Isolation and identification of seven glucuronide conjugates of andrographolide in human urine

Drug Metabolism and Disposition

Volumn 33, Issue 4, 2005, Pages 555-562

  Cui, Liang ^a   Qiu, Feng ^a   Yao, Xinsheng ^a,b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Traditional Chinese Med/N P R C   (China)

Author keywords

[No Author keywords available]

Indexed keywords

14 DEOXY 12 HYDROXY ANDROGRAPHOLIDE 19 O BETA GLUCURONIDE; 14 DEOXY 12(13) EN ANDROGRAPHOLIDE 19 O BETA GLUCURONIDE; 14 DEOXYANDROGRAPHOLIDE 19 O BETA GLUCURONIDE; 3 OXOANDROGRAPHOLIDE 19 O BETA GLUCURONIDE; ANDROGRAPHOLIDE; ANDROGRAPHOLIDE 19 O [6' METHYL BETA GLUCURONIDE]; ANDROGRAPHOLIDE 19 O BETA GLUCURONIDE; DRUG METABOLITE; ISOANDROGRAPHOLIDE 19 O BETA GLUCURONIDE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITERPENES; GLUCURONIDES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ANDROGRAPHIS;

EID: 15344339360     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.104.001958     Document Type: Article

References (17)

1. Amroyan E, Gabrielian E, Panossian A, Wikman G, and Wagnar H (1999) Inhibitory effect of andrographotide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine 6:27-31.
2. Basak A, Cooper S, Roberge AG, Banik UK, Chretien M, and Seidah NG (1999) Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. Biochem J 338:107-113.
3. Cui L, Qiu F, Wang NL, and Yao XS (2004) Four new andrographolide metabolites in human urine. Chem Pharm Bull 52:772-775.
4. Handa SS and Sharma A (1990) Hepatoprotective activity of andrographolide against galactosamine & paracetamol intoxication in rats. Indian J Med Res 92:284-292.
5. He XJ, Li JK, Gao H, Qiu F, Hu K, Cui XM, and Yao XS (2003a) Four new andrographolide metabolites in rats. Tetrahedron 59:6603-6607.
6. He XJ, Li JK, Gao H, Qiu F, Hu K, Cui XM, and Yao XS (2003b) Six new andrographolide metabolites in rats. Chem Pharm Bull 51:586-589.
7. He XJ, Li JK, Gao H, Qiu F, Hu K, Cui XM, and Yao XS (2003c) Identification of a rare sulfonic acid metabolite of andrographolide in rats. Drug Metab Dispos 31:983-985.
8. Kumar RA, Sridevi K, Kumar NV, Nanduri S, and Rajagopal SJ (2004) Anticancer and immunostimulatory compounds from Andrographis paniculata. J Ethnopharmacol 92:291-295.
9. Matsuda T, Kuroyanagi M, Sugiyama S, Umehara K, Ueno A, and Nishi K (1994) Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. Chem Pharm Bull 42:1216-1225.
10. Meng ZM (1981) Studies on the structure of the adduct of andrographolide with sodium hydrogen sulfite. Acta Pharmacol Sin 16:571-575.
11. Panossian A, Hovhannisyan A, Mamikonyan G, Abrahamian H, Hambardzumyan E, Gabrielian E, Goukasova G, Wikman G, and Wagner H (2000) Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human. Phytomedicine 7:351-364.
12. Rajagopal S, Kumar RA, Deevi DS, Satyanarayana C, and Rajagopalan R (2003) Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. J Exp Ther Oncol 3:147-158.
13. Shen YC, Chen CF, and Chiou WF (2000) Suppression of rat neutrophil reactive oxygen species production and adhesion by the diterpenoid lactone andrographolide. Planta Med 66:314-317.
14. Shen YC, Chen CF, and Chiou WF (2002) Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect. Br J Pharmacol 135:399-406.
15. Shukla B, Visen PKS, Patnaik GK, and Dhawan BN (1992) Choleretic effect of andrographolide in rats and guinea pigs. Planta Med 58:146-149.
16. Stahl E (1969) Thin-layer Chromatography: A Laboratory Handbook. Springer-Verlag, New York.
17. Yu BC, Hung CR, Chen WC, and Cheng JT (2003) Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats. Planta Med 69:1075-1079.