Simultaneous determination of protein aggregation, degradation, and absolute molecular weight by size exclusion chromatography-multiangle laser light scattering

Analytical Biochemistry

Volumn 356, Issue 1, 2006, Pages 76-85

  Ye, Hongping ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Absolute molecular weight; Glycoproteins; Pharmaceutical proteins; Protein aggregation; Protein degradation; SEC MALLS

Indexed keywords

ANTIBODIES; BINARY ALLOYS; GLYCOPROTEINS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT SCATTERING; MAMMALS; MOLECULAR WEIGHT; REFRACTIVE INDEX; URANIUM ALLOYS; VANADIUM ALLOYS;

GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; MOLECULAR WEIGHT DETERMINATION; MULTIANGLE LASER LIGHT SCATTERING; PHARMACEUTICAL PROTEIN; PROTEIN AGGREGATION; PROTEIN DEGRADATION; SEC MALLS; SIMULTANEOUS DETERMINATIONS;

SIZE EXCLUSION CHROMATOGRAPHY;

ABCIXIMAB; BOVINE SERUM ALBUMIN; CHORIONIC GONADOTROPIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MONOCLONAL ANTIBODY; TRASTUZUMAB;

ARTICLE; COMPUTER PROGRAM; FEASIBILITY STUDY; GEL PERMEATION CHROMATOGRAPHY; GLYCOSYLATION; HEAT STRESS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LASER; LIGHT SCATTERING; MOLECULAR WEIGHT; ONLINE SYSTEM; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; REFRACTION INDEX; TEMPERATURE; ULTRAVIOLET RADIATION;

BOS TAURUS;

EID: 33747175672     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2006.05.025     Document Type: Article

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