1392-1397
    • Te Velde, A.A.1    Huijbens, R.J.F.2    Heije, K.3    De Vries, J.E.4    Figdor, C.G.5
  • 22
    • 0028924973 scopus 로고
    • Interleukin-4 inhibits the expression of tumor necrosis factors α and β, interleukins-1β and -6 and interferon-γ
    • Lee JD, Rhoades K, Economou JS. Interleukin-4 inhibits the expression of tumor necrosis factors α and β, interleukins-1β and -6 and interferon-γ. Immunol Cell Biol 1995; 73: 57-61.
    • (1995) Immunol Cell Biol , vol.73 , pp. 57-61
    • Lee, J.D.1    Rhoades, K.2    Economou, J.S.3
  • 23
    • 0027597302 scopus 로고
    • Cytokines and periodontal disease: Immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues
    • Fujihashi K, Kono Y, Beagley KW, et al. Cytokines and periodontal disease: immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues. J Periodontol 1993; 64: 400-406.
    • (1993) J Periodontol , vol.64 , pp. 400-406
    • Fujihashi, K.1    Kono, Y.2    Beagley, K.W.3
  • 24
    • 0027048455 scopus 로고
    • A localized absence of interleukin-4 triggers periodontal disease activity: A novel hypothesis
    • Shapira L, Van Dyke TE, Hart TC. A localized absence of interleukin-4 triggers periodontal disease activity: a novel hypothesis. Med Hypotheses 1992; 39: 319-322.
    • (1992) Med Hypotheses , vol.39 , pp. 319-322
    • Shapira, L.1    Van Dyke, T.E.2    Hart, T.C.3
  • 25
    • 0027930067 scopus 로고
    • Gingival cell IL-2 and IL-4 in early-onset periodontitis
    • Manhart SS, Reinhardt RA, Payne JB, et al. Gingival cell IL-2 and IL-4 in early-onset periodontitis. J Periodoniol 1994; 65: 807-813.
    • (1994) J Periodoniol , vol.65 , pp. 807-813
    • Manhart, S.S.1    Reinhardt, R.A.2    Payne, J.B.3
  • 27
    • 0029055017 scopus 로고
    • Cloning, characterization and antigen specificity of T-lymphocyte subsets extracted from gingival tissue of chronic adult periodontitis patients
    • Wassenaar A, Reinhardus C, Thepen T. Abraham-Inpijn L, Kievits F. Cloning, characterization and antigen specificity of T-lymphocyte subsets extracted from gingival tissue of chronic adult periodontitis patients. Infect Immun 1995; 63: 2147-2153.
    • (1995) Infect Immun , vol.63 , pp. 2147-2153
    • Wassenaar, A.1    Reinhardus, C.2    Thepen, T.3    Abraham-Inpijn, L.4    Kievits, F.5
  • 28
    • 0027356137 scopus 로고
    • Localization of interleukin-1 (IL-1) mRNA- Expressing macrophages in human inflamed gingiva and IL-1 activity in gingival crevicular fluid
    • Matsuki Y, Yamamoto T, Hara K. Localization of interleukin-1 (IL-1) mRNA- expressing macrophages in human inflamed gingiva and IL-1 activity in gingival crevicular fluid. J Periodont Res 1993; 28: 35-42.
    • (1993) J Periodont Res , vol.28 , pp. 35-42
    • Matsuki, Y.1    Yamamoto, T.2    Hara, K.3
  • 29
    • 0026455496 scopus 로고
    • Interleukin-1 beta (IL-1β) levels in gingival crevicular fluid from adults with previous evidence of destructive periodontitis; a cross sectional study
    • Wilton JMA, Bampton JLM, Griffiths GS, et al. Interleukin-1 beta (IL-1β) levels in gingival crevicular fluid from adults with previous evidence of destructive periodontitis; a cross sectional study. J Clin Periodontol 1992; 19: 53-57.
    • (1992) J Clin Periodontol , vol.19 , pp. 53-57
    • Wilton, J.M.A.1    Bampton, J.L.M.2    Griffiths, G.S.3
  • 30
    • 0030623608 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms for periodontal diseases: Role of Th1 and Th2 type cytokines in induction of mucosal inflammation
    • Yamamoto M, Fujihashi K, Hiroi T, McGhee JR, Van Dyke TE, Kiyono, H. Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. J Periodont Res 1997; 32: 115-119.
    • (1997) J Periodont Res , vol.32 , pp. 115-119
    • Yamamoto, M.1    Fujihashi, K.2    Hiroi, T.3    McGhee, J.R.4    Van Dyke, T.E.5    Kiyono, H.6
  • 32
    • 0023637502 scopus 로고
    • Interferon-gamrna potentiation of lipopolysaccharide-induced eicosanoid release from human monocytes
    • Nichols FC, Garrison SW. Interferon-gamrna potentiation of lipopolysaccharide-induced eicosanoid release from human monocytes. J Interferon Res 1987; 7: 121-129.
    • (1987) J Interferon Res , vol.7 , pp. 121-129
    • Nichols, F.C.1    Garrison, S.W.2
  • 33
    • 0029007640 scopus 로고
    • Ceramide: An endogenous regulator of apoptosis and growth suppression
    • Pushkareva M, Obeid LM, Hannun YA. Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunol Today 1995; 16: 294-297.
    • (1995) Immunol Today , vol.16 , pp. 294-297
    • Pushkareva, M.1    Obeid, L.M.2    Hannun, Y.A.3
  • 35
    • 0027692326 scopus 로고
    • Role of cytokines and inflammatory mediators in tissue destruction
    • Birkedal-Hansen H. Role of cytokines and inflammatory mediators in tissue destruction. J Periodont Res 1993; 28: 500-510.
    • (1993) J Periodont Res , vol.28 , pp. 500-510
    • Birkedal-Hansen, H.1
  • 36
    • 0028150643 scopus 로고
    • Effects of cytokines and periodontopathic bacteria on the leukocyte function-associated antigen 1/intercellular adhesion molecule 1 pathway in gingival fibroblasts in adult periodontitis
    • Hayashi J, Saito I, Ishikawa I, Miyasaka N. Effects of cytokines and periodontopathic bacteria on the leukocyte function-associated antigen 1/intercellular adhesion molecule 1 pathway in gingival fibroblasts in adult periodontitis. Infect Immun 1994; 62: 5205-5212.
    • (1994) Infect Immun , vol.62 , pp. 5205-5212
    • Hayashi, J.1    Saito, I.2    Ishikawa, I.3    Miyasaka, N.4
  • 37
    • 0027731546 scopus 로고
    • Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome
    • Casey LC, Balk RA, Bone RC. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Annu Intern Med 1993; 119: 771-778.
    • (1993) Annu Intern Med , vol.119 , pp. 771-778
    • Casey, L.C.1    Balk, R.A.2    Bone, R.C.3
  • 39
    • 0018980134 scopus 로고
    • Juvenile periodontitis. Some microbiological, histopathological and clinical characteristics
    • Liljenberg B, Lindhe J. Juvenile periodontitis. Some microbiological, histopathological and clinical characteristics. J Clin Periodontol 1980; 7: 48-61.
    • (1980) J Clin Periodontol , vol.7 , pp. 48-61
    • Liljenberg, B.1    Lindhe, J.2
  • 40
    • 0001913907 scopus 로고
    • Role of prostaglandins in high risk periodontitis patients
    • Genco RJ, Hamada S, Lehner T, Mergenhagen S. eds. Washington, DC: ASM Press
    • Offenbacher S, Collins JG, Yalda B, Haradon G. Role of prostaglandins in high risk periodontitis patients. In: Genco RJ, Hamada S, Lehner T, Mergenhagen S. eds. Molecular pathogenesis of periodontal disease. Washington, DC: ASM Press; 1994: 203-214.
    • (1994) Molecular Pathogenesis of Periodontal Disease , pp. 203-214
    • Offenbacher, S.1    Collins, J.G.2    Yalda, B.3    Haradon, G.4
  • 41
    • 0002427424 scopus 로고
    • Modulatory role of lymphocytes in periodontal inflammation
    • Genco RJ, Hamada S, Lehner T, Mergenhagen S. eds. Washington, DC: ASM Press
    • Taubman MA, Eastcott JW, Shimauchi H, Takeichi O, Smith DJ. Modulatory role of lymphocytes in periodontal inflammation. In: Genco RJ, Hamada S, Lehner T, Mergenhagen S. eds. Molecular pathogenesis of periodontal disease. Washington, DC: ASM Press; 1994: 147-157.
    • (1994) Molecular Pathogenesis of Periodontal Disease , pp. 147-157
    • Taubman, M.A.1    Eastcott, J.W.2    Shimauchi, H.3    Takeichi, O.4    Smith, D.J.5
  • 42
    • 0030137644 scopus 로고    scopus 로고
    • Detection of local and systemic cytokines in adult periodontitis
    • Prabhu A, Michalowicz BS, Mathur A. Detection of local and systemic cytokines in adult periodontitis. J Periodontol 1996; 67: 515-522.
    • (1996) J Periodontol , vol.67 , pp. 515-522
    • Prabhu, A.1    Michalowicz, B.S.2    Mathur, A.3
  • 43
    • 0030898968 scopus 로고    scopus 로고
    • Cell-mediated immune system regulation in periodontal diseases
    • Mathur A, Michalowicz BS. Cell-mediated immune system regulation in periodontal diseases. Crit Rev Oral Biol Med 1997; 8: 76-89.
    • (1997) Crit Rev Oral Biol Med , vol.8 , pp. 76-89
    • Mathur, A.1    Michalowicz, B.S.2
  • 44
    • 0028313190 scopus 로고
    • Modulation of immune responses to periodontal bacteria
    • Gemmell E, Seymour GJ. Modulation of immune responses to periodontal bacteria. Curr Opin Periodontol 1994: 28-38.
    • (1994) Curr Opin Periodontol , pp. 28-38
    • Gemmell, E.1    Seymour, G.J.2
  • 45
    • 0031152114 scopus 로고    scopus 로고
    • Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease
    • Gemmell E, Marshall RI, Seymour GJ. Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease. Periodontol 2000 1997; 14: 112-143.
    • (1997) Periodontol 2000 , vol.14 , pp. 112-143
    • Gemmell, E.1    Marshall, R.I.2    Seymour, G.J.3
  • 46
    • 43949163341 scopus 로고
    • Interleukin-12 and its role in the generation of Th1 cells
    • Trinchieri G. Interleukin-12 and its role in the generation of Th1 cells. Immunol Today 1993; 14: 335-337.
    • (1993) Immunol Today , vol.14 , pp. 335-337
    • Trinchieri, G.1
  • 47
    • 0029099391 scopus 로고
    • Effects of IL-12 on immune responses to microbial infections: A key mediator in regulating disease outcome
    • Biron CA, Gazzinelli RT. Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr Opin Immunol 1995; 7: 485-496.
    • (1995) Curr Opin Immunol , vol.7 , pp. 485-496
    • Biron, C.A.1    Gazzinelli, R.T.2
  • 48
    • 0028970736 scopus 로고
    • Endogenous IL-10 protects mice from death during septic peritonitis
    • Van der Poll T, Marchant A, Buurman WA, et al. Endogenous IL-10 protects mice from death during septic peritonitis. J Immunol 1995; 155: 5397-5401.
    • (1995) J Immunol , vol.155 , pp. 5397-5401
    • Van Der Poll, T.1    Marchant, A.2    Buurman, W.A.3
  • 49
    • 0028457301 scopus 로고
    • The protective nature of host responses in periodontal diseases
    • Ebersole JL, Taubman MA. The protective nature of host responses in periodontal diseases. Periodontol 2000 1994; 5: 112-141.
    • (1994) Periodontol 2000 , vol.5 , pp. 112-141
    • Ebersole, J.L.1    Taubman, M.A.2
  • 50
    • 0024636613 scopus 로고
    • 2 but not IL-1β in patients with adult periodontitis
    • 2 but not IL-1β in patients with adult periodontitis. J Periodont Res 1989; 24: 88-95.
    • (1989) J Periodont Res , vol.24 , pp. 88-95
    • Garrison, S.W.1    Nichols, F.C.2
  • 52
    • 0028030313 scopus 로고
    • Host response in patients with generalized refractory periodontitis
    • Hernichel-Gorbach E, Kornman KS, Holt SC, et al. Host response in patients with generalized refractory periodontitis. J Periodontol 1994; 65: 8-16.
    • (1994) J Periodontol , vol.65 , pp. 8-16
    • Hernichel-Gorbach, E.1    Kornman, K.S.2    Holt, S.C.3
  • 54
    • 0031014624 scopus 로고    scopus 로고
    • Systemic acute-phase reactants, C-reactive protein and haptoglobin in adult periodontitis
    • Ebersole JL, Machen RL, Steffen MJ, Willmann DE. Systemic acute-phase reactants, C-reactive protein and haptoglobin in adult periodontitis. Clin Exp Immunol 1997; 107: 347-352.
    • (1997) Clin Exp Immunol , vol.107 , pp. 347-352
    • Ebersole, J.L.1    Machen, R.L.2    Steffen, M.J.3    Willmann, D.E.4
  • 55
    • 0027292972 scopus 로고
    • Dental disease, fibrinogen and white cell count; links with myocardial infarction?
    • Kweider M, Lowe GD, Murray GD, Kinane DF, McGowan DA. Dental disease, fibrinogen and white cell count; links with myocardial infarction? Scott Med J 1993; 38: 73-74.
    • (1993) Scott Med J , vol.38 , pp. 73-74
    • Kweider, M.1    Lowe, G.D.2    Murray, G.D.3    Kinane, D.F.4    McGowan, D.A.5
  • 56
    • 0030637260 scopus 로고    scopus 로고
    • The interleukin-1 genotype as a severity factor in adult periodontal disease
    • Kornman KS, Crane A, Wang H-Y, et al. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol 1997; 24: 72-77.
    • (1997) J Clin Periodontol , vol.24 , pp. 72-77
    • Kornman, K.S.1    Crane, A.2    Wang, H.-Y.3
  • 57
    • 0026652591 scopus 로고
    • A Taq 1 polymorphism in the human interleukin-1 beta (IL-1β) gene correlates with secretion in vitro
    • Pociot F, Mølvig J, Wogensen L, Worsaae H, Nerup J. A Taq 1 polymorphism in the human interleukin-1 beta (IL-1β) gene correlates with secretion in vitro. Eur J Clin Invest 1992; 22: 396-402.
    • (1992) Eur J Clin Invest , vol.22 , pp. 396-402
    • Pociot, F.1    Mølvig, J.2    Wogensen, L.3    Worsaae, H.4    Nerup, J.5
  • 58
    • 0000176176 scopus 로고
    • Association between psoriasis, IL-1β gene polymorphism and IL-1β production
    • Abstr.
    • Di Giovine FS. Association between psoriasis, IL-1β gene polymorphism and IL-1β production. Cytokine 1995; 7: 606 (Abstr.).
    • (1995) Cytokine , vol.7 , pp. 606
    • Di Giovine, F.S.1


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