CCK-independent mTORC1 activation during dietary protein-induced exocrine pancreas growth

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 299, Issue 5, 2010, Pages

  Crozier, Stephen J ^a   Sans, M Dolors ^a   Wang, Jackie Y ^a   Lentz, Stephen I ^a   Ernst, Stephen A ^a   Williams, John A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Amino acids; Hyperplasia; Hypertrophy; Mammalian target of rapamycin complex 1; Pancreatic acinar cell

Indexed keywords

CALCINEURIN; CHOLECYSTOKININ; DNA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE; RAPAMYCIN; RNA; MTORC1 PROTEIN, MOUSE; PROTEIN KINASE B; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SIZE; CONTROLLED STUDY; DNA CONTENT; DNA SYNTHESIS; ENZYME RELEASE; MALE; MOUSE; NONHUMAN; ORGAN WEIGHT; PANCREAS DISEASE; PANCREAS FUNCTION; PANCREAS HYPERTROPHY; PANCREAS ISLET CELL HYPERPLASIA; PRIORITY JOURNAL; PROTEIN INTAKE; PROTEIN PHOSPHORYLATION; ANALYSIS OF VARIANCE; ANIMAL; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOUSE MUTANT; ORGAN SIZE; PANCREAS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CALCINEURIN; CHOLECYSTOKININ; DIETARY PROTEINS; MALE; MICE; MICE, KNOCKOUT; ORGAN SIZE; PANCREAS, EXOCRINE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 78149488752     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00445.2009     Document Type: Article

References (37)

1. Anderson HL, Benevenga NJ, Harper AE. Associations among food and protein intake, serine dehydratase, and plasma amino acids. Am J Physiol 214: 1008-1013, 1968.
2. Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N. Amino acid regulation of TOR complex 1. Am J Physiol Endocrinol Metab 296: E592-E602, 2009.
3. Bentzinger CF, Romanino K, Cloetta D, Lin S, Mascarenhas JB, Oliveri F, Xia J, Casanova E, Costa CF, Brink M, Zorzato F, Hall MN, Ruegg MA. Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab 8: 411-424, 2008.
4. Bragado MJ, Groblewski GE, Williams JA. p70s6k is activated by CCK in rat pancreatic acini. Am J Physiol Cell Physiol 273: C101-C109, 1997.
5. Brants F, Morisset J. Tropic effect of cholecystokinin-pancreozymin on pancreatic acinar cells from rats of different ages. Proc Soc Exp Biol Med 153: 523-527, 1976.
6. Crozier SJ, D'Alecy LG, Ernst SA, Ginsburg LE, Williams JA. Molecular mechanisms of pancreatic dysfunction induced by protein malnutrition. Gastroenterology 137: 1093-1101, 2009.
7. Crozier SJ, Kimball SR, Emmert SW, Anthony JC, Jefferson LS. Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J Nutr 135: 376-382, 2005.
8. Crozier SJ, Sans MD, Guo L, D'Alecy LG, Williams JA. Activation of the mTOR signalling pathway is required for pancreatic growth in protease- inhibitor-fed mice. J Physiol 573: 775-786, 2006.
9. Crozier SJ, Sans MD, Lang CH, D'Alecy LG, Ernst SA, Williams JA. CCK-induced pancreatic growth is not limited by mitogenic capacity in mice. Am J Physiol Gastrointest Liver Physiol 294: G1148-G1157, 2008.
10. Dabrowski A, Groblewski GE, Schafer C, Guan KL, Williams JA. Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cells. Am J Physiol Cell Physiol 273: C1472-C1479, 1997.
11. Dembinski AB, Johnson LR. Stimulation of pancreatic growth by secretin, caerulein, and pentagastrin. Endocrinology 106: 323-328, 1980.
12. Donella-Deana A, Krinks MH, Ruzzene M, Klee C, Pinna LA. Dephosphorylation of phosphopeptides by calcineurin (protein phosphatase 2B). Eur J Biochem 219: 109-117, 1994.
13. Goke B, Printz H, Koop I, Rausch U, Richter G, Arnold R, Adler G. Endogenous CCK release and pancreatic growth in rats after feeding a proteinase inhibitor (camostate). Pancreas 1: 509-515, 1986.
14. Green GM, Jurkowska G, Berube FL, Rivard N, Guan D, Morisset J. Role of cholecystokinin in induction and maintenance of dietary proteinstimulated pancreatic growth. Am J Physiol Gastrointest Liver Physiol 262: G740-G746, 1992.
15. Green GM, Levan VH, Liddle RA. Plasma cholecystokinin and pancreatic growth during adaptation to dietary protein. Am J Physiol Gastrointest Liver Physiol 251: G70-G74, 1986.
16. Groblewski GE, Yoshida M, Bragado MJ, Ernst SA, Leykam J, Williams JA. Purification and characterization of a novel physiological substrate for calcineurin in mammalian cells. J Biol Chem 273: 22738-22744, 1998.
17. Gurda GT, Guo L, Lee SH, Molkentin JD, Williams JA. Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo. Mol Biol Cell 19: 198-206, 2008.
18. Hara H, Narakino H, Kiriyama S, Kasai T. Induction of pancreatic growth and proteases by feeding a high amino acid diet does not depend on cholecystokinin in rats. J Nutr 125: 1143-1149, 1995.
19. Klionsky DJ, Cuervo AM, Seglen PO. Methods for monitoring autophagy from yeast to human. Autophagy 3: 181-206, 2007.
20. Lacourse KA, Swanberg LJ, Gillespie PJ, Rehfeld JF, Saunders TL, Samuelson LC. Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK. Am J Physiol Gastrointest Liver Physiol 276: G1302-G1309, 1999.
21. Liddle RA, Green GM, Conrad CK, Williams JA. Proteins but not amino acids, carbohydrates, or fats stimulate cholecystokinin secretion in the rat. Am J Physiol Gastrointest Liver Physiol 251: G243-G248, 1986.
22. Logsdon CD. Stimulation of pancreatic acinar cell growth by CCK, epidermal growth factor, and insulin in vitro. Am J Physiol Gastrointest Liver Physiol 251: G487-G494, 1986.
23. Martin DE, Hall MN. The expanding TOR signaling network. Curr Opin Cell Biol 17: 158-166, 2005.
24. McLaughlan JM. Relationship between protein quality and plasma amino acid levels. Fed Proc 22: 1122-1125, 1963.
25. Morisset J, Guan D, Jurkowska G, Rivard N, Green GM. Endogenous cholecystokinin, the major factor responsible for dietary protein-induced pancreatic growth. Pancreas 7: 522-529, 1992.
26. Nader GA, McLoughlin TJ, Esser KA. mTOR function in skeletal muscle hypertrophy: increased ribosomal RNA via cell cycle regulators. Am J Physiol Cell Physiol 289: C1457-C1465, 2005.
27. Niederau C, Liddle RA, Williams JA, Grendell JH. Pancreatic growth: interaction of exogenous cholecystokinin, a protease inhibitor, and a cholecystokinin receptor antagonist in mice. Gut 28: 63-69, 1987.
28. Polak P, Cybulski N, Feige JN, Auwerx J, Ruegg MA, Hall MN. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab 8: 399-410, 2008.
29. Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 6: 729-734, 2006.
30. Sans MD, Tashiro M, Vogel NL, Kimball SR, D'Alecy LG, Williams JA. Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin. J Nutr 136: 1792-1799, 2006.
31. Sans MD, Williams JA. Translational control of protein synthesis in pancreatic acinar cells. Int J Gastrointest Cancer 31: 107-115, 2002.
32. Sato T, Niikawa J, Usui I, Imamura T, Yoshida H, Tanaka S, Mitamura K. Pancreatic regeneration after ethionine-induced acute pancreatitis in rats lacking pancreatic CCK-A receptor gene expression. J Gastroenterol 38: 672-680, 2003.
33. Schick J, Verspohl R, Kern H, Scheele GA. Two distinct adaptive responses in the synthesis of exocrine pancreatic enzymes to inverse changes in protein and carbohydrate in the diet. Am J Physiol Gastrointest Liver Physiol 247: G611-G616, 1984.
34. Tashiro M, Dabrowski A, Guo LL, Sans MD, Williams JA. Calcineurin- dependent and independent signal transduction pathways activated with pancreatic growth. Pancreas 32: 314-320, 2006.
35. Tashiro M, Samuelson LC, Liddle RA, Williams JA. Calcineurin mediates pancreatic growth in protease inhibitor-treated mice. Am J Physiol Gastrointest Liver Physiol 286: G784-G790, 2004.
36. Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS. ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 284: 8023-8032, 2009.
37. Wang X, Proud CG. Nutrient control of TORC1, a cell-cycle regulator. Trends Cell Biol 19: 260-267, 2009.