Bee venom reduces atherosclerotic lesion formation via anti-inflammatory mechanism

American Journal of Chinese Medicine

Volumn 38, Issue 6, 2010, Pages 1077-1092

  Lee, Woo Ram ^a   Kim, Soo Jung ^a   Park, Ji Hyun ^a   Kim, Kyung Hyun ^a   Chang, Young Chae ^a   Park, Yoon Yup ^a   Lee, Kwang Gill ^b   Han, Sang Mi ^b   Yeo, Joo Hong ^b   Pak, Sok Cheon ^c   Park, Kwan Kyu ^a  

^a Catholic University of Daegu   (South Korea)

^b National Institute of Animal Science   (South Korea)

^c CHARLES STURT UNIVERSITY   (Australia)

Author keywords

Adhesion Molecules; Atherosclerosis; Cytokine; Inflammation

Indexed keywords

BEE VENOM; CHOLESTEROL; FIBRONECTIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; GENE CONTROL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APITHERAPY; ATHEROSCLEROSIS; BEE VENOMS; CYTOKINES; DIETARY FATS; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; FIBRONECTINS; INFLAMMATION MEDIATORS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1BETA; LIPIDS; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 78149432889     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X10008482     Document Type: Article

References (37)

1. Amin, A.R., M. Attur and S.B. Abramson. Nitric oxide synthase and cyclooxygenases: distribution, regulation, and intervention in arthritis. Curr. Opin. Rheumatol. 11: 202-209, 1999.
2. Boring, L., J. Gosling, M. Cleary and I.F. Charo. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394: 894-897, 1998.
3. Casós, K., M.P. Sáiz, J.I. Ruiz-Sanz and M.T. Mitjavila. Atherosclerosis prevention by a fish oil-rich diet in apoE(-/-) mice is associated with a reduction of endothelial adhesion molecules. Atherosclerosis 201(2): 306-317, 2008.
4. Dewberry, R., H. Holden, D. Crossman and S. Francis. Interleukin-1 receptor antagonist expression in human endothelial cells and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 20: 2394-2400, 2000.
5. Galea, J., J. Armstrong, P. Gadsdon, H. Holden, S.E. Francis and C.M. Holt. Interleukin-1 beta in coronary arteries of patients with ischemic heart disease. Arterioscler. Thromb. Vasc. Biol. 16: 1000-1006, 1996.
6. Gu, L., Y. Okada, S.K. Clinton, C. Gerard, G.K. Sukhova, P. Libby and B.J. Rollins. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol. Cell 2: 275-281, 1998.
7. Han, S.M., K.G. Lee, J.H. Yeo, H.Y. Kweon, S.O. Woo, M.Y. Lee, H.J. Baek and K.K. Park. Effect of venom from the Asian honeybee (Apis cerana Fab.) on LPS-induced nitric oxide and tumor necrosis factor-α production in RAW 264.7 cell line. J. Api. Res. 45: 131-136, 2006.
8. Han, S.M., K.G. Lee, J.H. Yeo, S.J. Hwang, C.H. Jang, P.J. Chenoweth and S.C. Pak. Effects of bee venom treatment on growth performance of young pigs. Am. J. Chin. Med. 37: 253-260, 2009.
9. Hansson, G.K., A.K. Robertson and C. Söderberg-Nauclér. Inflammation and atherosclerosis. Annu. Rev. Pathol. 1: 297-329, 2006.
10. Hider, R.C. Honeybee venom: a rich source of pharmacologically active peptides. Endeavour 12(2): 60-65, 1988.
11. Hung, C.F., T.F. Huang, B.H. Chen, J.M. Shieh, P.H. Wu and W.B. Wu. Lycopene inhibits TNFalpha-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion. Eur. J. Pharmacol. 586: 275-282, 2008.
12. Hwang, S.J., C.M. Ballantyne, A.R. Sharrett, L.C. Smith, C.E. Davis, A.M. Gotto Jr. and E. Boerwinkle. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study. Circulation 96: 4219-4225, 1997.
13. Isoda, K., S. Sawada, N. Ishigami, T. Matsuki, K. Miyazaki, M. Kusuhara, Y. Iwakura and F. Ohsuzu. Lack of interleukin-1 receptor antagonist modulates plaque composition in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 24: 1068-1073, 2004.
14. Jang, H.S., S.K. Kim, J.B. Han, H.J. Ahn, H. Bae and B.I. Min. Effects of bee venom on the proinflammatory responses in RAW264.7 macrophage cell line. J. Ethnopharmacol. 99: 157-160, 2005.
15. Kolachala, V.L., R. Bajaj, L. Wang, Y. Yan, J.D. Ritzenthaler, A.T. Gewirtz, J. Roman, D. Merlin and S.V. Sitaraman. Epithelial-derived fibronectin expression, signaling, and function in intestinal inflammation. J. Biol. Chem. 282: 32965-32973, 2007.
16. Lee, K.G., H.J. Cho, Y.S. Bae, K.K. Park, J.Y. Choe, I.K. Chung, M. Kim, J.H. Yeo, K.H. Park, Y.S. Lee, C.H. Kim and Y.C. Chang. Bee venom suppresses LPS-mediated NO/iNOS induction through inhibition of PKC-alpha expression. J. Ethnopharmacol. 123: 15-21, 2009.
17. Li, H., M.I. Cybulsky, M.A. Gimbrone Jr. and P. Libby. An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler. Thromb. 13: 197-204, 1993.
18. Matsumoto, T., H. Watanabe, T. Ueno, A. Tsunemi, B. Hatano, Y. Kusumi, M. Mitsumata, N. Fukuda, K. Matsumoto, S. Saito and H. Mugishima. Appropriate doses of granulocyte-colony stimulating factor reduced atherosclerotic plaque formation and increased plaque stability in cholesterol-fed rabbits. J. Atheroscler. Thromb. 17(1): 84-96, 2010.
19. Mo, S.J., E.W. Son, S.R. Lee, S.M. Lee, D.H. Shin and S. Pyo. CML-1 inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in endothelial cells through inhibition of IkB alpha kinase. J. Ethnopharmacol. 109: 78-86, 2007.
20. Moon, M.K., Y.J. Lee, J.S. Kim, D.G. Kang and H.S. Lee. Effect of caffeic acid on tumor necrosis factor-alpha-induced vascular inflammation in human umbilical vein endothelial cells. Biol. Pharm. Bull. 32: 1371-1377, 2009.
21. Nashed, B., B. Yeganeh, K.T. HayGlass and M.H. Moghadasian. Antiatherogenic effects of dietary plant sterols are associated with inhibition of proinflammatory cytokine production in Apo E-KO mice. J. Nutr. 135: 2438-2444, 2005.
22. Nizamutdinova, I.T., H.M. Oh, Y.N. Min, S.H. Park, M.J. Lee, J.S. Kim, M.H. Yean, S.S. Kang, Y.S. Kim, K.C. Chang and H.J. Kim. Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways. Int. Immunopharmacol. 7: 343-350, 2007.
23. Olofsson, P.S., Y. Sheikine, K. Jatta, M. Ghaderi, A. Samnegård, P. Eriksson and A. Sirsjö. A functional interleukin-1 receptor antagonist polymorphism influences atherosclerosis development. The interleukin-1beta: interleukin-1 receptor antagonist balance in atherosclerosis. Circulation J. 73: 1531-1536, 2009.
24. Ostos, M.A., D. Recalde, M.M. Zakin and D. Scott-Algara. Implication of natural killer T cells in atherosclerosis development during a LPS-induced chronic inflammation. FEBS Lett. 519: 23-29, 2002.
25. Park, H.J., S.H. Lee, D.J. Son, D.J., K.W. Oh, K.H. Kim, H.S. Song, G.J. Kim, G.T. Oh, D.Y. Yoon and J.T. Hong. Antiarthritic effect of bee venom: inhibition of inflammation mediator generation by suppression of NF-kappaB through interaction with the p50 subunit. Arthritis Rheum. 50: 3504-3515, 2004.
26. Pelletier, J.P., D. Jovanovic, J.C. Fernandes, P. Manning, J.R. Connor, M.G. Currie, J.A. Di Battista and J. Martel-Pelletier. Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase. Arthritis Rheum. 41: 1275-1286, 1998.
27. Pham, Y., Y. Tu, T. Wu, T.J. Allen, A.C. Calkin, A.M. Watson, J. Li, K.A. Jandeleit-Dahm, B.H. Toh, Z. Cao, M.E. Cooper and Z. Chai. Cell division autoantigen 1 plays a profibrotic role by modulating downstream signalling of TGF-beta in a murine diabetic model of atherosclerosis. Diabetologia 53: 170-179, 2010.
28. Poole, J.C. and H.W. Florey. Changes in the endothelium of the aorta and the behaviour of macrophages in experimental atheroma of rabbits. J. Pathol. Bacteriol. 75: 245-251, 1958.
29. Poston, R.N., D.O. Haskard, J.R. Coucher, N.P. Gall and R.R. Johnson-Tidey. Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am. J. Pathol. 140: 665-673, 1992.
30. Shi, Q., J.F. Vandeberg, C. Jett, K. Rice, M.M. Leland, L. Talley, R.S. Kushwaha, D.L. Rainwater, J.L. Vandeberg and X.L. Wang. Arterial endothelial dysfunction in baboons fed a highcholesterol, high-fat diet. Am. J. Clin. Nutr. 82: 751-759, 2005.
31. Son, D.J., J.W. Lee, Y.H. Lee, H.S. Song, C.K. Lee and J.T. Hong. Therapeutic application of antiarthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacol. Ther. 115: 246-270, 2007.
32. Stoll, G and M. Bendszus. Inflammation and atherosclerosis: novel insights into plaque formation and destabilization. Stroke 37: 1923-1932, 2006.
33. Tikellis, C., K.A. Jandeleit-Dahm, K. Sheehy, A. Murphy, J. Chin-Dusting, D. Kling, E. Sebokova, M.E. Cooper, J. Mizrahi and K.J. Woollard. Reduced plaque formation induced by rosiglitazone in an STZ-diabetes mouse model of atherosclerosis is associated with downregulation of adhesion molecules. Atherosclerosis 199(1): 55-64, 2008.
34. Waehre, T., A. Yndestad, C. Smith, T. Haug, S.H. Tunheim, L. Gullestad, S.S. Frøland, A.G. Semb, P. Aukrust and J.K. Damås. Increased expression of interleukin-1 in coronary artery disease with downregulatory effects of HMG-CoA reductase inhibitors. Circulation 109: 1966-1972, 2004.
35. Wan, J.B., S.M. Lee, J.D. Wang, N. Wang, C.W. He, Y.T. Wang and J.X. Kang. Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion. J. Agric. Food Chem. 57: 6692-6697, 2009.
36. Wilcox, J.N., N.A. Nelken, S.R. Coughlin, D. Gordon and T.J. Schall. Local expression of inflammatory cytokines in human atherosclerotic plaques. J. Atheroscler. Thromb. 1: S10-S13, 1994.
37. Zhou, X., G. Paulsson, S. Stemme and G.K. Hansson. Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice. J. Clin. Invest. 101: 1717-1725, 1998.