Moderate GSK-3β inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy

Angiogenesis

Volumn 13, Issue 3, 2010, Pages 269-277

  Hoang, Mien V ^a   Smith, Lois E H ^b   Senger, Donald R ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

catenin; Endothelial cell; Glycogen synthase kinase 3 ; Hypoxia; Neovascularization; Retinopathy

Indexed keywords

AR A 014418; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; PEPTIDE L803MTS; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; TDZD 8; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL FUNCTION; CELL JUNCTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REOXYGENATION; RETINA BLOOD FLOW; RETINA CELL; RETINA ISCHEMIA; RETINA NEOVASCULARIZATION; RETINOPATHY; TISSUE PERFUSION;

ANIMALS; ANOXIA; BETA CATENIN; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INTERCELLULAR JUNCTIONS; ISCHEMIA; MICE; MICE, INBRED C57BL; MORPHOGENESIS; PROTEIN KINASE INHIBITORS; REGIONAL BLOOD FLOW; RETINA; RETINAL NEOVASCULARIZATION; VASCULAR DISEASES;

EID: 78149408627     PISSN: 09696970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10456-010-9184-y     Document Type: Article

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