Investigation of PEG crystallization in frozen PEG-sucrose-water solutions: II. Characterization of the equilibrium behavior during freeze-thawing

Journal of Pharmaceutical Sciences

Volumn 99, Issue 11, 2010, Pages 4510-4524

  Bhatnagar, Bakul S ^a   Martin, Susan M ^b   Teagarden, Dirk L ^b   Shalaev, Evgenyi Y ^c   Suryanarayanan, Raj ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b PFIZER INC   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Cryo protectant; Crystallization; Eutectic melting; Freeze concentration; Freeze drying; Freeze thawing; Freezing point depression; Low temperature XRD; Lyophilization; PEG; Sucrose; Ternary phase diagram

Indexed keywords

MACROGOL; SUCROSE;

AQUEOUS SOLUTION; ARTICLE; CRYSTALLIZATION; FREEZE DRYING; FREEZE THAWING; HEATING; MELTING POINT; X RAY DIFFRACTION;

EID: 78149311529     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22182     Document Type: Article

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