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Volumn 71, Issue 12, 2010, Pages 1180-1186

Increased liver-infiltrating CD8+FoxP3+ regulatory T cells are associated with tumor stage in hepatocellular carcinoma patients

Author keywords

CD8+ T cells; FoxP3; Hepatocellular carcinoma; Regulatory T cells

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; TRANSCRIPTION FACTOR FOXP3;

EID: 78149414079     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2010.09.011     Document Type: Article
Times cited : (51)

References (38)
  • 1
    • 38349159248 scopus 로고    scopus 로고
    • Clinical cancer advances 2007: Major research advances in cancer treatment, prevention, and screening-a report from the American Society of Clinical Oncology
    • Gralow J., Ozols R.F., Bajorin D.F., Cheson B.D., Sandler H.M., Winer E.P., et al. Clinical cancer advances 2007: Major research advances in cancer treatment, prevention, and screening-a report from the American Society of Clinical Oncology. J Clin Oncol 2008, 26:313-325.
    • (2008) J Clin Oncol , vol.26 , pp. 313-325
    • Gralow, J.1    Ozols, R.F.2    Bajorin, D.F.3    Cheson, B.D.4    Sandler, H.M.5    Winer, E.P.6
  • 2
  • 3
    • 0031890627 scopus 로고    scopus 로고
    • Clinicopathological study on hepatocellular carcinoma with lymphocytic infiltration
    • Wada Y., Nakashima O., Kutami R., Yamamoto O., Kojiro M. Clinicopathological study on hepatocellular carcinoma with lymphocytic infiltration. J Hepatol 1998, 27:407-414.
    • (1998) J Hepatol , vol.27 , pp. 407-414
    • Wada, Y.1    Nakashima, O.2    Kutami, R.3    Yamamoto, O.4    Kojiro, M.5
  • 4
    • 77549084467 scopus 로고    scopus 로고
    • Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients
    • Chew V., Tow C., Teo M., Wong H.L., Chan J., Gehring A., et al. Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients. J Hepatol 2010, 52:370-379.
    • (2010) J Hepatol , vol.52 , pp. 370-379
    • Chew, V.1    Tow, C.2    Teo, M.3    Wong, H.L.4    Chan, J.5    Gehring, A.6
  • 5
    • 16844378685 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma
    • Ormandy L.A., Hillemann T., Wedemeyer H., Manns M.P., Greten T.F., Korangy F. Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res 2005, 65:2457-2464.
    • (2005) Cancer Res , vol.65 , pp. 2457-2464
    • Ormandy, L.A.1    Hillemann, T.2    Wedemeyer, H.3    Manns, M.P.4    Greten, T.F.5    Korangy, F.6
  • 6
    • 33847384529 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis
    • Kobayashi N., Hiraoka N., Yamagami W., Ojima H., Kanai Y., Kosuge T., et al. FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis. Clin Cancer Res 2007, 13:902-911.
    • (2007) Clin Cancer Res , vol.13 , pp. 902-911
    • Kobayashi, N.1    Hiraoka, N.2    Yamagami, W.3    Ojima, H.4    Kanai, Y.5    Kosuge, T.6
  • 7
    • 16244393380 scopus 로고    scopus 로고
    • Compromised lymphocytes infiltrate hepatocellular carcinoma: The role of T-regulatory cells
    • Unitt E., Rushbrook S.M., Marshall A., Davies S., Gibbs P., Morris L.S., et al. Compromised lymphocytes infiltrate hepatocellular carcinoma: The role of T-regulatory cells. Hepatology 2005, 41:722-730.
    • (2005) Hepatology , vol.41 , pp. 722-730
    • Unitt, E.1    Rushbrook, S.M.2    Marshall, A.3    Davies, S.4    Gibbs, P.5    Morris, L.S.6
  • 8
    • 34447277894 scopus 로고    scopus 로고
    • Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
    • Gao Q., Qiu S.J., Fan J., Zhou J., Wang X.Y., Xiao Y.S., et al. Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol 2007, 25:2586-2593.
    • (2007) J Clin Oncol , vol.25 , pp. 2586-2593
    • Gao, Q.1    Qiu, S.J.2    Fan, J.3    Zhou, J.4    Wang, X.Y.5    Xiao, Y.S.6
  • 9
    • 33745699342 scopus 로고    scopus 로고
    • Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma
    • Yang X.H., Yamagiwa S., Ichida T., Matsuda Y., Sugahara S., Watanabe H., et al. Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma. J Hepatol 2006, 45:254-262.
    • (2006) J Hepatol , vol.45 , pp. 254-262
    • Yang, X.H.1    Yamagiwa, S.2    Ichida, T.3    Matsuda, Y.4    Sugahara, S.5    Watanabe, H.6
  • 10
    • 68549136586 scopus 로고    scopus 로고
    • Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients
    • Zhou J., Ding T., Pan W., Zhu L.Y., Li L., Zheng L. Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients. Int J Cancer 2009, 125:1640-1648.
    • (2009) Int J Cancer , vol.125 , pp. 1640-1648
    • Zhou, J.1    Ding, T.2    Pan, W.3    Zhu, L.Y.4    Li, L.5    Zheng, L.6
  • 11
    • 34250005419 scopus 로고    scopus 로고
    • Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients
    • Fu J., Xu D., Liu Z., Shi M., Zhao P., Fu B., et al. Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology 2007, 132:2328-2339.
    • (2007) Gastroenterology , vol.132 , pp. 2328-2339
    • Fu, J.1    Xu, D.2    Liu, Z.3    Shi, M.4    Zhao, P.5    Fu, B.6
  • 12
    • 77955515915 scopus 로고    scopus 로고
    • Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy
    • Coe D., Begom S., Addey C., White M., Dyson J., Chai J.G. Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy. Cancer Immunol Immunother 2010, 59:1367-1377.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 1367-1377
    • Coe, D.1    Begom, S.2    Addey, C.3    White, M.4    Dyson, J.5    Chai, J.G.6
  • 13
    • 77951734602 scopus 로고    scopus 로고
    • In situ vaccination combined with androgen ablation and regulatory T-cell depletion reduces castration-resistant tumor burden in prostate-specific pten knockout mice
    • 1
    • Akins E.J., Moore M.L., Tang S., Willingham M.C., Tooze J.A., Dubey P. In situ vaccination combined with androgen ablation and regulatory T-cell depletion reduces castration-resistant tumor burden in prostate-specific pten knockout mice. Cancer Res 2010, 70:3473-3482. 1.
    • (2010) Cancer Res , vol.70 , pp. 3473-3482
    • Akins, E.J.1    Moore, M.L.2    Tang, S.3    Willingham, M.C.4    Tooze, J.A.5    Dubey, P.6
  • 14
    • 0037128654 scopus 로고    scopus 로고
    • Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells
    • Gilliet M., Liu Y.J. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J Exp Med 2002, 195:695-704.
    • (2002) J Exp Med , vol.195 , pp. 695-704
    • Gilliet, M.1    Liu, Y.J.2
  • 15
    • 85047690427 scopus 로고    scopus 로고
    • Regulatory functions of CD8+CD28- T cells in an autoimmune disease model
    • Najafian N., Chitnis T., Salama A.D., Zhu B., Benou C., Yuan X., et al. Regulatory functions of CD8+CD28- T cells in an autoimmune disease model. J Clin Invest 2003, 112:1037-1048.
    • (2003) J Clin Invest , vol.112 , pp. 1037-1048
    • Najafian, N.1    Chitnis, T.2    Salama, A.D.3    Zhu, B.4    Benou, C.5    Yuan, X.6
  • 16
    • 4344675302 scopus 로고    scopus 로고
    • Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity
    • Manavalan J.S., Kim-Schulze S., Scotto L., Naiyer A.J., Vlad G., Colombo P.C., et al. Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity. Int Immunol 2004, 16:1055-1068.
    • (2004) Int Immunol , vol.16 , pp. 1055-1068
    • Manavalan, J.S.1    Kim-Schulze, S.2    Scotto, L.3    Naiyer, A.J.4    Vlad, G.5    Colombo, P.C.6
  • 19
    • 33646371011 scopus 로고    scopus 로고
    • FoxP3 expressing CD4+ CD25+ and CD8+CD28- T regulatory cells in the peripheral blood of patients with lung cancer and pleural mesothelioma
    • Meloni F., Morosini M., Solari N., Passadore I., Nascimbene C., Novo M., et al. FoxP3 expressing CD4+ CD25+ and CD8+CD28- T regulatory cells in the peripheral blood of patients with lung cancer and pleural mesothelioma. Hum Immunol 2006, 67:1-12.
    • (2006) Hum Immunol , vol.67 , pp. 1-12
    • Meloni, F.1    Morosini, M.2    Solari, N.3    Passadore, I.4    Nascimbene, C.5    Novo, M.6
  • 20
    • 38849191927 scopus 로고    scopus 로고
    • CD8+ CD28- T regulatory lymphocytes inhibiting T-cell proliferative and cytotoxic functions infiltrate human cancers
    • Filaci G., Fenoglio D., Fravega M., Ansaldo G., Borgonovo G., Traverso P., et al. CD8+ CD28- T regulatory lymphocytes inhibiting T-cell proliferative and cytotoxic functions infiltrate human cancers. J Immunol 2007, 179:4323-4334.
    • (2007) J Immunol , vol.179 , pp. 4323-4334
    • Filaci, G.1    Fenoglio, D.2    Fravega, M.3    Ansaldo, G.4    Borgonovo, G.5    Traverso, P.6
  • 21
    • 57649101649 scopus 로고    scopus 로고
    • CD8+ regulatory T cells, their suppressive mechanisms, and regulation in cancer
    • Wang R.F. CD8+ regulatory T cells, their suppressive mechanisms, and regulation in cancer. Hum Immunol 2008, 69:811-814.
    • (2008) Hum Immunol , vol.69 , pp. 811-814
    • Wang, R.F.1
  • 22
    • 37249067503 scopus 로고    scopus 로고
    • CD8+ FoxP3+ regulatory T cells mediate immunosuppression in prostate cancer
    • Kiniwa Y., Miyahara Y., Wang H.Y., Peng W., Peng G., Wheeler T.M., et al. CD8+ FoxP3+ regulatory T cells mediate immunosuppression in prostate cancer. Clin Cancer Res 2007, 13:6947-6958.
    • (2007) Clin Cancer Res , vol.13 , pp. 6947-6958
    • Kiniwa, Y.1    Miyahara, Y.2    Wang, H.Y.3    Peng, W.4    Peng, G.5    Wheeler, T.M.6
  • 23
    • 20444485236 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma
    • Wei S., Kryczek I., Zou L., Daniel B., Cheng P., Mottram P., et al. Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma. Cancer Res 2005, 65:5020-5026.
    • (2005) Cancer Res , vol.65 , pp. 5020-5026
    • Wei, S.1    Kryczek, I.2    Zou, L.3    Daniel, B.4    Cheng, P.5    Mottram, P.6
  • 24
    • 33745820353 scopus 로고    scopus 로고
    • Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor: Influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells
    • Jarnicki A.G., Lysaght J., Todryk S., Mills K.H. Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor: Influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells. J Immunol 2006, 177:896-904.
    • (2006) J Immunol , vol.177 , pp. 896-904
    • Jarnicki, A.G.1    Lysaght, J.2    Todryk, S.3    Mills, K.H.4
  • 25
    • 63849224217 scopus 로고    scopus 로고
    • Identification of CD8+CD25+FoxP3+ suppressive T cells in colorectal cancer tissue
    • Chaput N., Louafi S., Bardier A., Charlotte F., Vaillant J.C., Menegaux F., et al. Identification of CD8+CD25+FoxP3+ suppressive T cells in colorectal cancer tissue. Gut 2009, 58:520-529.
    • (2009) Gut , vol.58 , pp. 520-529
    • Chaput, N.1    Louafi, S.2    Bardier, A.3    Charlotte, F.4    Vaillant, J.C.5    Menegaux, F.6
  • 27
    • 10744226674 scopus 로고    scopus 로고
    • Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes
    • Cosmi L., Liotta F., Lazzeri E., Francalanci M., Angeli R., Mazzinghi B., et al. Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes. Blood 2003, 102:4107-4114.
    • (2003) Blood , vol.102 , pp. 4107-4114
    • Cosmi, L.1    Liotta, F.2    Lazzeri, E.3    Francalanci, M.4    Angeli, R.5    Mazzinghi, B.6
  • 28
    • 33745323050 scopus 로고    scopus 로고
    • Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B
    • Xu D., Fu J., Jin L., Zhang H., Zhou C., Zou Z., et al. Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol 2006, 177:739-747.
    • (2006) J Immunol , vol.177 , pp. 739-747
    • Xu, D.1    Fu, J.2    Jin, L.3    Zhang, H.4    Zhou, C.5    Zou, Z.6
  • 30
    • 33947687864 scopus 로고    scopus 로고
    • Four functionally distinct populations of human effector-memory CD8+ T lymphocytes
    • Romero P., Zippelius A., Kurth I., Pittet M.J., Touvrey C., Iancu E.M., et al. Four functionally distinct populations of human effector-memory CD8+ T lymphocytes. J Immunol 2007, 178:4112-4119.
    • (2007) J Immunol , vol.178 , pp. 4112-4119
    • Romero, P.1    Zippelius, A.2    Kurth, I.3    Pittet, M.J.4    Touvrey, C.5    Iancu, E.M.6
  • 31
    • 4143141823 scopus 로고    scopus 로고
    • The immunobiology of cancer immunosurveillance and immunoediting
    • Dunn G.P., Old L.J., Schreiber R.D. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 2004, 21:137-148.
    • (2004) Immunity , vol.21 , pp. 137-148
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 32
    • 67650966949 scopus 로고    scopus 로고
    • Profile of tumor antigen-specific CD8 T cells in patients with hepatitis B virus-related hepatocellular carcinoma
    • Gehring A.J., Ho Z.Z., Tan A.T., Aung M.O., Lee K.H., Tan K.C., et al. Profile of tumor antigen-specific CD8 T cells in patients with hepatitis B virus-related hepatocellular carcinoma. Gastroenterology 2009, 137:682-690.
    • (2009) Gastroenterology , vol.137 , pp. 682-690
    • Gehring, A.J.1    Ho, Z.Z.2    Tan, A.T.3    Aung, M.O.4    Lee, K.H.5    Tan, K.C.6
  • 33
    • 78650621479 scopus 로고    scopus 로고
    • PD-1 and PD-L1 upregulation promotes CD8(+) T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients
    • [Epub ahead of print]
    • Shi F., Shi M., Zeng Z., Qi R.Z., Liu Z.W., Zhang J.Y., et al. PD-1 and PD-L1 upregulation promotes CD8(+) T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients. Int J Cancer 2010, [Epub ahead of print].
    • (2010) Int J Cancer
    • Shi, F.1    Shi, M.2    Zeng, Z.3    Qi, R.Z.4    Liu, Z.W.5    Zhang, J.Y.6
  • 34
    • 70350234729 scopus 로고    scopus 로고
    • Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions
    • Wu K., Kryczek I., Chen L., Zou W., Welling T.H. Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions. Cancer Res 2009, 69:8067-8075.
    • (2009) Cancer Res , vol.69 , pp. 8067-8075
    • Wu, K.1    Kryczek, I.2    Chen, L.3    Zou, W.4    Welling, T.H.5
  • 36
    • 55249089647 scopus 로고    scopus 로고
    • Intrahepatic regulatory T cells are phenotypically distinct from their peripheral counterparts in chronic HBV patients
    • Stoop J.N., Claassen M.A., Woltman A.M., Binda R.S., Kuipers E.J., Janssen H.L., et al. Intrahepatic regulatory T cells are phenotypically distinct from their peripheral counterparts in chronic HBV patients. Clin Immunol 2008, 129:419-427.
    • (2008) Clin Immunol , vol.129 , pp. 419-427
    • Stoop, J.N.1    Claassen, M.A.2    Woltman, A.M.3    Binda, R.S.4    Kuipers, E.J.5    Janssen, H.L.6
  • 37
    • 77249118149 scopus 로고    scopus 로고
    • Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis
    • Claassen M.A., de Knegt R.J., Tilanus H.W., Janssen H.L., Boonstra A. Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis. J Hepatol 2010, 52:315-321.
    • (2010) J Hepatol , vol.52 , pp. 315-321
    • Claassen, M.A.1    de Knegt, R.J.2    Tilanus, H.W.3    Janssen, H.L.4    Boonstra, A.5
  • 38
    • 28244441236 scopus 로고    scopus 로고
    • Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells
    • Endharti A.T., Rifa I.M., Shi Z., Fukuoka Y., Nakahara Y., Kawamoto Y., et al. Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells. J Immunol 2005, 175:7093-7097.
    • (2005) J Immunol , vol.175 , pp. 7093-7097
    • Endharti, A.T.1    Rifa, I.M.2    Shi, Z.3    Fukuoka, Y.4    Nakahara, Y.5    Kawamoto, Y.6


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