A rapid and sensitive UPLC-ESI MS method for analysis of isofraxidin, a natural antistress compound, and its metabolites in rat plasma

Journal of Separation Science

Volumn 30, Issue 18, 2007, Pages 3202-3206

  Sun, Hui ^a,b   Lv, Haitao ^b   Zhang, Yanmei ^b   Wang, Xijun ^b   Bi, Kaishun ^a   Cao, Hongxin ^c  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

^c INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

Isofraxidin; Metabolite; Rat; UPLC ESI MS

Indexed keywords

ANTIFATIGUE; ANTISTRESS; IMMUNO-ACCOMONDATING EFFECTS; ISOFRAXIDIN;

DRUG PRODUCTS; EXTRACTION; MASS SPECTROMETRY; METABOLITES; MOLECULAR POLARITY; RATS;

LIQUID CHROMATOGRAPHY;

5 HYDROXYL 6,7 DIMETHOXYCOUMARIN; 5,6 DIHYDROXYL 7 METHOXYCOUMARIN; DRUG METABOLITE; ISOFRAXIDIN; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CALIBRATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ISOLATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRAPERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

ANIMALS; BIOLOGICAL PRODUCTS; CHROMATOGRAPHY, LIQUID; COUMARINS; MALE; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TIME FACTORS;

ELEUTHEROCOCCUS SENTICOSUS; RATTUS;

EID: 38049079843     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200700251     Document Type: Article

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