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Volumn 130, Issue 12, 2010, Pages 2760-2767

Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; CALGRANULIN B; ENHANCED GREEN FLUORESCENT PROTEIN; INTERLEUKIN 6; LENS EPITHELIUM DERIVED GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PSORIASIN;

EID: 78149465979     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.203     Document Type: Article
Times cited : (28)

References (46)
  • 1
    • 0033676752 scopus 로고    scopus 로고
    • T(9;11)(p22;p15 in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF)
    • Ahuja HG, Hong J, Aplan PD et al. (2000) t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF). Cancer Res 60:6227-9
    • (2000) Cancer Res , vol.60 , pp. 6227-6229
    • Ahuja, H.G.1    Hong, J.2    Aplan, P.D.3
  • 2
    • 8544237744 scopus 로고    scopus 로고
    • Interleukin-11 production is increased in organ cultures of lesional skin of patients with active plaque-type psoriasis as compared with nonlesional and normal skin. Similarity to interleukin-1 beta, interleukin-6 and interleukin-8
    • Ameglio F, Bonifati C, Fazio M et al. (1997) Interleukin-11 production is increased in organ cultures of lesional skin of patients with active plaque-type psoriasis as compared with nonlesional and normal skin. Similarity to interleukin-1 beta, interleukin-6 and interleukin-8. Arch Dermatol Res 289:399-403
    • (1997) Arch Dermatol Res , vol.289 , pp. 399-403
    • Ameglio, F.1    Bonifati, C.2    Fazio, M.3
  • 3
    • 33746177400 scopus 로고    scopus 로고
    • Signaling downstream of p38 in psoriasis
    • Arthur JS, Darragh J (2006) Signaling downstream of p38 in psoriasis. J Invest Dermatol 126:1689-91
    • (2006) J Invest Dermatol , vol.126 , pp. 1689-1691
    • Arthur, J.S.1    Darragh, J.2
  • 4
    • 0036625960 scopus 로고    scopus 로고
    • The role of STATs in apoptosis
    • Battle TE, Frank DA (2002) The role of STATs in apoptosis. Curr Mol Med 2:381-92
    • (2002) Curr Mol Med , vol.2 , pp. 381-392
    • Battle, T.E.1    Frank, D.A.2
  • 5
    • 0035923665 scopus 로고    scopus 로고
    • SP600125, an anthrapyr-azolone inhibitor of Jun N-terminal kinase
    • Bennett BL, Sasaki DT, Murray BW et al. (2001) SP600125, an anthrapyr-azolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 98:13681-6
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13681-13686
    • Bennett, B.L.1    Sasaki, D.T.2    Murray, B.W.3
  • 6
    • 21644455704 scopus 로고    scopus 로고
    • Psoriasis: Dysregulation of innate immunity
    • Bos JD, de Rie MA, Teunissen MB et al. (2005) Psoriasis: dysregulation of innate immunity. Br J Dermatol 152:1098-107
    • (2005) Br J Dermatol , vol.152 , pp. 1098-1107
    • Bos, J.D.1    De Rie, M.A.2    Teunissen, M.B.3
  • 7
    • 0023852747 scopus 로고
    • Normal keratiniza-tion in a spontaneously immortalized aneuploid human keratinocyte cell line
    • Boukamp P, Petrussevska RT, Breitkreutz D et al. (1988) Normal keratiniza-tion in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 106:761-71
    • (1988) J Cell Biol , vol.106 , pp. 761-771
    • Boukamp, P.1    Petrussevska, R.T.2    Breitkreutz, D.3
  • 8
    • 25444435193 scopus 로고    scopus 로고
    • Getting under the skin: The immunogenetics of psoriasis
    • Bowcock AM, Krueger JG (2005) Getting under the skin: the immunogenetics of psoriasis. Nat Rev Immunol 5:699-711
    • (2005) Nat Rev Immunol , vol.5 , pp. 699-711
    • Bowcock, A.M.1    Krueger, J.G.2
  • 10
    • 0037406261 scopus 로고    scopus 로고
    • S100 protein subcellular localization during epidermal differentiation and psoriasis
    • Broome AM, Ryan D, Eckert RL (2003) S100 protein subcellular localization during epidermal differentiation and psoriasis. J Histochem Cytochem 51:675-85
    • (2003) J Histochem Cytochem , vol.51 , pp. 675-685
    • Broome, A.M.1    Ryan, D.2    Eckert, R.L.3
  • 11
    • 33745745419 scopus 로고    scopus 로고
    • Retroviral DNA integration: HIV and the role of LEDGF/p75
    • Ciuffi A, Bushman FD (2006) Retroviral DNA integration: HIV and the role of LEDGF/p75. Trends Genet 22:388-95
    • (2006) Trends Genet , vol.22 , pp. 388-395
    • Ciuffi, A.1    Bushman, F.D.2
  • 12
    • 69249103708 scopus 로고    scopus 로고
    • Transcriptional regulation of vascular endothelial growth factor C by oxidative and thermal stress is mediated by lens epithelium-derived growth factor/p75
    • Cohen B, Addadi Y, Sapoznik S et al. (2009) Transcriptional regulation of vascular endothelial growth factor C by oxidative and thermal stress is mediated by lens epithelium-derived growth factor/p75. Neoplasia 11:921-33
    • (2009) Neoplasia , vol.11 , pp. 921-933
    • Cohen, B.1    Addadi, Y.2    Sapoznik, S.3
  • 13
    • 34547154349 scopus 로고    scopus 로고
    • P38 MAP-kinases pathway regulation, function and role in human diseases
    • Cuenda A, Rousseau S (2007) p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta 1773:1358-75
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 1358-1375
    • Cuenda, A.1    Rousseau, S.2
  • 14
    • 34047274469 scopus 로고    scopus 로고
    • Lens epithelium-derived growth factor is an Hsp70-2 regulated guardian of lysosomal stability in human cancer
    • Daugaard M, Kirkegaard-Sorensen T, Ostenfeld MS et al. (2007) Lens epithelium-derived growth factor is an Hsp70-2 regulated guardian of lysosomal stability in human cancer. Cancer Res 67:2559-67
    • (2007) Cancer Res , vol.67 , pp. 2559-2567
    • Daugaard, M.1    Kirkegaard-Sorensen, T.2    Ostenfeld, M.S.3
  • 15
    • 0032552994 scopus 로고    scopus 로고
    • MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products
    • Duncia JV, Santella JB III, Higley CA et al. (1998) MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg Med Chem Lett 8:2839-44
    • (1998) Bioorg Med Chem Lett , vol.8 , pp. 2839-2844
    • Duncia, J.V.1    Santella III, J.B.2    Higley, C.A.3
  • 16
    • 40949121441 scopus 로고    scopus 로고
    • Transcriptional profiling defines the roles of ERK and p38 kinases in epidermal keratinocytes
    • Gazel A, Nijhawan RI, Walsh R et al. (2008) Transcriptional profiling defines the roles of ERK and p38 kinases in epidermal keratinocytes. J Cell Physiol 215:292-308
    • (2008) J Cell Physiol , vol.215 , pp. 292-308
    • Gazel, A.1    Nijhawan, R.I.2    Walsh, R.3
  • 17
    • 0032538795 scopus 로고    scopus 로고
    • Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation
    • Ge H, Si Y, Roeder RG (1998) Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. EMBO J 17:6723-9
    • (1998) EMBO J , vol.17 , pp. 6723-6729
    • Ge, H.1    Si, Y.2    Roeder, R.G.3
  • 18
    • 27544476971 scopus 로고    scopus 로고
    • The role of IL-6 and STAT3 in inflammation and cancer
    • Hodge DR, Hurt EM, Farrar WL (2005) The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 41:2502-12
    • (2005) Eur J Cancer , vol.41 , pp. 2502-2512
    • Hodge, D.R.1    Hurt, E.M.2    Farrar, W.L.3
  • 19
    • 34249803226 scopus 로고    scopus 로고
    • LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelo-genic leukemia patients and protects leukemia cells from apoptosis in vitro
    • Huang TS, Myklebust LM, Kjarland E et al. (2007) LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelo-genic leukemia patients and protects leukemia cells from apoptosis in vitro. Mol Cancer 6:31
    • (2007) Mol Cancer , vol.6 , pp. 31
    • Huang, T.S.1    Myklebust, L.M.2    Kjarland, E.3
  • 20
    • 73649085805 scopus 로고    scopus 로고
    • Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity
    • Hughes S, Jenkins V, Dar MJ et al. (2010) Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity. J Biol Chem 285:541-54
    • (2010) J Biol Chem , vol.285 , pp. 541-554
    • Hughes, S.1    Jenkins, V.2    Dar, M.J.3
  • 21
    • 2342461732 scopus 로고    scopus 로고
    • Unique keratinization process in psoriasis: Late differentiation markers are abolished because of the premature cell death
    • Iizuka H, Takahashi H, Honma M et al. (2004) Unique keratinization process in psoriasis: late differentiation markers are abolished because of the premature cell death. J Dermatol 31:271-6
    • (2004) J Dermatol , vol.31 , pp. 271-276
    • Iizuka, H.1    Takahashi, H.2    Honma, M.3
  • 22
    • 4944267474 scopus 로고    scopus 로고
    • The AP-1 DNA binding activity is decreased in lesional psoriatic skin compared to nonlesional psoriatic skin
    • Johansen C, Kragballe K, Rasmussen M et al. (2004) The AP-1 DNA binding activity is decreased in lesional psoriatic skin compared to nonlesional psoriatic skin. Br J Dermatol 151:600-7
    • (2004) Br J Dermatol , vol.151 , pp. 600-607
    • Johansen, C.1    Kragballe, K.2    Rasmussen, M.3
  • 23
    • 13244284850 scopus 로고    scopus 로고
    • The mitogen-activated protein kinases p38 and ERK1/2 are increased in lesional psoriatic skin
    • Johansen C, Kragballe K, Westergaard M et al. (2005) The mitogen-activated protein kinases p38 and ERK1/2 are increased in lesional psoriatic skin. Br J Dermatol 152:37-42
    • (2005) Br J Dermatol , vol.152 , pp. 37-42
    • Johansen, C.1    Kragballe, K.2    Westergaard, M.3
  • 24
    • 0029911368 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2
    • Kramer RM, Roberts EF, Um SL et al. (1996) p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2. J Biol Chem 271:27723-9
    • (1996) J Biol Chem , vol.271 , pp. 27723-27729
    • Kramer, R.M.1    Roberts, E.F.2    Um, S.L.3
  • 25
    • 20444497652 scopus 로고    scopus 로고
    • Psoriasis-recent advances in understanding its pathogenesis and treatment
    • Krueger G, Ellis CN (2005) Psoriasis-recent advances in understanding its pathogenesis and treatment. J Am Acad Dermatol 53:S94-100
    • (2005) J Am Acad Dermatol , vol.53
    • Krueger, G.1    Ellis, C.N.2
  • 26
    • 0026042087 scopus 로고
    • Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin
    • Madsen P, Rasmussen HH, Leffers H et al. (1991) Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin. J Invest Dermatol 97:701-12
    • (1991) J Invest Dermatol , vol.97 , pp. 701-712
    • Madsen, P.1    Rasmussen, H.H.2    Leffers, H.3
  • 27
    • 0041856142 scopus 로고    scopus 로고
    • LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells
    • Maertens G, Cherepanov P, Pluymers W et al. (2003) LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. J Biol Chem 278:33528-39
    • (2003) J Biol Chem , vol.278 , pp. 33528-33539
    • Maertens, G.1    Cherepanov, P.2    Pluymers, W.3
  • 28
    • 0041464828 scopus 로고    scopus 로고
    • Aberrant signalling and transcription factor activation as an explanation for the defective growth control and differentiation of keratinocytes in psoriasis: A hypothesis
    • McKenzie RC, Sabin E (2003) Aberrant signalling and transcription factor activation as an explanation for the defective growth control and differentiation of keratinocytes in psoriasis: a hypothesis. Exp Dermatol 12:337-45
    • (2003) Exp Dermatol , vol.12 , pp. 337-345
    • McKenzie, R.C.1    Sabin, E.2
  • 29
    • 70350092520 scopus 로고    scopus 로고
    • Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75
    • Mediavilla-Varela M, Pacheco FJ, Almaguel F et al. (2009) Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75. Mol Cancer 8:68
    • (2009) Mol Cancer , vol.8 , pp. 68
    • Mediavilla-Varela, M.1    Pacheco, F.J.2    Almaguel, F.3
  • 30
    • 0035123417 scopus 로고    scopus 로고
    • Autoantibodies in atopic dermatitis
    • Muro Y (2001) Autoantibodies in atopic dermatitis. J Dermatol Sci 25:171-8
    • (2001) J Dermatol Sci , vol.25 , pp. 171-178
    • Muro, Y.1
  • 31
    • 0037402389 scopus 로고    scopus 로고
    • LEDGF activation of PKC gamma and gap junction disassembly in lens epithelial cells
    • Nguyen TA, Boyle DL, Wagner LM et al. (2003) LEDGF activation of PKC gamma and gap junction disassembly in lens epithelial cells. Exp Eye Res 76:565-72
    • (2003) Exp Eye Res , vol.76 , pp. 565-572
    • Nguyen, T.A.1    Boyle, D.L.2    Wagner, L.M.3
  • 32
    • 0033916267 scopus 로고    scopus 로고
    • Autoantibodies to DFS70 kd/transcription coactivator p75 in atopic dermatitis and other conditions
    • Ochs RL, Muro Y, Si Y et al. (2000) Autoantibodies to DFS70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. J Allergy Clin Immunol 105:1211-20
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 1211-1220
    • Ochs, R.L.1    Muro, Y.2    Si, Y.3
  • 33
    • 14244257153 scopus 로고    scopus 로고
    • Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal alpha-helical domain
    • Ogawa Y, Sugiura K, Watanabe A et al. (2004) Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal alpha-helical domain. J Autoimmun 23:221-33
    • (2004) J Autoimmun , vol.23 , pp. 221-233
    • Ogawa, Y.1    Sugiura, K.2    Watanabe, A.3
  • 34
    • 14244259323 scopus 로고    scopus 로고
    • Autoantibodies to DFS70/LEDGF are increased in alopecia areata patients
    • Okamoto M, Watanabe A, Ogawa Y et al. (2004) Autoantibodies to DFS70/LEDGF are increased in alopecia areata patients. J Autoimmun 23:257-66
    • (2004) J Autoimmun , vol.23 , pp. 257-266
    • Okamoto, M.1    Watanabe, A.2    Ogawa, Y.3
  • 35
    • 33748946363 scopus 로고    scopus 로고
    • PAI-1 transcriptional regulation during the G0-4G1 transition in human epidermal keratinocytes
    • Qi L, Allen RR, Lu Q et al. (2006) PAI-1 transcriptional regulation during the G0-4G1 transition in human epidermal keratinocytes. J Cell Biochem 99:495-507
    • (2006) J Cell Biochem , vol.99 , pp. 495-507
    • Qi, L.1    Allen, R.R.2    Lu, Q.3
  • 36
    • 13444269249 scopus 로고    scopus 로고
    • Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
    • Sano S, Chan KS, Carbajal S et al. (2005) Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med 11:43-9
    • (2005) Nat Med , vol.11 , pp. 43-49
    • Sano, S.1    Chan, K.S.2    Carbajal, S.3
  • 37
    • 0035987224 scopus 로고    scopus 로고
    • LEDGF, a survival factor, activates stress-related genes
    • Shinohara T, Singh DP, Fatma N (2002) LEDGF, a survival factor, activates stress-related genes. Prog Retin Eye Res 21:341-58
    • (2002) Prog Retin Eye Res , vol.21 , pp. 341-358
    • Shinohara, T.1    Singh, D.P.2    Fatma, N.3
  • 38
    • 0032976273 scopus 로고    scopus 로고
    • Lens epithelium derived growth factor: Increased resistance to thermal and oxidative stresses
    • Singh DP, Ohguro N, Chylack LT Jr et al. (1999) Lens epithelium derived growth factor: increased resistance to thermal and oxidative stresses. Invest Ophthalmol Vis Sci 40:1444-51
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 1444-1451
    • Singh, D.P.1    Ohguro, N.2    Chylack Jr., L.T.3
  • 39
    • 0032829119 scopus 로고    scopus 로고
    • Anti-annexin v antibodies and digital ischemia in patients with scleroderma
    • Sugiura K, Muro Y (1999) Anti-annexin V antibodies and digital ischemia in patients with scleroderma. J Rheumatol 26:2168-72
    • (1999) J Rheumatol , vol.26 , pp. 2168-2172
    • Sugiura, K.1    Muro, Y.2
  • 40
    • 84940363675 scopus 로고    scopus 로고
    • The unfolded protein response is activated in differentiating epidermal keratinocytes
    • Sugiura K, Muro Y, Futamura K et al. (2009) The unfolded protein response is activated in differentiating epidermal keratinocytes. J Invest Dermatol 129:2126-35
    • (2009) J Invest Dermatol , vol.129 , pp. 2126-2135
    • Sugiura, K.1    Muro, Y.2    Futamura, K.3
  • 41
    • 33845757502 scopus 로고    scopus 로고
    • LEDGF/DFS70, a major autoantigen of atopic dermatitis, is a component of keratohyalin granules
    • Sugiura K, Muro Y, Nishizawa Y et al. (2007) LEDGF/DFS70, a major autoantigen of atopic dermatitis, is a component of keratohyalin granules. J Invest Dermatol 127:75-80
    • (2007) J Invest Dermatol , vol.127 , pp. 75-80
    • Sugiura, K.1    Muro, Y.2    Nishizawa, Y.3
  • 42
    • 13844288120 scopus 로고    scopus 로고
    • SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung
    • Underwood DC, Osborn RR, Bochnowicz S et al. (2000) SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung. Am J Physiol Lung Cell Mol Physiol 279:L895-902
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.279
    • Underwood, D.C.1    Osborn, R.R.2    Bochnowicz, S.3
  • 43
    • 0024387924 scopus 로고
    • Ki-67 detects a nuclear matrix-associated proliferation-related antigen. I. Intracellular localization during interphase
    • Verheijen R, Kuijpers HJ, Schlingemann RO et al. (1989) Ki-67 detects a nuclear matrix-associated proliferation-related antigen. I. Intracellular localization during interphase. J Cell Sci 92:123-30
    • (1989) J Cell Sci , vol.92 , pp. 123-130
    • Verheijen, R.1    Kuijpers, H.J.2    Schlingemann, R.O.3
  • 44
    • 1542283747 scopus 로고    scopus 로고
    • Anti-DFS70 antibodies in 597 healthy hospital workers
    • Watanabe A, Kodera M, Sugiura K et al. (2004) Anti-DFS70 antibodies in 597 healthy hospital workers. Arthritis Rheum 50:892-900
    • (2004) Arthritis Rheum , vol.50 , pp. 892-900
    • Watanabe, A.1    Kodera, M.2    Sugiura, K.3
  • 45
    • 36148934536 scopus 로고    scopus 로고
    • Expression and localization of the activated mitogen-activated protein kinase in lesional psoriatic skin
    • Yu XJ, Li CY, Dai HY et al. (2007) Expression and localization of the activated mitogen-activated protein kinase in lesional psoriatic skin. Exp Mol Pathol 83:413-8
    • (2007) Exp Mol Pathol , vol.83 , pp. 413-418
    • Yu, X.J.1    Li, C.Y.2    Dai, H.Y.3
  • 46
    • 19644367000 scopus 로고    scopus 로고
    • Activation and signaling of the p38 MAP kinase pathway
    • Zarubin T, Han J (2005) Activation and signaling of the p38 MAP kinase pathway. Cell Res 15:11-8
    • (2005) Cell Res , vol.15 , pp. 11-18
    • Zarubin, T.1    Han, J.2


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