Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects

Neurobiology of Disease

Volumn 41, Issue 1, 2011, Pages 111-118

  Amo, Taku ^a,e   Sato, Shigeto ^b   Saiki, Shinji ^b   Wolf, Alexander M ^a   Toyomizu, Masaaki ^c   Gautier, Clement A ^d   Shen, Jie ^d   Ohta, Shigeo ^a   Hattori, Nobutaka ^b  

^a NIPPON MEDICAL SCHOOL GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d HARVARD MEDICAL SCHOOL   (United States)

^e NATIONAL DEFENSE ACADEMY   (Japan)

Author keywords

Membrane potential; Mitochondria; Modular kinetic analysis; Oxidative phosphorylation; Parkin; Parkinson's disease; PINK1; Proton leak; Reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATE; HYDROGEN PEROXIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE INDUCED PUTATIVE KINASE 1; PHOSPHOTRANSFERASE; PROTON; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; EMBRYO CELL; FIBROBLAST; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; RESPIRATORY CHAIN; WILD TYPE;

ANIMALS; CELL RESPIRATION; CELLS, CULTURED; FIBROBLASTS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL DISEASES; NEURONS; PARKINSON DISEASE; PROTEIN KINASES; PROTONS;

EID: 78349309594     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2010.08.027     Document Type: Article

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