메뉴 건너뛰기




Volumn 70, Issue 9, 2010, Pages 3473-3482

In situ vaccination combined with androgen ablation and regulatory T-cell depletion reduces castration-resistant tumor burden in prostate-specific Pten knockout mice

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CHROMIUM 51; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

EID: 77951734602     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-2490     Document Type: Article
Times cited : (35)

References (47)
  • 1
    • 0014217744 scopus 로고
    • Endocrine-induced regression of cancers
    • Huggins C. Endocrine-induced regression of cancers. Science 1967;156:1050-1054
    • (1967) Science , vol.156 , pp. 1050-1054
    • Huggins, C.1
  • 2
    • 0026475342 scopus 로고
    • Challenges in the management of prostate cancer
    • Crawford ED. Challenges in the management of prostate cancer. Br J Urol 1992;70Suppl 1:33-38
    • (1992) Br J Urol , vol.70 , Issue.SUPPL. 1 , pp. 33-38
    • Crawford, E.D.1
  • 3
    • 34547700498 scopus 로고    scopus 로고
    • Impact of androgendeprivation therapy on the immune system: Implications for combination therapy of prostate cancer
    • Aragon-Ching JB, Williams KM, Gulley JL. Impact of androgendeprivation therapy on the immune system: implications for combination therapy of prostate cancer. Front Biosci 2007;12:4957-4971
    • (2007) Front Biosci , vol.12 , pp. 4957-4971
    • Aragon-Ching, J.B.1    Williams, K.M.2    Gulley, J.L.3
  • 4
    • 33644591595 scopus 로고    scopus 로고
    • Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen
    • DOI 10.1007/s00262-005-0064-z
    • Hess PR, Boczkowski D, Nair SK, Snyder D, Gilboa E. Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen. Cancer Immunol Immunother 2006;55:672-683 (Pubitemid 43312163)
    • (2006) Cancer Immunology, Immunotherapy , vol.55 , Issue.6 , pp. 672-683
    • Hess, P.R.1    Boczkowski, D.2    Nair, S.K.3    Snyder, D.4    Gilboa, E.5
  • 5
    • 33646432202 scopus 로고    scopus 로고
    • Effect of medical castration on CD4+ CD25+ T cells, CD8+ T cell IFN-γ expression, and NK cells: A physiological role for testosterone and/or its metabolites
    • Page ST, Plymate SR, Bremner WJ, et al. Effect of medical castration on CD4+ CD25+ T cells, CD8+ T cell IFN-γ expression, and NK cells: a physiological role for testosterone and/or its metabolites. Am J Physiol Endocrinol Metab 2006;290:E856-63.
    • (2006) Am J Physiol Endocrinol Metab , vol.290
    • Page, S.T.1    Plymate, S.R.2    Bremner, W.J.3
  • 6
    • 8444230022 scopus 로고    scopus 로고
    • Augmentation of T cell levels and responses induced by androgen deprivation
    • Roden AC, Moser MT, Tri SD, et al. Augmentation of T cell levels and responses induced by androgen deprivation. J Immunol 2004;173:6098-6108
    • (2004) J Immunol , vol.173 , pp. 6098-6108
    • Roden, A.C.1    Moser, M.T.2    Tri, S.D.3
  • 7
    • 20244380618 scopus 로고    scopus 로고
    • Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen
    • Drake CG, Doody AD, Mihalyo MA, et al. Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen. Cancer Cell 2005;7:239-249
    • (2005) Cancer Cell , vol.7 , pp. 239-249
    • Drake, C.G.1    Doody, A.D.2    Mihalyo, M.A.3
  • 8
    • 4143110451 scopus 로고    scopus 로고
    • The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer
    • DOI 10.1038/sj.bjc.6601943
    • McArdle PA, Canna K, McMillan DC, McNicol AM, Campbell R, Underwood MA. The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer. Br J Cancer 2004;91:541-543 (Pubitemid 39093576)
    • (2004) British Journal of Cancer , vol.91 , Issue.3 , pp. 541-543
    • McArdle, P.A.1    Canna, K.2    McMillan, D.C.3    McNicol, A.-H.4    Campbell, R.5    Underwood, M.A.6
  • 9
    • 0028032388 scopus 로고
    • Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma
    • Vesalainen S, Lipponen P, Talja M, Syrjanen K. Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma. Eur J Cancer 1994;30A:1797-1803
    • (1994) Eur J Cancer , vol.30 A , pp. 1797-1803
    • Vesalainen, S.1    Lipponen, P.2    Talja, M.3    Syrjanen, K.4
  • 11
    • 33745149378 scopus 로고    scopus 로고
    • + T cells specific for prostate-specific antigen and level of disease in patients with prostate cancer
    • DOI 10.1016/j.clim.2005.12.008, PII S1521661605004274
    • Elkord E, Rowbottom AW, Kynaston H, Williams PE. Correlation between CD8+ T cells specific for prostate-specific antigen and level of disease in patients with prostate cancer. Clin Immunol 2006;120:91-98 (Pubitemid 43903383)
    • (2006) Clinical Immunology , vol.120 , Issue.1 , pp. 91-98
    • Elkord, E.1    Rowbottom, A.W.2    Kynaston, H.3    Williams, P.E.4
  • 12
    • 27144517441 scopus 로고    scopus 로고
    • Differential CTLs specific for prostate-specific antigen in healthy donors and patients with prostate cancer
    • DOI 10.1093/intimm/dxh309
    • Elkord E, Williams PE, Kynaston H, Rowbottom AW. Differential CTLs specific for prostate-specific antigen in healthy donors and patients with prostate cancer. Int Immunol 2005;17:1315-1325 (Pubitemid 41488005)
    • (2005) International Immunology , vol.17 , Issue.10 , pp. 1315-1325
    • Elkord, E.1    Williams, P.E.2    Kynaston, H.3    Rowbottom, A.W.4
  • 13
    • 0035873903 scopus 로고    scopus 로고
    • Naturally occurring prostate cancer antigen-specific T cell responses of a Th1 phenotype can be detected in patients with prostate cancer
    • McNeel DG, Nguyen LD, Ellis WJ, Higano CS, Lange PH, Disis ML. Naturally occurring prostate cancer antigen-specific T cell responses of a Th1 phenotype can be detected in patients with prostate cancer. Prostate 2001;47:222-229
    • (2001) Prostate , vol.47 , pp. 222-229
    • McNeel, D.G.1    Nguyen, L.D.2    Ellis, W.J.3    Higano, C.S.4    Lange, P.H.5    Disis, M.L.6
  • 14
    • 0036322373 scopus 로고    scopus 로고
    • Induction of Tc2 cells with specificity for prostate-specific antigen from patients with hormone-refractory prostate cancer
    • DOI 10.1007/s00262-002-0281-7
    • Perambakam S, Xue BH, Sosman JA, Peace DJ. Induction of Tc2 cells with specificity for prostate-specific antigen from patients with hormone-refractory prostate cancer. Cancer Immunol Immunother 2002;51:263-270 (Pubitemid 34810707)
    • (2002) Cancer Immunology, Immunotherapy , vol.51 , Issue.5 , pp. 263-270
    • Perambakam, S.1    Xue, B.-H.2    Sosman, J.A.3    Peace, D.J.4
  • 15
    • 0035807916 scopus 로고    scopus 로고
    • T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer
    • Mercader M, Bodner BK, Moser MT, et al. T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer. Proc Natl Acad Sci U S A 2001;98:14565-14570
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 14565-14570
    • Mercader, M.1    Bodner, B.K.2    Moser, M.T.3
  • 16
    • 33750807427 scopus 로고    scopus 로고
    • CD4+CD25high T cells are enriched in the tumor and peripheral blood of prostate cancer patients
    • Miller AM, Lundberg K, Ozenci V, et al. CD4+CD25high T cells are enriched in the tumor and peripheral blood of prostate cancer patients. J Immunol 2006;177:7398-7405
    • (2006) J Immunol , vol.177 , pp. 7398-7405
    • Miller, A.M.1    Lundberg, K.2    Ozenci, V.3
  • 17
    • 48849103649 scopus 로고    scopus 로고
    • Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing
    • Sfanos KS, Bruno TC, Maris CH, et al. Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clin Cancer Res 2008;14:3254-3261
    • (2008) Clin Cancer Res , vol.14 , pp. 3254-3261
    • Sfanos, K.S.1    Bruno, T.C.2    Maris, C.H.3
  • 18
  • 19
    • 33745941651 scopus 로고    scopus 로고
    • Immunohistochemical analysis of CD4+ and CD8+ T-cell subsets in high risk human papillomavirus-associated pre-malignant and malignant lesions of the uterine cervix
    • Monnier-Benoit S, Mauny F, Riethmuller D, et al. Immunohistochemical analysis of CD4+ and CD8+ T-cell subsets in high risk human papillomavirus- associated pre-malignant and malignant lesions of the uterine cervix. Gynecol Oncol 2006;102:22-31.
    • (2006) Gynecol Oncol , vol.102 , pp. 22-31
    • Monnier-Benoit, S.1    Mauny, F.2    Riethmuller, D.3
  • 20
    • 29444442811 scopus 로고    scopus 로고
    • Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    • Sato E, Olson SH, Ahn J, et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A 2005;102:18538-18543
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18538-18543
    • Sato, E.1    Olson, S.H.2    Ahn, J.3
  • 21
    • 0346655327 scopus 로고    scopus 로고
    • Prostate tumor microenvironment alters immune cells and prevents long-term survival in an orthotopic mouse model following flt3-ligand/CD40- ligand immunotherapy
    • Ciavarra RP, Holterman DA, Brown RR, et al. Prostate tumor microenvironment alters immune cells and prevents long-term survival in an orthotopic mouse model following flt3-ligand/CD40-ligand immunotherapy. J Immunother 2004;27:13-26.
    • (2004) J Immunother , vol.27 , pp. 13-26
    • Ciavarra, R.P.1    Holterman, D.A.2    Brown, R.R.3
  • 22
    • 19944427289 scopus 로고    scopus 로고
    • Peripheral T cell tolerance occurs early during spontaneous prostate cancer development and can be rescued by dendritic cell immunization
    • Degl'Innocenti E, Grioni M, Boni A, et al. Peripheral T cell tolerance occurs early during spontaneous prostate cancer development and can be rescued by dendritic cell immunization. Eur J Immunol 2005;35:66-75.
    • (2005) Eur J Immunol , vol.35 , pp. 66-75
    • Degl'Innocenti, E.1    Grioni, M.2    Boni, A.3
  • 23
    • 34047213998 scopus 로고    scopus 로고
    • Dendritic cells program non-immunogenic prostate-specific T cell responses beginning at early stages of prostate tumorigenesis
    • Mihalyo MA, Hagymasi AT, Slaiby AM, Nevius EE, Adler AJ. Dendritic cells program non-immunogenic prostate-specific T cell responses beginning at early stages of prostate tumorigenesis. Prostate 2007;67:536-546
    • (2007) Prostate , vol.67 , pp. 536-546
    • Mihalyo, M.A.1    Hagymasi, A.T.2    Slaiby, A.M.3    Nevius, E.E.4    Adler, A.J.5
  • 25
    • 0036839573 scopus 로고    scopus 로고
    • Clonal deletion of simian virus 40 large T antigen-specific T cells in the transgenic adenocarcinoma of mouse prostate mice: An important role for clonal deletion in shaping the repertoire of T cells specific for antigens overexpressed in solid tumors
    • Zheng X, Gao JX, Zhang H, Geiger TL, Liu Y, Zheng P. Clonal deletion of simian virus 40 large T antigen-specific T cells in the transgenic adenocarcinoma of mouse prostate mice: an important role for clonal deletion in shaping the repertoire of T cells specific for antigens overexpressed in solid tumors. J Immunol 2002;169:4761-4769
    • (2002) J Immunol , vol.169 , pp. 4761-4769
    • Zheng, X.1    Gao, J.X.2    Zhang, H.3    Geiger, T.L.4    Liu, Y.5    Zheng, P.6
  • 26
    • 39149129661 scopus 로고    scopus 로고
    • Peripheral T-cell tolerance associated with prostate cancer is independent from CD4 +CD25+ regulatory T cells
    • Degl'Innocenti E, Grioni M, Capuano G, et al. Peripheral T-cell tolerance associated with prostate cancer is independent from CD4 +CD25+ regulatory T cells. Cancer Res 2008;68:292-300.
    • (2008) Cancer Res , vol.68 , pp. 292-300
    • Degl'Innocenti, E.1    Grioni, M.2    Capuano, G.3
  • 27
    • 16844361893 scopus 로고    scopus 로고
    • Altered immunity accompanies disease progression in a mouse model of prostate dysplasia
    • Tien AH, Xu L, Helgason CD. Altered immunity accompanies disease progression in a mouse model of prostate dysplasia. Cancer Res 2005;65:2947-2955
    • (2005) Cancer Res , vol.65 , pp. 2947-2955
    • Tien, A.H.1    Xu, L.2    Helgason, C.D.3
  • 28
    • 33244472107 scopus 로고    scopus 로고
    • Tumor-infiltrating T lymphocytes: Friends or foes?
    • Yu P, Fu YX. Tumor-infiltrating T lymphocytes: friends or foes? Lab Invest 2006;86:231-245
    • (2006) Lab Invest , vol.86 , pp. 231-245
    • Yu, P.1    Fu, Y.X.2
  • 29
    • 10744222860 scopus 로고    scopus 로고
    • Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
    • Wang S, Gao J, Lei Q, et al. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 2003;4:209-221
    • (2003) Cancer Cell , vol.4 , pp. 209-221
    • Wang, S.1    Gao, J.2    Lei, Q.3
  • 30
    • 10744227434 scopus 로고    scopus 로고
    • Priming of naive T cells inside tumors leads to eradication of established tumors
    • Yu P, Lee Y, Liu W, et al. Priming of naive T cells inside tumors leads to eradication of established tumors. Nat Immunol 2004;5:141-149
    • (2004) Nat Immunol , vol.5 , pp. 141-149
    • Yu, P.1    Lee, Y.2    Liu, W.3
  • 31
    • 0035113825 scopus 로고    scopus 로고
    • Generation of a prostate epithelial cellspecific Cre transgenic mouse model for tissue-specific gene ablation
    • Wu X, Wu J, Huang J, et al. Generation of a prostate epithelial cellspecific Cre transgenic mouse model for tissue-specific gene ablation. Mech Dev 2001;101:61-69
    • (2001) Mech Dev , vol.101 , pp. 61-69
    • Wu, X.1    Wu, J.2    Huang, J.3
  • 32
    • 0031030349 scopus 로고    scopus 로고
    • The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68
    • Dubey P, Hendrickson RC, Meredith SC, et al. The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68. J Exp Med 1997;185:695-705.
    • (1997) J Exp Med , vol.185 , pp. 695-705
    • Dubey, P.1    Hendrickson, R.C.2    Meredith, S.C.3
  • 33
    • 34447121369 scopus 로고    scopus 로고
    • Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development
    • Jiao J, Wang S, Qiao R, et al. Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development. Cancer Res 2007;67:6083-6091
    • (2007) Cancer Res , vol.67 , pp. 6083-6091
    • Jiao, J.1    Wang, S.2    Qiao, R.3
  • 34
    • 0030860498 scopus 로고    scopus 로고
    • Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model
    • Foster BA, Gingrich JR, Kwon ED, Madias C, Greenberg NM. Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Cancer Res 1997;57:3325-3330
    • (1997) Cancer Res , vol.57 , pp. 3325-3330
    • Foster, B.A.1    Gingrich, J.R.2    Kwon, E.D.3    Madias, C.4    Greenberg, N.M.5
  • 35
    • 35449006679 scopus 로고    scopus 로고
    • Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance
    • Cao X, Cai SF, Fehniger TA, et al. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity 2007;27:635-646
    • (2007) Immunity , vol.27 , pp. 635-646
    • Cao, X.1    Cai, S.F.2    Fehniger, T.A.3
  • 36
    • 42249115188 scopus 로고    scopus 로고
    • Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp3+ regulatory T cells
    • Ladoire S, Arnould L, Apetoh L, et al. Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp3+ regulatory T cells. Clin Cancer Res 2008;14:2413-2420
    • (2008) Clin Cancer Res , vol.14 , pp. 2413-2420
    • Ladoire, S.1    Arnould, L.2    Apetoh, L.3
  • 37
    • 33745851479 scopus 로고    scopus 로고
    • CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
    • Quezada SA, Peggs KS, Curran MA, Allison JP. CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J Clin Invest 2006;116:1935-1945
    • (2006) J Clin Invest , vol.116 , pp. 1935-1945
    • Quezada, S.A.1    Peggs, K.S.2    Curran, M.A.3    Allison, J.P.4
  • 38
    • 52449102477 scopus 로고    scopus 로고
    • Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures
    • Dieu-Nosjean MC, Antoine M, Danel C, et al. Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures. J Clin Oncol 2008;26:4410-4417
    • (2008) J Clin Oncol , vol.26 , pp. 4410-4417
    • Dieu-Nosjean, M.C.1    Antoine, M.2    Danel, C.3
  • 39
    • 62449250053 scopus 로고    scopus 로고
    • Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome
    • Gobert M, Treilleux I, Bendriss-Vermare N, et al. Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res 2009;69:2000-2009
    • (2009) Cancer Res , vol.69 , pp. 2000-2009
    • Gobert, M.1    Treilleux, I.2    Bendriss-Vermare, N.3
  • 40
    • 0028814924 scopus 로고
    • Impact of the Crohn's-like lymphoid reaction on staging of right-sided colon cancer: Results of multivariate analysis
    • Harrison JC, Dean PJ, el-Zeky F, Vander Zwaag R. Impact of the Crohn's-like lymphoid reaction on staging of right-sided colon cancer: results of multivariate analysis. Hum Pathol 1995;26:31-38
    • (1995) Hum Pathol , vol.26 , pp. 31-38
    • Harrison, J.C.1    Dean, P.J.2    El-Zeky, F.3    Vander Zwaag, R.4
  • 41
    • 33751501463 scopus 로고    scopus 로고
    • Random migration precedes stable target cell interactions of tumor-infiltrating T cells
    • Mrass P, Takano H, Ng LG, et al. Random migration precedes stable target cell interactions of tumor-infiltrating T cells. J Exp Med 2006;203:2749-2761
    • (2006) J Exp Med , vol.203 , pp. 2749-2761
    • Mrass, P.1    Takano, H.2    Ng, L.G.3
  • 42
    • 51049108540 scopus 로고    scopus 로고
    • Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
    • Quezada SA, Peggs KS, Simpson TR, Shen Y, Littman DR, Allison JP. Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma. J Exp Med 2008;205:2125-2138
    • (2008) J Exp Med , vol.205 , pp. 2125-2138
    • Quezada, S.A.1    Peggs, K.S.2    Simpson, T.R.3    Shen, Y.4    Littman, D.R.5    Allison, J.P.6
  • 43
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-336
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 44
    • 0041914332 scopus 로고    scopus 로고
    • The role of PTEN in the progression and survival of prostate cancer
    • Deocampo ND, Huang H, Tindall DJ. The role of PTEN in the progression and survival of prostate cancer. Minerva Endocrinol 2003;28:145-153
    • (2003) Minerva Endocrinol , vol.28 , pp. 145-153
    • Deocampo, N.D.1    Huang, H.2    Tindall, D.J.3
  • 45
    • 44349089700 scopus 로고    scopus 로고
    • Treg depletion inhibits efficacy of cancer immunotherapy: Implications for clinical trials
    • Curtin JF, Candolfi M, Fakhouri TM, et al. Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials. PLoS One 2008;3:e1983.
    • (2008) PLoS One , vol.3
    • Curtin, J.F.1    Candolfi, M.2    Fakhouri, T.M.3
  • 46
    • 2442585121 scopus 로고    scopus 로고
    • Co-inhibitory molecules of the B7-28 family in the control of T-cell immunity
    • Chen L. Co-inhibitory molecules of the B7-28 family in the control of T-cell immunity. Nat Rev Immunol 2004;4:336-347
    • (2004) Nat Rev Immunol , vol.4 , pp. 336-347
    • Chen, L.1
  • 47
    • 65349156913 scopus 로고    scopus 로고
    • Costimulatory and coinhibitory receptors in anti-tumor immunity
    • Driessens G, Kline J, Gajewski TF. Costimulatory and coinhibitory receptors in anti-tumor immunity. Immunol Rev 2009;229:126-144
    • (2009) Immunol Rev , vol.229 , pp. 126-144
    • Driessens, G.1    Kline, J.2    Gajewski, T.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.