In vivo metabolism of chemical constituents of traditional Chinese Materia Medica: Research and discussion

Journal of International Pharmaceutical Research

Volumn 37, Issue 5, 2010, Pages 321-328

  Qiu, Feng ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Activity; In vivo, metabolism; Isolation; Metabolites; Structural elucidation; Traditional Chinese materia medica constituents

Indexed keywords

ALOIN; BERBERINE; GARDENOSIDE; GENIPOSIDE; GENTIOPICRIN; GLYCYRRHIZIC ACID; ICARIIN; ISOORIENTIN; PAEONIFLORIN; PLANT GLYCOSIDE; SAIKOSAPONIN; SENNOSIDE; SWERTIAMARIN; UNCLASSIFIED DRUG;

BIOTRANSFORMATION; CHEMICAL COMPOSITION; CHINESE MEDICINE; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG EFFICACY; DRUG METABOLISM; GASTROINTESTINAL TRACT; IN VIVO STUDY; LIVER; MEDICAL RESEARCH; REVIEW;

EID: 78149343522     PISSN: 16740440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (46)

1. Kim DH, Jung EA, Sohng IS, et al. Intestinal bacterial metabolism of flavonoids and its relation to some biological activities[J].Arch Pharm Res, 1998, 21(1): 17-23.
2. Hattori M, Shu YZ, Shimizu M, et al. Metabolism of paeoniflorin and related compounds by human intestinal bacteria[J]. Chem Pharm Bull, 1985, 33: 3838-3846.
3. Hattori M, Namba T, Akao T, et al. Metabolism of sennosides by human intestinal bacteria[J]. Pharmacology, 1988, 36 (Suppl 1): 172-179.
4. Akao T, Che QM, Kobashi K, et al. Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins[J]. Appl Environ Microbiol, 1994,60(3):1041-1043.
5. Akao T, Che QM, Kobashi K, et al. A purgative action of barbaloin is induced by Eubacterium sp. strain BAR, a human intestinal anaerobe, capable of transforming barbaloin to aloe-emodin anthrone[J]. Biol Pharm Bull, 1996, 19(1): 136-138.
6. Che QM, Akao T, Hattori M, et al. Isolation of a human intestinal bacterium capable of transforming barbaloin to aloe-emodin anthrone[J]. Planta Med, 1991, 57(1):15-19.
7. Hattori M, Sakamoto T, Kobashi K, et al. Metabolism of glycyrrhizin by human intestinal flora[J]. Planta Med, 1983, 48(5):38-42.
8. Hattori M, Shu YZ, el-Sedawy AI, et al. Metabolism of homoorientin by human intestinal bacteria[J]. J Nat Prod, 1988, 51(5):874-878.
9. El-Sedawy AI, Shu YZ, Hattori M, et al. Metabolism of swertiamarin from Swertia japonica by human intestinal bacteria [J]. Planta Med, 1989, 55: 147-150.
10. El-Sedawy AI, Hattori M, Kobayashi K, et al. Metabolism of gentiopicroside (gentiopicrin) by human intestinal bacteria[J]. Chem Pharm Bull, 1989, 37:2435-2437.
11. Kawata Y, Hattori M, Akao T, et al. Formation of nitrogen-containing metabolites from geniposide and gardenoside by human intestinal bacteria[J]. Planta Med, 1991, 57(6):536-542.
12. Kida H, Akao T, Meselhy MR, et al. Enzymes responsible for the metabolism of saikosaponins from Eubacterium sp. A- 44, a human intestinal anaerobe[J]. Biol Pharm Bull, 1997, 20(12):1274-1278.
13. Akao T, Hattori M, Namba T, et al. Metabolic activation of crude drug components by intestinal bacterial enzymes[J]. Med Pharm Soc Wanan-Yaku, 1992, 9: 1-13.
14. Bursztyka J, Perdu E, Tulliez J, et al. Comparison of genistein metabolism in rats and humans using liver microsomes and hepatocytes[J]. Food Chem Toxicol, 2008, 46(3):939-948.
15. Brand W, Boersma MG, Bik H, et al. Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples[J]. Drug Metab Dispos, 2010,38(4):617-625.
16. Wong YC, Zhang L, Lin G, et al. Intestinal first-pass glucuronidation activities of selected dihydroxyflavones[J]. Int J Pharm, 2009, 366(1/2):14-20.
17. Stohs SJ, Reinke LA, El-Olemy MM. Metabolism in vitro of digitoxigenin by rat liver homogenates[J]. Biochem Pharmacol, 1971, 20(2):437-446.
18. Obatomi DK, Thanh NT, Brant S, et al. The toxic mechanism and metabolic effects of atractyloside in precision-cut pig kidney and liver slices[J]. Arch Toxicol, 1998, 72: 524-530.
19. Sun H, Lv HT, Zhang YM, et al. A rapid and sensitive UPLC-ESI MS method for analysis of isofraxidin, a natural antistress compound, and its metabolites in rat plasma[J]. J Sep Sci, 2007, 30: 3202-3206.
20. Wang X, Sun W, Sun H, et al. Analysis of the constituents in the rat plasma after oral administration of Yin Chen Hao Tang by UPLC/Q-TOF-MS/MS[J]. J Pharm Biomed Anal, 2008, 46(3):477-90.
21. Zeng YC, Qiu F, Liu Y, et al. Isolation and identification of phase 1 metabolites of demethoxycurcumin in rats[J]. Drug Metab Dispos, 2007, 35(9): 1564-1573.
22. He XJ, Li JK, Gao H, et al. Four new andrographolide metabolites in rats[J]. Tetrahedron, 2003, 59(34): 6603-6607.
23. He XJ, Li JK, Gao H, et al. Identification of a rare sulfonic acid metabolite of andrographolide in rats[J]. Drug Metab Dispos, 2003, 31(8): 983-985.
24. Cui L, Chan W, Qiu F, et al. Identification of four urea adducts of andrographolide in humans[J]. Drug Metab Lett, 2008, 2(4): 261-268.
25. Lou Y, Zhang H, He H, et al. Isolation and identification of phase 1 metabolites of curcumenol in rats[J/OL]. Drug Metab Dispos, 2010, published online before print. [2010-08-03]. http://dmd.aspetjournals.org/content/early/ 2010/08/03/dmd.110.034215.full.pdf+html.
26. Qiu F, Zhu ZY, Kang N, et al. Isolation and identification of urinary metabolites of berberine in rats and humans [J]. Drug Metab Dispos, 2008, 36(11): 2159-2165.
27. He XJ, Li JK, Gao H, et al. Six new andrographolide metabolites in rats[J]. Chem Pharm Bull, 2003, 51(5): 586-589.
28. Cui L, Qiu F, Yao XS. Isolation and identification of seven glucuronide conjugates of andrographolide in human urine[J]. Drug Metab Dispos, 2005, 33(4): 555-562.
29. Cui L, Qiu F, Wang NL, et al. Four new andrographolide metabolites in human urine[J]. Chem Pharm Bull, 2004, 52(6): 772-775.
30. Xia HJ, Qiu F, Zhu S, et al. Isolation and identification of ten metabolites of breviscapine in rat urine[J]. Biol Pharm Bull, 2007, 30(7): 1308-1316.
31. Paul D, Standifer KM, Inturrisi CE, et al. Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite[J]. J Pharmacol Exp Ther, 1989, 251(2): 477-483.
32. Francés B, Gout R, Campistron G, et al. Morphine-6-glucuronide is more mu-selective and potent in analgesic tests than morphine[J]. Prog Clin Biol Res, 1990, 328: 477-480.
33. Dahan A, van Dorp E, Smith T, et al. Morphine-6-glucuronide (M6G) for postoperative pain relief[J]. Eur J Pain, 2008, 12(4):403-411.
34. Kobayashi K, Nishimura T, Kusaka M, et al. Metabolism of sennoside by human intestinal bacteria[J]. Planta Med, 1980, 40:225-236.
35. Huang J, Yuan L, Wang X, et al. Icariine and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro[J]. Life Sci, 2007, 81(10) : 832-840.
36. Qiu F, Komatsu K, Saito K, et al. Pharmacological properties of traditional medicines. XXI. Analysis of plasma, urine and bile of rats after oral administration of water extract of mori cortex[J]. J Nat Med, 1996, 50(2): 103-108.
37. Zhaxi M, Chen LX, Li X, et al. Three major metabolites of mulberroside A in rat intestinal contents and feces[J]. Planta Med, 2010, 76(4):362-364.
38. Qiu F, Komatsu K, Saito K, et al. Pharmacological properties of traditional medicines. XXII. Pharmacokinetic study of mulberroside A and its metabolites in rat[J]. Biol Pharm Bull, 1996, 19(11): 1463-1467.
39. Qiu F, Yao X, Kano Y. Elucidation of the bioactive constituents in traditional Chinese medicine"Mori Cortex". Studies in plant science6, advances in plant glycosides[J]. Chem Biol, 1997, 281-289.