Stem cells in the diabetic infarcted heart

Heart Failure Reviews

Volumn 15, Issue 6, 2010, Pages 581-588

  Glass, Carley E ^b   Singal, Pawan K ^a   Singla, Dinender K ^b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Diabetes; Embryonic stem cells; Hyperglycemia; Myocardial infarction; Oxidative stress

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ALLOXAN DIABETES MELLITUS; APOPTOSIS; CELL REGENERATION; DIABETES MELLITUS; DYSLIPIDEMIA; EMBRYONIC STEM CELL; GLUCOSE BLOOD LEVEL; GLYCOSYLATION; HEART EJECTION FRACTION; HEART FAILURE; HEART INFARCTION; HEMATOPOIETIC STEM CELL; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERTENSION; IMPAIRED GLUCOSE TOLERANCE; INCIDENCE; INSULIN RESISTANCE; MESENCHYMAL STEM CELL; MONONUCLEAR CELL; MORBIDITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PLURIPOTENT STEM CELL; REVIEW; RISK FACTOR; STEM CELL; STEM CELL TRANSPLANTATION; STREPTOZOCIN DIABETES;

ANIMALS; DIABETES COMPLICATIONS; HEART FAILURE; HUMANS; HYPERGLYCEMIA; INSULIN RESISTANCE; METABOLIC SYNDROME X; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; OXIDATIVE STRESS; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME;

EID: 78149357221     PISSN: 13824147     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10741-010-9172-8     Document Type: Review

References (83)

1. D Aronson EJ Rayfield JH Chesebro 1997 Mechanisms determining course and outcome of diabetic patients who have had acute myocardial infarction Ann Intern Med 126 296 306 1:STN:280:DyaK2s7nt1yrsw%3D%3D 9036802
2. S Rahman T Rahman AA Ismail AR Rashid 2007 Diabetes-associated macrovasculopathy: pathophysiology and pathogenesis Diabetes Obes Metab 9 767 780 1:CAS:528:DC%2BD2sXhtlOlsLvI 10.1111/j.1463-1326.2006.00655.x 17924861 (Pubitemid 47555200)
3. SL Woodfield CF Lundergan JS Reiner SW Greenhouse MA Thompson SC Rohrbeck Y Deychak ML Simoons RM Califf EJ Topol AM Ross 1996 Angiographic findings and outcome in diabetic patients treated with thrombolytic therapy for acute myocardial infarction: the GUSTO-I experience J Am Coll Cardiol 28 1661 1669 1:CAS:528:DyaK2sXks12lsA%3D%3D 10.1016/S0735-1097(96)00397-X 8962549 (Pubitemid 26426217)
4. DK Singla TA Hacker L Ma PS Douglas R Sullivan GE Lyons TJ Kamp 2006 Transplantation of embryonic stem cells into the infarcted mouse heart: formation of multiple cell types J Mol Cell Cardiol 40 195 200 1:CAS:528:DC%2BD28XkvFCi 10.1016/j.yjmcc.2005.09.001 16288779 (Pubitemid 43012130)
5. DK Singla GE Lyons TJ Kamp 2007 Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling Am J Physiol Heart Circ Physiol 293 H1308 H1314 1:CAS:528:DC%2BD2sXptlyrtrs%3D 10.1152/ajpheart.01277.2006 17416601 (Pubitemid 47254236)
6. JY Min Y Yang KL Converso L Liu Q Huang JP Morgan YF Xiao 2002 Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats J Appl Physiol 92 288 296 10.1063/1.1481962 11744672 (Pubitemid 34783313)
7. D Jing A Parikh JM Canty Jr ES Tzanakakis 2008 Stem cells for heart cell therapies Tissue Eng Part B Rev 14 393 406
8. A Tenerz I Lonnberg C Berne G Nilsson J Leppert 2001 Myocardial infarction and prevalence of diabetes mellitus. Is increased casual blood glucose at admission a reliable criterion for the diagnosis of diabetes? Eur Heart J 22 1102 1110 1:STN:280:DC%2BD3Mznt1GlsA%3D%3D 10.1053/euhj.2000.2445 11428850 (Pubitemid 32666651)
9. VL Roger SA Weston Y Gerber JM Killian SM Dunlay AS Jaffe MR Bell J Kors BP Yawn SJ Jacobsen 2010 Trends in incidence, severity, and outcome of hospitalized myocardial infarction Circulation 121 863 869 10.1161/ CIRCULATIONAHA.109.897249 20142444
10. SM Haffner S Lehto T Ronnemaa K Pyorala M Laakso 1998 Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction N Engl J Med 339 229 234 1:STN:280:DyaK1czivVKgsg%3D%3D 10.1056/NEJM199807233390404 9673301 (Pubitemid 28350165)
11. G Hu P Jousilahti Q Qiao M Peltonen S Katoh J Tuomilehto 2005 The gender-specific impact of diabetes and myocardial infarction at baseline and during follow-up on mortality from all causes and coronary heart disease J Am Coll Cardiol 45 1413 1418 10.1016/j.jacc.2005.01.039 15862411 (Pubitemid 40615611)
12. V Lundberg B Stegmayr K Asplund M Eliasson F Huhtasaari 1997 Diabetes as a risk factor for myocardial infarction: population and gender perspectives J Intern Med 241 485 492 1:STN:280:DyaK1Mvislaktg%3D%3D 10.1111/j.1365-2796.1997. tb00006.x 10497624
13. CD Lee AR Folsom JS Pankow FL Brancati 2004 Cardiovascular events in diabetic and nondiabetic adults with or without history of myocardial infarction Circulation 109 855 860 10.1161/01.CIR.0000116389.61864.DE 14757692 (Pubitemid 38252737)
14. KH Mak EJ Topol 2000 Emerging concepts in the management of acute myocardial infarction in patients with diabetes mellitus J Am Coll Cardiol 35 563 568 1:STN:280:DC%2BD3c7nvFajsg%3D%3D 10.1016/S0735-1097(99)00628-2 10716456 (Pubitemid 30167012)
15. A Lomuscio M Castagnone D Vergani A Verzoni A Beltrami R Ravaglia L Pozzoni 1991 Clinical correlation between diabetic and non diabetic patients with myocardial infarction Acta Cardiol 46 543 554 1:STN:280: DyaK387mtVCnug%3D%3D 1789049
16. DA Rees JC Alcolado 2005 Animal models of diabetes mellitus Diabet Med 22 359 370 1:CAS:528:DC%2BD2MXktVOntLw%3D 10.1111/j.1464-5491.2005.01499.x 15787657 (Pubitemid 40516231)
17. PM Nishina S Lowe J Wang B Paigen 1994 Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow Metabolism 43 549 553 1:CAS:528:DyaK2cXitFCgsr8%3D 10.1016/0026-0495(94) 90194-5 8177042 (Pubitemid 24145459)
18. KR McGaffin B Zou CF McTiernan CP O'Donnell 2009 Leptin attenuates cardiac apoptosis after chronic ischaemic injury Cardiovasc Res 83 313 324 1:CAS:528:DC%2BD1MXnvVOkt7w%3D 10.1093/cvr/cvp071 19233863
19. S Gundewar JW Calvert JW Elrod DJ Lefer 2007 Cytoprotective effects of N, N, N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes Am J Physiol Heart Circ Physiol 293 H2462 H2471 1:CAS:528:DC%2BD2sXht1Wlu77N 10.1152/ajpheart.00392.2007 17630348 (Pubitemid 47605893)
20. K Srinivasan P Ramarao 2007 Animal models in type 2 diabetes research: an overview Indian J Med Res 125 451 472 1:STN:280:DC%2BD2s3os12jsA%3D%3D 17496368
21. JJ Greer DP Ware DJ Lefer 2006 Myocardial infarction and heart failure in the db/db diabetic mouse Am J Physiol Heart Circ Physiol 290 146 153 10.1152/ajpheart.00583.2005
22. H Iwatsuka A Shino Z Suzuoki 1970 General survey of diabetic features of yellow KK mice Endocrinol Jpn 17 23 35 1:CAS:528:DyaE3cXkvFKmsLs%3D 5468422
23. MP Chandler EE Morgan TA McElfresh TA Kung JH Rennison BD Hoit ME Young 2007 Heart failure progression is accelerated following myocardial infarction in type 2 diabetic rats Am J Physiol Heart Circ Physiol 293 H1609 H1616 1:CAS:528:DC%2BD2sXhtVOqtr3L 10.1152/ajpheart.01338.2006 17545473 (Pubitemid 47367207)
24. AM Cohen E Rosenmann T Rosenthal 1993 The Cohen diabetic (non-insulin-dependent) hypertensive rat model. Description of the model and pathologic findings Am J Hypertens 6 989 995 1:STN:280:DyaK2c7otlCqsQ%3D%3D 8136099
25. S Weksler-Zangen C Yagil DH Zangen A Ornoy HJ Jacob Y Yagil 2001 The newly inbred cohen diabetic rat: a nonobese normolipidemic genetic model of diet-induced type 2 diabetes expressing sex differences Diabetes 50 2521 2529 1:CAS:528:DC%2BD3MXotFGis74%3D 10.2337/diabetes.50.11.2521 11679430 (Pubitemid 33642770)
26. S Matsushima S Kinugawa T Yokota N Inoue Y Ohta S Hamaguchi H Tsutsui 2009 Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes Am J Physiol Heart Circ Physiol 297 H409 H416 1:CAS:528:DC%2BD1MXovVKitLY%3D 10.1152/ajpheart. 01332.2008 19465539
27. GD Thakker NG Frangogiannis M Bujak P Zymek JW Gaubatz AK Reddy G Taffet LH Michael ML Entman CM Ballantyne 2006 Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction Am J Physiol Heart Circ Physiol 291 H2504 H2514 1:CAS:528:DC%2BD28Xht1GnsbzP 10.1152/ajpheart.00322.2006 16731644
28. JP Huang SS Huang JY Deng LM Hung 2009 Impairment of insulin-stimulated Akt/GLUT4 signaling is associated with cardiac contractile dysfunction and aggravates I/R injury in STZ-diabetic rats J Biomed Sci 16 77 1:CAS:528:DC%2BC3cXotlaqug%3D%3D 10.1186/1423-0127-16-77 19706162
29. GY Song YJ Wu YJ Yang JJ Li HL Zhang HJ Pei ZY Zhao ZH Zeng RT Hui 2009 The accelerated post-infarction progression of cardiac remodelling is associated with genetic changes in an untreated streptozotocin-induced diabetic rat model Eur J Heart Fail 11 911 921 10.1093/eurjhf/hfp117 19789393
30. T Miki T Miura H Hotta M Tanno T Yano T Sato Y Terashima A Takada S Ishikawa K Shimamoto 2009 Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition Diabetes 58 2863 2872 1:CAS:528:DC%2BD1MXhsFKlu77M 10.2337/db09-0158 19755525
31. RA Dixon SM Davidson AM Wynne DM Yellon CC Smith 2009 The cardioprotective actions of leptin are lost in the Zucker obese (fa/fa) rat J Cardiovasc Pharmacol 53 311 317 1:CAS:528:DC%2BD1MXkslaksr4%3D 10.1097/FJC.0b013e31819d6152 19390347
32. SB Kristiansen B Lofgren NB Stottrup D Khatir JE Nielsen-Kudsk TT Nielsen HE Botker A Flyvbjerg 2004 Ischaemic preconditioning does not protect the heart in obese and lean animal models of type 2 diabetes Diabetologia 47 1716 1721 1:STN:280:DC%2BD2crnvFWktA%3D%3D 10.1007/s00125-004-1514-4 15480537 (Pubitemid 40022406)
33. E Vahtola M Louhelainen H Forsten S Merasto J Raivio P Kaheinen V Kyto I Tikkanen J Levijoki E Mervaala 2010 Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat Cardiovasc Diabetol 9 5 10.1186/1475-2840-9-5 20105289
34. TS Li M Takahashi R Suzuki T Kobayashi H Ito A Mikamo K Hamano 2006 Pravastatin improves remodeling and cardiac function after myocardial infarction by an antiinflammatory mechanism rather than by the induction of angiogenesis Ann Thorac Surg 81 2217 2225 10.1016/j.athoracsur.2005.12.065 16731157 (Pubitemid 43775566)
35. E Bonora 2006 The metabolic syndrome and cardiovascular disease Ann Med 38 64 80 1:CAS:528:DC%2BD28XhtVGnsbs%3D 10.1080/07853890500401234 16448990 (Pubitemid 43177789)
36. J Durina A Remkova 2007 Prothrombotic state in metabolic syndrome Bratisl Lek Listy 108 279 280 1:STN:280:DC%2BD2snkvVGjsQ%3D%3D 17972542
37. D Tschoepe P Roesen 1998 Heart disease in diabetes mellitus: a challenge for early diagnosis and intervention Exp Clin Endocrinol Diabetes 106 16 24 1:CAS:528:DyaK1cXhtF2gu7k%3D 10.1055/s-0029-1211944 9516054
38. M Rizzo K Berneis 2007 Small dense low-density-lipoproteins and the metabolic syndrome Diabetes Metab Res Rev 23 14 20 1:CAS:528: DC%2BD2sXitFSmsb4%3D 10.1002/dmrr.694 17080469 (Pubitemid 46152481)
39. G Anfossi I Russo G Doronzo M Trovati 2007 Relevance of the vascular effects of insulin in the rationale of its therapeutical use Cardiovasc Hematol Disord Drug Targets 7 228 249 1:CAS:528:DC%2BD1cXhsFSjurY%3D 10.2174/187152907782793581 18220724 (Pubitemid 350302900)
40. E Cersosimo RA Defronzo 2006 Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases Diabetes Metab Res Rev 22 423 436 1:CAS:528:DC%2BD28Xhtlemu7%2FN 10.1002/dmrr.634 16506274 (Pubitemid 44774046)
41. HO Steinberg AD Baron 2002 Vascular function insulin resistance and fatty acids Diabetologia 45 623 634 1:CAS:528:DC%2BD38XlsVWkt7o%3D 10.1007/s00125-002-0800-2 12107742 (Pubitemid 34810686)
42. A Zinn S Felson E Fisher A Schwartzbard 2008 Reassessing the cardiovascular risks and benefits of thiazolidinediones Clin Cardiol 31 397 403 10.1002/clc.20312 18781598
43. F Palumbo C Bianchi R Miccoli PS Del 2003 Hyperglycaemia and cardiovascular risk Acta Diabetol 40 Suppl 2 S362 S369 10.1007/s00592-003-0121-z 14704870 (Pubitemid 37549049)
44. DA Chyun LH Young 2006 Diabetes mellitus and cardiovascular disease Nurs Clin North Am 41 681 685 10.1016/j.cnur.2006.07.007 17059982 (Pubitemid 44596273)
45. M Bartnik A Norhammar L Ryden 2007 Hyperglycaemia and cardiovascular disease J Intern Med 262 145 156 1:CAS:528:DC%2BD2sXhtVens7nN 10.1111/j.1365-2796.2007.01831.x 17645583 (Pubitemid 47087633)
46. M Brownlee 2001 Biochemistry and molecular cell biology of diabetic complications Nature 414 813 820 1:CAS:528:DC%2BD38Xhtlyltg%3D%3D 10.1038/414813a 11742414 (Pubitemid 34000785)
47. G Basta AM Schmidt CR De 2004 Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes Cardiovasc Res 63 582 592 1:CAS:528:DC%2BD2cXmslertLc%3D 10.1016/j.cardiores. 2004.05.001 15306213 (Pubitemid 39078671)
48. KV Ramana D Chandra S Srivastava A Bhatnagar SK Srivastava 2003 Nitric oxide regulates the polyol pathway of glucose metabolism in vascular smooth muscle cells FASEB J 17 417 425 1:CAS:528:DC%2BD3sXitFehsrk%3D 10.1096/fj.02-0722com 12631581 (Pubitemid 36292957)
49. D Bonnefont-Rousselot 2002 Glucose and reactive oxygen species Curr Opin Clin Nutr Metab Care 5 561 568 1:CAS:528:DC%2BD38Xmslartrg%3D 10.1097/00075197-200209000-00016 12172481 (Pubitemid 40684653)
50. D Jay H Hitomi KK Griendling 2006 Oxidative stress and diabetic cardiovascular complications Free Radic Biol Med 40 183 192 1:CAS:528: DC%2BD28XksVeitA%3D%3D 10.1016/j.freeradbiomed.2005.06.018 16413400 (Pubitemid 43069343)
51. RJ Clark PM McDonough E Swanson SU Trost M Suzuki M Fukuda WH Dillmann 2003 Diabetes and the accompanying hyperglycemia impairs cardiomyocyte calcium cycling through increased nuclear O-GlcNAcylation J Biol Chem 278 44230 44237 1:CAS:528:DC%2BD3sXoslWmt7Y%3D 10.1074/jbc.M303810200 12941958 (Pubitemid 37377167)
52. M Federici R Menghini A Mauriello ML Hribal F Ferrelli D Lauro P Sbraccia LG Spagnoli G Sesti R Lauro 2002 Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells Circulation 106 466 472 1:CAS:528:DC%2BD38XmsVaguro%3D 10.1161/01.CIR.0000023043.02648.51 12135947 (Pubitemid 34803692)
53. K Watanabe RA Thandavarayan N Gurusamy S Zhang AJ Muslin K Suzuki H Tachikawa M Kodama Y Aizawa 2009 Role of 14-3-3 protein and oxidative stress in diabetic cardiomyopathy Acta Physiol Hung 96 277 287 1:CAS:528: DC%2BC3cXjt1WntLY%3D 10.1556/APhysiol.96.2009.3.3 19706371
54. M Peppa P Stavroulakis SA Raptis 2009 Advanced glycoxidation products and impaired diabetic wound healing Wound Repair Regen 17 461 472 10.1111/j.1524-475X.2009.00518.x 19614910
55. L Zheng TS Kern 2009 Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy Front Biosci 14 3974 3987 1:CAS:528: DC%2BD1MXltlWku70%3D 10.2741/3505 19273327
56. SA Madsen-Bouterse RA Kowluru 2008 Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives Rev Endocr Metab Disord 9 315 327 1:CAS:528:DC%2BD1cXht1yrurrN 10.1007/s11154-008-9090-4 18654858
57. Y Hamada H Fujii M Fukagawa 2009 Role of oxidative stress in diabetic bone disorder Bone 45 Suppl 1 S35 S38 1:CAS:528:DC%2BD1MXmtVaisr8%3D
58. MA Potenza S Gagliardi C Nacci MR Carratu' M Montagnani 2009 Endothelial dysfunction in diabetes: from mechanisms to therapeutic targets Curr Med Chem 16 94 112 1:CAS:528:DC%2BD1MXjsFGqsr4%3D 10.2174/092986709787002853 19149564
59. H Ha IA Hwang JH Park HB Lee 2008 Role of reactive oxygen species in the pathogenesis of diabetic nephropathy Diabetes Res Clin Pract 82 Suppl 1 S42 S45 1:CAS:528:DC%2BD1cXhtlGhurjK 10.1016/j.diabres.2008.09.017 18845352
60. C Figueroa-Romero M Sadidi EL Feldman 2008 Mechanisms of disease: the oxidative stress theory of diabetic neuropathy Rev Endocr Metab Disord 9 301 314 1:CAS:528:DC%2BD1cXht1yrurrO 10.1007/s11154-008-9104-2 18709457
61. FC Di S Cuzzocrea F Rossi R Marfella M D'Amico 2006 Oxidative stress as the leading cause of acute myocardial infarction in diabetics Cardiovasc Drug Rev 24 77 87 10.1111/j.1527-3466.2006.00077.x (Pubitemid 46696918)
62. MK Misra M Sarwat P Bhakuni R Tuteja N Tuteja 2009 Oxidative stress and ischemic myocardial syndromes Med Sci Monit 15 RA209 RA219 1:CAS:528: DC%2BD1MXhs1Witb7E 19789524
63. M Hori K Nishida 2009 Oxidative stress and left ventricular remodelling after myocardial infarction Cardiovasc Res 81 457 464 1:CAS:528: DC%2BD1MXhtlKitb0%3D 10.1093/cvr/cvn335 19047340
64. FA Lopez S Casado 2001 Heart failure, redox alterations and endothelial dysfunction Hypertension 38 1400 1405 10.1161/hy1101.098549
65. D Kumar BI Jugdutt 2003 Apoptosis and oxidants in the heart J Lab Clin Med 142 288 297 1:CAS:528:DC%2BD3sXpsVSgsLg%3D 10.1016/S0022-2143(03)00148-3 14647032 (Pubitemid 37487398)
66. D Kumar H Lou PK Singal 2002 Oxidative stress and apoptosis in heart dysfunction Herz 27 662 668 10.1007/s00059-002-2430-3 12439637 (Pubitemid 35415251)
67. T Backlund E Palojoki A Saraste A Eriksson P Finckenberg V Kyto P Lakkisto E Mervaala LM Voipio-Pulkki M Laine I Tikkanen 2004 Sustained cardiomyocyte apoptosis and left ventricular remodelling after myocardial infarction in experimental diabetes Diabetologia 47 325 330 1:STN:280: DC%2BD2c7jsVGlsw%3D%3D 10.1007/s00125-003-1311-5 14722653 (Pubitemid 38315370)
68. LG Melo AS Pachori D Kong M Gnecchi K Wang RE Pratt VJ Dzau 2004 Molecular and cell-based therapies for protection, rescue and repair of ischemic myocardium: reasons for cautious optimism Circulation 109 2386 2393 10.1161/01.CIR.0000128597.37025.00 15159329 (Pubitemid 38684140)
69. L Cai W Li G Wang L Guo Y Jiang YJ Kang 2002 Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway Diabetes 51 1938 1948 1:CAS:528:DC%2BD38XktlSktbc%3D 10.2337/diabetes.51.6.1938 12031984
70. D Kumar S Robertson KD Burns 2004 Evidence of apoptosis in human diabetic kidney Mol Cell Biochem 259 67 70 1:CAS:528:DC%2BD2cXisVKrs78%3D 10.1023/B:MCBI.0000021346.03260.7e 15124909 (Pubitemid 38519217)
71. S Ejaz I Chekarova A Ejaz A Sohail CW Lim 2008 Importance of pericytes and mechanisms of pericyte loss during diabetes retinopathy Diabetes Obes Metab 10 53 63 1:CAS:528:DC%2BD1cXislCrsrs%3D 17941874
72. SS Kamboj RK Vasishta R Sandhir 2010 N-acetylcysteine inhibits hyperglycemia-induced oxidative stress and apoptosis markers in diabetic neuropathy J Neurochem 112 77 91 1:CAS:528:DC%2BC3cXhs1Ghsg%3D%3D 10.1111/j.1471-4159.2009.06435.x 19840221
73. QH Tuo H Zeng A Stinnett H Yu JL Aschner DF Liao JX Chen 2008 Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis Am J Physiol Heart Circ Physiol 294 H2547 H2557 1:CAS:528:DC%2BD1cXnsVaktr8%3D 10.1152/ajpheart.01250.2007 18408125
74. T Backlund P Lakkisto E Palojoki T Gronholm A Saraste P Finckenberg E Mervaala I Tikkanen M Laine 2007 Activation of protective and damaging components of the cardiac renin-angiotensin system after myocardial infarction in experimental diabetes J Renin Angiotensin Aldosterone Syst 8 66 73 1:CAS:528:DC%2BD2sXhtVWgtLrL 10.3317/jraas.2007.018 17703432 (Pubitemid 47272469)
75. B Swynghedauw 1999 Molecular mechanisms of myocardial remodeling Physiol Rev 79 215 262 1:CAS:528:DyaK1MXhs1Cgu7k%3D 9922372
76. P Menasche 2008 Skeletal myoblasts and cardiac repair J Mol Cell Cardiol 45 545 553 1:CAS:528:DC%2BD1cXhtlSgsrrI 10.1016/j.yjmcc.2007.11.009 18187148
77. H Kim SW Kim D Nam S Kim YS Yoon 2009 Cell therapy with bone marrow cells for myocardial regeneration Antioxid Redox Signal 11 1897 1911 1:CAS:528:DC%2BD1MXotVentb0%3D 10.1089/ars.2009.2486 19203213
78. TJ Nelson A Martinez-Fernandez S Yamada C Perez-Terzic Y Ikeda A Terzic 2009 Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells Circulation 120 408 416 10.1161/CIRCULATIONAHA.109.865154 19620500
79. JG Cleland N Freemantle AP Coletta AL Clark 2006 Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE and PROACTIVE Eur J Heart Fail 8 105 110 1:CAS:528:DC%2BD28XkvFWn 10.1016/j.ejheart.2005.12.003 16387630 (Pubitemid 43012109)
80. JA Govaert RJ Swijnenburg S Schrepfer X Xie KE van der Bogt G Hoyt W Stein KJ Ransohoff RC Robbins JC Wu 2009 Poor functional recovery after transplantation of diabetic bone marrow stem cells in ischemic myocardium J Heart Lung Transplant 28 1158 1165 10.1016/j.healun.2009.06.018 19782602
81. MT Bdel Aziz MF El-Asmar M Haidara HM Atta NK Roshdy LA Rashed D Sabry MA Youssef AT Bdel Aziz M Moustafa 2008 Effect of bone marrow-derived mesenchymal stem cells on cardiovascular complications in diabetic rats Med Sci Monit 14 BR249 BR255
82. JH Li N Zhang JA Wang 2008 Improved anti-apoptotic and anti-remodeling potency of bone marrow mesenchymal stem cells by anoxic pre-conditioning in diabetic cardiomyopathy J Endocrinol Invest 31 103 110 1:STN:280: DC%2BD1c3gsVWguw%3D%3D 18362500 (Pubitemid 351596969)
83. N Zhang J Li R Luo J Jiang JA Wang 2008 Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy Exp Clin Endocrinol Diabetes 116 104 111 1:CAS:528: DC%2BD1cXjslCjtrw%3D 10.1055/s-2007-985154 18286426 (Pubitemid 351363380)