Modeling and simulation of fed-batch protein refolding process

Biotechnology Progress

Volumn 20, Issue 4, 2004, Pages 1213-1219

  Dong, Xiao Yan ^a   Shi, Guang Quan ^a   Li, Wei ^a   Sun, Yan ^a  

^a TIANJIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; CONCENTRATION (PROCESS); MATHEMATICAL MODELS; PROTEINS; RATE CONSTANTS;

DENATURED-REDUCED LYSOZYME; FED-BATCH PROCESS; FED-BATCH PROTEIN REFOLDING PROCESS;

BIOTECHNOLOGY;

GUANIDINE; LYSOZYME;

ARTICLE; CHEMICAL MODEL; CHEMISTRY; KINETICS; PROTEIN FOLDING;

GUANIDINE; KINETICS; MODELS, CHEMICAL; MURAMIDASE; PROTEIN FOLDING;

VISCUM; VISCUM ALBUM;

EID: 4043177596     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp0499597     Document Type: Article

References (22)

1. Batas, B.; Chaudhuri, J. B. Protein refolding at high concentration using size-exclusion chromatography. Biotechnol. Bioeng. 1996, 50, 16-23.
2. Buswell, A. M.; Ebtinger, M.; Vertés, A. A.; Middelberg, A. P. J. Effect of operating variables on the yield of recombinant trypsinogen for a pulse-fed dilution-refolding reactor. Biotechnol. Bioeng. 2002, 77, 435-444.
3. Buswell, A. M.; Middelberg, A. P. J. Critical analysis of lysozyme refolding kinetics. Biotechnol. Prog. 2002, 18, 470-475.
4. Buswell, A. M.; Middelberg, A. P. J. A new scheme for lysozyme refolding and aggregation. Biotechnol. Bioeng. 2003, 83, 567-577.
5. Bowden, G. A.; Paredes, A. M.; Georgiou, G. Structure and morphology of protein inclusion-bodies in Escherichia coll. Bio/Technology 1991, 9, 725-730.
6. De Bernardez Clark, E. Refolding of recombinant proteins. Curr. Opin. Biotechnol. 1998, 9, 157-163.
7. De Bernardez Clark, E. Protein refolding for industrial processes. Curr. Opin. Biotechnol. 2001, 12, 202-207.
8. De Bernardez Clark, E.; Hevehan, D. L.; Szela, S.; Maachupalli-Reddy, J. Oxidative renaturation of hen egg-white lysozyme: Folding vs aggregation. Biotechnol. Prog. 1998, 14, 47-54.
9. Dong, X.-Y.; Shi, J.-H.; Sun, Y. Cooperative effect of the artificial chaperones and guanidinium chloride on lysozyme renaturation at high concentrations. Biotechnol. Prog. 2002, 18, 663-665.
10. Fischer, B.; Perry, B.; Sumner, I.; Goodenough, P. A novel sequential procedure to enhance the renaturation of recombinant protein from inclusion bodies. Protein Eng. 1992, 5, 593-596.
11. Fischer, B.; Sumner, I.; Goodenough, P. Renaturation of lysozyme - Temperature dependence of renaturation rate, renaturation yield, and aggregation: Identification of hydrophobic folding intermediates. Arch. Biochem. Biophys. 1993, 306, 183-187.
12. Goldberg, M. E.; Ruldoph, R.; Jaenicke, R. A kinetic study of the competition between renaturation and aggregation during the refolding of denatured-reduced egg white lysozyme. Biochemistry 1991, 30, 2790-2797.
13. Hevehan, D. L.; De Bernardez Clark, E. Oxidative renaturation of lysozyme at high concentrations. Biotechnol. Bioeng. 1997, 54, 221-230.
14. Katoh, S.; Katoh, Y. Continuous refolding of lysozyme with fed-batch addition of denatured protein solution. Process Biochem. 2000, 35, 1119-1124.
15. Katoh, S.; Sezai, Y.; Yamaguchi, T.; Katoh, Y.; Yagi, H.; Nohara, D. Refolding of enzymes in a fed-batch operation. Process Biochem. 1999, 35, 297-300.
16. Katoh, Y.; Farshbaf, M.; Kurooka, N.; Nohara, D.; Katoh, S. High yield refolding of lysozyme and carbonic anhydrase at high protein concentrations. J. Chem. Eng. Jpn. 2000, 33, 773-777.
17. Kotlarski, N.; O'Neill, B. K.; Francis, G. L.; Middelberg, A. P. J. Design analysis for refolding monomeric protein. AIChE J. 1997, 43, 2123-2132.
18. Lee, C. T.; Buswell, A. M.; Middelberg, A. P. J. The influence of mixing on lysozyme renaturation during refolding in an oscillatory flow and a stirred-tank reactor. Chem. Eng. Sci. 2002, 57, 1679-1684.
19. Maachupalli-Reddy, J.; Kelley, B. D.; De Bernardez Clark, E. Effect of inclusion body contaminants on the oxidative renaturation of hen egg white lysozyme. Biotechnol. Prog. 1997, 13, 144-150.
20. Middelberg, A. P. J.; O'Neill, B. K. Harvesting recombinant protein inclusion bodies. In Bioprocessing and Bioseparation: A Handbook; Subramanian, G., Ed.; Wiley-VCH: New York, 1998; pp 81-106.
21. Valax, P.; Georgiou, G. Molecular characterization of protein inclusion bodies in Escherichia coli. I. Composition. Biotechnol. Prog. 1993, 9, 539-547.
22. Wetlaufer, D. B.; Johnson, E. R.; Clauss, L. Rapid nonenzymic regeneration of reduced human leukemia lysozyme. In Lysozyme; Osserman, E. F., Canfield, R. E., Beychok, S., Eds.; Academic: New York, 1974; pp 269-280.