Locked onto the target: Increasing the efficiency of antagomirzymes using locked nucleic acid modifications

Biochemistry

Volumn 49, Issue 44, 2010, Pages 9449-9456

  Kaur, Harleen ^a   Scaria, Vinod ^a   Maiti, Souvik ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CLEAVAGE EFFICIENCY; FUNCTIONAL ACTIVITIES; FUNCTIONAL VALIDATION; IN-VITRO; LOCKED NUCLEIC ACID; LUCIFERASE REPORTER ASSAYS; MICRORNAS; Q-RT-PCR; QUANTITATIVE ESTIMATES; QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION; RELATIVE ACTIVITIES; SUBSTRATE BINDING;

DNA; FUNCTIONAL POLYMERS; NUCLEIC ACIDS;

POLYMERASE CHAIN REACTION;

ANTAGOMIRZYME; DNA; LOCKED NUCLEIC ACID; MICRORNA; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; DNA MODIFICATION; ENZYME METABOLISM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; NUCLEIC ACID HYBRIDIZATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION;

BASE SEQUENCE; CELL LINE; CLONING, MOLECULAR; DNA, CATALYTIC; GENES, REPORTER; HUMANS; LUCIFERASES; MICRORNAS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; POLYMERASE CHAIN REACTION; SUBSTRATE SPECIFICITY;

EID: 78149355643     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101185k     Document Type: Article

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