Novel cellular microarray assay for profiling T-cell peptide antigen specificities

Journal of Proteome Research

Volumn 9, Issue 11, 2010, Pages 5629-5637

  Yue, C ^a   Oelke, M ^b   Paulaitis, M E ^a   Schneck, J P ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cellular microarray; high throughput screening; HLA Ig; human leukocyte antigen; immune response; infectious diseases; influenza; T cells; vaccines

Indexed keywords

DIMER; HLA A2 ANTIGEN; IMMUNOGLOBULIN; T LYMPHOCYTE RECEPTOR;

ANTIGEN SPECIFICITY; ARTICLE; BLOOD; CD8+ T LYMPHOCYTE; CELL COUNT; CELL ISOLATION; CELL SPECIFICITY; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; T LYMPHOCYTE SUBPOPULATION;

CD8-POSITIVE T-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; HIGH-THROUGHPUT SCREENING ASSAYS; HLA-A2 ANTIGEN; HUMANS; MICROARRAY ANALYSIS; RECEPTORS, ANTIGEN, T-CELL; SENSITIVITY AND SPECIFICITY; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTES, CYTOTOXIC; TISSUE ARRAY ANALYSIS;

EID: 78149365747     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100447b     Document Type: Article

References (38)

1. Frahm, N. Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes Nat. Immunol. 2006, 7, 173-178 (Pubitemid 43135883)
2. Sette, A.; Peters, B. Immune epitope mapping in the post-genomic era: lessons for vaccine development Curr. Opin. Immunol. 2007, 19, 106-110
3. Yewdell, J. T. W.; Bennink, J. R. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses Annu. Rev. Immunol. 1999, 17, 51-88
4. Arstila, T. P. A direct estimate of the human alpha beta T cell receptor diversity Science 1999, 286 (5441) 958-961
5. Altman, J. D. Phenotypic analysis of antigen-specific T lymphocytes Science 1996, 274 (5284) 94-96
6. Greten, T. F. Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19-specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients Proc. Natl. Acad. Sci. U.S.A. 1998, 95 (13) 7568-7573
7. Chen, D. S. Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarray. PloS Med. 2005, 2 (10) 1018-1030
8. Deviren, G. Detection of antigen-specific T cells on p/MHC microarrays J. Mol. Recognit. 2007, 20 (1) 32-38
9. Soen, Y. Detection and characterization of cellular immune responses using peptide-MHC microarrays PloS Biol. 2003, 1 (3) 429-438
10. Kwong, G. A. Modular Nucleic Acid Assembled p/MHC Microarrays for Multiplexed Sorting of Antigen-Specific T Cells J. Am. Chem. Soc. 2009, 131 (28) 9695-9703
11. Stone, J. D.; Walter, J.; Demkowicz, E.; Stern, L. J. HLA-restricted epitope identification and detection of functional T cell responses by using MHC-peptide and costimualtory microarrays Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 3744-3749
12. Nishioka, G. M.; Markey, A. A.; Holloway, C. K. Protein damage in drop-on-demand printers J. Am. Chem. Soc. 2004, 126 (50) 16320-16321
13. Zhu, H.; Snyder, M. Protein chip technology Curr. Opin. Chem. Biol. 2003, 7, 55-63
14. Delehanty, J. B.; Ligler, F. S. Method for printing functional protein microarrays BioTechniques 2003, 34, 380-385
15. Wu, P.; Grainger, D. W. Comparison of hydroxylated print additives on antibody microarray performance J. Proteome Res. 2006, 5 (11) 2956-2965
16. Liu, Y. S. Optimization of printing buffer for protein microarrays based on aldehyde-modified glass slides Front. Biosci. 2007, 12, 3768-3773
17. Ajikumar, P. K. Carboxyl-terminated dendrimer-coated bioactive interface for protein microarray: High-sensitivity detection of antigen in complex biological samples Langmuir 2007, 23 (10) 5670-5677
18. Davis, M. M. Ligand recognition by alpha beta T cell receptors Annu. Rev. Immunol. 1998, 16, 523-544
19. Armstrong, K. M. Thermodynamics of T-cell receptor-peptide/MHC interactions: progress and opportunities J. Mol. Recognit. 2008, 21, 275-287
20. Chan, P. Y. Influence of Receptor Lateral Mobility on Adhesion Strengthening between Membranes Containing Lfa-3 and Cd2 J. Cell Biol. 1991, 115 (1) 245-255
21. Parham, P.; Barnstable, C. J.; Bodmer, W. F. Use of a Monoclonal Antibody (W6-32) in Structural Studies of Hla-a, B, C Antigens J. Immunol. 1979, 123 (1) 342-349
22. Tanabe, M. Structural and Functional-Analysis of Monomorphic Determinants Recognized by Monoclonal-Antibodies Reacting with the Hla Class-I Alpha-3 Domain J. Immunol. 1992, 148 (10) 3202-3209
23. Ware, R. Human Cd8(+) T-Lymphocyte Clones Specific for T-Cell Receptor V-Beta Families Expressed on Autologous Cd4(+) T-Cells Immunity 1995, 2 (2) 177-184
24. Genestier, L. Fas-independent apoptosis of activated T cells induced by antibodies to the HLA class I alpha 1 domain Blood 1997, 90 (9) 3629-3639
25. Schneck, J. P.; et al. Monitoring antigen-specific T cells using MHC-Ig dimers. In Short protocols in immunology: a compendium of methods from current protocols in immunology; Coligan, J. E., et al., Eds.; Wiley: New York, 2005; pp 15-2 - 15-11.
26. Ndhlovu, Z. M. Dynamic regulation of functionally distinct virus-specific T cells Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 3669-3674
27. Buchli, R. Real-time measurement of in vitro peptide binding to soluble HLA-A 0201 by fluorescence polarization Biochemistry 2004, 43 (46) 14852-14863
28. Rodenko, B. Generation of peptide-MHC class I complexes through UV-mediated ligand exchange Nat. Protoc. 2006, 1 (3) 1120-1132
29. Arakawa, T.; Kita, Y.; Timasheff, S. N. Protein precipitation and denaturation by dimethyl sulfoxide Biophys. Chem. 2007, 131 (1-3) 62-70
30. Parnham, P. Use of a monoclonal antibody (W6/32) in structural studies of HLA-a,b,c antigens J. Immunol. 1979, 123 (1) 342-349
31. Oelke, M. Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig-coated artificial antigen-presenting cells Nat. Med. 2003, 9 (5) 619-624
32. Yewdell, J. W. Confronting complexity: Real-world immunodominance in antiviral CD8(+) T cell responses Immunity 2006, 25 (4) 533-543
33. Gianfrani, C. Human memory CTL response specific for influenza A virus is broad and multispecific Hum. Immunol. 2000, 61 (5) 438-452
34. Fahmy, T. M. Probing T cell membrane organization using dimeric MHC-Ig complexes J. Immunol. Methods 2002, 268, 93-106
35. Kedziershka, K. Finding multiple needles in one immune haystack Nat. Methods 2009, 6 (7) 489-490
36. Newell, E. W. Simultaneous detection of many T-cell specificities using combinatorial tetramer staining Nat. Methods 2009, 6 (7) 497-499
37. Hadrup, S. R. Parallel detection of antigen-specific T-cell responses by multi-dimensional encoding of MHC multimers Nat. Methods 2009, 6 (7) 520-526
38. Grakoui, A. The immunological synapse: A molecular machine controlling T cell activation Science 1999, 285 (5425) 221-227 (Pubitemid 29329988)