Epigenetic enhancement of p66Shc during cellular replicative or premature senescence

Toxicology

Volumn 278, Issue 2, 2010, Pages 189-194

  Zhang, Wenjuan ^a,b   Ji, Weidong ^b   Yang, Linqing ^b   Xu, Yuling ^b   Yang, Jianping ^b   Zhuang, Zhixiong ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b SHENZHEN CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Cellular senescence; Epigenetic; Histone modification; Methylation; P66Shc

Indexed keywords

BISULFITE; CYTOPLASM PROTEIN; HISTONE H3; HISTONE H4; HYDROGEN PEROXIDE; LYSINE; P66SHC PROTEIN; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CELL AGING; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LUNG FIBROBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ACETYLATION; CELL AGING; CELLS, CULTURED; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; FIBROBLASTS; HISTONES; HUMANS; HYDROGEN PEROXIDE; LUNG; METHYLATION; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SHC SIGNALING ADAPTOR PROTEINS; SULFITES;

EID: 78149465728     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.07.011     Document Type: Article

References (21)

1. Baylin S.B., Ohm J.E. Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?. Nat. Rev. Cancer 2006, 6:107-116.
2. Berry A., Capone F., Giorgio M., Pelicci P.G., de Kloet E.R., Alleva E., Minghetti L., Cirulli F. Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice. Exp. Gerontol. 2007, 42:37-45.
3. Bosutti A., Scaggiante B., Grassi G., Guarnieri G., Biolo G. Overexpression of the elongation factor 1A1 relates to muscle proteolysis and proapoptotic p66(ShcA) gene transcription in hypercatabolic trauma patients. Metabolism 2007, 56:1629-1634.
4. Camici G.G., Schiavoni M., Francia P., Bachschmid M., Martin-Padura I., Hersberger M., Tanner F.C., Pelicci P., Volpe M., Anversa P., Lüscher T.F., Cosentino F. Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:5217-5222.
5. Campisi J., d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell. Biol. 2007, 8:729-740.
6. Favetta L.A., Robert C., King W.A., Betts D.H. Expression profiles of p53 and p66shc during oxidative stress-induced senescence in fetal bovine fibroblasts. Exp. Cell. Res. 2004, 299:36-48.
7. Finkel T., Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 2000, 408:239-247.
8. Fraga M.F. Genetic and epigenetic regulation of aging. Curr. Opin. Immunol. 2009, 21:446-453.
9. Haendeler J., Hoffmann J., Diehl J.F., Vasa M., Spyridopoulos I., Zeiher A.M., Dimmeler S. Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ. Res. 2004, 94:768-775.
10. Hake S.B., Xiao A., Allis C.D. Linking the epigenetic 'language' of covalent histone modifications to cancer. Br. J. Cancer. 2007, 96(Suppl):R31-39.
11. 2. Cell Signal. 2007, 19:410-418.
12. Lee S.K., Kim H.S., Song Y.J., Joo H.K., Lee J.Y., Lee K.H., Cho E.J., Cho C.H., Park J.B., Jeon B.H. Alteration of p66shc is associated with endothelial dysfunction in the abdominal aortic coarctation of rats. FEBS Lett. 2008, 582:2561-2566.
13. Lopez-Serra L., Ballestar E., Fraga M.F., Alaminos M., Setien F., Esteller M. A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer. Cancer Res. 2006, 66:8342-8346.
14. Migliaccio E., Giorgio M., Pelicci P.G. Apoptosis and aging: role of p66Shc redox protein. Antioxid. Redox Signal 2006, 8:600-608.
15. Nemoto S., Finkel T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 2002, 295:2450-2452.
16. Pandolfi S., Bonafe M., Di Tella L., Tiberi L., Salvioli S., Monti D., Sorbi S., Franceschi C. p66shc is highly expressed in fibroblasts from centenarians. Mech. Ageing Dev. 2005, 126:839-844.
17. Trinei M., Berniakovich I., Beltrami E., Migliaccio E., Fassina A., Pelicci P., Giorgio M. P66Shc signals to age. Aging (Albany NY). 2009, 1:503-510.
18. Trinei M., Berniakovich I., Pelicci P.G., Giorgio M. Mitochondrial DNA copy number is regulated by cellular proliferation: a role for Ras and p66Shc. Biochim. Biophys. Acta 2006, 1757:624-630.
19. Ventura A., Luzi L., Pacini S., Baldari C.T., Pelicci P.G. The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. J. Biol. Chem. 2002, 277:22370-22376.
20. Yu B.P., Chung H.Y. Adaptive mechanisms to oxidative stress during aging. Mech. Ageing Dev. 2006, 127:436-443.
21. Zhang W., Ji W., Yang J., Yang L., Chen W., Zhuang Z. Comparison of global DNA methylation profiles in replicative versus premature senescence. Life Sci. 2008, 83:475-480.