Suppressive effect on lipopolysaccharide-induced proinflammatory mediators by Citrus aurantium L. in macrophage RAW 264.7 cells via NF-κB signal pathway

Evidence-based Complementary and Alternative Medicine

Volumn 2011, Issue , 2011, Pages

  Kim, Gon Sup ^a   Kang, Sang Rim ^a   Han, Dae Yong ^a   Park, Kwang Il ^a   Park, Hyeon Soo ^a   Cho, Yong Bae ^a   Lee, Hu Jang ^a   Lee, Won Sup ^b   Ryu, Chung Ho ^a   Ha, Yeong Lae ^a   Lee, Do Hoon ^a   Kim, Jin A ^a  

^a Gyeongsang National University   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; SOUR ORANGE EXTRACT; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOMODULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SOUR ORANGE;

EID: 78349297594     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2011/248592     Document Type: Article

References (47)

1. Nogata Y., Sakamoto K., Shiratsuchi H., Ishii T., Yano M., Ohta H., Flavonoid composition of fruit tissues of citrus species Bioscience, Biotechnology and Biochemistry 2006 70 1 178 192
2. Fugh-Berman A., Myers A., Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research Experimental Biology and Medicine 2004 229 8 698 704
3. Jung K. H., Ha E., Kim M. J., Won H.-J., Zheng L. T., Kim H. K., Hong S. J., Chung J. H., Yim S.-V., Suppressive effects of nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression by Citrus reticulata extract in RAW 264.7 macrophage cells Food and Chemical Toxicology 2007 45 8 1545 1550
4. Nogata Y., Sakamoto K., Shiratsuchi H., Ishii T., Yano M., Ohta H., Flavonoid composition of fruit tissues of citrus species Bioscience, Biotechnology and Biochemistry 2006 70 1 178 192
5. Manthey J. A., Grohmann K., Guthrie N., Biological properties of citrus flavonoids pertaining to cancer and inflammation Current Medicinal Chemistry 2001 8 2 135 153
6. Manthey J. A., Grohmann K., Montanari A., Ash K., Manthey C. L., Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-α expression by human monocytes Journal of Natural Products 1999 62 3 441 444
7. Murakami A., Nakamura Y., Torikai K., Tanaka T., Koshiba T., Koshimizu K., Kuwahara S., Takahashi Y., Ogawa K., Yano M., Tokuda H., Nishino H., Mimaki Y., Sashida Y., Kitanaka S., Ohigashi H., Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion mice Cancer Research 2000 60 18 5059 5066
8. Sakata K., Hirose Y., Qiao Z., Tanaka T., Mori H., Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line Cancer Letters 2003 199 2 139 145
9. Wadleigh D. J., Reddy S. T., Kopp E., Ghosh S., Herschman H. R., Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages Journal of Biological Chemistry 2000 275 9 6259 6266
10. Erwig L.-P., Rees A. J., Macrophage activation and programming and its role for macrophage function in glomerular inflammation Kidney and Blood Pressure Research 1999 22 1-2 21 25
11. Kim J.-B., Han A.-R., Park E.-Y., Kim J.-Y., Cho W., Lee J., Seo E.-K., Lee K.-T., Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by poncirin through the NF-κB inactivation in RAW 264.7 macrophage cells Biological and Pharmaceutical Bulletin 2007 30 12 2345 2351
12. Jung H.-W., Seo U.-K., Kim J.-H., Leem K.-H., Park Y.-K., Flower extract of Panax notoginseng attenuates lipopolysaccharide-induced inflammatory response via blocking of NF-κB signaling pathway in murine macrophages Journal of Ethnopharmacology 2009 122 2 313 319
13. Tayeh M. A., Marletta M. A., Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor Journal of Biological Chemistry 1989 264 33 19654 19658
14. Kleinert H., Pautz A., Linker K., Schwarz P. M., Regulation of the expression of inducible nitric oxide synthase European Journal of Pharmacology 2004 500 13 255 266
15. Bingham C. O. III, The pathogenesis of rheumatoid arthritis: pivotal cytokines involved in bone degradation and imflammation Journal of Rheumatology 2002 29 65 3 9
16. Blantz R. C., Munger K., Role of nitric oxide in inflammatory conditions Nephron 2002 90 4 373 378
17. Perner A., Rask-Madsen J., Review article: the potential role of nitric oxide in chronic inflammatory bowel disorders Alimentary Pharmacology and Therapeutics 1999 13 2 135 144
18. Tracey K. J., Tumor necrosis factor (cachectin) in the biology of septic shock syndrome Circulatory Shock 1991 35 2 123 128
19. DuBois R. N., Abramson S. B., Crofford L., Gupta R. A., Simon L. S., Van De Putte L. B. A., Lipsky P. E., Cyclooxygenase in biology and disease FASEB Journal 1998 12 12 1063 1073
20. Smith W. L., DeWitt D. L., Garavito R. M., Cyclooxygenases: structural, cellular, and molecular biology Annual Review of Biochemistry 2000 69 145 182
21. Lai C.-S., Li S., Chai C.-Y., Lo C.-Y., Ho C.-T., Wang Y.-J., Pan M.-H., Inhibitory effect of citrus 5-hydroxy-3,6,7,8,3′,4′- hexamethoxyflavone on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice Carcinogenesis 2007 28 12 2581 2588
22. Pahl H. L., Activators and target genes of Rel/NF-κB transcription factors Oncogene 1999 18 49 6853 6866
23. Baeuerle P. A., Baltimore D., NF-κB: ten years after Cell 1996 87 1 13 20
24. Chao W.-W., Hong Y.-H., Chen M.-L., Lin B.-F., Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-κB trans-activation activity and LPS-induced inflammation Journal of Ethnopharmacology 2010 129 2 244 249
25. Wu L.-C., Fan N.-C., Lin M.-H., Chu I.-R., Huang S.-J., Hu C.-Y., Han S.-Y., Anti-inflammatory effect of spilanthol from Spilanthes acmella on murine macrophage by down-regulating LPS-induced inflammatory mediators Journal of Agricultural and Food Chemistry 2008 56 7 2341 2349
26. Lee W. S., Baek Y.-I., Kim J.-R., Cho K.-H., Sok D.-E., Jeong T.-S., Antioxidant activities of a new lignan and a neolignan from Saururus chinensis Bioorganic and Medicinal Chemistry Letters 2004 14 22 5623 5628
27. Sang S., Hong J., Wu H., Liu J., Yang C. S., Pan M.-H., Badmaev V., Ho C.-T., Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols Journal of Agricultural and Food Chemistry 2009 57 22 10645 10650
28. Kim E. H., Shim B., Kang S., Jeong G., Lee J.-S., Yu Y.-B., Chun M., Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules Journal of Ethnopharmacology 2009 126 2 320 331
29. Nam N.-H., Naturally occurring NF-κB inhibitors Mini-Reviews in Medicinal Chemistry 2006 6 8 945 951
30. Kim H. K., Cheon B. S., Kim Y. H., Kim S. Y., Kim H. P., Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships Biochemical Pharmacology 1999 58 5 759 765
31. Benavente-Garca O., Castillo J., Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity Journal of Agricultural and Food Chemistry 2008 56 15 6185 6205
32. Choi S.-Y., Ko H.-C., Ko S.-Y., Hwang J.-H., Park J.-G., Kang S.-H., Han S.-H., Yun S.-H., Kim S.-J., Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits Biological and Pharmaceutical Bulletin 2007 30 4 772 778
33. Bodet C., La V. D., Epifano F., Grenier D., Naringenin has anti-inflammatory properties in macrophage and ex vivo human whole-blood models Journal of Periodontal Research 2008 43 4 400 407
34. Lin N., Sato T., Takayama Y., Mimaki Y., Sashida Y., Yano M., Ito A., Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages Biochemical Pharmacology 2003 65 12 2065 2071
35. Zieliska-Przyjemska M., Ignatowicz E., Citrus fruit flavonoids influence on neutrophil apoptosis and oxidative metabolism Phytotherapy Research 2008 22 12 1557 1562
36. Saleem M., Afaq F., Adhami V. M., Mukhtar H., Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice Oncogene 2004 23 30 5203 5214
37. Chen C.-H., Sheu M.-T., Chen T.-F., Wang Y.-C., Hou W.-C., Liu D.-Z., Chung T.-C., Liang Y.-C., Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways Biochemical Pharmacology 2006 72 8 1001 1009
38. Cho W., Nam J.-W., Kang H.-J., Windono T., Seo E.-K., Lee K.-T., Zedoarondiol isolated from the rhizoma of Curcuma heyneana is involved in the inhibition of iNOS, COX-2 and pro-inflammatory cytokines via the downregulation of NF-κB pathway in LPS-stimulated murine macrophages International Immunopharmacology 2009 9 9 1049 1057
39. Lin Y.-L., Lin J.-K., (-)-epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-α B Molecular Pharmacology 1997 52 3 465 472
40. Woo K. J., Jeong Y.-J., Inoue H., Park J.-W., Kwon T. K., Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity FEBS Letters 2005 579 3 705 711
41. Blancke F., Claeys M. J., Jorens P., Vermeiren G., Bosmans J., Wuyts F. L., Vrints C. J., Systemic inflammation and reperfusion injury in patients with acute myocardial infarction Mediators of Inflammation 2005 2005 6 385 389
42. Laskin D. L., Laskin J. D., Role of macrophages and inflammatory mediators in chemically induced toxicity Toxicology 2001 160 1-3 111 118
43. Isomura I., Morita A., Regulation of NF-κB signaling by decoy oligodeoxynucleotides Microbiology and Immunology 2006 50 8 559 563
44. Kim Y. H., Kim D. H., Lim H., Baek D.-Y., Shin H.-K., Kim J.-K., The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages Biological and Pharmaceutical Bulletin 2009 32 4 651 656
45. Lawrence T., Gilroy D. W., Colville-Nash P. R., Willoughby D. A., Possible new role for NF-κB in the resolution of inflammation Nature Medicine 2001 7 12 1291 1297
46. Zhao L., Tao J.-Y., Zhang S.-L., Jin F., Pang R., Dong J.-H., N-butanol extract from melilotus suaveolens ledeb affects pro- and anti-inflammatory cytokines and mediators Evidence-Based Complementary and Alternative Medicine 2010 7 1 97 106
47. Choi S.-Y., Hwang J.-H., Ko H.-C., Park J.-G., Kim S.-J., Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-κB and ROS production in LPS-activated RAW 264.7 cells Journal of Ethnopharmacology 2007 113 1 149 155