Size-exclusion chromatographic protein refolding: Fundamentals, modeling and operation

Journal of Chromatography A

Volumn 1217, Issue 49, 2010, Pages 7723-7737

  Freydell, Esteban J ^a   van der Wielen, Luuk A M ^a   Eppink, Michel H M ^b   Ottens, Marcel ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b MSD   (Netherlands)

Author keywords

Modeling; On column refolding; Size exclusion chromatography

Indexed keywords

ACTIVITY MEASUREMENTS; CHARACTERISTIC TIME; COLUMN LENGTHS; CRITICAL STEPS; DIRECT LINKS; EXPERIMENTAL EVIDENCE; FEED CONCENTRATION; GEL FILTRATION; IN-SILICO; MASS BALANCE; MASS DISTRIBUTION; MECHANISTIC MODELING; MECHANISTIC MODELS; MODELING; MODELING STRATEGY; ON-COLUMN REFOLDING; PERFORMANCE INDICATORS; PROCESS VARIABLES; PROTEIN REFOLDING; REACTION MECHANISM; REACTION SCHEMES; REACTOR MODELS; REFOLDING; SYSTEMATIC ANALYSIS;

BENCHMARKING; CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; GEL PERMEATION CHROMATOGRAPHY; GELS; PROTEINS;

SIZE EXCLUSION CHROMATOGRAPHY;

ARTICLE; BATCH REACTOR; CHEMICAL ANALYSIS; CHEMICAL REACTION KINETICS; DATA ANALYSIS; GEL PERMEATION CHROMATOGRAPHY; INTERMETHOD COMPARISON; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROCESS DESIGN; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN FOLDING; QUANTITATIVE STUDY; THEORETICAL STUDY;

CHROMATOGRAPHY, GEL; COMPUTER SIMULATION; KINETICS; MODELS, MOLECULAR; PROTEIN REFOLDING; PROTEINS;

EID: 78249231394     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.10.038     Document Type: Article

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