Molecular Mechanisms of Pancreatic Dysfunction Induced by Protein Malnutrition

Gastroenterology

Volumn 137, Issue 3, 2009, Pages

  Crozier, Stephen J ^a   D'Alecy, Louis G ^a   Ernst, Stephen A ^a   Ginsburg, Lauren E ^a   Williams, John A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; CONTROLLED STUDY; ENZYME RELEASE; MALE; MOUSE; NONHUMAN; ORGAN GROWTH; PANCREAS ATROPHY; PANCREAS DISEASE; PRIORITY JOURNAL; PROTEIN INTAKE; PROTEIN MALNUTRITION; PROTEIN PHOSPHORYLATION;

EID: 69249129754     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.04.058     Document Type: Article

References (41)

1. Pavlov I.P. The work of digestive glands (1910), C. Griffin and Co, London, UK
2. Williams C.D. A nutritional disease of childhood associated with a maize diet. Arch Dis Child 8 (1933) 423-433
3. Davies J.N.P. The essential pathology of kwashiorkor. Lancet 1 (1948) 317-320
4. Blackburn W.R., and Vinijchaikul K. The pancreas in kwashiorkor. An electron microscopic study. Lab Invest 20 (1969) 305-318
5. Schick J., Verspohl R., Kern H., et al. Two distinct adaptive responses in the synthesis of exocrine pancreatic enzymes to inverse changes in protein and carbohydrate in the diet. Am J Physiol 247 (1984) G611-G616
6. Green G.M., Levan V.H., and Liddle R.A. Plasma cholecystokinin and pancreatic growth during adaptation to dietary protein. Am J Physiol 251 (1986) G70-G74
7. Lee P.C., and Lebenthal E. Prenatal and Postnatal development of the human exocrine pancreas. In: Go V.L.W., DiMagno E.P., Gardner J.D., et al. (Eds). The pancreas: biology, pathobiology, and disease (1993), Raven Press Ltd, New York, NY 57-73
8. Niederau C., Liddle R.A., Williams J.A., et al. Pancreatic growth: interaction of exogenous cholecystokinin, a protease inhibitor, and a cholecystokinin receptor antagonist in mice. Gut 28 (1987) 63-69
9. Liddle R.A., Goldfine I.D., and Williams J.A. Bioassay of plasma cholecystokinin in rats: effects of food, trypsin inhibitor, and alcohol. Gastroenterology 87 (1984) 542-549
10. Goke B., Printz H., Koop I., et al. Endogenous CCK release and pancreatic growth in rats after feeding a proteinase inhibitor (camostate). Pancreas 1 (1986) 509-515
11. Melmed R.N., El-Aaser A.A., and Holt S.J. Hypertrophy and hyperplasia of the neonatal rat exocrine pancreas induced by orally administered soybean trypsin inhibitor. Biochim Biophys Acta 421 (1976) 280-288
12. Tashiro M., Samuelson L.C., Liddle R.A., et al. Calcineurin mediates pancreatic growth in protease inhibitor-treated mice. Am J Physiol Gastrointest Liver Physiol 286 (2004) G784-G790
13. Sato T., Niikawa J., Usui I., et al. Pancreatic regeneration after ethionine-induced acute pancreatitis in rats lacking pancreatic CCK-A receptor gene expression. J Gastroenterol 38 (2003) 672-680
14. Sato N., Suzuki S., Kanai S., et al. Different effects of oral administration of synthetic trypsin inhibitor on the pancreas between cholecystokinin-A receptor gene knockout mice and wild type mice. Jpn J Pharmacol 89 (2002) 290-295
15. Hara H., Narakino H., Kiriyama S., et al. Induction of pancreatic growth and proteases by feeding a high amino acid diet does not depend on cholecystokinin in rats. J Nutr 125 (1995) 1143-1149
16. Lacourse K.A., Swanberg L.J., Gillespie P.J., et al. Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK. Am J Physiol 276 (1999) G1302-G1309
17. Crozier S.J., Sans M.D., Guo L., et al. Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice. J Physiol 573 (2006) 775-786
18. DiMagno M.J., Hao Y., Tsunoda Y., et al. Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice. Am J Physiol 286 (2004) G428-G436
19. Svoboda D., Grady H., and Higginson J. The effects of chronic protein deficiency in rats. II. Biochemical and ultrastructural changes. Lab Invest 15 (1966) 731-749
20. Shamji A.F., Nghiem P., and Schreiber S.L. Integration of growth factor and nutrient signaling: implications for cancer biology. Mol Cell 12 (2003) 271-280
21. Arsham A.M., and Neufeld T.P. Thinking globally and acting locally with TOR. Curr Opin Cell Biol 18 (2006) 589-597
22. Alessi D.R., Andjelkovic M., Caudwell B., et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15 (1996) 6541-6551
23. Kabeya Y., Mizushima N., Ueno T., et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19 (2000) 5720-5728
24. Liang X.H., Jackson S., Seaman M., et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402 (1999) 672-676
25. Sandri M., Sandri C., Gilbert A., et al. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117 (2004) 399-412
26. Bodine S.C., Latres E., Baumhueter S., et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294 (2001) 1704-1708
27. Sans M.D., Lee S.H., D'Alecy L.G., et al. Feeding activates protein synthesis in mouse pancreas at the translational level without increase in mRNA. Am J Physiol Gastrointest Liver Physiol 287 (2004) G667-G675
28. Herman L., and Fitzgerald P.J. Restitution of pancreatic acinar cells following ethionine. J Cell Biol 12 (1962) 297-312
29. Marsh W.H., Goldsmith S., Crocco J., et al. Pancreatic acinar cell regeneration. II. Enzymatic, nucleic acid, and protein changes. Am J Pathol 52 (1968) 1013-1037
30. Baumler M.D., Nelson D.W., Ney D.M., et al. Loss of exocrine pancreatic stimulation during parenteral feeding suppresses digestive enzyme expression and induces Hsp70 expression. Am J Physiol Gastrointest Liver Physiol 292 (2007) G857-G866
31. Klionsky D.J., Cuervo A.M., and Seglen P.O. Methods for monitoring autophagy from yeast to human. Autophagy 3 (2007) 181-206
32. Pitchumoni C.S., and Scheele G.A. Interdependence of nutrition and exocrine pancreas function. In: Go V.L.W., DiMagno E.P., Gardner J.D., et al. (Eds). The pancreas: biology, pathobiology, and disease (1993), Raven Press Ltd, New York, NY 449-473
33. Gingras A.C., Raught B., and Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 68 (1999) 913-963
34. Yamaguchi S., Ishihara H., Yamada T., et al. ATF4-mediated induction of 4E-BP1 contributes to pancreatic β-cell survival under endoplasmic reticulum stress. Cell Metab 7 (2008) 269-276
35. Sans M.D., and Williams J.A. Translational control of protein synthesis in pancreatic acinar cells. Int J Gastrointest Cancer 31 (2002) 107-115
36. Kimball S.R. The role of nutrition in stimulating muscle protein accretion at the molecular level. Biochem Soc Trans 35 (2007) 1298-1301
37. Nobukuni T., Joaquin M., Roccio M., et al. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A 102 (2005) 14238-14243
38. Floyd Jr. J.C., Fajans S.S., Pek S., et al. Synergistic effect of essential amino acids and glucose upon insulin secretion in man. Diabetes 19 (1970) 109-115
39. Lee C.H., Inoki K., Karbowniczek M., et al. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J 26 (2007) 4812-4823
40. Liddle R.A., Green G.M., Conrad C.K., et al. Proteins but not amino acids, carbohydrates, or fats stimulate cholecystokinin secretion in the rat. Am J Physiol 251 (1986) G243-G248
41. Sans M.D., Tashiro M., Vogel N.L., et al. Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin. J Nutr 136 (2006) 1792-1799