A formulated red ginseng extract rescues PC12 cells from PCB-induced oxidative cell death through Nrf2-mediated upregulation of heme oxygenase-1 and glutamate cysteine ligase

Toxicology

Volumn 278, Issue 1, 2010, Pages 131-139

  Park, So Hyun ^a   Jang, Jung Hee ^b   Chen, Chu Yue ^a   Na, Hye Kyung ^c   Surh, Young Joon ^a  

^a Seoul National University   (South Korea)

^b Daegu Haany University   (South Korea)

^c Sungshin Women's University   (South Korea)

Author keywords

Ginseng; Glutamate cysteine ligase; Heme oxygenase 1; NF E2 related factor 2; Polychlorinated biphenyls; Reactive oxygen species; Red ginseng extract

Indexed keywords

GINSENG EXTRACT; GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; POLYCHLORINATED BIPHENYL; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; RED GINSENG EXTRACT; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CELL PROTECTION; CYTOTOXICITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; APOPTOSIS; BUTADIENES; CELL SURVIVAL; CHROMONES; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTAMATE-CYSTEINE LIGASE; HEME OXYGENASE-1; MEMBRANE POTENTIAL, MITOCHONDRIAL; MORPHOLINES; NF-E2-RELATED FACTOR 2; NITRILES; OXIDATIVE STRESS; PANAX; PC12 CELLS; PLANT EXTRACTS; POLYCHLORINATED BIPHENYLS; PROTEIN KINASE INHIBITORS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; UP-REGULATION;

PANAX GINSENG; RATTUS;

EID: 78149415856     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.04.003     Document Type: Article

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